☆ 4.7 Article Proceedings Paper

Clinical heterogeneity of extranodal NK/T-cell lymphoma, nasal type: a national survey of the Korean Cancer Study Group

ANNALS OF ONCOLOGY (2008)

Journal

ANNALS OF ONCOLOGY

Volume 19, Issue 8, Pages 1477-1484

Publisher

OXFORD UNIV PRESS

DOI: 10.1093/annonc/mdn147

Keywords

clinical heterogeneity; NK/T-cell lymphoma; prognostic factor

Funding

Korea Health Promotion Institute [A062260, A050564, A070001] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
National Research Foundation of Korea [R13-2002-025-01001-0] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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Abstract

Background: This national survey was undertaken to propose the classification of extranodal natural killer (NK)/T-cell lymphoma (NTCL) subtypes and to clarify a clinical heterogeneity. Patients and methods: Two hundred and eighty patients newly diagnosed as NTCL were enrolled from 22 Korean medical centers. Two subsets were compared: one involving the upper aerodigestive tract (UAT) and another involving the non-upper aerodigestive tract (NUAT) region, which comprises the skin, gastrointestinal tract, and liver or soft tissues. Clinical prognostic factors, survival outcomes, and independent predictors for survival were compared between each subset. Results: NUAT-NTCL (59 patients) had significantly higher proportions of disseminated disease, aggressive biologic features, and unfavorable host reactions compared with UAT-NTCL (221 patients). NUAT-NTCL had shortened 5-year overall survival (OS) (22% versus 41%, P = 0.001). Ann Arbor staging, the International Prognostic Index, and the NTCL prognostic index failed to predict the OS of NUAT-NTCL, but did predict the OS in UAT-NTCL. Independent predictors for OS by multivariate analyses differed between each subset. In the NUAT subset, extranodal sites and regional nodes predicted the OS, while Ann Arbor staging, age, performance status, and lactate dehydrogenase level predicted the OS in the UAT subset. Conclusion: NUAT-NTCL may represent a distinctive disease entity in terms of clinical factors, independent predictors, and survival outcomes.

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Clinical characteristics and treatment of NK/T-cell lymphoma-associated HLH

Guangqiang Meng, Jingshi Wang, Tingting Cui, Zhao Wang

Summary: Natural killer (NK)/T-cell lymphoma-associated hemophagocytic lymphohistiocytosis (NK/T-LAHLH) is a rare and life-threatening disorder. The clinical characteristics and appropriate treatment options for this disease are still unclear. This study found that patients with NK/T-LAHLH were younger and had more severe clinical features, while the L-DEP/DEP regimen may have a better response rate than the VP-16 + dexamethasone-based regimens.

ANNALS OF HEMATOLOGY (2022)