Article
Plant Sciences
Yongwoo Jeong, Ho Jung Bae, Keontae Park, Hyo Jeoung Bae, Xingquan Yang, Young-Jin Cho, Seo Yun Jung, Dae Sik Jang, Jong Hoon Ryu
Summary: Scrophularia buergeriana may be a potential treatment for mental illness, especially schizophrenia, by supplying kidney Yin and reducing blood heat to alleviate symptoms.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Gang Li, Shijie Xu, Ung Gu Kang
Summary: Repeated administration of drugs of abuse leads to behavioral sensitization, which is also observed with MK-801, a NMDA receptor antagonist. This study investigated the characteristics of MK-801-induced behavioral sensitization and found that it occurred rapidly with only five consecutive treatments. The optimal dose for sensitization was identified, which corresponded to typical doses of abused NMDA antagonists. Changes were observed in the expression and phosphorylation of NMDA receptor subunits after MK-801-induced behavioral sensitization.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Psychiatry
Tsung-Yu Pan, Yi-Ju Pan, Shih-Jen Tsai, Che-Wen Tsai, Feng-Yi Yang
Summary: This study investigated the efficacy of low-intensity pulsed ultrasound (LIPUS) in treating psychiatric symptoms and anxiety-like behaviors. The results showed that LIPUS stimulation improved deficits in locomotor activity and sensorimotor gating, improved anxiety-like behavior, and modulated the activity of NMDA receptors and c-Fos. Therefore, LIPUS may be a potentially valuable antipsychotic treatment for schizophrenia.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Neurosciences
Alessandro Piva, Lucia Caffino, Francesca Mottarlini, Nicholas Pintori, Fernando Castillo Diaz, Fabio Fumagalli, Cristiano Chiamulera
Summary: The study found distinct effects of ketamine and MK-801 in the rat brain, with ketamine inducing a pattern of enhanced excitability while MK-801 causing sparse changes. The two substances showed different effects on glutamate synapses in different brain areas, with ketamine leading to fine tuning of glutamatergic synapses compared to MK-801.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
N. Berrios-Cartagena, M. M. Rubio-Davila, I Rivera-Delgado, M. M. Feliciano-Bonilla, E. A. De Cardona-Julia, J. G. Ortiz
Summary: The study found that zinc interacts with glutamate in rat cortical synaptic membranes, enhancing the binding of NMDA receptors. Additionally, lead and mercury impact NMDA or AMPA receptors, with zinc partially reversing these effects in certain concentrations. These interactions help clarify the roles of zinc, lead, and mercury in physiological and pathological conditions.
NEUROCHEMICAL RESEARCH
(2021)
Article
Nutrition & Dietetics
Jia-Quan Liang, Xi Chen, Yong Cheng
Summary: The study demonstrates that paeoniflorin can alleviate schizophrenia-like behaviors through inhibiting the oxidative stress pathway. The potential mechanisms of restoring neuronal expression and preventing neurotoxicity were also revealed.
FRONTIERS IN NUTRITION
(2022)
Article
Neurosciences
Wenjuan Yu, Hongwei Fang, Lei Zhang, Miaowen Hu, Sidi He, Huafang Li, Hao Zhu
Summary: Treatment with MK-801 enhances proliferation of hippocampal astrocytes and upregulates BDNF mRNA expression. The NMDA, PI3K, and ERK1/2 signaling pathways may be involved in regulating MK-801-induced BDNF upregulation. These findings suggest that astrocytes may play a role in the acute neurological and behavioral response to MK-801 treatment.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Patrick Latuske, Moritz von Heimendahl, Serena Deiana, Carsten T. Wotjak, Johann du Hoffmann
Summary: Cognitive flexibility is crucial for healthy functioning and is often impaired in neuropsychiatric diseases. Probabilistic reversal learning (PRL), a commonly used method to measure cognitive flexibility, is often limited in rodents. A novel rat PRL task that occurs at longer intervals demonstrates increased sensitivity to drugs, offering potential for testing and developing novel treatments for cognitive impairment in human patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Hyo Jeoung Bae, Ho Jung Bae, Jae Youn Kim, Keontae Park, Xingquan Yang, Seo Yun Jung, Se Jin Park, Dong Hyun Kim, Chan Young Shin, Jong Hoon Ryu
Summary: Schizophrenia is associated with neuroinflammation and elevated cytokine levels. Lansoprazole, a proton pump inhibitor, has been found to reduce neurotoxicity and inflammatory cytokines. This study investigated whether lansoprazole could ameliorate schizophrenia-like symptoms in mice. Results showed that lansoprazole improved sensorimotor gating deficits, spatial learning, and social deficits, without causing motor coordination deficits. Lansoprazole also decreased inflammatory cytokines in the cortex but not in the hippocampus. These findings suggest that lansoprazole could be a potential treatment for schizophrenia patients with specific symptoms, without motor-related adverse effects.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Clinical Neurology
Francini Franscescon, Thiele P. Souza, Talise E. Muller, Paula Michelotti, Julia Canzian, Flavia Stefanello, Denis B. Rosemberg
Summary: Schizophrenia is a chronic neuropsychiatric disorder characterized by a shortened lifespan and impaired social and vocational functioning, often involving dysfunctions in the hypothalamic-pituitary-adrenal axis and cortisol regulation. Taurine, with its neuroprotective properties, shows promise in targeting various brain disorders, including schizophrenia, by modulating behaviors and neuroendocrine responses. The study on zebrafish models suggests that taurine can have a protective effect on behaviors and neuroendocrine responses associated with MK-801-induced schizophrenia-like phenotypes.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Neurosciences
Jeonghoon Lee, Seonghoo Huh, Kyungtaek Park, Nuree Kang, Hyun Sook Yu, Hong Geun Park, Yong Sik Kim, Ung Gu Kang, Sungho Won, Se Hyun Kim
Summary: This study investigates the antipsychotic-like actions of electroconvulsive therapy (ECT) by studying the effects of repeated treatments of electroconvulsive seizure on a neurodevelopmental animal model of schizophrenia. The study reveals that ECT reverses the behavioral changes induced by the schizophrenia model and produces transcriptional changes in inflammatory, insulin, and mitophagy pathways.
PSYCHOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Masahito Sawahata, Hiroki Asano, Taku Nagai, Norimichi Ito, Takao Kohno, Toshitaka Nabeshima, Mitsuharu Hattori, Kiyofumi Yamada
Summary: The study showed that microinjection of recombinant Reelin into the medial prefrontal cortex prevented recognition memory impairment induced by MK-801, highlighting the potential therapeutic effects of Reelin on cognitive deficits associated with schizophrenia. Despite this positive effect, Reelin treatment did not ameliorate deficits in sensory-motor gating and short-term memory in the animal model of schizophrenia. The results suggest that Reelin acts on its receptors to suppress neural activity in the mPFC, thereby preventing cognitive deficits induced by MK-801.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Environmental Sciences
Murat Sirri Akosman, Ruhi Turkmen, Hasan Huseyin Demirel
Summary: The study demonstrated that resveratrol has a protective effect against glial cell infiltration and shrinkage of nerve cell nuclei induced by MK-801 in the brain. However, it did not correct behavioral disorders and demyelination of schizophrenia. Resveratrol partially prevented oxidative damage but not significantly.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Paulina Cieslik, Anna Siekierzycka, Adrianna Radulska, Agata Ploska, Grzegorz Burnat, Piotr Branski, Leszek Kalinowski, Joanna M. Wieronska
Summary: The study reveals that chronic administration of MK-801 or scopolamine decreases the availability of L-arginine and alters its derivatives in the brain. Both compounds impair eNOS-derived NO production, with no significant impact on nNOS. They also affect the expression of various enzymes and proteins related to NO pathways. MK-801 induces a decrease in cGMP levels and NMDA expression in the hippocampus, while scopolamine administration results in increased cGMP production and decreased NMDA receptor expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Dongwoo Yu, Seul Ah Mun, Sang Woo Kim, Dae-Chul Cho, Chi Heon Kim, Inbo Han, Subum Lee, Sang -Woo Lee, Kyoung-Tae Kim
Summary: D-serine exacerbates neuropathic pain after traumatic spinal cord injury by mediating the NMDA receptor. NMDA receptor antagonists alleviate neuropathic pain after traumatic spinal cord injury.
Article
Radiology, Nuclear Medicine & Medical Imaging
Salvatore Bongarzone, Filippo Basagni, Teresa Sementa, Nisha Singh, Caleb Gakpetor, Vincent Faugeras, Jayanta Bordoloi, Antony D. Gee
NUCLEAR MEDICINE AND BIOLOGY
(2019)
Article
Chemistry, Medicinal
Federico Luzi, Vilius Savickas, Carlotta Taddei, Stefan Hader, Nisha Singh, Antony D. Gee, Salvatore Bongarzone
FUTURE MEDICINAL CHEMISTRY
(2020)
Review
Endocrinology & Metabolism
Gitte M. Knudsen, Melanie Ganz, Stefan Appelhoff, Ronald Boellaard, Guy Bormans, Richard E. Carson, Ciprian Catana, Doris Doudet, Antony D. Gee, Douglas N. Greve, Roger N. Gunn, Christer Halldin, Peter Herscovitch, Henry Huang, Sune H. Keller, Adriaan A. Lammertsma, Rupert Lanzenberger, Jeih-San Liow, Talakad G. Lohith, Mark Lubberink, Chul H. Lyoo, J. John Mann, Granville J. Matheson, Thomas E. Nichols, Martin Norgaard, Todd Ogden, Ramin Parsey, Victor W. Pike, Julie Price, Gaia Rizzo, Pedro Rosa-Neto, Martin Schain, Peter J. H. Scott, Graham Searle, Mark Slifstein, Tetsuya Suhara, Peter S. Talbot, Adam Thomas, Mattia Veronese, Dean F. Wong, Maqsood Yaqub, Francesca Zanderigo, Sami Zoghbi, Robert B. Innis
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2020)
Article
Chemistry, Medicinal
Salvatore Bongarzone, Teresa Sementa, Joel Dunn, Jayanta Bordoloi, Kavitha Sunassee, Philip J. Blower, Antony Gee
JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Article
Biochemical Research Methods
Francesca Goudou, Antony D. Gee, Salvatore Bongarzone
Summary: A copper-catalysed radiosynthesis was developed to obtain carbon-11-labelled carboxylic acids by reacting terminal alkynes with cyclotron-produced carbon-11 carbon dioxide in the presence of DBU. This method resulted in a small library of C-11-labelled propiolic acid derivatives with radiochemical yields ranging from 7% to 28% in a total synthesis time of 15 min from end of bombardment (EOB).
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
(2021)
Review
Chemistry, Multidisciplinary
Antonio Shegani, Steven Kealey, Federico Luzi, Filippo Basagni, Joana do Mar Machado, Sevban Dogan Ekici, Alessandra Ferocino, Antony D. Gee, Salvatore Bongarzone
Summary: The presence of PET centers at major hospitals and the improvement of PET scanner sensitivity have increased interest in PET tracer development using carbon-11. Methodological improvements and automated modules have allowed the development of carbon-11 tracers for clinical use. Radiolabeling natural compounds with carbon-11 has provided important information on their biochemistry and in vivo behavior.
Article
Chemistry, Medicinal
Igor C. Fontana, Debora G. Souza, Diogo O. Souza, Antony Gee, Eduardo R. Zimmer, Salvatore Bongarzone
Summary: The excitatory amino acid transporter 2 (EAAT2) is crucial for the clearance and recycling of glutamate, the major excitatory neurotransmitter in the brain. Dysfunctions in EAAT2 can lead to neurodegenerative diseases, such as ALS and AD. Detecting EAAT2 in the living human brain is important for improving diagnosis and therapy for these diseases. This article discusses the role of EAAT2 and presents potential activators for therapy and molecular imaging tools for diagnosis.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Correction
Chemistry, Medicinal
Igor C. Fontana, Debora G. Souza, Diogo O. Souza, Antony Gee, Eduardo R. Zimmer, Salvatore Bongarzone
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Correction
Chemistry, Multidisciplinary
Antonio Shegani, Steven Kealey, Federico Luzi, Filippo Basagni, Joana do Mar Machado, Sevban Dogan Ekici, Alessandra Ferocino, Antony D. Gee, Salvatore Bongarzone
Article
Chemistry, Multidisciplinary
Tatsuya Kikuchi, Masanao Ogawa, Toshimitsu Okamura, Antony D. Gee, Ming-Rong Zhang
Summary: This study reports a simple and efficient method for the production of [C-11]HCN that can be easily implemented in C-11 production facilities, eliminating the need for a dedicated infrastructure.
Review
Chemistry, Organic
Federico Luzi, Antony D. Gee, Salvatore Bongarzone
Summary: PET requires positron-emitting nuclides, with C-11 being advantageous due to the ubiquity of carbon atoms in biomolecules, but quick, robust, and chemospecific radiolabelling strategies are needed due to its short half-life and low production scale. The use of silicon-based chemistry for C-11-labelling has been proposed as a rapid and effective method, showing broad applicability and high efficiency in organic chemistry.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Julia E. Blower, Michelle T. Ma, Fahad A. I. Al-Salemee, Antony D. Gee
Summary: Nitrogen-13 is a PET radionuclide that can be used to label molecules of biological and pharmaceutical interest despite its short half-life. By adapting a specific synthetic reaction, a library of labeled compounds can be prepared, which has significant implications for clinical applications.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Salvatore Bongarzone, Nicola Raucci, Igor Camargo Fontana, Federico Luzi, Antony D. Gee
CHEMICAL COMMUNICATIONS
(2020)
Article
Chemistry, Multidisciplinary
Rhiannon Beard, David C. A. Gaboriau, Antony D. Gee, Edward W. Tate
Letter
Chemistry, Medicinal
Heinz H. Coenen, Antony D. Gee, Michael Adam, Gunnar Antoni, Cathy S. Cutler, Yasuhisa Fujibayashi, Jae Min Jeong, Robert H. Mach, Thomas L. Mindt, Victor W. Pike, Albert D. Windhorst
EJNMMI RADIOPHARMACY AND CHEMISTRY
(2019)
