Article
Clinical Neurology
Karri Kaivola, Zalak Shah, Ruth Chia, Sonja W. Scholz
Summary: The GBA gene is associated with risk for dementia with Lewy bodies (DLB) in patients without the APOE ε4 allele, while the APOE ε4 allele is associated with DLB co-pathology with Alzheimer's disease. APOE ε4 is not an independent driver of alpha-synuclein pathology in pure DLB, but GBA plays a significant role in the pure DLB subgroup.
Article
Clinical Neurology
Young-gun Lee, Seun Jeon, Sung Woo Kang, Byoung Seok Ye
Summary: This study found that mixed pathologies are common in Alzheimer's disease and dementia with Lewy bodies, and the effects of amyloid beta and dopaminergic depletion on brain perfusion and clinical symptoms have not been elucidated.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Alice Tisserand, Benjamin Cretin, Mary Mondino, Anne Botzung, Lea Sanna, Catherine Demuynck, Pierre Anthony, Candice Muller, Olivier Bousiges, Nathalie Philippi, Frederic Blanc
Summary: This study aimed to investigate the association between photophobia and dementia with Lewy bodies (DLB). The study found that photophobia was more frequent in DLB patients and was associated with decreased gray matter in the right precentral cortex and the eyelid motor region. This finding is important for understanding the pathological mechanism of DLB.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Han Soo Yoo, Seong Ho Jeong, Kyeong Taek Oh, Sangwon Lee, Young H. Sohn, Byoung Seok Ye, Mijin Yun, Phil Hyu Lee
Summary: Yoo et al. investigated the relationship between striatal dopamine depletion, brain metabolism, and cognition in patients with dementia with Lewy bodies. They found that striatal dopamine loss and brain hypometabolism are closely related, impacting cognition in a specific manner, and predicting cognitive decline. Brain hypometabolism was found to be more relevant to longitudinal cognitive outcomes than striatal dopaminergic degeneration in patients with Lewy body dementia.
Review
Clinical Neurology
Melissa J. Armstrong
Summary: Dementia with Lewy bodies (DLB) is a specific presentation of a pathological alpha-synucleinopathy, with recent advances including updated diagnostic criteria and recognition of prodromal states. Research shows common co-occurrence of Alzheimer's disease pathology in individuals with DLB, impacting biomarker use and progression. Identifying biomarkers and effective therapies remain key areas of focus for future research in DLB.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2021)
Review
Cell Biology
Augoustos Tsamourgelis, Peter Swann, Leonidas Chouliaras, John T. O'Brien
Summary: Dementia with Lewy Bodies (DLB) is the second most common neurodegenerative dementia. Proteomics has revealed protein dysregulation in the brain and peripheral tissues in DLB, which shares common features with other dementias but also has unique protein signatures. Identifying novel protein targets and diagnostic biomarkers could lead to new therapeutics and improved clinical trials for DLB.
AGEING RESEARCH REVIEWS
(2023)
Article
Clinical Neurology
Xudong Li, Miaoxin Shen, Ziling Han, Jinsong Jiao, Xiaopeng Tong
Summary: The gesture imitation test is a valuable tool for detecting DLB and differentiating DLB from ADD, especially in Items 1 and 4.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Yueyi Yu, Xinyi Xia, Xiaosheng Meng, Dan Li, Qi Qin
Summary: This study investigated the feasibility of using plasma p-tau181 and A beta(42) as potential biomarkers to differentiate AD and DLB. The results showed that plasma p-tau181 was significantly lower in DLB than in AD and healthy controls, while plasma A beta(42) was significantly higher in DLB than in AD but lower than in healthy controls. Both plasma biomarkers showed good accuracy in distinguishing DLB from healthy controls, while A beta(42) had better accuracy than p-tau181 in discriminating DLB from AD. These findings confirm the high diagnostic value of plasma p-tau181 and A beta(42) for distinguishing patients with DLB from healthy controls.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Geriatrics & Gerontology
Guili Zhang, Shuai Liu, Zhichao Chen, Zhihong Shi, Wenzheng Hu, Lingyun Ma, Xiaodan Wang, Xudong Li, Yong Ji
Summary: Elevated plasma total homocysteine (tHcy) levels were independently associated with dementia with Lewy bodies (DLB) and Alzheimer's disease (AD). The association was stronger for DLB than for AD, and future longitudinal studies are needed to confirm the causative role of tHcy in DLB.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Psychiatry
Ming-Chyi Pai, Chiu-Jun Yang, Sheng-Yu Fan
Summary: This study investigated the differences in time perception performance between prodromal AD and prodromal DLB patients. The findings revealed that prodromal AD patients exhibited imprecision and overestimation of time, while prodromal DLB patients tended to underestimate time intervals. The study suggests that the clinical and pathological severity of these two prodromal dementia stages may differ.
FRONTIERS IN PSYCHIATRY
(2021)
Review
Biochemistry & Molecular Biology
Olivier Bousiges, Frederic Blanc
Summary: Dementia with Lewy Bodies (DLB) is a common cognitive neurodegenerative disease with clinical similarity to Alzheimer's disease (AD). This review examines the interest of different biomarkers in distinguishing DLB from AD, with a focus on cerebrospinal fluid (CSF), brain MRI, FP-CIT SPECT, MIBG SPECT, and PET. FP-CIT SPECT shows high interest in discriminating DLB and AD, while other biomarkers like MIBG SPECT, perfusion SPECT, FDG PET, and CSF biomarkers have lower validity. The potential of CSF synuclein RT-QuIC as a discrimination tool is highlighted, but its application in clinical routine needs further demonstration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Psychology, Clinical
Alan J. Thomas, Calum A. Hamilton, Sally Barker, Rory Durcan, Sarah Lawley, Nicola Barnett, Michael Firbank, Gemma Roberts, Louise M. Allan, John O'Brien, John-Paul Taylor, Paul C. Donaghy
Summary: Impaired olfaction may serve as a potential biomarker for early Lewy body disease, particularly in cases of mild cognitive impairment with Lewy bodies (MCI-LB). Olfactory function was significantly worse in individuals with probable MCI-LB compared to those with MCI-AD and healthy controls. A lower cutoff score of ≤ 7 on the SS-16 is recommended for identifying early LB disease in memory services.
INTERNATIONAL PSYCHOGERIATRICS
(2022)
Article
Biochemistry & Molecular Biology
Matthieu Lilamand, Josue Clery, Agathe Vrillon, Francois Mouton-Liger, Emmanuel Cognat, Sinead Gaubert, Claire Hourregue, Matthieu Martinet, Julien Dumurgier, Jacques Hugon, Elodie Bouaziz-Amar, Claire Paquet
Summary: This study found that cerebrospinal fluid levels of alpha-synuclein differ significantly between DLB and AD, suggesting its potential as a biomarker for distinguishing between these two diseases. CSF alpha-synuclein is associated with other AD biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Psychology, Multidisciplinary
Sandro Iannaccone, Elise Houdayer, Alfio Spina, Gianluca Nocera, Federica Alemanno
Summary: This study investigated the use of electroencephalography quantified with statistical pattern recognition (qEEG-SPR) as a tool for diagnosing dementia and differentiating dementia with Lewy bodies (DLB). The results showed that qEEG-SPR had high sensitivity and specificity for identifying dementia and DLB. It is a non-invasive, low-cost, and environmentally friendly method that can be implemented in healthcare settings.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Neuroimaging
Wen-Ying Ma, Qun Yao, Guan-Jie Hu, Hong-Lin Ge, Chen Xue, Ying-Ying Wang, Yi-Xin Yan, Chao-Yong Xiao, Jing-Ping Shi, Jiu Chen
Summary: The study revealed different patterns of functional reorganization in DLB and AD patients, with the conversion and redistribution of rich club nodes possibly playing a causal role in disease-specific outcomes. This could serve as a potential biomarker for more accurate prevention and treatment strategies.
NEUROIMAGE-CLINICAL
(2022)
Article
Pharmacology & Pharmacy
Kusui Yuka, Daisuke Nishizawa, Junko Hasegawa, Kyosuke Uno, Hajime Miyanishi, Hiroshi Ujike, Norio Ozaki, Toshiya Inada, Nakao Iwata, Ichiro Sora, Masaomi Iyo, Mitsuhiko Yamada, Naoki Kondo, Moo-Jun Won, Nobuya Naruse, Kumi Uehara-Aoyama, Kazutaka Ikeda, Atsumi Nitta
CURRENT PHARMACEUTICAL DESIGN
(2020)
Article
Genetics & Heredity
Koya Fukunaga, Eiji Hishinuma, Masahiro Hiratsuka, Ken Kato, Takuji Okusaka, Takeo Saito, Masashi Ikeda, Teruhiko Yoshida, Hitoshi Zembutsu, Nakao Iwata, Taisei Mushiroda
Summary: NGS technology was used to identify novel CYP2D6 variants in the Japanese population, with in vitro metabolic studies used to predict CYP2D6 phenotype. The study identified 14 CYP2D6 variants not previously registered in the database, with 10 novel haplotypes registered. Based on metabolic activity, several alleles were predicted to be nonfunctional, and individuals were designated as normal, intermediate, or poor metabolizers. This research provides valuable insights into the effects of different CYP2D6 haplotypes on in vitro metabolic activities.
JOURNAL OF HUMAN GENETICS
(2021)
Review
Biochemistry & Molecular Biology
Taro Kishi, Toshikazu Ikuta, Yuki Matsuda, Kenji Sakuma, Makoto Okuya, Ikuo Nomura, Masakazu Hatano, Nakao Iwata
Summary: This study conducted a network meta-analysis to compare the efficacy, safety, and acceptability of pharmacological interventions for adults with acute bipolar mania. The results showed that some antipsychotics, carbamazepine, lithium, tamoxifen, and valproate were effective for acute mania, while aripiprazole, olanzapine, quetiapine, and risperidone had better acceptability compared to the placebo.
MOLECULAR PSYCHIATRY
(2022)
Article
Psychiatry
Yuichi Esaki, Kenji Obayashi, Keigo Saeki, Kiyoshi Fujita, Nakao Iwata, Tsuyoshi Kitajima
Summary: The study found significant associations between circadian activity rhythms and mood episode relapses in patients with bipolar disorder.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Neurosciences
Masakazu Hatano, Ippei Takeuchi, Kanade Yamashita, Aoi Morita, Kaori Tozawa, Takashi Sakakibara, Genta Hajitsu, Manako Hanya, Shigeki Yamada, Nakao Iwata, Hiroyuki Kamei
Summary: The study aimed to investigate factors affecting medication adherence among schizophrenia patients. Results showed no significant differences in satisfaction levels and DAI-10 scores among different antipsychotic formulations. Patients exhibited individual preferences in formulation selection and significantly higher satisfaction levels and adherence scores when involved in shared decision-making with physicians.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2021)
Article
Psychiatry
Yuichi Esaki, Kenji Obayashi, Keigo Saeki, Kiyoshi Fujita, Nakao Iwata, Tsuyoshi Kitajima
Summary: This study suggests that keeping the bedroom dark at night may help prevent hypomanic and manic episodes in patients with bipolar disorder, without a significant association with depressive episodes.
ACTA PSYCHIATRICA SCANDINAVICA
(2022)
Review
Psychiatry
Taro Kishi, Kenji Sakuma, Nakao Iwata
Summary: This systematic review and meta-analysis examined the effectiveness of mitochondrial modulators in the treatment of obsessive-compulsive and related disorders. The study found that N-acetylcysteine was beneficial in improving overall symptoms and anxiety-related scale scores. However, no other mitochondrial modulators showed superior efficacy compared to placebo in other outcomes.
TRANSLATIONAL PSYCHIATRY
(2022)
Review
Biochemistry & Molecular Biology
Taro Kishi, Toshikazu Ikuta, Kenji Sakuma, Makoto Okuya, Masakazu Hatano, Yuki Matsuda, Nakao Iwata
Summary: This study compared the efficacy, acceptability, tolerability, and safety of antidepressants in the maintenance phase treatment of adults with major depressive disorder (MDD) through a systematic review and network meta-analysis. The results showed that desvenlafaxine, paroxetine, venlafaxine, and vortioxetine had reasonable efficacy, acceptability, and tolerability in the treatment of adults with stable MDD.
MOLECULAR PSYCHIATRY
(2023)
Article
Clinical Neurology
Yuichi Esaki, Kenji Obayashi, Keigo Saeki, Kiyoshi Fujita, Nakao Iwata, Tsuyoshi Kitajima
Summary: This study investigated the association between light exposure in daily life and circadian activity rhythms in patients with bipolar disorder. The results showed that daytime light exposure was positively associated with circadian activity rhythms, while nighttime light exposure was negatively associated.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Letter
Biochemistry & Molecular Biology
Taro Kishi, Kenji Sakuma, Masakazu Hatano, Makoto Okuya, Yuki Matsuda, Masaki Kato, Nakao Iwata
MOLECULAR PSYCHIATRY
(2023)
Review
Psychiatry
Taro Kishi, Kenji Sakuma, Nakao Iwata
Summary: A systematic review and meta-analysis showed that paliperidone palmitate (PP) may be a useful treatment option for adults with acute symptoms of schizophrenia. However, further noninferiority studies comparing PP with paliperidone extended-release (PAL-ER) are needed to provide more solid evidence.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Hirona Yamamoto, Hyeon-Cheol Lee-Okada, Masashi Ikeda, Takumi Nakamura, Takeo Saito, Atsushi Takata, Takehiko Yokomizo, Nakao Iwata, Tadafumi Kato, Takaoki Kasahara
Summary: Large-scale genome-wide association studies have shown that the fatty acid desaturase (FADS) locus is implicated in bipolar disorder. To investigate this further, mutant mice lacking Fads1/2 genes were generated. These mice exhibited bipolar swings in activity, accompanied by abnormal circadian rhythms and altered lipid composition in the brain. Supplementation with certain fatty acids prevented the episodic behavioral changes. This study provides a GWAS-based model to understand the involvement of lipids and their metabolisms in the pathogenesis and treatment of bipolar disorder.
MOLECULAR PSYCHIATRY
(2023)
Letter
Biochemistry & Molecular Biology
Taro Kishi, Toshikazu Ikuta, Kenji Sakuma, Masakazu Hatano, Yuki Matsuda, Shinsuke Kito, Nakao Iwata
MOLECULAR PSYCHIATRY
(2023)
Article
Clinical Neurology
Yuichi Esaki, Kenji Obayashi, Keigo Saeki, Kiyoshi Fujita, Nakao Iwata, Tsuyoshi Kitajima
Summary: This study examined the association between sleep disturbance and mood episode relapses in patients with bipolar disorder. The results revealed a significant correlation between variability in sleep time and the recurrence of mood episodes, indicating that inconsistent sleep time is associated with shorter duration between mood episode relapses. The findings suggest that maintaining consistency in sleep time may help prevent the relapse of mood episodes in bipolar disorder.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Taro Kishi, Toshikazu Ikuta, Yuki Matsuda, Kenji Sakuma, Makoto Okuya, Kazuo Mishima, Nakao Iwata
Summary: The study investigated the efficacy of antipsychotics and mood stabilizers for patients with bipolar disorder in the maintenance phase. Results showed that most active treatments performed better than placebo in terms of recurrence rate, depressive episode, and manic episode, indicating overall effectiveness in treatment outcomes.
MOLECULAR PSYCHIATRY
(2021)