From targets to targeted therapies and molecular profiling in non-small cell lung carcinoma

Crizotinib and Testing for ALK

(2017) Alice T. Shaw et al.   Journal of the National Comprehensive Cancer Network

Bridging the Gap: Moving Predictive and Prognostic Assays from Research to Clinical Use

(2012) P. M. Williams et al.   CLINICAL CANCER RESEARCH

ROS1 Rearrangements Define a Unique Molecular Class of Lung Cancers

(2012) Kristin Bergethon et al.   JOURNAL OF CLINICAL ONCOLOGY

Pretreatment Epidermal Growth Factor Receptor (EGFR) T790M Mutation Predicts Shorter EGFR Tyrosine Kinase Inhibitor Response Duration in Patients With Non–Small-Cell Lung Cancer

(2012) Kang-Yi Su et al.   JOURNAL OF CLINICAL ONCOLOGY

EGFR Mutation Heterogeneity and the Mixed Response to EGFR Tyrosine Kinase Inhibitors of Lung Adenocarcinomas

(2012) Z.-Y. Chen et al.   ONCOLOGIST

Implementing multiplexed genotyping of non-small-cell lung cancers into routine clinical practice

(2011) L. V. Sequist et al.   ANNALS OF ONCOLOGY

Role of Cytology in the Management of Non–Small-Cell Lung Cancer

(2011) Andrew H. Fischer et al.   JOURNAL OF CLINICAL ONCOLOGY

Heterogeneous Distribution of EGFR Mutations Is Extremely Rare in Lung Adenocarcinoma

(2011) Yasushi Yatabe et al.   JOURNAL OF CLINICAL ONCOLOGY

Comparison of KRAS and EGFR gene status between primary non-small cell lung cancer and local lymph node metastases: implications for clinical practice

(2011) Leina Sun et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

A Platform for Rapid Detection of Multiple Oncogenic Mutations With Relevance to Targeted Therapy in Non–Small-Cell Lung Cancer

(2011) Zengliu Su et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Screening of Anaplastic Lymphoma Kinase Rearrangement by Immunohistochemistry in Non-small Cell Lung Cancer: Correlation with Fluorescence In Situ Hybridization

(2011) Jin Ho Paik et al.   Journal of Thoracic Oncology

Correlation of IHC and FISH for ALK Gene Rearrangement in Non-small Cell Lung Carcinoma: IHC Score Algorithm for FISH

(2011) Eunhee S. Yi et al.   Journal of Thoracic Oncology

Suitability of Thoracic Cytology for New Therapeutic Paradigms in Non-small Cell Lung Carcinoma: High Accuracy of Tumor Subtyping and Feasibility of EGFR and KRAS Molecular Testing

(2011) Natasha Rekhtman et al.   Journal of Thoracic Oncology

Tissue sampling in lung cancer: A review in light of the MERIT experience

(2011) Martin Reck et al.   LUNG CANCER

Role of randomized phase III trials in an era of effective targeted therapies

(2011) Manish R. Sharma et al.   Nature Reviews Clinical Oncology

Equipoise and the Dilemma of Randomized Clinical Trials

(2011) Franklin G. Miller et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pathological Diagnosis and Classification of Lung Cancer in Small Biopsies and Cytology: Strategic Management of Tissue for Molecular Testing

(2011) William Travis et al.   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

Clinical Implementation of Comprehensive Strategies to Characterize Cancer Genomes: Opportunities and Challenges

(2011) L. E. MacConaill et al.   Cancer Discovery

The BATTLE Trial: Personalizing Therapy for Lung Cancer

(2011) Edward S. Kim et al.   Cancer Discovery

High-Throughput Detection of Actionable Genomic Alterations in Clinical Tumor Samples by Targeted, Massively Parallel Sequencing

(2011) Nikhil Wagle et al.   Cancer Discovery

KRAS mutation status in primary nonsmall cell lung cancer and matched metastases

(2010) Alexis B. Cortot et al.   CANCER

Preexistence and Clonal Selection of MET Amplification in EGFR Mutant NSCLC

(2010) Alexa B. Turke et al.   CANCER CELL

The Cross-Validated Adaptive Signature Design

(2010) B. Freidlin et al.   CLINICAL CANCER RESEARCH

A Novel, Highly Sensitive Antibody Allows for the Routine Detection of ALK-Rearranged Lung Adenocarcinomas by Standard Immunohistochemistry

(2010) M. Mino-Kenudson et al.   CLINICAL CANCER RESEARCH

Rapid targeted mutational analysis of human tumours: a clinical platform to guide personalized cancer medicine

(2010) Dora Dias-Santagata et al.   EMBO Molecular Medicine

Ethics of Mandatory Research Biopsy for Correlative End Points Within Clinical Trials in Oncology

(2010) Jeffrey Peppercorn et al.   JOURNAL OF CLINICAL ONCOLOGY

Pilot Study Using Molecular Profiling of Patients' Tumors to Find Potential Targets and Select Treatments for Their Refractory Cancers

(2010) Daniel D. Von Hoff et al.   JOURNAL OF CLINICAL ONCOLOGY

Discordance of Molecular Biomarkers Associated with Epidermal Growth Factor Receptor Pathway between Primary Tumors and Lymph Node Metastasis in Non-small Cell Lung Cancer

(2010) Sarah Park et al.   Journal of Thoracic Oncology

Advances in understanding cancer genomes through second-generation sequencing

(2010) Matthew Meyerson et al.   NATURE REVIEWS GENETICS

Anaplastic Lymphoma Kinase Inhibition in Non–Small-Cell Lung Cancer

(2010) Eunice L. Kwak et al.   NEW ENGLAND JOURNAL OF MEDICINE

Core Needle Lung Biopsy Specimens: Adequacy for EGFR and KRAS Mutational Analysis

(2009) Stephen B. Solomon et al.   AMERICAN JOURNAL OF ROENTGENOLOGY

EGFR/KRAS/BRAF Mutations in Primary Lung Adenocarcinomas and Corresponding Locoregional Lymph Node Metastases

(2009) K. Schmid et al.   CLINICAL CANCER RESEARCH

Endobronchial ultrasound-guided transbronchial needle aspiration for identifying EGFR mutations

(2009) I. Garcia-Olive et al.   EUROPEAN RESPIRATORY JOURNAL

Adequacy and complications of computed tomography-guided core needle biopsy on non-small cell lung cancers for epidermal growth factor receptor mutations demonstration: 18-gauge or 20-gauge biopsy needle

(2009) Yun-Chung Cheung et al.   LUNG CANCER

Sequencing technologies — the next generation

(2009) Michael L. Metzker   NATURE REVIEWS GENETICS

Comparison of epidermal growth factor receptor mutations between primary and corresponding metastatic tumors in tyrosine kinase inhibitor-naive non-small-cell lung cancer

(2008) C.-H. Gow et al.   ANNALS OF ONCOLOGY

Comparison of EGFR and K-RAS gene status between primary tumours and corresponding metastases in NSCLC

(2008) A Kalikaki et al.   BRITISH JOURNAL OF CANCER

Intratumor heterogeneity of epidermal growth factor receptor mutations in lung cancer and its correlation to the response to gefitinib

(2008) Kazuya Taniguchi et al.   CANCER SCIENCE

Bayesian adaptive design for targeted therapy development in lung cancer — a step toward personalized medicine

(2008) Xian Zhou et al.   Clinical Trials

Detection of Mutations inEGFRin Circulating Lung-Cancer Cells

(2008) Shyamala Maheswaran et al.   NEW ENGLAND JOURNAL OF MEDICINE