Article
Biochemistry & Molecular Biology
Joris van de Haar, Xuhui Ma, Salo N. Ooft, Pim W. van der Helm, Louisa R. Hoes, Sara Mainardi, David J. Pinato, Kristi Sun, Lisa Salvatore, Giampaolo Tortora, Ina Valeria Zurlo, Silvana Leo, Riccardo Giampieri, Rossana Berardi, Fabio Gelsomino, Valeria Merz, Federica Mazzuca, Lorenzo Antonuzzo, Gerardo Rosati, Chara Stavraka, Paul Ross, Maria Grazia Rodriquenz, Michele Pavarana, Carlo Messina, Timothy Iveson, Federica Zoratto, Anne Thomas, Elisabetta Fenocchio, Margherita Ratti, Ilaria Depetris, Massimiliano Cergnul, Cristina Morelli, Michela Libertini, Alessandro Parisi, Michele De Tursi, Nicoletta Zanaletti, Ornella Garrone, Janet Graham, Raffaella Longarini, Stefania Maria Gobba, Angelica Petrillo, Emiliano Tamburini, Nicla La Verde, Fausto Petrelli, Vincenzo Ricci, Lodewyk F. A. Wessels, Michele Ghidini, Alessio Cortellini, Emile E. Voest, Nicola Valeri
Summary: Genomic analysis identified KRAS(G12) mutations as potential biomarkers of resistance to trifluridine/tipiracil treatment in metastatic colorectal cancer. Real-world data and phase 3 clinical trial data confirmed the significant association between KRAS(G12) mutations and reduced overall survival. These findings provide important implications for precision medicine in approximately 28% of patients with metastatic colorectal cancer.
Article
Genetics & Heredity
Chunguang Guo, Zaoqu Liu, Yin Yu, Yunfang Chen, Hui Liu, Yaming Guo, Zhenyu Peng, Gaopo Cai, Zhaohui Hua, Xinwei Han, Zhen Li
Summary: This study comprehensively analyzed the clinical and somatic mutation data of ICC patients from large-scale cohorts, and identified TP53 and KRAS as the common high-frequency mutation genes associated with poor prognosis. The study also classified patients into different mutation phenotypes and found that Double-Hit patients had a dismal prognosis and high TMB. Through chemotherapy sensitivity analysis, the study identified several drugs sensitive to ICC patients.
FRONTIERS IN GENETICS
(2022)
Article
Gastroenterology & Hepatology
Hyehyun Jeong, Kyu-pyo Kim, Jae Ho Jeong, Dae Wook Hwang, Jae Hoon Lee, Ki-Hun Kim, Deok-Bog Moon, Myung Ah Lee, Se Jun Park, Hong Jae Chon, Jin-hong Park, Ji Sung Lee, Baek-Yeol Ryoo, Changhoon Yoo
Summary: The effectiveness of adjuvant gemcitabine plus cisplatin (GemCis) therapy was evaluated in a homogeneous group of high-risk patients with resected, lymph node-positive extrahepatic cholangiocarcinoma. The study found that adjuvant GemCis did not improve survival outcomes compared with capecitabine in this patient population.
Article
Medicine, General & Internal
Rona Yaeger, Jared Weiss, Meredith S. Pelster, Alexander Spira, Minal Barve, Sai-Hong Ou, Ticiana A. Leal, Tanios S. Bekaii-Saab, Cloud P. Paweletz, Grace A. Heavey, James G. Christensen, Karen Velastegui, Thian Kheoh, Hirak Der-Torossian, Samuel J. Klempner
Summary: In this study, the researchers investigated the clinical efficacy of adagrasib in combination with cetuximab for heavily pretreated patients with metastatic colorectal cancer harboring mutant KRAS G12C. The results showed that the overall response rate was 19% in the adagrasib monotherapy group, with a median progression-free survival of 5.6 months, and 46% in the combination therapy group, with a median progression-free survival of 6.9 months. Both groups experienced reversible adverse events.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Multidisciplinary Sciences
Methi Wathikthinnakon, Piriya Luangwattananun, Nunghathai Sawasdee, Chutipa Chiawpanit, Vannajan Sanghiran Lee, Piyarat Nimmanpipug, Yingmanee Tragoolpua, Siriphorn Rotarayanont, Thanich Sangsuwannukul, Nattaporn Phanthaphol, Yupanun Wutti-in, Chalermchai Somboonpatarakun, Thaweesak Chieochansin, Mutita Junking, Jatuporn Sujjitjoon, Pa-thai Yenchitsomanus, Aussara Panya
Summary: This study proposes a novel approach for treating cholangiocarcinoma by combining gemcitabine and PD-L1xCD3 BiTE, which enhances the cytotoxicity of T lymphocytes against CCA cells.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Concetta Panebianco, Federica Pisati, Annacandida Villani, Annapaola Andolfo, Marynka Ulaszewska, Edoardo Bellini, Carmelapia Ferro, Renato Lombardi, Fabrizio Orsenigo, Tiziana Pia Latiano, Beatrice Belmonte, Claudio Tripodo, Francesco Perri, Valerio Pazienza
Summary: Pancreatic cancer has a low survival rate due to late diagnosis and resistance to therapies. The authors studied the effects of a specific probiotic blend on mice with pancreatic cancer and found that it reduced chemotherapy side effects and decreased cancer-associated stromatogenesis. The results suggest that manipulating the microbiota could be a desirable strategy to improve the quality of life and increase the chance of cure for pancreatic cancer patients.
CELL DEATH DISCOVERY
(2023)
Article
Mathematical & Computational Biology
Bastian Ulmer, Margarete Odenthal, Reinhard Buettner, Wilfried Roth, Michael Kloth
Summary: Recent progress in predicting tumor dependency on frequently mutated RAS-pathway oncogenes highlights the importance of identifying specific inhibitors independent of mutational status. This study combines machine learning-based modeling and whole transcriptome data to successfully predict KRAS dependency in cancer cell lines without gain-of-function mutations. The results suggest the potential for targeted therapeutic approaches in KRAS dependent cancers with wild type status.
NPJ SYSTEMS BIOLOGY AND APPLICATIONS
(2022)
Article
Medicine, General & Internal
Maximilian N. Kinzler, Christina Klasen, Falko Schulze, Eva Herrmann, Andreas A. Schnitzbauer, Joerg Trojan, Stefan Zeuzem, Peter J. Wild, Dirk Walter
Summary: Intrahepatic cholangiocarcinoma (iCCA), the most frequent subtype of cholangiocarcinoma (CCA), has seen an increased incidence globally. This study aimed to assess the impact of fibrosis on survival in iCCA patients undergoing palliative chemotherapy. The results showed that fibrosis did not significantly affect overall survival (OS) or progression-free survival (PFS) in iCCA patients. However, patients with cirrhosis and iCCA receiving palliative chemotherapy had lower OS rates.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Jonathan M. Loree, Yucai Wang, Muddassir A. Syed, Alexey Sorokin, Oluwadara Coker, Joanne Xiu, Benjamin A. Weinberg, Ari M. Vanderwalde, Anteneh Tesfaye, Victoria M. Raymond, Benjamin Miron, Gabi Tarcic, Ori Zelichov, Russell R. Broaddus, Patrick Kwok Shing Ng, Kang Jin Jeong, Yiu Huen Tsang, Gordon B. Mills, Michael J. Overman, Axel Grothey, John L. Marshall, Scott Kopetz
Summary: The study identified a high prevalence of atypical RAS mutations in colorectal cancer patients, which were associated with poor prognosis. Activating atypical variants were the most common in clinical cohorts, providing the best evidence to guide treatment.
CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Ryusei Matsuyama, Ryutaro Mori, Yohei Ota, Yuki Homma, Yasuhiro Yabusita, Seigo Hiratani, Takashi Murakami, Yu Sawada, Kentaro Miyake, Yasuhiro Shimizu, Takafumi Kumamoto, Itaru Endo
Summary: Gemcitabine/S-1 combination neoadjuvant chemotherapy shows promising efficacy and tolerability in the treatment of perihilar cholangiocarcinoma.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Catherine G. Tran, Paolo Goffredo, Sarah L. Mott, Mohammed O. Suraju, Julia F. Kohn, Aditi Mishra, Jean-Nicolas Vauthey, Imran Hassan
Summary: This study investigates the impact of laterality, microsatellite instability (MSI), and KRAS status on conditional overall survival (COS) in colon cancer. The results show that mKRAS is associated with worse COS, suggesting a more aggressive biological behavior.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Review
Immunology
Wei Zhang, Chu Luo, Zun-Yi Zhang, Bi-Xiang Zhang, Xiao-Ping Chen
Summary: The combination of lenvatinib and pembrolizumab with GP chemotherapy achieved significant tumor reduction and decreased tumor marker levels in a patient with unresectable ICC. The patient underwent successful liver resection and has survived 15 months without recurrence or metastasis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Robert C. G. Martin, Kerri A. Simo, Paul Hansen, Flavio Rocha, Prejesh Philips, Kelly M. McMasters, Clifton M. Tatum, Lawrence R. Kelly, Michael Driscoll, Vivek R. Sharma, Todd S. Crocenzi, Charles R. Scoggins
Summary: This study assessed the efficacy of irinotecan drug-eluting beads (DEBIRI) therapy in combination with systemic therapy for unresectable intrahepatic cholangiocarcinoma (ICC). The results showed that the combination therapy significantly improved downsizing to resection, progression-free survival, and overall survival.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Review
Immunology
Zhongyan Zhang, Xin Wang, Hehe Li, Huimin Sun, Jianhong Chen, Hongfeng Lin
Summary: We present a case of advanced intrahepatic cholangiocarcinoma (ICC) where radical surgery was not feasible due to tumor invasion. Six cycles of gemcitabine and oxaliplatin (GEMOX) regimen combined with camrelizumab immunotherapy achieved a partial response and successful tumor conversion. The patient subsequently underwent successful radical surgical resection, indicating that the GEMOX regimen combined with camrelizumab could be a potential conversion therapy strategy for advanced ICC patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Lu Zou, Xuechuan Li, Xiangsong Wu, Jiujie Cui, Xuya Cui, Xiaoling Song, Tai Ren, Xusheng Han, Yidi Zhu, Huaifeng Li, Wenguang Wu, Xu'an Wang, Wei Gong, Liwei Wang, Maolan Li, Wan Yee Lau, Yingbin Liu
Summary: For patients with advanced or metastatic CCA, first-line mFOLFIRINOX showed more promising results compared to Gemox, with higher disease control rate and longer progression-free survival.
Letter
Radiology, Nuclear Medicine & Medical Imaging
Lawrence Bonne, Filip Van Herpe, Chris Verslype, Jo Peluso, Geert Maleux
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2023)
Article
Oncology
Cedric Nesti, Konstantin Braeutigam, Marta Benavent, Laura Bernal, Hessa Boharoon, Johan Botling, Antonin Bouroumeau, Iva Brcic, Maximilian Brunner, Guillaume Cadiot, Maria Camara, Emanuel Christ, Thomas Clerici, Ashley K. Clift, Hamish Clouston, Lorenzo Cobianchi, Jaroslaw B. Cwikla, Kosmas Daskalakis, Andrea Frilling, Rocio Garcia-Carbonero, Simona Grozinsky-Glasberg, Jorge Hernando, Valerie Hervieu, Johannes Hofland, Pernille Holmager, Frediano Inzani, Henning Jann, Paula Jimenez-Fonseca, Enes Kacmaz, Daniel Kaemmerer, Gregory Kaltsas, Branislav Klimacek, Ulrich Knigge, Agnieszka Kolasinska-Cwikla, Walter Kolb, Beata Kos-Kudla, Catarina Alisa Kunze, Stefania Landolfi, Stefano La Rosa, Carlos Lopez Lopez, Kerstin Lorenz, Maurice Matter, Peter Mazal, Claudia Mestre-Alagarda, Patricia Morales del Burgo, Els J. M. Nieveen van Dijkum, Kira Oleinikov, Lorenzo A. Orci, Francesco Panzuto, Marianne Pavel, Marine Perrier, Henrik Mikael Reims, Guido Rindi, Anja Rinke, Maria Rinzivillo, Xavier Sagaert, Ilker Satiroglu, Andreas Selberherr, Alexander R. Siebenhuener, Margot E. T. Tesselaar, Michael J. Thalhammer, Espen Thiis-Evensen, Christos Toumpanakis, Timon Vandamme, Jose G. van den Berg, Alessandro Vanoli, Marie-Louise F. van Velthuysen, Chris Verslype, Stephan A. Vorburger, Alessandro Lugli, John Ramage, Marcel Zwahlen, Aurel Perren, Reto M. Kaderli
Summary: This study investigated whether patients with 1-2 cm appendiceal neuroendocrine tumors (NETs) need to undergo right-sided hemicolectomy, and found that right-sided hemicolectomy is not necessary after appendectomy for appendiceal NETs. Furthermore, it was found that regional lymph node metastases of appendiceal NETs are clinically irrelevant and additional postoperative exclusion of metastases and histopathological evaluation of risk factors is not supported. These findings should inform the development of treatment guidelines.
Review
Endocrinology & Metabolism
Wim Laleman, Michael Praktiknjo, Mette Munk Lauridsen, Lawrence Bonne, Emma Vanderschueren, Chris Verslype, Aleksander Krag, Jonel Trebicka, Geert Maleux
Summary: Spontaneous portosystemic shunts are often overlooked as a cause of hepatic encephalopathy associated with cirrhosis. They are considered as radiological biomarkers of clinically significant portal hypertension and have a clinical impact on complications related to portal hypertension. Interventional radiology embolization is a direct method to target these shunts.
METABOLIC BRAIN DISEASE
(2023)
Article
Surgery
Thomas Winckelmans, Dennis A. A. Wicherts, Isabelle Parmentier, Celine De Meyere, Chris Verslype, Mathieu D'Hondt
Summary: This study compares the experience of robotic liver surgery (RLS) with conventional laparoscopic liver surgery (LLS). The results show that RLS has less blood loss, shorter length of stay, but higher surgical costs.
WORLD JOURNAL OF SURGERY
(2023)
Article
Pharmacology & Pharmacy
Can G. Leineweber, Miriam Rabehl, Anne Pietzner, Nadine Rohwer, Michael Rothe, Maciej Pech, Bruno Sangro, Rohini Sharma, Chris Verslype, Bristi Basu, Christian Sengel, Jens Ricke, Nils Helge Schebb, Karsten-H. Weylandt, Julia Benckert
Summary: Hepatocellular carcinoma (HCC) is a leading cause of cancer death, and the medical treatment options are limited. The multikinase inhibitor sorafenib has been widely used for systemic therapy in advanced HCC. This study shows that sorafenib affects the levels of polyunsaturated fatty acids (PUFA)-derived epoxygenated metabolites, indicating that specific supplementation with DHA could increase levels of the epoxy compound 19,20-EDP with potential anti-tumor activity in HCC patients receiving sorafenib therapy.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Ecology
Manon Coone, Isabel Vanoverberghe, Shira Houwenhuyse, Chris Verslype, Ellen Decaestecker
Summary: The depletion of oxygen due to increased stratification and decreased solubility is a significant chemical change in aquatic ecosystems under global environmental change, leading to increased exposure of aquatic organisms to hypoxic conditions. Understanding the effects of hypoxia on key ecological species and their microbial communities is crucial for predicting the response of aquatic communities to this environmental disturbance. In this study, the (sub-)lethal effects of hypoxia on Daphnia, a keystone species in freshwater ecosystems, were examined, along with the potential role of the microbial community in the phenotypic switch and tolerance to hypoxia. The results showed phenotypic plasticity in Daphnia performance traits, as well as changes in species richness and community composition of the microbial community, suggesting the importance of the microbiome in phenotypic plasticity and hypoxia tolerance in Daphnia.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2023)
Article
Oncology
A. Coolbrandt, H. Tobback, R. Govaerts, L. Vandezande, M. Vinckx, A. Laenen, H. Wildiers, C. Verslype, J. Dekervel, F. Van Herpe, E. Van Cutsem
Summary: This study aimed to evaluate the effect of hand/foot-cooling on oxaliplatin-induced peripheral neuropathy (OIPN). The results showed that the use of cooling devices significantly reduced the incidence of OIPN and improved acute OIPN symptoms. Patients generally felt comfortable with the intervention.
Article
Immunology
Willem Roosens, Frederik Staels, Sien Van Loo, Stephanie Humblet-Baron, Isabelle Meyts, Hadewijch De Samblanx, Chris Verslype, Hannah van Malenstein, Schalk van der Merwe, Wim Laleman, Rik Schrijvers
Summary: Common variable immunodeficiency (CVID) associated liver disease is an underrecognized and poorly studied non-infectious complication that lacks an established treatment. However, our case and literature review suggest a potential beneficial effect of rituximab for treating liver complications, which warrants further research.
FRONTIERS IN IMMUNOLOGY
(2023)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
H. Leupe, E. Pauwels, T. Vandamme, B. Van den Broeck, W. Lybaert, J. Dekervel, J. Jaekers, F. Cleeren, J. Hofland, A. Brouwers, M. Koole, G. Bormans, E. Van Cutsem, K. Geboes, C. Verslype, S. Stroobants, C. M. Deroose
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Meeting Abstract
Endocrinology & Metabolism
O. Islam, K. Sarti, C. Verslype, J. L. Van Laethem, Hassan R. Kalantari, J. Janssens, A. Hendlisz, W. Lybaert, M. Peeters, I Borbath, T. Vandamme
JOURNAL OF NEUROENDOCRINOLOGY
(2023)
Meeting Abstract
Endocrinology & Metabolism
John D. Robbert, M. Guyot, T. Killian, C. Verslype, D. Lambrechts, G. Bergers
JOURNAL OF NEUROENDOCRINOLOGY
(2023)
Meeting Abstract
Endocrinology & Metabolism
Bidakhvidi N. Ahmadi, G. Lens, V. Vandecaveye, S. Grauwels, W. Deckers, J. Dekervel, C. Verslype, E. van Cutsem, M. Koole, K. Goffin, K. van Laere, C. M. Deroose
JOURNAL OF NEUROENDOCRINOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Sarah Cappuyns, Gino Philips, Vincent Vandecaveye, Bram Boeckx, Rogier Schepers, Thomas Van Brussel, Ingrid Arijs, Aurelie Mechels, Ayse Bassez, Francesca Lodi, Joris Jaekers, Halit Topal, Baki Topal, Orian Bricard, Junbin Qian, Eric Van Cutsem, Chris Verslype, Diether Lambrechts, Jeroen Dekervel
JOURNAL OF HEPATOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Sarah Cappuyns, Marta Pique-Gili, Roger Esteban-Fabro, Gino Philips, Roser Pinyol, Vincent Vandecaveye, Jordi Abril-Fornaguera, Philipp Haber, Chris Verslype, Eric Van Cutsem, Diether Lambrechts, Augusto Villanueva, Jeroen Dekervel, Josep Llovet
JOURNAL OF HEPATOLOGY
(2023)
Article
Surgery
M. D'Hondt, A. Devooght, E. Willems, D. Wicherts, C. De Meyere, I Parmentier, A. Provoost, H. Pottel, C. Verslype
Summary: This study evaluates the short-term outcomes and cost differences of robotic liver surgery (RLS) compared to laparoscopic liver surgery (LLS). The findings indicate that RLS has comparable short-term outcomes to LLS but with shorter operative time, lower intraoperative blood loss, and shorter hospital stay. The cost analysis also shows that RLS is more cost-effective compared to LLS.
JOURNAL OF ROBOTIC SURGERY
(2023)