Review
Behavioral Sciences
Katelyne Tursini, Steven Le Cam, Raymund Schwan, Gregory Gross, Karine Angioi-Duprez, Jean-Baptiste Conart, Irving Remy, Florent Bernardin, Vincent Laprevote, Elea Knobloch, Tiphaine Ricaud, Aline Rahnema, Valerie Louis-Dorr, Thomas Schwitzer
Summary: This article discusses the use of visual electrophysiology and neuropsychological assessment to improve the diagnosis and treatment of patients with bipolar disorder. The results show that the combination of these measurement methods can provide more information about the specific damages and pathophysiological characteristics of bipolar disorder patients.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Psychology, Clinical
Hanne Lie Kjaerstad, Fillip Ferreira Eikeseth, Maj Vinberg, Lars Vedel Kessing, Kamilla Miskowiak
Summary: Recent research found that patients with bipolar disorder (BD) exhibit diverse neurocognitive impairments, which are associated with affective cognition deficits. This study replicated previous findings of neurocognitive subgroups in BD patients, and revealed a link between neurocognition patterns and impairments in affective cognition. Additionally, first-degree relatives of cognitively impaired patients showed signs of inherited risk for BD.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Clinical Neurology
Laura Montejo, Esther Jimenez, Brisa Sole, Andrea Murru, Nestor Arbelo, Antonio Benabarre, Marc Valenti, Derek Clougher, Manuel Arturo Rodriguez, Roger Borras, Anabel Martinez-Aran, Eduard Vieta, Caterina del Mar Bonnin, Carla Torrent
Summary: This study found significant cognitive heterogeneity in older adults with bipolar disorder, with patients being divided into three distinct clusters based on the severity of cognitive impairment. Factors such as older age, late onset, higher number of psychiatric admissions, and lower psychosocial functioning were associated with greater cognitive impairment. Conversely, factors like younger age, more education, and higher estimated IQ were associated with preserved cognitive functioning.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Caterina del Mar Bonnin, Brisa Sole, Maria Reinares, Aitana Garcia-Estela, Ludovic Samalin, Anabel Martinez-Aran, Jose Sanchez-Moreno, Francesc Colom, Eduard Vieta, Diego Hidalgo-Mazzei
Summary: The study investigated the impact of specific cognitive deficits on the use of a psychoeducational smartphone app in patients with bipolar disorder. Results showed that cognitive deficits did not significantly affect the usability and retention of the app.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychology, Clinical
Julian Macoveanu, Jeff Zarp Petersen, Patrick M. Fisher, Lars Vedel Kessing, Gitte Moos Knudsen, Kamilla Woznica Miskowiak
Summary: This study used fMRI to investigate cognitive deficits in patients with bipolar disorder and unipolar disorder. The results showed that these patients had hypo-activity in certain brain regions associated with cognitive control, as well as hyper-activity in other brain regions associated with default mode network.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Yolanda Canada, Ana Sabater, Pilar Sierra, Vicent Balanza-Martinez, Michael Berk, Seetal Dodd, Pablo Navalon, Lorenzo Livianos, Ana Garcia-Blanco
Summary: The study found that individuals with bipolar disorder, regardless of benzodiazepine treatment, exhibit impairments in memory and processing speed, but those using benzodiazepines showed additional impairments in executive functioning.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2021)
Article
Neurosciences
Ivan J. J. Torres, Ruiyang Ge, Alexander McGirr, Fidel Vila-Rodriguez, Sharon Ahn, Jayasree Basivireddy, Nazlin Walji, Sophia Frangou, Raymond W. W. Lam, Lakshmi N. N. Yatham
Summary: This study evaluated whether intermittent theta burst stimulation (iTBS) leads to cognitive improvements and increased hippocampal volumes in bipolar depression. The results showed that although there were no significant improvements in cognitive variables, the active group did exhibit an increase in left hippocampal volume, which was associated with improvements in nonverbal memory. These findings suggest the presence of prefrontal-temporal neuroplasticity that may support cognitive change in future studies of iTBS in bipolar disorder.
DIALOGUES IN CLINICAL NEUROSCIENCE
(2023)
Article
Clinical Neurology
Jeff Zarp Petersen, Cristina Varo, Cecilie F. Skovsen, Caroline V. Ott, Hanne L. Kjaerstad, Eduard Vieta, Catherine J. Harmer, Gitte M. Knudsen, Lars V. Kessing, Julian Macoveanu, Kamilla W. Miskowiak
Summary: Cognitive impairment in bipolar disorder originates from the failure to recruit key regions in the cognitive control network (CCN) and to suppress task-irrelevant default mode network (DMN) activity during cognitive performance.
Article
Neurosciences
Kinjal Doshi, Stacey L. Henderson, Qianqian Fan, Kian F. Wong, Julian Lim
Summary: The study found that a cognition-focused mindfulness-based intervention had significant improvements in global cognition and delayed memory in MCI patients, although it did not show advantages over usual treatment. Depression did not change in the MBT group, and only reductions in depression were associated with improvements in cognitive functioning in this group.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Keera N. Fishman, Andrea R. Ashbaugh, Richard H. Swartz
Summary: The study found that goal setting had a positive impact on cognitive function after stroke, particularly in executive function, attention/working memory, and verbal learning. This suggests that more than 3 months after stroke, vascular cognitive impairment is not a fixed deficit, and motivation may play a role in improvement.
Article
Psychiatry
Kuniyoshi Toyoshima, Yuki Kako, Atsuhito Toyomaki, Yusuke Shimizu, Teruaki Tanaka, Shin Nakagawa, Takeshi Inoue, Anabel Martinez-Aran, Eduard Vieta, Ichiro Kusumi
Summary: The euthymic state of bipolar disorder is often characterized by impaired cognitive function. Cognitive complaints, objective cognitive functions, and illness awareness were found to be associated in Japanese patients. Both subjective and objective cognitive functions were found to be associated with illness awareness in remitted bipolar outpatients.
PSYCHIATRY RESEARCH
(2021)
Article
Clinical Neurology
Andrea Horta-Barba, Saul Martinez-Horta, Jesus Perez-Perez, Arnau Puig-Davi, Natascia de Lucia, Giuseppe de Michele, Elena Salvatore, Stefanie Kehrer, Josef Priller, Simone Migliore, Ferdinando Squitieri, Anna Castaldo, Caterina Mariotti, Veronica Mananes, Jose Luis Lopez-Sendon, Noelia Rodriguez, Asuncion Martinez-Descals, Filipa Julio, Cristina Januario, Marianna Delussi, Marina de Tommaso, Sandra Noguera, Jesus J. Ruiz-Idiago, Emilia Sitek, Renata Wallner, Angela Nuzzi, Javier Pagonabarraga, Jaime Kulisevsky
Summary: This study developed a specific assessment tool, the Parkinson's Disease-Cognitive Rating Scale (PD-CRS), to evaluate the cognitive status of Huntington's disease patients and monitor the progression of cognitive impairment. Through evaluating 180 gene-positive patients, criteria for classifying normal cognition, mild cognitive impairment, and dementia were established, and the PD-CRS demonstrated good sensitivity and specificity. Additionally, the PD-CRS captured cognitive progression in different cognitive groups and showed sensitivity to change in mild cognitive impairment and dementia.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Roger S. McIntyre, Yena Lee, Nelson B. Rodrigues, Flora Nasri, Guohui Lao, Wan Zeng, Biru Ye, Ripeng Li, Joshua D. Rosenblat, Rodrigo B. Mansur, Mehala Subramaniapillai, Leanna M. W. Lui, Kayla M. Teopiz, Tao Liu, Jiaqi Xiong, Ruoxi Zhang, Weicong Lu, Guiyun Xu, Xiong Huang, Kangguang Lin
Summary: This pilot study investigated the effects of rTMS on cognitive function in patients with bipolar disorder, demonstrating significant improvements in select cognitive domains for the active rTMS group compared to the sham group. No dyscognitive effects were observed across subdomains.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Bernadette Wendel, Sergi Papiol, Till F. M. Andlauer, Joerg Zimmermann, Jens Wiltfang, Carsten Spitzer, Fanny Senner, Eva C. Schulte, Max Schmauss, Sabrina K. Schaupp, Jonathan Repple, Eva Reininghaus, Jens Reimer, Daniela Reich-Erkelenz, Nils Opel, Susanne Meinert, Carsten Konrad, Farahnaz Kloehn-Saghatolislam, Tilo Kircher, Janos L. Kalman, Georg Juckel, Andreas Jansen, Markus Jaeger, Maria Heilbronner, Martin von Hagen, Katrin Gade, Christian Figge, Andreas J. Fallgatter, Detlef E. Dietrich, Udo Dannlowski, Ashley L. Comes, Monika Budde, Bernhard T. Baune, Volker Arolt, Ion-George Anghelescu, Heike Anderson-Schmidt, Kristina Adorjan, Peter Falkai, Thomas G. Schulze, Heike Bickeboeller, Urs Heilbronner
Summary: The study found that executive functions improved across diagnostic groups and identified nine genome-wide significant SNPs associated with performance change over time. The findings were replicated in a separate study, demonstrating the potential of longitudinally measured phenotypes to reveal novel genetic associations.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Psychology, Clinical
B. Sole, C. M. Bonnin, J. Radua, L. Montejo, B. Hogg, E. Jimenez, M. Reinares, E. Valls, C. Varo, I Pacchiarotti, M. Valenti, M. Garriga, I Torres, A. Martinez-Aran, E. Vieta, C. Torrent
Summary: The study found that patients with better cognitive performance, particularly in terms of verbal memory and executive functions at baseline, are likely to have better functional outcomes in the long-term follow-up after receiving functional remediation for bipolar disorder.
PSYCHOLOGICAL MEDICINE
(2022)
Editorial Material
Clinical Neurology
Marsal Sanches
JOURNAL OF NERVOUS AND MENTAL DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Albert J. Fenoy, Joao Quevedo, Jair C. Soares
Summary: In this article, the medial forebrain bundle and its importance in the modulation of affective disorders such as major depression is discussed. The role of the reward system in depression, particularly in anhedonia and lack of motivation, is emphasized. Recent trials have shown promising results in using deep brain stimulation (DBS) to alleviate depressive symptoms through modulation of this white matter pathway.
MOLECULAR PSYCHIATRY
(2022)
Article
Clinical Neurology
Satyajit Mohite, Haitham Salem, Thiago Cordeiro, Jonika Tannous, Benson Mwangi, Sudhakar Selvaraj, Jair C. Soares, Marsal Sanches, Antonio L. Teixeira
Summary: This study found that euthymic patients with bipolar disorder have lower volumes in certain brain regions compared to healthy controls, with negative correlation between interferon-gamma levels and right medial-orbitofrontal volume, and positive correlation between interleukin-10 levels and left posterior cingulate volume, suggesting the involvement of inflammatory pathways in structural brain changes in bipolar disorder.
Article
Clinical Neurology
Mehmet A. Camkurt, Tomas Melicher, Benson Mwangi, Mon-Ju Wu, Bo Cao, Cristian P. Zeni, Jonika Tannous, Giovana Zunta-Soares, Khader Hasan, Marsal Sanches, Jair C. Soares
Summary: This study found significantly decreased fractional anisotropy (FA) in six brain areas of offspring of patients with BD, suggesting a potential endophenotype for BD. In contrast, FA values in three regions were increased in controls, indicating differences in brain structure between the groups.
Article
Psychiatry
Alexandre P. Diaz, Brisa S. Fernandes, Joao Quevedo, Marsal Sanches, Jair C. Soares
Summary: Treatment-resistant bipolar depression (TRBD) is common in patients with bipolar disorders, but there are limited interventions. This review identified promising new interventions for TRBD, including both pharmacological and non-pharmacological treatments. More research is needed to personalize current treatments.
BRAZILIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Giselli Scaini, Brittany L. Mason, Alexandre P. Diaz, Manish K. Jha, Jair C. Soares, Madhukar H. Trivedi, Joao Quevedo
Summary: Recent studies have shown that mitochondrial dysfunction and dysregulated neuroinflammatory pathways play a role in major depressive disorder (MDD). This study found differences in markers of mitochondrial dynamics, mitophagy, autophagy, and apoptosis in MDD patients compared to healthy controls, with higher levels of specific proteins associated with mitochondrial dysfunction in MDD patients. Furthermore, inflammation and protein levels related to mitochondrial dynamics and mitophagy were found to influence the severity of depressive symptoms in MDD patients.
MOLECULAR PSYCHIATRY
(2022)
Review
Biochemistry & Molecular Biology
Edison Leung, Ethan W. Lau, Andi Liang, Constanza de Dios, Robert Suchting, Linda Ostlundh, Joseph C. Masdeu, Masahiro Fujita, Marsal Sanches, Jair C. Soares, Sudhakar Selvaraj
Summary: This study systematically reviews the pathophysiological mechanisms of bipolar and major depressive disorders, focusing on synaptic proteins and RNA alterations. Meta-analysis results indicate specific changes in synaptic proteins and RNAs in both disorders, although conflicting results are observed due to small sample sizes and variations in data sources.
MOLECULAR PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Albert J. Fenoy, Paul E. Schulz, Marsal Sanches, Sudhakar Selvaraj, Christina L. Burrows, Bashar Asir, Christopher R. Conner, Joao Quevedo, Jair C. Soares
Summary: This study demonstrates that deep brain stimulation to the superolateral branch of the medial forebrain bundle is an effective therapy for treatment resistant depression, with sustained antidepressant effects observed for up to 5 years. Evaluation of modulated fiber tracts reveals significant prefrontal/orbitofrontal connectivity to the target region in all responders.
MOLECULAR PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Christopher R. Conner, Joao Quevedo, Jair C. Soares, Albert J. Fenoy
Summary: This study used PET imaging to observe brain metabolic changes in patients with treatment-resistant depression who underwent deep brain stimulation (DBS). The results showed significant decreases in metabolism in the bilateral caudate, mediodorsal thalamus, and dorsal anterior cingulate cortex at 6 to 12 months post-surgery, as well as a decrease in the left ventral prefrontal cortex at 12 months post-surgery. These metabolic changes were correlated with clinical response.
MOLECULAR PSYCHIATRY
(2022)
Letter
Biochemistry & Molecular Biology
Albert J. Fenoy, Joao Quevedo, Jair C. Soares
MOLECULAR PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Rafaela C. Cordeiro, Camila N. C. Lima, Gabriel R. Fries, Giovana Zunta-Soares, Jair C. Soares, Joao Quevedo, Giselli Scaini
Summary: This study investigates the impact of mitochondrial dysfunction on bipolar disorder (BD). The study finds that BD patients have a lower mitochondrial health index (MHI) compared to non-psychiatry controls, with a negative correlation between MHI and cell-free mtDNA levels. The study further reveals that MHI is related to the expression of mitochondria quality control (MQC) proteins, and a longer illness duration, worse functional status, and higher depressive symptoms are associated with lower MHI and higher cell-free mtDNA levels.
MOLECULAR PSYCHIATRY
(2023)
Article
Psychology, Multidisciplinary
Mirona Letitia Dobri, Alexandre Paim Diaz, Sudhakar Selvaraj, Joao Quevedo, Consuelo Walss-Bass, Jair C. Soares, Marsal Sanches
Summary: Schizophrenia and bipolar disorder share many similarities in terms of their premorbid course, clinical profile, genetic factors and treatment approaches. Neuroimaging studies show that they both involve structural changes and functional dysconnectivity in critical brain regions, suggesting a continuum between these two disorders.
BEHAVIORAL SCIENCES
(2022)
