Review
Pharmacology & Pharmacy
Tao Yang, Yilin Xiong, Yufei Zeng, Yan Wang, Jing Zeng, Jie Liu, Shangfu Xu, Li-Sheng Li
Summary: Lung cancer, especially non-small cell lung cancer (NSCLC), is still the leading cause of cancer-related deaths worldwide. Despite some clinical advancements in conventional treatments, the survival rate of NSCLC remains low. In recent years, immunotherapy, including antibody therapy and cell therapy, has emerged as a new frontier in lung cancer research, particularly immune checkpoint inhibitors (ICI). These approaches have significantly improved the survival rate and treatment response in NSCLC patients by enhancing the immune system and targeting tumor cells more effectively. This paper provides a comprehensive review of the relevant targets, clinical progress, and adverse reactions of various immunotherapies, as well as their combination therapies, aiming to offer better treatment options for NSCLC.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Daria Maniero, Greta Lorenzon, Ilaria Marsilio, Anna D'Odorico, Edoardo Vincenzo Savarino, Fabiana Zingone
Summary: This study found that the gluten-free diet is associated with an increased risk of weight gain and the development of metabolic disorders. Evaluating the nutritional status using specific parameters, the study found that patients with celiac disease had a poorer nutritional status at diagnosis compared to healthy controls, but their nutritional status significantly improved after following a gluten-free diet.
Article
Rheumatology
Marco Di Battista, Simone Barsotti, Alessia Monaco, Alessandra Rossi, Alessandra Della Rossa, Marta Mosca
Summary: The study found that SSc patients had lower values of phase angle, basal metabolic rate, and body cellular mass, along with an increase in extracellular water compared to healthy controls. Age correlated with ECW and inversely with PhA in SSc patients. Female sex, anemia, hypoalbuminemia, reflux, and early satiety/abdominal distension were associated with relevant alterations in BIVA results.
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Oncology
Zeynep Oruc, Ahmet Akbay, M. Ali Kaplan, Idris Oruc, Zuhat Urakci, Mehmet Kucukoner, Abdurrahman Isikdogan
Summary: This study investigates the effect of body fat mass ratio on survival and prognosis in patients with advanced non-small-cell lung cancer. The results demonstrate that body fat mass ratio is an important prognostic factor for these patients.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2022)
Article
Oncology
Yumeng Tian, Lu Xu, Xin Li, Heming Li, Mingfang Zhao
Summary: SMARCA4, a transcription activator, is an ATP-dependent catalytic subunit of SWI/SNF chromatin-remodeling complexes. It plays a role in regulating chromatin structure and gene expression and is a tumor suppressor in non-small-cell lung cancers (NSCLCs). NSCLC patients with SMARCA4 alterations have a poor response to chemotherapy and prognosis. This review summarizes the biological functions of SMARCA4, its role in NSCLC development, and potential therapeutic approaches.
Article
Public, Environmental & Occupational Health
Xianghui Yang, Liyong Deng, Min Li, Yongjie Zhou, Guihua Wang
Summary: This study evaluated the association between socioeconomic status (SES) factors and cancer-specific survival (CSS) in patients with non-small cell lung cancer (NSCLC). A novel TNM-SES staging system was proposed, which showed superior predictive value compared to the traditional TNM stage.
FRONTIERS IN PUBLIC HEALTH
(2022)
Letter
Medicine, General & Internal
Hollis Viray, Deepa Rangachari, Daniel B. Costa
Summary: The study reported initial data of trastuzumab deruxtecan in the treatment of lung cancers with ERBB2 mutations, including patients who had previously received ineffective ERBB2 tyrosine kinase inhibitors.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Oncology
Giuseppe Giaccone, Yongfeng He
Summary: Lung cancer is the leading cause of cancer related death, with two major histological subtypes, NSCLC and SCLC. Transformation from NSCLC to SCLC can cause treatment resistance, potentially due to therapy-induced changes or clonal selection. This article discusses the potential mechanisms, cell of origin, and genomic alterations in both de novo and transformed SCLC, as well as treatment options including chemotherapy, radiotherapy, TKIs, immunotherapy, and antiangiogenic agents.
SEMINARS IN CANCER BIOLOGY
(2023)
Article
Nutrition & Dietetics
Camila Pugliese, Artur Figueiredo Delgado, Katia Tomie Kozu, Lucia Maria de Arruda Campos, Nadia Emi Aikawa, Clovis Artur Silva, Adriana Maluf Elias
Summary: This study aimed to assess body composition using bioelectrical impedance and food intake in juvenile dermatomyositis patients. The findings suggest that bioelectrical impedance can be a useful auxiliary exam in the medical and nutritional follow-up of JDM patients.
Article
Nutrition & Dietetics
Edoardo Rosato, Antonietta Gigante, Chiara Pellicano, Amalia Colalillo, Danilo Alunni-Fegatelli, Maurizio Muscaritoli
Summary: The study aimed to investigate the association between nutritional status and mortality in patients with systemic sclerosis (SSc). The phase angle (PhA) derived from bioelectrical impedance analysis was found to be a parameter of nutritional status and a marker of mortality. The results showed that patients with lower PhA values had a higher risk of malnutrition and lower survival rates. Rating: 8 out of 10.
Review
Oncology
Ningning Yan, Sanxing Guo, Huixian Zhang, Ziheng Zhang, Shujing Shen, Xingya Li
Summary: This review summarizes the characteristics and challenges of BRAF mutations in NSCLC, as well as the treatment strategies and resistance mechanisms of BRAF-targeted therapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
John V. Heymach, David Harpole, Tetsuya Mitsudomi, Janis M. Taube, Gabriella Galffy, Maximilian Hochmair, Thomas Winder, Ruslan Zukov, Gabriel Garbaos, Shugeng Gao, Hiroaki Kuroda, Gyula Ostoros, Tho V. Tran, Jian You, Kang-Yun Lee, Lorenzo Antonuzzo, Zsolt Papai-Szekely, Hiroaki Akamatsu, Bivas Biswas, Alexander Spira, Jeffrey Crawford, Ha T. Le, Mike Aperghis, Gary J. Doherty, Helen Mann, Tamer M. Fouad, Martin Reck, AEGEAN Invest
Summary: In resectable non-small-cell lung cancer patients, perioperative durvalumab plus neoadjuvant chemotherapy showed significantly improved event-free survival and pathological complete response compared to neoadjuvant chemotherapy alone, with a similar safety profile.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Cell Biology
Haiyang Guo, Jun Zhang, Chao Qin, Hang Yan, Tao Liu, Haiyang Hu, Shengjie Tang, Shoujun Tang, Haining Zhou
Summary: This review summarizes the current and potential therapies for non-small-cell lung cancer (NSCLC), with a focus on targeted therapies and immunotherapies. It highlights the future role of metabolic therapies and combination therapies in NSCLC.
Article
Medicine, General & Internal
Isa Mambetsariev, Leonidas Arvanitis, Jeremy Fricke, Rebecca Pharaon, Angel R. Baroz, Michelle Afkhami, Marianna Koczywas, Erminia Massarelli, Ravi Salgia
Summary: EGFR-mutated lung adenocarcinoma patients can transform into SCLC after receiving TKI therapy. This study evaluated 9 patients who underwent such transformation and found that they had unique clinical, molecular, and histological characteristics at different time points. The findings are important for understanding the molecular heterogeneity and clinical outcomes of this EGFR TKI resistance subtype.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Yimin Wang, Chuling Li, Zimu Wang, Zhaofeng Wang, Ranpu Wu, Ying Wu, Yong Song, Hongbing Liu
Summary: This systematic review evaluated the efficacy and safety of immunotherapy in early and late lung cancer, finding that immunotherapy has better efficacy in early lung cancer compared to advanced lung cancer, especially when combined with chemotherapy. In terms of safety, immunotherapy, either alone or in combination with other therapies, was found to be safer in early lung cancer than in advanced lung cancer.
Article
Engineering, Biomedical
J. O. B. Diniz, D. A. Dias Junior, L. B. da Cruz, G. L. F. da Silva, J. L. Ferreira, D. B. Q. Pontes, A. C. Silva, A. C. de Paiva, M. Gattas
Summary: In this article, a deep learning method for heart segmentation from planning CT is proposed and it has been proven to be effective.
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING-IMAGING AND VISUALIZATION
(2023)
Article
Orthopedics
Samantha Gomes de Alegria, Beatriz Luiza Pinheiro Alves Azevedo, Jessica Gabriela Messias Oliveira, Matheus Mello da Silva, Damara Guedes Gardel, Thiago Thomaz Mafort, Agnaldo Jose Lopes
Summary: This study examined the impact of therapist-oriented home rehabilitation (TOHR) on functional capacity, physical function, hand function, and quality of life (QoL) among women with systemic sclerosis (SSc). The results showed that after TOHR, there was a significant reduction in total time and manual time for TGlittre tasks, improvement in hand function and QoL.
JOURNAL OF BACK AND MUSCULOSKELETAL REHABILITATION
(2023)
Article
Computer Science, Information Systems
Mauricio M. Almeida, Joao D. S. Almeida, Geraldo B. Junior, Aristofanes C. Silva, Anselmo C. Paiva
Summary: The use of data is crucial for various processes such as business and scientific endeavors. However, data consumption can be hindered by sample losses. To address this, we propose a new method that transforms time series into images and utilizes a conditional generative adversarial network (cGAN) pix2pix GAN for imputation. Results indicate that the network outperforms other methods in 50% of the datasets based on ASMAPE and MAE evaluations. Furthermore, the proposed network demonstrates its ability to learn time series features and capitalize on spatial and temporal features for imputation.
IEEE LATIN AMERICA TRANSACTIONS
(2023)
Article
Orthopedics
Joao Eduardo de Azevedo Vieira, Thiago Thomaz Mafort, Laura Braga Monnerat, Mariana Soares da Cal, Angelo Thomaz Abalada Ghetti, Agnaldo Jose Lopes
Summary: This study evaluated muscle function and quality of life in patients with post-acute COVID-19 syndrome at 3, 6, 9, and 12 months, and assessed their associations with general fatigue and lung function. The results showed a progressive improvement in quality of life, general fatigue, and pulmonary function during the 12 months of follow-up, with more pronounced improvement in the first 6 months. There was a relationship between functionality and quality of life in these patients.
JOURNAL OF BACK AND MUSCULOSKELETAL REHABILITATION
(2023)
Article
Health Care Sciences & Services
Mauro Ribeiro Balata, Arthur Sa Ferreira, Ariane da Silva Sousa, Laura Felipe Meinertz, Luciana Milhomem de Sa, Vinicius Guterres Araujo, Jannis Papathanasiou, Agnaldo Jose Lopes
Summary: This study evaluated the functional capacity in patients with NDD-CKD using the Glittre-ADL test and found a correlation between TGlittre time and handgrip strength (HGS) as well as physical activity level (PAL). Incorporating the TGlittre into the evaluation of these patients may improve risk stratification and personalized care.
Article
Health Care Sciences & Services
Gabriel Parisotto, Luis Felipe Fonseca Reis, Mauricio Sant'Anna Junior, Jannis Papathanasiou, Agnaldo Jose Lopes, Arthur Sa Ferreira
Summary: This study explored the association between multiple risk factors and musculoskeletal function in adults hospitalized for acute coronary syndrome. The strongest linear association was found between drinking habits and the total number of cardiovascular disease risk factors, followed by smoking load. Furthermore, handgrip strength and respiratory muscle strength were associated with mean blood pressure, drinking habits, and body mass index.
Article
Medicine, General & Internal
Laura Braga Monnerat, Elisa Barbosa Louzada, Vanessa Godinho Souza Braga, Mariana Soares da Cal, Agnaldo Jose Lopes, Thiago Thomaz Mafort
Summary: This article reports a case of a rare disease called pseudochylothorax and provides a detailed description of its characteristics. Pseudochylothorax is characterized by pleural effusion rich in lipids, typically with a cloudy, milky appearance. The case report includes the patient's medical history, clinical presentation, and diagnostic methods, as well as recommendations for diagnosis and treatment.
AMERICAN JOURNAL OF CASE REPORTS
(2023)
Article
Engineering, Biomedical
Nathalia Alves de Oliveira Saraiva, Iasmim de Oliveira Farias, Brenda Mesquita dos Santos, Rosemere Saldanha Xavierc, Agnaldo Jose Lopes
Summary: Muscle function and lung function are key factors in determining the 6-min walking distance in patients with diffuse cutaneous systemic sclerosis-associated interstitial lung disease.
CLINICAL BIOMECHANICS
(2023)
Article
Respiratory System
Vanessa Joaquim Ribeiro Moco, Aline Almeida Gulart, Agnaldo Jose Lopes, Arthur de Sa Ferreira, Luis Felipe da Fonseca Reis
Summary: Home exercises with minimal resources can improve activities of daily living, reduce dyspnea, and enhance health status and quality of life in individuals with COPD.
COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2023)
Article
Multidisciplinary Sciences
Cristiane Pires Motta, Davi Luiz Olimpio da Silva, Lohana Resende da Costa, Giselle Faria Galhardo, Agnaldo Jose Lopes
Summary: This study used TGlittre to compare patients with PTBB to patients with NPTBB and evaluate the determinants of performance during TGlittre. The results showed that PTBB patients had lower than expected performance on TGlittre, and lung volume and QMS were the important factors affecting performance.
Article
Multidisciplinary Sciences
Elizabeth Jauhar Cardoso Bessa, Felipe de Miranda Carbonieri Ribeiro, Rosana Souza Rodrigues, Claudia Henrique da Costa, Rogerio Rufino, Geraldo da Rocha Castelar Pinheiro, Agnaldo Jose Lopes
Summary: This study found that lung function, extent of lung involvement, and age are associated with poorly distributed ventilation in patients with RA. In addition, respiratory symptoms and deteriorated physical function are closely related to the distribution of ventilation in these patients.
Article
Respiratory System
Bruno Tavares Caldas, Fernando Carlos Vetromille Ribeiro, Joao Santos Pereira, Wilma Costa Souza, Agnaldo Jose Lopes, Pedro Lopes de Melo
Summary: Respiratory oscillometry simplifies lung function analysis in Parkinson's disease (PD) and has high diagnostic accuracy in early and more advanced stages of the disease. Different stages of PD are associated with respiratory abnormalities including increased peripheral resistance, reductions in dynamic compliance, and an increase in resonance frequency.
BMC PULMONARY MEDICINE
(2023)
Article
Rehabilitation
Isabelle da Nobrega Ferreira, Ariane Moreira Carneiro de Oliveira, Brenda Mesquita dos Santos, Agnaldo Jose Lopes
Summary: This study evaluated the association between TGlittre test and measures of pulmonary function, body balance, and quality of life in patients undergoing thoracic surgery in the preoperative period. It also found that TGlittre test may be a prognostic test for postoperative complications, especially with respect to chest tube duration.
PHYSIOTHERAPY THEORY AND PRACTICE
(2023)
Article
Computer Science, Information Systems
Alan Carlos de Moura Lima, Lisle Faray de Paiva, Geraldo Braz Jr, Joao Dallyson S. de Almeida, Aristofanes Correa Silva, Miguel Tavares Coimbra, Anselmo Cardoso de Paiva
Summary: The gastrointestinal tract plays a crucial role in digestion, but it is susceptible to diseases such as colorectal cancer. Colorectal cancer is highly lethal, originating from benign tumors called colorectal polyps. Early detection is vital but challenging due to limitations in diagnostic techniques. Computer-aided detection using colonoscopy images has been developed to improve detection quality, and this study proposes a two-stage method using transformers. The results show satisfactory performance, with average precision reaching 91-92% in different datasets. This study demonstrates the efficient use of depth maps, salient object-extracted maps, and transformers for polyp detection in colonoscopy images.
Article
Rehabilitation
Joao Eduardo de Azevedo Vieira, Arthur de Sa Ferreira, Laura Braga Monnerat, Mariana Soares da Cal, Angelo Thomaz Abalada Ghetti, Thiago Thomaz Mafort, Agnaldo Jose Lopes
Summary: This study built prediction models for the Post-COVID-19 Functional Status (PCFS) scale using sociodemographic data, clinical findings, lung function, and muscle strength. The results showed that worse general fatigue and handgrip strength were associated with more severe physical function impairments in patients with post-COVID-19 syndrome. Additionally, a history of prior hospitalization resulted in worse physical function. Prediction models incorporating objective measures can better assess the physical function of these patients and aid in the selection of candidates for a physical reconditioning program.
JOURNAL OF BODYWORK AND MOVEMENT THERAPIES
(2024)
