SPECT and PET imaging in Alzheimer’s disease

Review and Meta-Analysis of Biomarkers and Diagnostic Imaging in Alzheimer's Disease

(2018) Lisa M. Bloudek et al.   JOURNAL OF ALZHEIMERS DISEASE

Amyloid Deposition in Early Onset versus Late Onset Alzheimer's Disease

(2018) Hanna Cho et al.   JOURNAL OF ALZHEIMERS DISEASE

Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F-18]-T807

(2018) David T. Chien et al.   JOURNAL OF ALZHEIMERS DISEASE

Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F18]-T808

(2018) David T. Chien et al.   JOURNAL OF ALZHEIMERS DISEASE

Early identification of MCI converting to AD: a FDG PET study

(2017) Marco Pagani et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

18F-Florbetaben PET beta-amyloid binding expressed in Centiloids

(2017) Christopher C. Rowe et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

3-(Benzyloxy)-1-(5-[18F]fluoropentyl)-5-nitro-1H-indazole: a PET radiotracer to measure acetylcholinesterase in brain

(2017) Soledad Fernández et al.   Future Medicinal Chemistry

Preclinical Evaluation of18F-RO6958948,11C-RO6931643, and11C-RO6924963 as Novel PET Radiotracers for Imaging Tau Aggregates in Alzheimer Disease

(2017) Michael Honer et al.   JOURNAL OF NUCLEAR MEDICINE

Tau-imaging in neurodegeneration

(2017) Gérard N. Bischof et al.   METHODS

Clinically Different Stages of Alzheimer's Disease Associated by Amyloid Deposition with [11C]-PIB PET Imaging

(2017) Shizuo Hatashita et al.   JOURNAL OF ALZHEIMERS DISEASE

Kinetic analysis of the translocator protein positron emission tomography ligand [18F]GE-180 in the human brain

(2016) Claire Feeney et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Decreased in vivo availability of the cannabinoid type 2 receptor in Alzheimer’s disease

(2016) Rawaha Ahmad et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Imaging in-vivo tau pathology in Alzheimer’s disease with THK5317 PET in a multimodal paradigm

(2016) Konstantinos Chiotis et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Standardized Expression of 18F-NAV4694 and 11C-PiB  -Amyloid PET Results with the Centiloid Scale

(2016) C. C. Rowe et al.   JOURNAL OF NUCLEAR MEDICINE

Comparison of Early-Phase 11C-Deuterium-L-Deprenyl and 11C-Pittsburgh Compound B PET for Assessing Brain Perfusion in Alzheimer Disease

(2016) E. Rodriguez-Vieitez et al.   JOURNAL OF NUCLEAR MEDICINE

11 C-PBR28 binding to translocator protein increases with progression of Alzheimer's disease

(2016) William C. Kreisl et al.   NEUROBIOLOGY OF AGING

Amyloid Imaging: Poised for Integration into Medical Practice

(2016) Keshav Anand et al.   Neurotherapeutics

Dynamic PET Measures of Tau Accumulation in Cognitively Normal Older Adults and Alzheimer’s Disease Patients Measured Using [18F] THK-5351

(2016) Samuel N. Lockhart et al.   PLoS One

The Centiloid Project: Standardizing quantitative amyloid plaque estimation by PET

(2015) William E. Klunk et al.   Alzheimers & Dementia

Florbetaben PET imaging to detect amyloid beta plaques in Alzheimer's disease: Phase 3 study

(2015) Osama Sabri et al.   Alzheimers & Dementia

Preclinical properties and humanin vivoassessment of123I-ABC577 as a novel SPECT agent for imaging amyloid-β

(2015) Yoshifumi Maya et al.   BRAIN

Diagnostic accuracy of 18F amyloid PET tracers for the diagnosis of Alzheimer’s disease: a systematic review and meta-analysis

(2015) Elizabeth Morris et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

[18F]THK-5117 PET for assessing neurofibrillary pathology in Alzheimer’s disease

(2015) Ryuichi Harada et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Advantages in functional imaging of the brain

(2015) Walter Mier et al.   Frontiers in Human Neuroscience

Dementia with Lewy bodies can be well-differentiated from Alzheimer's disease by measurement of brain acetylcholinesterase activity-a [11C]MP4A PET study

(2015) H. Shimada et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

PET Quantification of Tau Pathology in Human Brain with 11C-PBB3

(2015) Y. Kimura et al.   JOURNAL OF NUCLEAR MEDICINE

Tau imaging: early progress and future directions

(2015) Victor L Villemagne et al.   LANCET NEUROLOGY

P-glycoprotein expression and amyloid accumulation in human aging and Alzheimer's disease: preliminary observations

(2015) Catherine Chiu et al.   NEUROBIOLOGY OF AGING

FIBT versus florbetaben and PiB: a preclinical comparison study with amyloid-PET in transgenic mice

(2015) Behrooz H Yousefi et al.   EJNMMI Research

Visualization of regional tau deposits using 3H-THK5117 in Alzheimer brain tissue

(2015) Laetitia Lemoine et al.   Acta Neuropathologica Communications

High Affinity Radiopharmaceuticals Based Upon Lansoprazole for PET Imaging of Aggregated Tau in Alzheimer’s Disease and Progressive Supranuclear Palsy: Synthesis, Preclinical Evaluation, and Lead Selection

(2014) Maria V. Fawaz et al.   ACS Chemical Neuroscience

In vivo tau imaging: Obstacles and progress

(2014) Victor L. Villemagne et al.   Alzheimers & Dementia

Non-invasive assessment of Alzheimer’s disease neurofibrillary pathology using 18F-THK5105 PET

(2014) Nobuyuki Okamura et al.   BRAIN

Developments in Tau PET Imaging

(2014) Eduardo Rigon Zimmer et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

In vivo evaluation of a novel tau imaging tracer for Alzheimer’s disease

(2014) Victor L. Villemagne et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Radiosynthesis, Photoisomerization, Biodistribution, and Metabolite Analysis of 11C-PBB3 as a Clinically Useful PET Probe for Imaging of Tau Pathology

(2014) H. Hashimoto et al.   JOURNAL OF NUCLEAR MEDICINE

In Vivo SPECT Imaging of Amyloid-  Deposition with Radioiodinated Imidazo[1,2-a]Pyridine Derivative DRM106 in a Mouse Model of Alzheimer's Disease

(2014) C.-J. Chen et al.   JOURNAL OF NUCLEAR MEDICINE

Predictive Accuracy of Amyloid Imaging for Progression From Mild Cognitive Impairment to Alzheimer Disease With Different Lengths of Follow-up

(2014) Yan Ma et al.   MEDICINE

Florbetapir F 18 amyloid PET and 36-month cognitive decline:a prospective multicenter study

(2014) P M Doraiswamy et al.   MOLECULAR PSYCHIATRY

Exploratory analyses of regional human brain distribution of the PET tau tracer F18-labeled T807 (AV-1541) in subjects with normal cognitive function or cognitive impairment thought to be due to Alzheimer's disease

(2013) Mark Mintun et al.   Alzheimers & Dementia

Amyloid Deposition and Cognition in Older Adults: The Effects of Premorbid Intellect

(2013) K. Duff et al.   ARCHIVES OF CLINICAL NEUROPSYCHOLOGY

Effect of amyloid on memory and non-memory decline from preclinical to clinical Alzheimer’s disease

(2013) Yen Ying Lim et al.   BRAIN

[18F]Flutemetamol amyloid-beta PET imaging compared with [11C]PIB across the spectrum of Alzheimer’s disease

(2013) Shizuo Hatashita et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Synthesis and preliminary evaluation of 2-arylhydroxyquinoline derivatives for tau imaging

(2013) Tetsuro Tago et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Neuropathologic Heterogeneity Does Not Impair Florbetapir-Positron Emission Tomography Postmortem Correlates

(2013) Brittany N. Dugger et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Novel 18F-Labeled Arylquinoline Derivatives for Noninvasive Imaging of Tau Pathology in Alzheimer Disease

(2013) N. Okamura et al.   JOURNAL OF NUCLEAR MEDICINE

Imaging markers for Alzheimer disease: Which vs how

(2013) G. B. Frisoni et al.   NEUROLOGY

Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls

(2013) Masahiro Maruyama et al.   NEURON

[18F]DPA-714: Direct Comparison with [11C]PK11195 in a Model of Cerebral Ischemia in Rats

(2013) Hervé Boutin et al.   PLoS One

18F-florbetaben Aβ imaging in mild cognitive impairment

(2013) Kevin Ong et al.   Alzheimers Research & Therapy

Pittsburgh compound B and the postmortem diagnosis of alzheimer disease

(2012) Dana M. Niedowicz et al.   ANNALS OF NEUROLOGY

Amyloid imaging in Alzheimer's disease: comparison of florbetapir and Pittsburgh compound-B positron emission tomography

(2012) David A Wolk et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Amyloid-  Imaging with Pittsburgh Compound B and Florbetapir: Comparing Radiotracers and Quantification Methods

(2012) S. M. Landau et al.   JOURNAL OF NUCLEAR MEDICINE

Evidence for Astrocytosis in Prodromal Alzheimer Disease Provided by 11C-Deuterium-L-Deprenyl: A Multitracer PET Paradigm Combining 11C-Pittsburgh Compound B and 18F-FDG

(2012) S. F. Carter et al.   JOURNAL OF NUCLEAR MEDICINE

Cerebral PET with florbetapir compared with neuropathology at autopsy for detection of neuritic amyloid-β plaques: a prospective cohort study

(2012) Christopher M Clark et al.   LANCET NEUROLOGY

Selectivity requirements for diagnostic imaging of neurofibrillary lesions in Alzheimer's disease: A simulation study

(2012) Kelsey N. Schafer et al.   NEUROIMAGE

Perfusion SPECT studies with mapping of Brodmann areas in differentiating Alzheimer’s disease from frontotemporal degeneration syndromes

(2012) Varvara Valotassiou et al.   NUCLEAR MEDICINE COMMUNICATIONS

Predicting Future Clinical Changes of MCI Patients Using Longitudinal and Multimodal Biomarkers

(2012) Daoqiang Zhang et al.   PLoS One

Translational studies on regulation of brain docosahexaenoic acid (DHA) metabolism in vivo

(2012) Stanley I. Rapoport   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Alzheimer Disease: New Concepts on Its Neurobiology and the Clinical Role Imaging Will Play

(2012) Clifford R. Jack   RADIOLOGY

Evaluation of [11C]N-Methyl Lansoprazole as a Radiopharmaceutical for PET Imaging of Tau Neurofibrillary Tangles

(2012) Xia Shao et al.   ACS Medicinal Chemistry Letters

Greater Responsiveness to Donepezil in Alzheimer Patients With Higher Levels of Acetylcholinesterase Based on Attention Task Scores and a Donepezil PET Study

(2011) Masashi Kasuya et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

Longitudinal assessment of Aβ and cognition in aging and Alzheimer disease

(2011) Victor L. Villemagne et al.   ANNALS OF NEUROLOGY

[11C]Enzastaurin, the first design and radiosynthesis of a new potential PET agent for imaging of protein kinase C

(2011) Min Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease

(2011) M. T. Fodero-Tavoletti et al.   BRAIN

Individualized quantification of brain β-amyloid burden: results of a proof of mechanism phase 0 florbetaben PET trial in patients with Alzheimer’s disease and healthy controls

(2011) Henryk Barthel et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Amyloid Imaging with 18F-Florbetaben in Alzheimer Disease and Other Dementias

(2011) V. L. Villemagne et al.   JOURNAL OF NUCLEAR MEDICINE

Cerebral amyloid-β PET with florbetaben (18F) in patients with Alzheimer's disease and healthy controls: a multicentre phase 2 diagnostic study

(2011) Henryk Barthel et al.   LANCET NEUROLOGY

Cerebrovascular disease, beta-amyloid, and cognition in aging

(2011) Natalie L. Marchant et al.   NEUROBIOLOGY OF AGING

2010 Alzheimer's disease facts and figures

(2010)   Alzheimers & Dementia

Alzheimers Disease: SPECT and PET Tracers for Beta-Amyloid Imaging

(2010) V. Valotassiou et al.   Current Alzheimer Research

In vivo imaging of neuroinflammation: a comparative study between [18F]PBR111, [11C]CLINME and [11C]PK11195 in an acute rodent model

(2010) Nadja Van Camp et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

(2010) Lars M. Ittner et al.   NATURE REVIEWS NEUROSCIENCE

Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging

(2010) Christopher C. Rowe et al.   NEUROBIOLOGY OF AGING

Carbon 11–Labeled Pittsburgh Compound B and Carbon 11–Labeled (R)-PK11195 Positron Emission Tomographic Imaging in Alzheimer Disease

(2009) Clayton A. Wiley et al.   ARCHIVES OF NEUROLOGY

Progression of Mild Cognitive Impairment to Dementia in Clinic- vs Community-Based Cohorts

(2009) Sarah Tomaszewski Farias et al.   ARCHIVES OF NEUROLOGY

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

(2009) Clifford R Jack et al.   LANCET NEUROLOGY

Conversion of amyloid positive and negative MCI to AD over 3 years: An 11C-PIB PET study

(2009) A. Okello et al.   NEUROLOGY

Evaluation of CLINDE as potent translocator protein (18 kDa) SPECT radiotracer reflecting the degree of neuroinflammation in a rat model of microglial activation

(2008) Nicolas Arlicot et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Imaging Neuroinflammation in Alzheimer's Disease with Radiolabeled Arachidonic Acid and PET

(2008) G. Esposito et al.   JOURNAL OF NUCLEAR MEDICINE

Multicenter Standardized 18F-FDG PET Diagnosis of Mild Cognitive Impairment, Alzheimer's Disease, and Other Dementias

(2008) L. Mosconi et al.   JOURNAL OF NUCLEAR MEDICINE

[11C]PIB-amyloid binding and levels of Aβ40 and Aβ42 in postmortem brain tissue from Alzheimer patients

(2008) Marie M. Svedberg et al.   NEUROCHEMISTRY INTERNATIONAL

Translocator protein 18 kDa (TSPO): Molecular sensor of brain injury and repair

(2008) Ming-Kai Chen et al.   PHARMACOLOGY & THERAPEUTICS

Neuroimaging in Dementia

(2008) Paolo Vitali et al.   SEMINARS IN NEUROLOGY

PET imaging of amyloid deposition in patients with mild cognitive impairment

(2007) Anton Forsberg et al.   NEUROBIOLOGY OF AGING