☆ 4.7 Letter

'Pre-cachexia': a non-existing phenomenon in cancer?

ANNALS OF ONCOLOGY (2014)

Journal

ANNALS OF ONCOLOGY

Volume 25, Issue 8, Pages 1668-1669

Publisher

OXFORD UNIV PRESS

DOI: 10.1093/annonc/mdu178

Keywords

-

Categories

Oncology

Ask authors/readers for more resources

Protocol

Community support

Reagent

Community support

Authors

I am an author on this paper

Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7

Not enough ratings

Secondary Ratings

Novelty

-

Significance

-

Scientific rigor

-

Rate this paper

Recommended

Article Nutrition & Dietetics

Piceatannol, a Dietary Polyphenol, Alleviates Adipose Tissue Loss in Pre-Clinical Model of Cancer-Associated Cachexia via Lipolysis Inhibition

Jonathan C. Kershaw, Bennett D. Elzey, Xiao-Xuan Guo, Kee-Hong Kim

Summary: This study investigates the role of piceatannol in cancer-associated lipolysis and cachexia-induced weight loss. The results show that piceatannol can reduce cancer-associated lipolysis and preserve adipose tissue, protecting tumor-bearing mice against weight loss in the early stages of cancer-associated cachexia.

NUTRIENTS (2022)

Add to Collection

Article Oncology

Pre-existing tumor host immunity characterization in resected non-small cell lung cancer

Pedro Rocha, Maite Rodrigo, Laura Moliner, Silvia Menendez, Laura Masfarre, Nil Navarro, Raul Del Rey-Vergara, Miguel Galindo-Campos, Alvaro Taus, Mario Giner, Ignacio Sanchez, Alberto Rodriguez-Fuster, Rafael Aguilo, Roberto Chalela, Albert Sanchez-Font, Josep Belda, Victor Curull, Lara Pijuan, David Casadevall, Sergi Clave, Beatriz Bellosillo, Julia Perera-Bel, Laura Comerma, Edurne Arriola

Summary: This study found differences in the tumor immune microenvironment (TIME) of early-stage non-small cell lung cancer (NSCLC) patients, which were associated with histology, PD-L1 expression, and molecular subgroups. Furthermore, infiltration of CD103+ immune cells was associated with patient survival.

LUNG CANCER (2023)

Add to Collection

Review Biochemistry & Molecular Biology

Biomarkers for Cancer Cachexia: A Mini Review

Zhipeng Cao, Kening Zhao, Irvin Jose, Nick J. Hoogenraad, Laura D. Osellame

Summary: Cancer cachexia is common in cancer patients, limiting treatment options due to decreased tolerance to chemotherapy and radiotherapy. Current diagnostic criteria based on weight loss and muscle function may be limiting and late for treatment. Biomarkers could supplement current diagnostic criteria and assess potential treatments.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Maternal Pre-Existing Diabetes: A Non-Inherited Risk Factor for Congenital Cardiopathies

Stephanie Ibrahim, Benedicte Gaborit, Marien Lenoir, Gwenaelle Collod-Beroud, Sonia Stefanovic

Summary: Congenital heart defects (CHDs), the most common form of birth defects in humans, are complex and difficult to understand. While genetic factors can explain only a minority of cases, environmental risk factors also contribute to the development of CHDs. Maternal pregestational diabetes is associated with an increased risk, but the specific molecular mechanisms remain unclear. This review summarizes key findings on the molecular mechanisms altered in cardiac development under hyperglycemic conditions, presents experimental modeling techniques, and suggests new approaches for understanding and prevention.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Add to Collection

Article Geriatrics & Gerontology

Hand grip strength-based cachexia index as a predictor of cancer cachexia and prognosis in patients with cancer

Hailun Xie, Guotian Ruan, Lishuang Wei, Heyang Zhang, Yizhong Ge, Qi Zhang, Shiqi Lin, Mengmeng Song, Xi Zhang, Xiaoyue Liu, Xiangrui Li, Kangping Zhang, Ming Yang, Meng Tang, Chun-Hua Song, Jialiang Gan, Han-Ping Shi

Summary: The hand grip strength-based cancer cachexia index (H-CXI) is a simple and practical predictor for cancer cachexia and prognosis in patients with cancer.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2023)

Add to Collection

Review Biochemistry & Molecular Biology

Optimising Outcomes in Non Small Cell Lung Cancer: Targeting Cancer Cachexia

Iain Phillips, Mark Stares, Lindsay Allan, Judith Sayers, Richard Skipworth, Barry Laird

Summary: Lung cancer is the most common malignancy worldwide and the leading cause of cancer death. However, many patients with advanced lung cancer are too unwell for treatment, leading to poor outcomes. Cancer cachexia, which is common in patients with Non-Small Cell Lung Cancer, is one of the reasons patients are not fit for treatment. There is emerging data suggesting that multi-modal intervention may have a role in treating cachexia.

FRONTIERS IN BIOSCIENCE-LANDMARK (2022)

Add to Collection

Article Medicine, General & Internal

New-Onset Atrial Fibrillation in Acute Myocardial Infarction Is a Different Phenomenon than Other Pre-Existing Types of That Arrhythmia

Monika Raczkowska-Golanko, Krzysztof Mlodzinski, Grzegorz Raczak, Marcin Gruchala, Ludmila Danilowicz-Szymanowicz

Summary: New-onset atrial fibrillation (NOAF) in acute myocardial infarction (AMI) can identify patients with the worst clinical in-hospital course and outcomes compared to other types of AF.

JOURNAL OF CLINICAL MEDICINE (2022)

Add to Collection

Article Oncology

Cachexia Index as a Prognostic Indicator in Patients with Gastric Cancer: A Retrospective Study

Can Gong, Qianyi Wan, Rui Zhao, Xinrong Zuo, Yi Chen, Tao Li

Summary: This study investigated the prognostic value of the cachexia index (CXI) in gastric cancer (GC) patients. The results showed that low CXI was associated with advanced tumor stage, increased levels of inflammatory markers, and decreased levels of nutritional markers. Furthermore, patients with low CXI had a poorer overall survival and a higher risk of postoperative complications. The combination of CXI with cachexia, low BMI, or advanced TNM stage could further predict a worse prognosis.

CANCERS (2022)

Add to Collection

Article Oncology

Survival of cancer patients with pre-existing heart disease

Ciaran O'Neill, David W. Donnelly, Mark Harbinson, Therese Kearney, Colin R. Fox, Gerard Walls, Anna Gavin

Summary: While cancer outcomes have improved over time, this study in Northern Ireland shows that cancer patients with pre-existing cardiovascular diseases have poorer outcomes. The high prevalence of cardiovascular diseases may contribute to the poorer cancer outcomes at a national level.

BMC CANCER (2022)

Add to Collection

Article Pharmacology & Pharmacy

Prognostic Value of Nivolumab Clearance in Non-Small Cell Lung Cancer Patients for Survival Early in Treatment

Leila S. Otten, Berber Piet, Demy van den Haak, Robert D. Schouten, Milou Schuurbiers, Sushil K. Badrising, Emmy Boerrigter, Sjaak A. Burgers, Rob ter Heine, Michel M. van den Heuvel

Summary: This study investigates the prognostic potential of nivolumab clearance for overall survival in early-stage non-small cell lung cancer patients. The results suggest that nivolumab clearance is indicative of patient survival and could serve as a prognostic biomarker. However, further research is needed to improve its accuracy and reliability.

CLINICAL PHARMACOKINETICS (2023)

Add to Collection

Article Biochemistry & Molecular Biology

Low-Dose Metformin as a Monotherapy Does Not Reduce Non-Small-Cell Lung Cancer Tumor Burden in Mice

Nicole L. Stott Bond, Didier Dreau, Ian Marriott, Jeanette M. Bennett, Michael J. Turner, Susan T. Arthur, Joseph S. Marino

Summary: The study found that metformin treatment did not significantly reduce NSCLC tumor burden in mouse models, nor did it have significant effects on key tumor cell division and inflammation markers or improve skeletal muscle health. Further research is needed to explore combination treatments with metformin as a potential supportive drug rather than a monotherapy to mitigate cancer progression.

BIOMEDICINES (2021)

Add to Collection

Review Geriatrics & Gerontology

Non-steroidal anti-inflammatory drugs for treatment of cancer cachexia: A systematic review

Megan Bowers, Brittany Cucchiaro, Joanne Reid, Adrian Slee

Summary: Cancer cachexia (CC) is a syndrome characterized by muscle loss and functional impairment driven by inflammation. There is insufficient evidence to support the use of non-steroidal anti-inflammatory drugs (NSAIDs) for the treatment of CC, and more research is needed to determine their efficacy and safety. The lack of patient involvement in clinical trials is also a concern.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2023)

Add to Collection

Article Food Science & Technology

Fish Oil Diet during Pre-mating, Gestation, and Lactation in Adult Offspring Rats on Cancer Cachexia Prevention

Sarah Christine Pereira de Oliveira, Natalia Angelo da Silva Miyaguti, Steven Thomas Russell, Natalia Tobar, Murilo Vieira Geraldo, Maria Cristina Cintra Gomes-Marcondes

Summary: Maternal nutritional supplementation with fish oil during pre-mating, gestation, and lactation can positively impact muscle protein expression, liver function, and lipid metabolism in adult offspring, reducing cancer susceptibility and cachexia damages.

MOLECULAR NUTRITION & FOOD RESEARCH (2021)

Add to Collection

Article Oncology

Impacts of pre-existing diabetes mellitus on colorectal cancer in a mice model

Yangbo Lv, Shuiquan Lin, Mingsheng Liu, Lihui Wang, Xiaoyu Wang, Li Cui, Jianguang Xu

Summary: This study investigated and analyzed the effects of diabetes mellitus (DM) on colorectal cancer (CRC), showing that DM can affect the progression of CRC and alter the immune response and gut microbiome.

CANCER MEDICINE (2023)

Add to Collection

Article Biochemistry & Molecular Biology

A Ketogenic Diet in Combination with Gemcitabine Mitigates Pancreatic Cancer-Associated Cachexia in Male and Female KPC Mice

Natalia E. Cortez, Suraj Pathak, Cecilia Rodriguez Lanzi, Brian V. Hong, Ryman Crone, Rasheed Sule, Fangyi Wang, Shuai Chen, Aldrin V. Gomes, Keith Baar, Gerardo G. Mackenzie

Summary: Cancer-associated cachexia (CAC) contributes to pancreatic ductal adenocarcinoma (PDAC) mortality. Dietary interventions, such as a ketogenic diet (KD), combined with gemcitabine has been shown to enhance survival in a mouse model of PDAC. This study investigates the effect of KD and gemcitabine on skeletal muscle mass in PDAC mice. The results suggest that KD can preserve muscle mass and further research is needed to determine its clinical efficacy in combating CAC in PDAC patients.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Add to Collection

Article Nutrition & Dietetics

Decision-making regarding oral nutritional supplements for nursing home residents with advanced dementia: A cross-sectional pilot study

Mieke van Hamersveld-Kramer, Sander I. B. Perry, Eva Lodewijks, Emmelyne Vasse, Marian A. E. de van der Schueren

Summary: This study evaluated the differences in factors considered important by Dutch dietitians, physicians, and SDMs when making decisions about oral nutritional supplements for nursing home residents with advanced dementia, as well as differences in opinions regarding whether ONS prolongs life. Despite all groups prioritizing quality of life, there were variations in their perceptions of other factors and the life-prolonging effect of ONS.

JOURNAL OF HUMAN NUTRITION AND DIETETICS (2022)

Add to Collection

Article Public, Environmental & Occupational Health

The protein gap-increasing protein intake in the diet of community-dwelling older adults: a simulation study

Marije H. Verwijs, Marian A. E. de van der Schueren, Marga C. Ocke, Jacco Ditewig, Joost O. Linschooten, Annet J. C. Roodenburg, Lisette C. P. G. M. de Groot

Summary: This study assesses the effect of replacing low protein foods with protein-rich alternatives on the protein intake of Dutch community-dwelling older adults. The results show that this replacement can significantly increase protein intake in older adults.

PUBLIC HEALTH NUTRITION (2022)

Add to Collection

Article Oncology

Clinical judgment of the need for professional mental health care in patients with cancer: a qualitative study among oncologists and nurses

Jeanet F. Karchoud, Anja J. Th C. M. de Kruif, Femke Lamers, Myra E. van Linde, Joyce M. Van Dodewaard-de Jong, Annemarie M. J. Braamse, Mirjam A. G. Sprangers, Aartjan T. F. Beekman, Henk M. W. Verheul, Joost Dekker

Summary: This study explores the indicators and strategies used by oncologists and nurses to determine the need for professional mental health care in cancer patients. The findings suggest that oncologists and nurses consider multiple factors, including the patient's emotional well-being and specific indicators of emotional problems, when making the decision to refer patients for professional mental health care.

JOURNAL OF CANCER SURVIVORSHIP (2023)

Add to Collection

Article Nutrition & Dietetics

Protein Intake among Community-Dwelling Older Adults: The Influence of (Pre-) Motivational Determinants

Marije H. Verwijs, Annemien Haveman-Nies, Jos W. Borkent, Joost O. Linschooten, Annet J. C. Roodenburg, Lisette C. P. G. M. de Groot, Marian A. E. de van der Schueren

Summary: An adequate protein intake is important for healthy ageing, but nearly 50% of Dutch community-dwelling older adults do not meet protein recommendations. This study found that knowledge and social support were independently associated with protein intake, suggesting that interventions should focus on increasing knowledge and social support.

NUTRIENTS (2022)

Add to Collection

Article Nutrition & Dietetics

Comparison of the prevalence of 21 GLIM phenotypic and etiologic criteria combinations and association with 30-day outcomes in people with cancer: A retrospective observational study

Nicole Kiss, Belinda Steer, Marian de van der Schueren, Jenelle Loeliger, Roohallah Alizadehsani, Lara Edbrooke, Irene Deftereos, Erin Laing, Abbas Khosravi

Summary: This study examined malnutrition prevalence in cancer patients using various diagnostic combinations of GLIM criteria and identified the combinations that best predicted mortality and unplanned hospital admission within 30 days. Results indicated that the combinations of weight loss and reduced muscle mass with reduced food intake or inflammation were crucial for predicting mortality, while the combinations of weight loss or reduced muscle mass with reduced food intake were key for predicting unplanned hospital admission.

CLINICAL NUTRITION (2022)

Add to Collection

Review Geriatrics & Gerontology

Mapping ongoing nutrition intervention trials in muscle, sarcopenia, and cachexia: a scoping review of future research

Camila E. Orsso, Montserrat Montes-Ibarra, Merran Findlay, Barbara S. van der Meij, Marian A. E. de van der Schueren, Francesco Landi, Alessandro Laviano, Carla M. Prado

Summary: Muscle loss is a common condition in aging and disease, and proper nutrition plays a crucial role in muscle maintenance. Many studies have been conducted to investigate the effects of specific nutrients on muscle mass or function. However, more research is needed to provide evidence-based recommendations. This scoping review compiled ongoing clinical trials that aim to explore the use of nutrition interventions in preventing or treating low muscle mass or function, sarcopenia, or cachexia. A total of 113 trials were included, with most focusing on adults with clinical conditions and using food supplements as the main intervention. Protein, amino acids, and beta-hydroxy-beta-methylbutyrate (HMB) were the top three nutrients under investigation. The primary outcomes of these trials were measures of muscle mass, strength, and physical performance. The findings of these trials can inform future research in this area and guide the development of evidence-based recommendations.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2022)

Add to Collection

Review Nutrition & Dietetics

The association between polypharmacy and malnutrition(risk) in older people: A systematic review

W. E. Kok, E. B. Haverkort, Y. A. Algra, J. Mollema, V. R. Y. Hollaar, E. Naumann, M. A. E. de van der Schueren, K. Jerkovic-Cosic

Summary: This systematic review demonstrated a significant association between polypharmacy and malnutrition, despite variations in the definition of polypharmacy among studies. Further research is needed to determine the impact of increased number and type of drugs on the risk of malnutrition.

CLINICAL NUTRITION ESPEN (2022)

Add to Collection

Article Nutrition & Dietetics

Nutritional problems of patients with COVID-19 receiving dietetic treatment in primary care

Anne Slotegraaf, Marian A. E. de van der Schueren, Nicolette J. Wierdsma, Peter J. M. Weijs, Hinke M. Kruizenga

Summary: This study examined the nutritional status, risk of sarcopaenia, and nutrition-related complaints of COVID-19 patients receiving dietetic treatment in primary care. The findings showed that a large proportion of patients were overweight or obese and had experienced unintentional weight loss due to COVID-19. Additionally, a significant number of both hospitalized and non-hospitalized patients had a high risk of sarcopaenia. The most commonly reported nutrition-related complaints included decreased appetite, shortness of breath, changed or loss of taste, and feeling of being full. These symptoms improved over time but remained prevalent for several months after infection.

JOURNAL OF HUMAN NUTRITION AND DIETETICS (2023)

Add to Collection

Article Oncology

The impact of nutrition on the lives of patients with digestive cancers: a position paper

Marianna Vitaloni, Riccardo Caccialanza, Paula Ravasco, Alfredo Carrato, Aleksandra Kapala, Marian de van der Schueren, Dora Constantinides, Eva Backman, David Chuter, Claudia Santangelo, Zorana Maravic

Summary: Nutritional intervention is crucial in cancer treatment, as it can reduce hospitalization time, improve quality of life, and prevent malnutrition. However, many European countries lack universal access to nutritional support for digestive cancer patients, highlighting the need for investment in qualified staff and resources.

SUPPORTIVE CARE IN CANCER (2022)

Add to Collection

Article Nursing

Factors influencing the delivery of nutritional care by nurses for hospitalised medical patients with malnutrition; a qualitative study

Gerda Van Den Berg, Hester Vermeulen, Tiffany Conroy, Harm Van Noort, Marian De Van Der Schueren, Getty Huisman-de Waal

Summary: This study explores nursing nutritional care delivery in hospitals through observations of nursing care and discussions with multidisciplinary professionals. It highlights the crucial role of nurses in identifying and treating malnutrition and emphasizes the importance of a systematic nursing approach combined with patient participation to counteract malnutrition effectively.

JOURNAL OF CLINICAL NURSING (2023)

Add to Collection

Article Geriatrics & Gerontology

Nutritional Status Is Associated With Clinical Progression in Alzheimer's Disease: The NUDAD Project

Astrid S. Doorduijn, Marian A. E. de van der Schueren, Ondine van de Rest, Francisca A. de Leeuw, Heleen M. A. Hendriksen, Charlotte E. Teunissen, Philip Scheltens, Wiesje M. van der Flier, Marjolein Visser

Summary: Nutritional parameters are related to cognitive decline and incidence of dementia in cognitively normal adults. However, there is a lack of clinical studies on the role of nutrition in predementia stages and mild stages of AD dementia. This research provides evidence supporting the importance of nutritional factors in potentially preventing or delaying cognitive decline.

JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION (2023)

Add to Collection

Article Nutrition & Dietetics

Effects of Nutritional Interventions in Older Adults with Malnutrition or at Risk of Malnutrition on Muscle Strength and Mortality: Results of Pooled Analyses of Individual Participant Data from Nine RCTs

Judith I. van Zwienen-Pot, Ilse Reinders, Lisette C. P. G. M. de Groot, Anne Marie Beck, Ilana Feldblum, Inken Jobse, Floor Neelemaat, Marian A. E. de van der Schueren, Danit R. Shahar, Ellen T. H. C. Smeets, Michael Tieland, Hanneke A. H. Wijnhoven, Dorothee Volkert, Marjolein Visser

Summary: There is inconsistent evidence on the clinical effectiveness of nutritional intervention in improving muscle strength and mortality in older adults with malnutrition. This study examines the effects of nutritional interventions on these outcomes and explores if participant characteristics influence these effects.

NUTRIENTS (2023)

Add to Collection

Article Rehabilitation

EVALUATION OF ALLIED HEALTHCARE IN PATIENTS RECOVERING FROM COVID-19: STUDY PROTOCOL AND BASELINE DATA OF A NATIONAL PROSPECTIVE COHORT STUDY

Rob A. De Bie, Arie C. Verburg, Carla Agasi-Idenburg, Edith H. C. Cup, Carolien Dekker, Johanna M. Van Dongen, Edwin Geleijn, Marissa H. G. Gerards, Maud Graff, Ron Van Heerde, Hanneke Kalf, Marly Kammerer, Renee A. Kool, Anja De Kruif, Hinke M. Kruizenga, Marike Van der Leeden, Ton A. F. Lenssen, Willemijn M. Meijer, Raymond Ostelo, Amber Ronteltap, Marike Van der Schaaf, Sonja Van Oers, Marian A. E. De Van der Schueren, Anne I. Slotegraaf, Cindy Veenhof, Thomas J. Hoogeboom, Philip J. Van der Wees

Summary: This study aims to evaluate the recovery trajectories of COVID-19 patients receiving treatment from allied health professionals in the Netherlands. The study utilizes a prospective cohort design and employs both quantitative and qualitative measures to assess various aspects of patient recovery, including participation, quality of life, fatigue, physical functioning, and costs. Preliminary results indicate that patients experienced severe symptoms during the infection period and faced significant limitations in daily activities. This study will provide crucial evidence and insights for the treatment of COVID-19 patients in their recovery process.

JOURNAL OF REHABILITATION MEDICINE (2022)

Add to Collection

Meeting Abstract Oncology

Machine learning-based prediction of adverse outcomes from malnutrition in people with cancer

Nicole Kiss, Belinda Steer, Marian de van der Schueren, Jenelle Loeliger, Roohallah Alizadehsani, Lara Edbrooke, Irene Deftereos, Erin Laing, Abbas Khosravi

ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2022)

Add to Collection

Article Geriatrics & Gerontology

Behavioral and Cognitive Problems as Determinants of Malnutrition in Long-Term Care Facilities, a Cross-Sectional and Prospective Study

Jos W. Borkent, H. P. J. van Hout, E. J. M. Feskens, E. Naumann, M. A. E. de van der Schueren

Summary: There are associations between behavior and cognitive problems and malnutrition in LTCFs. Residents with these problems have an increased risk of being malnourished at admission or during their stay.

JOURNAL OF NUTRITION HEALTH & AGING (2022)

Add to Collection

No Data Available

© Peeref 2019-2024. All rights reserved.