Review
Oncology
Jose Alejandro Perez-Fidalgo, Eugenia Ortega, Jordi Ponce, Andres Redondo, Isabel Sevilla, Claudia Valverde, Josep Isern Verdum, Enrique de Alava, Mar Galera Lopez, Gloria Marquina, Ana Sebio
Summary: Uterine sarcomas are rare and diverse, making diagnosis, surgical management, and systemic treatment challenging; treatment decisions should involve a multidisciplinary tumor board; evidence is limited, often based on case series or clinical trials including these tumors with other soft tissue sarcomas. These guidelines summarize the relevant evidence on the diagnosis, staging, pathological disparities, surgical management, systemic treatment, and follow-up of uterine sarcomas.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2023)
Review
Dermatology
Jyoti Kumari, Kinnor Das, Anant Patil, Mahsa Babaei, Clay J. Cockerell, Mohamad Goldust
Summary: This review article discusses the epidemiology, clinical features, diagnosis, and therapy of different types of cutaneous sarcomas. Cutaneous sarcomas have a negative impact on quality of life and histological evaluation is crucial for diagnosis. Complete surgical removal is the main treatment option and the prognosis for cutaneous sarcomas is generally favorable. Patients should be treated at specialized centers.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Takao Itoi, Shomei Ryozawa, Akio Katanuma, Hiroki Kawashima, Eisuke Iwasaki, Shinichi Hashimoto, Kenjiro Yamamoto, Toshiharu Ueki, Yoshinori Igarashi, Kazuo Inui, Naotaka Fujita, Kazuma Fujimoto
Summary: The Clinical Practice Guidelines for Endoscopic Papillectomy (EP) developed by the Japan Gastroenterological Endoscopy Society provide guidance on the indications, preparations, techniques, adverse events, outcomes, remnants/recurrences, and follow-up of EP. These guidelines, based on scientific approach, are essential for the current clinical practice of EP.
DIGESTIVE ENDOSCOPY
(2022)
Review
Health Care Sciences & Services
Giuliana Giacobbe, Vincenza Granata, Piero Trovato, Roberta Fusco, Igino Simonetti, Federica De Muzio, Carmen Cutolo, Pierpaolo Palumbo, Alessandra Borgheresi, Federica Flammia, Diletta Cozzi, Michela Gabelloni, Francesca Grassi, Vittorio Miele, Antonio Barile, Andrea Giovagnoni, Nicoletta Gandolfo
Summary: Gender Medicine is a branch of medicine that studies the differences in diseases between men and women. It is important to value these differences in healthcare in order to provide personalized therapies and gender-specific prevention initiatives. This article assesses potential gender differences in clinical-radiological practice and their impact on health and healthcare.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Endocrinology & Metabolism
Christopher R. McCartney, Maureen D. Corrigan, Matthew T. Drake, Ghada El-Hajj Fuleihan, Mary T. Korytkowski, Robert W. Lash, David C. Lieb, Anthony L. McCall, Ranganath Muniyappa, Thomas Piggott, Nancy Santesso, Holger J. Schunemann, Wojtek Wiercioch, Marie E. McDonnell, M. Hassan Murad
Summary: In order to enhance the trustworthiness of its clinical practice guidelines, the Endocrine Society has adopted new policies and methods, including the inclusion of non-endocrinologist experts and implementation of a stricter conflict of interest policy.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Medicine, General & Internal
Celine Jacobs, Lore Lapeire
Summary: Soft tissue sarcomas are rare mesenchymal tumors with limited treatment options. Advanced molecular techniques have identified new therapeutic targets, allowing for more personalized treatment and improved prognosis.
Article
Immunology
Anette Tarp Hansen, Anna Soderstrom, Charlotte Svaerke Jorgensen, Carsten Schade Larsen, Mikkel Steen Petersen, Jens Magnus Bernth Jensen
Summary: The study found that only 17% of adult patients with suspected primary immunodeficiency diseases fully complied with the AAAAI guidelines for diagnostic vaccination, indicating the guidelines are difficult to follow. Furthermore, the arbitrary choices of serotype-specific antibodies for interpretation heavily influenced the data interpretation, revealing an inherent flaw in the guidelines. The proposed revised protocol of diagnostic vaccination, subsequent antibody measurements, and data interpretation using Z-scores provided more robust clinical results compared to interpretation according to the AAAAI guidelines.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Toto Holmebakk, Anne Marit Wiedswang, Leonardo A. Meza-Zepeda, Ivar Hompland, Ingvild V. K. Lobmaier, Jeanne-Marie Berner, Stephan Stoldt, Kjetil Boye
Summary: In patients with gastric GIST, over 90% of tumors in the upper third were sensitive to imatinib. Tumors with a transmural growth pattern were strongly associated with a high mitotic index and poorer survival outcomes compared to luminal or exophytic tumors.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Review
Gastroenterology & Hepatology
Hitoshi Yoshiji, Sumiko Nagoshi, Takemi Akahane, Yoshinari Asaoka, Yoshiyuki Ueno, Koji Ogawa, Takumi Kawaguchi, Masayuki Kurosaki, Isao Sakaida, Masahito Shimizu, Makiko Taniai, Shuji Terai, Hiroki Nishikawa, Yoichi Hiasa, Hisashi Hidaka, Hiroto Miwa, Kazuaki Chayama, Nobuyuki Enomoto, Tooru Shimosegawa, Tetsuo Takehara, Kazuhiko Koike
Summary: The latest edition of the clinical practice guidelines for liver cirrhosis includes new background and future research questions, as well as updates based on international standards and recent findings. It covers various aspects of liver cirrhosis treatment, complication management, and clinically important issues, incorporating the latest information and references to international guidelines.
JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Nicky Janssen, Jean H. T. Daemen, Elise J. van Polen, Nadine A. Coorens, Yanina J. L. Jansen, Aimee J. P. M. Franssen, Karel W. E. Hulsewe, Yvonne L. J. Vissers, Frank -Martin Haecker, Jose R. Milanez de Campos, Erik R. de Loos, Chest Wall Int Grp Collaborator Grp
Summary: This study aims to evaluate the consensus and controversies regarding the diagnostic protocol, indications for surgical correction, and postoperative evaluation of pectus excavatum. Through multiple rounds of survey, consensus was reached on certain topics, aiding in the standardization of pectus excavatum care.
ANNALS OF THORACIC SURGERY
(2023)
Review
Oncology
J. Y. Blay, E. Palmerini, J. Bollard, S. Aguiar Jr, M. Angel, B. Araya, R. Badilla, D. Bernabeu, F. Campos, C. H. S. Caro-Sanchez, A. Carvajal Montoya, S. Casavilca-Zambrano, V Castro-Oliden, M. Chacon, M. A. Clara-Altamirano, P. Collini, R. Correa Genoroso, F. D. Costa, M. Cuellar, A. P. dei Tos, H. R. Dominguez Malagon, D. M. Donati, A. Dufresne, M. Eriksson, M. Farias-Loza, A. M. Frezza, T. Frisoni, D. Y. Garcia-Ortega, H. Gerderblom, F. Gouin, M. C. Gomez-Mateo, A. Gronchi, J. Haro, N. Hindi, L. Huanca, N. Jimenez, M. Karanian, B. Kasper, A. Lopes, B. B. Lopes David, A. Lopez-Pousa, G. Lutter, R. G. Maki, H. Martinez-Said, J. L. Martinez-Tlahuel, C. A. Mello, J. M. Morales Perez, D. S. Moura, S. A. Nakagawa, A. G. Nascimento, E. J. Ortiz-Cruz, S. Patel, Y. Pfluger, S. Provenzano, A. Righi, A. Rodriguez, T. G. Santos, K. Scotlandi, M. L. G. Silva, T. Soule, S. Stacchiotti, C. M. Valverde, F. Waisberg, E. Zamora Estrada, J. Martin-Broto
Summary: Bone sarcoma is a rare disease with a low incidence in adult population. The multidisciplinary management and expert discussion of diagnostic and therapeutic strategies are essential for these patients. The Sarcoma European Latin-American Network (SELNET) aims to improve clinical outcomes in sarcoma care, with a specific focus on Latin-American countries. The Clinical Practice Guidelines (CPG) developed by SELNET provide a standardized approach to diagnose, treat, and follow-up bone sarcoma patients in the Latin-American context.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Review
Oncology
Chiara Trevisiol, Massimo Gion, Alberto Vaona, Aline S. C. Fabricio, Elisa Roca, Lisa Licitra, Salvatore Alfieri, Paolo Bossi
Summary: The study investigated the clinical utility of circulating EBV-DNA (cEBV-DNA) in clinical practice guidelines and found that half of the available guidelines provide recommendations for its clinical use, but there are still methodological issues in standardizing the quantitative determination of cEBV-DNA.
Article
Multidisciplinary Sciences
Myoung Kyu Lee, Sae Byol Kim, Beomsu Shin
Summary: The study investigated the clinical characteristics of patients with chronic pulmonary aspergillosis based on spirometric patterns, revealing differences in features between restrictive and obstructive patterns. Further research is needed to explore the clinical significance of these findings.
Review
Oncology
Zhigang Zhang, Xiao Cao, Qi Wang, Qiuyu Yang, Mingyao Sun, Long Ge, Jinhui Tian
Summary: This study evaluated the quality of clinical practice guidelines for cancer pain and identified limitations in knowledge. The findings showed that the methodological quality of these guidelines fluctuated widely, and the reporting rates in some domains were very low.
FRONTIERS IN ONCOLOGY
(2022)
Review
Immunology
Rachel M. Reeves, Maarten van Wijhe, Toni Lehtonen, Luca Stona, Anne C. Teirlinck, Liliana Vazquez Fernandez, You Li, Richard Osei-Yeboah, Thea K. Fischer, Terho Heikkinen, Michiel van Boven, Hakon Boas, Daniele Dona, Elisa Barbieri, Harry Campbell
Summary: This systematic review aimed to identify clinical practice guidelines (CPGs) for the prevention of respiratory syncytial virus (RSV) infection across Europe. The study found discrepancies in recommendations for palivizumab prophylaxis for premature infants and children with various diseases. The study recommends that agencies adopt the RIGHT reporting requirements to improve the presentation of evidence-based decisions.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Oncology
Sandro Pasquali, Emanuela Palmerini, Vittorio Quagliuolo, Javier Martin-Broto, Antonio Lopez-Pousa, Giovanni Grignani, Antonella Brunello, Jean-Yves Blay, Oscar Tendero, Robert Diaz-Beveridge, Virginia Ferraresi, Iwona Lugowska, Gabriele Infante, Luca Braglia, Domenico Franco Merlo, Valeria Fontana, Emanuela Marchesi, Davide Maria Donati, Elena Palassini, Giuseppe Bianchi, Andrea Marrari, Carlo Morosi, Silvia Stacchiotti, Silvia Bague, Jean Michel Coindre, Angelo Paolo Dei Tos, Piero Picci, Paolo Bruzzi, Rosalba Miceli, Paolo Giovanni Casali, Alessandro Gronchi
Summary: The study investigated the benefit of neoadjuvant chemotherapy in soft tissue sarcoma patients based on prognostic stratification using the Sarculator nomogram. It found that high-risk patients treated with AI performed better than predicted, supporting the efficacy of neoadjuvant AI in STS.
Article
Immunology
Melissa Bersanelli, Giulia Mazzaschi, Patrizia Giannatempo, Daniele Raggi, Elena Fare, Marco Maruzzo, Umberto Basso, Ugo De Giorgi, Francesca Vignani, Giuseppe Luigi Banna, Marco Stellato, Rosa Tambaro, Emanuele Naglieri, Tania Losanno, Giuseppe Procopio, Sandro Pignata, Andrea Necchi, Sebastiano Buti
Summary: The study found that the prognosis of unselected UTUC patients is still unsatisfactory, but the Sonpavde score can be used as a useful tool in treatment decision-making process.
Article
Biochemistry & Molecular Biology
Gaia Codolo, Nicola Facchinello, Nicole Papa, Ambra Bertocco, Sara Coletta, Clara Benna, Luigi Dall'Olmo, Simone Mocellin, Natascia Tiso, Marina de Bernard
Summary: The Helicobacter pylori Neutrophil Activating Protein (HP-NAP) possesses immunomodulatory properties and can activate cytotoxic Th1 responses, inhibiting tumor growth and impacting the activity of macrophages. Using a zebrafish model, it was found that HP-NAP efficiently inhibits melanoma growth and metastasis by recruiting macrophages with a pro-inflammatory profile, highlighting the crucial role of activated macrophages in countering tumor growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Antonella Brunello, Antonella Galiano, Stefania Schiavon, Mariateresa Nardi, Alessandra Feltrin, Ardi Pambuku, Chiara De Toni, Alice Dal Col, Evelina Lamberti, Chiara Pittarello, Francesca Bergamo, Umberto Basso, Marco Maruzzo, Silvia Finotto, Maital Bolshinsky, Silvia Stragliotto, Letizia Procaccio, Mario Domenico Rizzato, Fabio Formaglio, Giuseppe Lombardi, Sara Lonardi, Vittorina Zagonel
Summary: This study describes the activity and performance of a simultaneous-care outpatient clinic (SCOC) at the Veneto Institute of Oncology-IRCCS. The results emphasize the importance of close collaboration between oncologists and palliative care teams in meeting the needs of cancer patients. Furthermore, the introduction of performance indicators allows for accurate assessment of the team's work.
Article
Dermatology
Alessandra Buja, Massimo Rugge, Giuseppe De Luca, Manuel Zorzi, Chiara De Toni, Claudia Cozzolino, Antonella Vecchiato, Paolo Del Fiore, Saveria Tropea, Romina Spina, Vincenzo Baldo, Carlo Riccardo Rossi, Simone Mocellin
Summary: This study investigated the association between direct costs for melanoma and the patients' clinical and histological characteristics. The results showed that factors such as mitoses, vertical growth, and absence of tumor-infiltrating lymphocytes were associated with higher direct costs.
DERMATOLOGY AND THERAPY
(2022)
Article
Oncology
Marco Fiore, Silva Ljevar, Sandro Pasquali, Daniele Morelli, Dario Callegaro, Roberta Sanfilippo, Marta Barisella, Claudia Sangalli, Rosalba Miceli, Alessandro Gronchi
Summary: Inflammatory biomarkers and neutrophil-to-lymphocyte ratio (NLR) are associated with prognosis in several tumors. Data on sarcomas are limited, and this study aimed to investigate the relationship between prognostic biomarkers and NLR in retroperitoneal sarcoma (RPS). The results showed that NLR was an independent predictor for overall survival in RPS.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Lorenzo Conti, Fahmina Buriro, Marco Baia, Sandro Pasquali, Rosalba Miceli, Laura De Rosa, Alessandro Gronchi, Marco Fiore
Summary: Limb-sparing surgery is the preferred treatment for primary extremity soft tissue sarcoma, but amputation is still necessary for selected patients, especially elderly or those with advanced disease.
Article
Oncology
Sebastiano Buti, Umberto Basso, Diana Giannarelli, Ugo De Giorgi, Marco Maruzzo, Roberto Iacovelli, Luca Galli, Camillo Porta, Francesco Carrozza, Giuseppe Procopio, Giuseppe Fonarini, Giovanni Lo Re, Matteo Santoni, Roberto Sabbatini, Antonio Cusmai, Paolo Andrea Zucali, Carlo Aschele, Editta Baldini, Elena Zafarana, Adolfo Favaretto, Silvana Leo, Alketa Hamzaj, Rosanna Mirabelli, Franco Nole', Silvia Zai, Claudio Chini, Cristina Masini, Sonia Fatigoni, Andrea Rocchi, Emiliano Tamburini, Alessio Cortellini, Melissa Bersanelli
Summary: We developed a drug-based score to predict prognosis and treatment response in advanced cancer patients receiving immune checkpoint inhibitors (ICIs), and validated its value in a population of metastatic renal cell carcinoma patients treated with ipilimumab plus nivolumab. The model considers the use of certain drugs before immunotherapy initiation and demonstrated significant and clinically meaningful predictions for overall survival and progression-free survival. Further development will involve analyzing the gut microbiome and its link to drug exposure and immune sensitivity.
JOURNAL OF IMMUNOTHERAPY
(2023)
Article
Cell Biology
Valentina Zuco, Sandro Pasquali, Monica Tortoreto, Stefano Percio, Valentina Doldi, Marta Barisella, Paola Collini, Gian Paolo Dagrada, Silvia Brich, Patrizia Gasparini, Marco Fiore, Michela Casanova, Anna Maria Frezza, Alessandro Gronchi, Silvia Stacchiotti, Andrea Ferrari, Nadia Zaffaroni
Summary: This study used a patient-derived xenograft (PDX) model to evaluate the effectiveness of different drugs against desmoplastic small round cell tumor (DSRCT). It was found that doxorubicin, pazopanib, and larotrectenib had moderate antitumor effects, while trabectedin had higher activity. Vinorelbine, irinotecan, and eribulin achieved nearly complete tumor growth inhibition. The combination of irinotecan with either eribulin or trabectedin resulted in complete responses. This study highlights the importance of patient-derived preclinical models in exploring new treatments for DSRCT.
DISEASE MODELS & MECHANISMS
(2023)
Article
Oncology
Sara Elena Rebuzzi, Matteo Brunelli, Francesca Galuppini, Valerio Gaetano Vellone, Alessio Signori, Fabio Catalano, Alessandra Damassi, Gabriele Gaggero, Pasquale Rescigno, Marco Maruzzo, Sara Merler, Francesca Vignani, Alessia Cavo, Umberto Basso, Michele Milella, Olimpia Panepinto, Manlio Mencoboni, Marta Sbaraglia, Angelo Paolo Dei Tos, Veronica Murianni, Malvina Cremante, Miguel Angel Llaja Obispo, Michele Maffezzoli, Giuseppe Luigi Banna, Sebastiano Buti, Giuseppe Fornarini
Summary: This study identified differential immunohistochemical patterns in the tumors of patients who responded and did not respond to nivolumab, an immunotherapy. Tumors in responders showed poor presence of CD4+ immune cells, high expression of CD56 on tumor cells, and high expression of phosphorylated mTOR protein. Further investigation with genomic analysis is planned to examine the prognostic role of the tumor microenvironment.
Article
Medicine, Research & Experimental
Michele Dionese, Umberto Basso, Francesco Pierantoni, Eleonora Lai, Nicolo Cavasin, Elisa Erbetta, Salim Jubran, Giorgio Bonomi, Davide Bimbatti, Marco Maruzzo
Summary: Inflammation indexes at baseline are prognostic for patients with metastatic urothelial carcinoma treated with immune checkpoint inhibitors. A lower neutrophil-to-lymphocyte ratio (NLR) and monocyte-to-lymphocyte ratio (MLR) are associated with longer progression-free survival (PFS) and overall survival (OS), as well as higher overall response rate (ORR) and disease control rate (DCR). Patients who experience immune-related adverse events (irAEs) also have longer PFS and OS.
Article
Oncology
Silvia Stacchiotti, Giacomo Giulio Baldi, Anna Maria Frezza, Carlo Morosi, Francesca Gabriella Greco, Paola Collini, Marta Barisella, Gian Paolo Dagrada, Nadia Zaffaroni, Sandro Pasquali, Alessandro Gronchi, Paul Huang, Matilde Ingrosso, Gabriele Tine, Rosalba Miceli, Paolo Giovanni Casali
Summary: This study investigated the activity of regorafenib in advanced solitary fibrous tumour (SFT). The results showed that regorafenib demonstrated activity in SFT, with 30% of patients being progression-free at one year. However, the overall response rate (ORR) and median progression-free survival (mPFS) were lower compared to other antiangiogenic agents.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Giuseppe Luigi Banna, Umberto Basso, Emilio Francesco Giunta, Lucia Fratino, Sara Elena Rebuzzi, Sebastiano Buti, Marco Maruzzo, Ugo De Giorgi, Veronica Murianni, Marika Cinausero, Helga Lipari, Teresa Gamba, Orazio Caffo, Davide Bimbatti, Arianna Dri, Alessandra Mosca, Paola Ermacora, Francesca Vignani, Aichi Msaki, Barbara Bonifacio, Valentina Lombardo, Vincenza Conteduca, Giuseppe Fornarini, Pasquale Rescigno
Summary: This study investigated prognostic factors for older patients with metastatic castrate-resistant prostate cancer (mCRPC) receiving androgen receptor pathway inhibitors (ARPIs) treatment. It found that G8 assessment score <= 14 and PSA decline >= 50% were independent factors associated with worse radiographic progression-free survival and overall survival.
Article
Oncology
Alessandra Buja, Massimo Rugge, Giuseppe De Luca, Emanuela Bovo, Manuel Zorzi, Chiara De Toni, Claudia Cozzolino, Antonella Vecchiato, Paolo Del Fiore, Romina Spina, Sandro Cinquetti, Vincenzo Baldo, Carlo Riccardo Rossi, Simone Mocellin
Summary: This study focuses on the changing incidence of cutaneous malignant melanoma (CMM) in Veneto region and its Alpine area in Northeast Italy, finding a significant increase in CMM incidence over the past 30 years, particularly among Alpine residents, especially younger females. Clinicopathological profile of CMM is associated with the place of residence. These findings have important implications for CMM prevention strategies.
Article
Oncology
Sara Elena Rebuzzi, Luigi Cerbone, Alessio Signori, Matteo Santoni, Veronica Murianni, Ugo De Giorgi, Giuseppe Procopio, Camillo Porta, Michele Milella, Umberto Basso, Francesco Massari, Marco Maruzzo, Roberto Iacovelli, Nicola Battelli, Luca Carmisciano, Giuseppe Luigi Banna, Sebastiano Buti, Giuseppe Fornarini
Summary: This study validated the predictive and prognostic role of the Meet-URO score in patients receiving cabozantinib for metastatic renal cell carcinoma. The Meet-URO score was found to provide more accurate prognostic stratification than the IMDC score and is an easy-to-use tool with no additional costs.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2022)
