Article
Oncology
Zhenxing Lu, Yintong Teng, Xiaodong Ning, Hao Wang, Weijing Feng, Caiwen Ou
Summary: This study found that among patients with stage I and stage II classic Hodgkin lymphoma (cHL), the risk of cardiovascular disease (CVD) mortality exceeded that of cHL mortality over time, with CVD becoming the leading cause of death.
Editorial Material
Hematology
Peter W. M. Johnson
Summary: The study shows that treating relapsed or refractory HL with PD-1 antibody nivolumab has a high response rate, making it an attractive option for second-line therapy.
Letter
Immunology
Janina Trauth, Thomas Discher, Moritz Fritzenwanker, Can Imirzalioglu, Tobias Arnold, Dagmar Steiner, Elvira Richter, Laura Crisponi, Bodo Grimbacher, Susanne Herold
Summary: Mycobacterium genavense infection, a rare nontuberculous mycobacteria infection, usually occurs in heavily immunocompromised patients. We report a case of disseminated M. genavense infection preceding Hodgkin lymphoma in a patient without obvious risk factors for this infection.
EMERGING INFECTIOUS DISEASES
(2022)
Review
Medicine, General & Internal
Pauline Brice, Eric de Kerviler, Jonathan W. Friedberg
Summary: Classical Hodgkin lymphoma is a relatively common lymphoma that is generally considered highly curable with standard first-line chemotherapy and radiotherapy, although some patients may not be cured or may experience late toxic effects leading to premature death. Recent changes in the gold standard of chemotherapy, now often including immunotherapy in relapse settings, have further impacted treatment outcomes.
Article
Hematology
Simone de Vries, Inge M. Krul, Michael Schaapveld, Cecile P. M. Janus, Saskia E. Rademakers, Judith M. Roesink, Marten R. Nijziel, Berthe M. P. Aleman, Flora E. van Leeuwen
Summary: Male survivors of Hodgkin lymphoma who received chest radiotherapy have a significantly increased risk of breast cancer. The risk is higher for those who received chest radiotherapy and alkylating chemotherapy compared to those who only received chest radiotherapy.
Article
Pathology
Jonathan R. Fromm, Claire Tang, Kikkeri N. Naresh
Summary: Using flow cytometric analysis, it was found that the percentage of HRS cells is associated with treatment response and patient age, and the subtype also affects the proportion of B cells.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Environmental Sciences
Joseph Boyle, Mary H. Ward, James R. Cerhan, Nathaniel Rothman, David C. Wheeler
Summary: Many studies have found associations between neighborhood deprivation and disease, emphasizing the importance of social determinants of health. However, when studying diseases with long latency periods such as cancers, considering the timing of exposures for deprivation becomes more important.
ENVIRONMENTAL RESEARCH
(2023)
Article
Medicine, General & Internal
H. Dean Hosgood, Meghan Davitt, Richard Cawthon, Stephanie J. Weinstein, Batel Blechter, Jason Y. Y. Wong, Mohammad L. Rahman, Wei Hu, Satu Mannisto, Demetrius Albanes, Nathaniel Rothman, Qing Lan
Summary: This study suggests that a higher fraction of mitochondrial DNA with breaks is associated with an increased risk of non-Hodgkin lymphoma (NHL).
Article
Endocrinology & Metabolism
Barbara Swiechowicz, Anna Kasielska-Trojan, John T. Manning, Boguslaw Antoszewski
Summary: Hashimoto thyroiditis and Graves' disease are autoimmune thyroid diseases that occur more frequently in women. The 2D:4D digit ratio may be associated with prenatal estrogen and testosterone levels. In women, higher 2D:4D is found in those with Hashimoto thyroiditis, while lower 2D:4D is found in those with Graves' disease.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Environmental Sciences
Joseph Boyle, Mary H. Ward, James R. Cerhan, Nathaniel Rothman, David C. Wheeler
Summary: This study assessed the association between historic environmental pollutant emissions and chemical mixtures in house dust with non-Hodgkin lymphoma (NHL). The results showed a significant positive association between RSEI scores and NHL in long-term residents in Detroit, while significant inverse associations were found in two other study centers. These findings highlight the importance of considering historic and cumulative environmental exposures and using residential histories for diseases with long latency periods like NHL.
ENVIRONMENTAL RESEARCH
(2023)
Article
Oncology
Anita Kumar, Carla Casulo, Ranjana H. Advani, Elizabeth Budde, Paul M. Barr, Connie L. Batlevi, Philip Caron, Louis S. Constine, Savita Dandapani, Esther Drill, Pamela Drullinsky, Jonathan W. Friedberg, Clare Grieve, Audrey Hamilton, Paul A. Hamlin, Richard T. Hoppe, Steven M. Horwitz, Ashlee Joseph, Niloufer Khan, Leana Laraque, Matthew J. Matasar, Alison J. Moskowitz, Ariela Noy, Maria Lia Palomba, Heiko Schoder, David J. Straus, Shreya Vemuri, Joanna Yang, Anas Younes, Andrew D. Zelenetz, Joachim Yahalom, Craig H. Moskowitz
Summary: The multicenter study showed that the BV+AVD regimen for newly diagnosed early-stage unfavorable-risk Hodgkin lymphoma is highly effective and well-tolerated. In patients with negative PET-4 results, consolidative radiation can be safely reduced or eliminated.
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Genetics & Heredity
Hui-Hui Fan, Lei Cui, Xiao-Xia Jiang, Ya-Dan Song, Shu-Shu Liu, Ke-Yun Wu, Hao-Jia Dong, Miao Mao, Begench Ovlyakulov, Hong-Mei Wu, Jian-Hong Zhu, Xiong Zhang
Summary: This study found that genetic variants of CLEC16A are associated with an increased risk of Parkinson's disease (PD) in the Han Chinese population. Specifically, the rs6498169 and rs7200786 variants were significantly associated with PD susceptibility, and rs6498169 was also associated with a specific subtype of PD. Functional annotation analysis suggested that rs6498169 may affect transcription factor binding and target gene expression. These findings highlight the pleiotropic role of CLEC16A and strengthen the association between PD and autoimmune diseases.
FRONTIERS IN GENETICS
(2022)
Review
Microbiology
Eric M. Brown, Jon Clardy, Ramnik J. Xavier
Summary: Metabolites from commensal gut microbes have significant impacts on host health through immune recognition and modulation of various metabolic pathways. The gut microbiota plays a dual role in transforming and synthesizing lipids, as well as breaking down dietary lipids to generate secondary metabolites with host regulatory properties. Recent research has highlighted the signaling activities of lipids, which have potential effects on host health and physiology. This review focuses on the functions of bioactive lipids in mammalian physiology, with a particular emphasis on immunity and metabolism.
CELL HOST & MICROBE
(2023)
Article
Immunology
Laura E. Martinez, Larry I. Magpantay, Yu Guo, Priya Hegde, Roger Detels, Shehnaz K. Hussain, Marta Epeldegui
Summary: The study revealed significantly higher levels of EVs bearing PD-L1, CD40, TNF-RII, and/or IL-6R alpha in AIDS-NHL cases compared to controls. EVs carrying these molecules were found to be significantly and positively associated with AIDS-NHL risk, suggesting their potential as biomarkers for early detection of NHL in PLWH.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Hematology
Sarah A. A. Milgrom, Jihyun Kim, Qinglin Pei, Inki Lee, Bradford S. S. Hoppe, Yue Wu, David Hodgson, Sandy Kessel, Kathleen M. M. McCarten, Kenneth Roberts, Andrea C. C. Lo, Peter D. D. Cole, Kara M. M. Kelly, Steve Y. Y. Cho
Summary: The Children's Oncology Group AHOD0831 study found that in high-risk Hodgkin lymphoma, using a positron emission tomography (PET) response-adapted approach, slow early responders (SERs) received more intensive therapy than rapid early responders (RERs). Furthermore, baseline PET-based characteristics may improve risk stratification. The study results showed that for RERs, low baseline total lesion glycolysis (TLG) was associated with good event-free survival (EFS), while high baseline TLG was associated with poor EFS. Therefore, patients with a high upfront tumor burden may benefit from intensified therapy, even if they achieve RER status.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Oncology
Elham Kharazmi, Kristina Sundquist, Jan Sundquist, Mahdi Fallah, Justo Lorenzo Bermejo
Summary: Women who undergo surgical removal of the gallbladder may have an increased risk of developing ovarian, breast, and uterine cancer, with the highest risk occurring within the first 6 months after surgery. It is important to screen these women for these cancers and consider intensifying cancer screening in the long-term follow-up.
Article
Biotechnology & Applied Microbiology
Li-Peng Hu, Wuqing Huang, Xu Wang, Chunjie Xu, Wei -Ting Qin, Dongxue Li, Guangang Tian, Qing Li, Yaoqi Zhou, Suyuan Chen, Hui-Zhen Nie, Yujun Hao, Jian Song, Xue-Li Zhang, Jan Sundquist, Kristina Sundquist, Jun Li, Shu-Heng Jiang, Zhi-Gang Zhang, Jianguang Ji
Summary: Research suggests that reversing gut fungal dysbiosis with terbinafine can inhibit the development of colorectal cancer (CRC). Terbinafine reduces fungal load, suppresses tumor cell proliferation, inhibits fungus-induced myeloid-derived suppressor cell expansion, and restores antitumor immune response.
Article
Oncology
Youqing Wang, Luyao Zhang, Fang Han, Runhua Li, Yongran Cheng, Xiyi Jiang, Liangyou Wang, Jinfei Chen, Jianguang Ji, Yuhua Zhang, Tianhui Chen
Summary: This study used period analysis to provide the most up-to-date 5-year relative survival rates for liver cancer patients in Taizhou, eastern China, and found significant improvement in the 5-year relative survival rates for liver cancer patients in the region from 2004 to 2018.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Guoqiao Zheng, Jan Sundquist, Kristina Sundquist, Jianguang Ji
Summary: Individuals with a family history of both CRCa-1 and CRCa-2 have a lower risk of CRC compared to individuals with only CRCa-1, which is related to the age of diagnosis of CRC in FDR and family relationships.
Article
Oncology
Jianguang Ji, Jan Sundquist, Kristina Sundquist, Guoqiao Zheng
Summary: This study found that the risk of lung cancer (LCa) is similar when a first-degree relative (FDR) is diagnosed with either LCa-1 or LCa-2. The risk is higher when the FDR is diagnosed with LCa-2 within a certain period of time after the first primary cancer. The risk of LCa is also increased for certain types of first primary cancers, such as ovarian, nervous system, upper aerodigestive tract, cervix, and non-Hodgkin lymphoma.
Editorial Material
Cell Biology
Yongye Huang, Jianguang Ji, Qi Zhao, Jun Song
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, General & Internal
Deqiang Zheng, Ning Li, Rui Hou, Xiaoyu Zhang, Lijuan Wu, Jan Sundquist, Kristina Sundquist, Jianguang Ji
Summary: By combining observational and mendelian randomization studies, this research found that the use of GLP-1 RAs significantly decreases the risk of diabetic retinopathy in patients with type 2 diabetes.
Article
Medicine, General & Internal
Naiqi Zhang, Jan Sundquist, Kristina Sundquist, Jianguang Ji
Summary: This study investigated whether the use of proguanil and atovaquone could reduce the risk of CRC in individuals with a family history of the disease, and found a significant negative association between proguanil/atovaquone use and CRC risk. Furthermore, there were significant dose- and duration-response correlations observed in the study.
Article
Cardiac & Cardiovascular Systems
Jun Xiao, Jianguang Ji, Naiqi Zhang, Xi Yang, Keyuan Chen, Liangwan Chen, Wuqing Huang
Summary: This study assessed the association between genetically predicted lipid traits, their modification through licensed or investigational targets, and heart failure. The results showed a significant relationship between genetically predicted LDL-C, TG, HDL-C, and ApoB levels and heart failure, mainly mediated by coronary heart disease. Drug target analysis identified PCSK9, CETP, and LPL as potential targets for heart failure prevention.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Yishan Liu, Jan Sundquist, Kristina Sundquist, Deqiang Zheng, Jianguang Ji
Summary: This study examined the long-term impact of childhood cancer on parental mental health, with a focus on potential sex differences between mothers and fathers. The results showed that the mental health of both parents was continuously affected by the diagnosis, but the impact was more severe for mothers. Therefore, tailored psychological services or interventions are necessary to support parents of children with cancer.
Article
Cardiac & Cardiovascular Systems
Ning Li, Xiaoyu Zhang, Meng Zhang, Lijuan Wu, Changwei Li, Yuesong Pan, Wei Wang, Jianguang Ji, Deqiang Zheng
Summary: This study used Mendelian randomization analysis to investigate the association between dyslipidemia and diabetic retinopathy (DR). The findings suggest a negative association between high-density lipoprotein cholesterol (HDL-C) levels and the development of DR, while CETP inhibitors were not found to be associated with DR. These results indicate a potential protective role of HDL-C in preventing DR.
Article
Oncology
Shan Huang, Nai-Qi Zhang, Chun-Jie Xu, Wu-Qing Huang, Dong-Xue Li, Jun Li, Lin-Li Yao, Kristina Sundquist, Jan Sundquist, Shu-Heng Jiang, Xin Xing, Li-Peng Hu, Zhi-Gang Zhang, Jianguang Ji, Xue-Li Zhang
Summary: Combined administration of dipyridamole and aspirin enhances the anti-cancer effect of aspirin against colorectal cancer by inducing endoplasmic reticulum stress and apoptosis.
Letter
Urology & Nephrology
Kari Hemminki, Jianguang Ji, Jan Sundquist
Article
Public, Environmental & Occupational Health
Yuying Wang, Yujie Zhang, Meng Zhang, Xiaoyu Zhang, Haibin Li, Youxin Wang, Wei Wang, Jianguang Ji, Lijuan Wu, Deqiang Zheng
Summary: This study aimed to explore the prevalence of adverse reactions to COVID-19 vaccination and provide direct evidence of vaccine safety for the elderly and those with underlying medical conditions. The prevalence of adverse reactions in these populations was found to be similar to that of the general population, suggesting that vaccination is safe for them.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2023)
Article
Medicine, General & Internal
Naiqi Zhang, Yanni Li, Jan Sundquist, Kristina Sundquist, Jianguang Ji
Summary: This study identified eight druggable target genes for breast cancer and suggested that raloxifene is an effective chemoprevention against breast cancer, using Mendelian randomization analysis and population-based validation.