Article
Chemistry, Multidisciplinary
Feham Peer-Zada, Dima Hamze, Julio Garcia
Summary: The study found that overweight and obese patients have an increase in cardiac fat, especially in epicardial and pericardial adipose tissue, and are more likely to experience decreased cardiac function. Although BMI does not significantly affect AF recurrence, overweight patients have slightly higher recurrence rates compared to obese patients.
APPLIED SCIENCES-BASEL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lei Chen, Min Zhang, Wensu Chen, Zhi Li, Yiwen Wang, Dongchen Liu, Yang Duan, Chaoqun Zhang, Zhirong Wang, Yuan Lu
Summary: This study investigates the relationship between left atrial strain and new-onset atrial fibrillation after ST-segment elevation myocardial infarction. The results show that right coronary artery, left ventricular ejection fraction, and different types of left atrial strain are risk factors for new-onset atrial fibrillation. The model including conduit strain has the best identification ability.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Raymundo A. Quintana, Tiffany Dong, Ramya Vajapey, Reza Reyaldeen, Deborah H. Kwon, Serge Harb, Tom Kai Ming Wang, Allan L. Klein
Summary: Atrial fibrillation (AF) is the most common arrhythmia worldwide and is often managed using multimodality imaging techniques, including transesophageal echocardiography and computed tomography. Imaging plays a crucial role in excluding left atrial thrombus before cardioversion and during left atrial appendage occlusion device implantation.
CIRCULATION-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Luuk H. G. A. Hopman, Mark J. Mulder, Anja M. van der Laan, Pranav Bhagirath, Ahmet Demirkiran, Martin B. von Bartheld, Michiel J. B. Kemme, Albert C. van Rossum, Cornelis P. Allaart, Marco J. W. Gotte
Summary: This study assesses the relationship between different left atrial (LA) strain methods and atrial fibrillation (AF) recurrence, comparing LA feature tracking (FT) strain with novel rapid LA strain approaches. The results show that both LA rapid strain and LA FT strain are associated with arrhythmia recurrence after ablation in AF patients. Therefore, LA rapid strain can be a convenient and reproducible alternative for assessing LA function in clinical practice.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hyungjoon Cho, Yongwon Cho, Jaemin Shim, Jong-il Choi, Young-Hoon Kim, Yu-Whan Oh, Sung Ho Hwang
Summary: LAA isolation group showed significantly higher incidence of LAA emptying in SP phase but lower LAA emptying flux and LA ejection fraction compared to LAA normal activity group. The LAA-EP was found to be independent from LAEF.
KOREAN JOURNAL OF RADIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Luuk H. G. A. Hopman, Anne-Lotte C. J. van der Lingen, Nikki van Pouderoijen, Judith Krabbenborg, Mark J. Mulder, Mischa T. Rijnierse, Pranav Bhagirath, Lourens F. H. J. Robbers, Albert C. van Rossum, Vokko P. van Halm, Marco J. W. Gotte, Cornelis P. Allaart
Summary: This study assesses the association between cardiac magnetic resonance imaging-derived atrial characteristics and the development of atrial fibrillation (AF) in patients with a dual-chamber implantable cardioverter-defibrillator or cardiac resynchronization therapy defibrillator. The results show that left atrial remodeling characteristics are associated with AF development in patients with dilated cardiomyopathy but not in patients with ischemic cardiomyopathy. Assessing atrial remodeling before device implantation may identify high-risk patients for AF.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Karl Georg Hausler, Felizitas A. Eichner, Peter U. Heuschmann, Jochen B. Fiebach, Tobias Engelhorn, Benjamin Blank, David Callans, Arif Elvan, Massimo Grimaldi, Jim Hansen, Gerhard Hindricks, Hussein R. Al-Khalidi, Lluis Mont, Jens Cosedis Nielsen, Jonathan P. Piccini, Ulrich Schotten, Sakis Themistoclakis, Johan Vijgen, Luigi Di Biase, Paulus Kirchhof
Summary: This study aimed to evaluate the impact of apixaban on brain damage in patients with atrial fibrillation (AF) after ablation. The study found a high incidence of acute brain lesions in patients treated with apixaban or vitamin K antagonist after ablation, but they were not associated with cognitive function. However, chronic white matter damage was associated with cognitive function before and after ablation, especially with age. This suggests that uninterrupted oral anticoagulation during AF ablation is safe.
Article
Multidisciplinary Sciences
Kwang-No Lee, Do Young Kim, Ki Yung Boo, Yun Gi Kim, Seung-Young Roh, Yong-Soo Baek, Dong-Hyeok Kim, Dae In Lee, Jaemin Shim, Jong-Il Choi, Gyo-Seung Hwang, Young-Hoon Kim
Summary: This study assessed the clinical implications of serum galectin-3 in patients with atrial fibrillation and found that higher galectin-3 levels were associated with increased risk of atrial fibrillation recurrence.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Marco Guglielmo, Sophie Rier, Giulia De Zan, Axel J. Krafft, Michaela Schmidt, Karl P. Kunze, Rene M. Botnar, Claudia Prieto, Jeroen van der Heijden, Vincent Van Driel, Hemanth Ramanna, Pim van der Harst, Ivo van der Bilt
Summary: This study evaluated whether cardiac magnetic resonance (CMR) can identify incomplete pulmonary vein antrum isolation (PVAI-L) immediately after radiofrequency catheter ablation (RFCA). The results showed that using 3D-TWILITE and 3D-LGE, PVAI-L can be visualized, while DB-STIR cannot accurately identify the ablation core.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Karl J. Weiss, Sarah B. Nasser, Tamar Bigvava, Adelina Doltra, Bernhard Schnackenburg, Alexander Berger, Markus S. Anker, Christian Stehning, Patrick Doeblin, Mohamed Abdelmeguid, Mohamed Talat, Rolf Gebker, Wael E-Naggar, Burkert Pieske, Sebastian Kelle
Summary: Vasodilator stress perfusion CMR showed excellent diagnostic and significant prognostic value in long-term follow-up of high-risk patients with persistent AF and suspected or known CAD.
Review
Cardiac & Cardiovascular Systems
Timothy M. Markman, Mirmilad Khoshknab, Saman Nazarian
Summary: Catheter ablation is increasingly used for atrial fibrillation patients, with ongoing challenges and limitations despite advancements in technology. The evolution of multimodality imaging, particularly cardiac CT and MRI, offers significant opportunities to improve safety and efficacy in ablation procedures.
Article
Radiology, Nuclear Medicine & Medical Imaging
Lutong Pu, Yike Diao, Jie Wang, Tingting Fang, Ziqian Xu, Jiayu Sun, Yucheng Chen
Summary: This study investigated the left atrial dysfunction of hypertrophic cardiomyopathy (HCM) patients using a rapid semi-automatic method and found that left atrial long-axis strain (LAS) can serve as a predictive value for atrial fibrillation (AF) occurrence in HCM patients.
EUROPEAN RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Michael Kuehne, Philipp Krisai, Michael Coslovsky, Nicolas Rodondi, Andreas Mueller, Jurg H. Beer, Peter Ammann, Angelo Auricchio, Giorgio Moschovitis, Daniel Hayoz, Richard Kobza, Dipen Shah, Frank Peter Stephan, Juerg Schlaepfer, Marcello Di Valentino, Stefanie Aeschbacher, Georg Ehret, Ceylan Eken, Andreas Monsch, Laurent Roten, Matthias Schwenkglenks, Anne Springer, Christian Sticherling, Tobias Reichlin, Christine S. Zuern, Pascal B. Meyre, Steffen Blum, Tim Sinnecker, Jens Wuerfel, Leo H. Bonati, David Conen, Stefan Osswald
Summary: In atrial fibrillation patients, brain infarcts are associated with cognitive decline. The majority of these infarcts are clinically silent and occur in patients receiving anticoagulation therapy.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Olga Shaihov-Teper, Eilon Ram, Nimer Ballan, Rafael Y. Brzezinski, Nili Naftali-Shani, Rula Masoud, Tamar Ziv, Nir Lewis, Yeshai Schary, La-Paz Levin-Kotler, David Volvovitch, Elchanan M. Zuroff, Sergei Amunts, Neta Regev-Rudzki, Leonid Sternik, Ehud Raanani, Lior Gepstein, Jonathan Leor
Summary: This study revealed, for the first time, a distinctive proinflammatory, profibrotic, and proarrhythmic signature of epicardial fat-derived extracellular vesicles in patients with atrial fibrillation, uncovering another pathway by which epicardial fat promotes the development of atrial myopathy and fibrillation.
Article
Peripheral Vascular Disease
Stefanie Aeschbacher, Steffen Blum, Pascal B. Meyre, Michael Coslovsky, Annina S. Vischer, Tim Sinnecker, Nicolas Rodondi, Juerg H. Beer, Giorgio Moschovitis, Elisavet Moutzouri, Christof Hunkeler, Thilo Burkard, Ceylan Eken, Laurent Roten, Christine S. Zuern, Christian Sticherling, Jens Wuerfel, Leo H. Bonati, David Conen, Stefan Osswald, Michael Kuehne
Summary: Blood pressure and hypertension in patients with atrial fibrillation are associated with the presence and extent of white matter lesions, but not with large noncortical or cortical infarcts.
Article
Immunology
Michael B. Rothberg, Priscilla Kim, Nabin K. Shrestha, Lisa Kojima, Larisa G. Tereshchenko
Summary: This retrospective cohort study found that previous infection with SARS-CoV-2 provides some degree of protection against reinfection with the Omicron variant, but the level of protection varies depending on the stage of infection and the similarity between variants. Full vaccination plus a booster significantly reduces the risk of hospitalization.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Lingyu Xu, Sohail Zahid, Mirmilad Khoshknab, Juwann Moss, Ronald D. Berger, Jonathan Chrispin, David Callans, Francis E. Marchlinski, Stefan L. Zimmerman, Yuchi Han, Benoit Desjardins, Natalia Trayanova, Saman Nazarian
Summary: Post-infarct myocardium contains viable corridors traversing scar or lipomatous metaplasia (LM). Ventricular tachycardia (VT) circuitry has been separately reported to associate with corridors that traverse LM and with repolarization heterogeneity. Lipomatous metaplasia is closely associated with prolonged local action potential duration of corridors and ARI dispersion, which may facilitate the propensity of VT circuit re-entry.
Article
Immunology
Nicole E. Winchester, Nabin K. Shrestha, Priscilla Kim, Larisa G. Tereshchenko, Michael B. Rothberg
Summary: SARS-CoV-2 infection during Delta predominance did not provide significant protection against BA.4/BA.5 infection and had minimal protection against hospitalization. In contrast, prior infection with BA.1/BA.2 and up-to-date vaccination provided modest protection against BA.4/BA.5 infection and hospitalization.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Atul E. Verma, David V. Haines, Lucas Boersma, Nitesh Sood, Andrea E. Natale, Francis Marchlinski, Hugh Calkins, Prashanthan L. Sanders, Douglas Packer, Karl-Heinz Kuck, Gerhard Hindricks, Birce Onal, Jeffrey Cerkvenik, Hiroshi B. Tada, David DeLurgio, PULSED AF Investigators
Summary: Pulsed field ablation is an effective and safe method for treating patients with atrial fibrillation. It has comparable effectiveness to traditional catheter ablation but with a lower rate of complications.
Article
Multidisciplinary Sciences
William J. Young, Jeffrey Haessler, Jan-Walter Benjamins, Linda Repetto, Jie Yao, Aaron Isaacs, Andrew R. Harper, Julia Ramirez, Sophie Garnier, Stefan van Duijvenboden, Antoine R. Baldassari, Maria Pina Concas, ThuyVy Duong, Luisa Foco, Jonas L. Isaksen, Hao Mei, Raymond Noordam, Casia Nursyifa, Anne Richmond, Meddly L. Santolalla, Colleen M. Sitlani, Negin Soroush, Sebastien Theriault, Stella Trompet, Stefanie Aeschbacher, Fariba Ahmadizar, Alvaro Alonso, Jennifer A. Brody, Archie Campbell, Adolfo Correa, Dawood Darbar, Antonio De Luca, Jean-Francois Deleuze, Christina Ellervik, Christian Fuchsberger, Anuj Goel, Christopher Grace, Xiuqing Guo, Torben Hansen, Susan R. Heckbert, Rebecca D. Jackson, Jan A. Kors, Maria Fernanda Lima-Costa, Allan Linneberg, Peter W. Macfarlane, Alanna C. Morrison, Pau Navarro, David J. Porteous, Peter P. Pramstaller, Alexander P. Reiner, Lorenz Risch, Ulrich Schotten, Xia Shen, Gianfranco Sinagra, Elsayed Z. Soliman, Monika Stoll, Eduardo Tarazona-Santos, Andrew Tinker, Katerina Trajanoska, Eric Villard, Helen R. Warren, Eric A. Whitsel, Kerri L. Wiggins, Dan E. Arking, Christy L. Avery, David Conen, Giorgia Girotto, Niels Grarup, Caroline Hayward, J. Wouter Jukema, Dennis O. Mook-Kanamori, Morten Salling Olesen, Sandosh Padmanabhan, Bruce M. Psaty, Cristian Pattaro, Antonio Luiz P. Ribeiro, Jerome I. Rotter, Bruno H. Stricker, Pim van der Harst, Cornelia M. van Duijn, Niek Verweij, James G. Wilson, Michele Orini, Philippe Charron, Hugh Watkins, Charles Kooperberg, Henry J. Lin, James F. Wilson, Jrgen K. Kanters, Nona Sotoodehnia, Borbala Mifsud, Pier D. Lambiase, Larisa G. Tereshchenko, Patricia B. Munroe
Summary: Using multi-ancestry genome-wide association studies, this research identified 61 loci related to spatial QRS-T angle and 11 loci related to frontal QRS-T angle. These loci also showed shared genetic influences with classical ECG traits and were associated with cardiovascular diseases. The findings provide insights into the biology of QRS-T angles and their relationships with cardiovascular traits and diseases, which can inform future research and risk prediction.
NATURE COMMUNICATIONS
(2023)
Letter
Cardiac & Cardiovascular Systems
Timothy M. M. Markman, Francis E. E. Marchlinski, Andrew E. E. Epstein, Saman Nazarian
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Alan Sugrue, Rand Ibrahim, Marvin Lu, Neal K. Bhatia, Laith Alkukhun, Joseph Adewumi, Robert D. Schaller, Francis E. Marchlinski, Benjamin D'Souza, Babak Nazer, Wendy Tzou, Faisal M. Merchant, David S. Frankel
Summary: A retrospective study on S-ICD patients undergoing sternotomy found that sternotomy did not increase the risks of damage to the S-ICD lead, inappropriate shocks from electrical noise due to interaction with sternal wires, and failure to terminate ventricular arrhythmias.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Ljuba Bacharova, Philippe Chevalier, Bulent Gorenek, Christian Jons, Yi-Gang Li, Emanuela T. Locati, Maren Maanja, Andres Ricardo Perez-Riera, Pyotr G. Platonov, Antonio Luiz P. Ribeiro, Douglas Schocken, Elsayed Z. Soliman, Jana Svehlikova, Larisa G. Tereshchenko, Martin Ugander, Niraj Varma, Elena Zaklyazminskaya, Takanori Ikeda
Summary: The ECG diagnosis of LVH is mainly based on the increased QRS voltage criteria in specific leads. However, clinical observations show increased QRS amplitude in only a minority of LVH patients. The low sensitivity of voltage criteria has been repeatedly confirmed.
JOURNAL OF ELECTROCARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Larisa G. Tereshchenko, Jafar Pourbemany, Kazi T. Haq, Hetal Patel, Jessica Hyde, Suha Quadri, Habiba Ibrahim, Aaron Tongpoon, Reyhane Pourbemany, Akram Khan
Summary: SARS-CoV-2 infection is associated with an increased risk of late cardiovascular outcomes, and further research is needed to better understand the electrophysiologic manifestations of post-acute CV sequelae of COVID-19.
JOURNAL OF ELECTROCARDIOLOGY
(2023)
Article
Medicine, General & Internal
Joshua K. Johnson, Daniel L. Young, Ning Guo, Larisa G. Tereshchenko, Maylyn Martinez, Jessica A. Hohman, Michael B. Rothberg
Summary: This study examined the patterns and costs of physical therapy for patients with pneumonia in US hospitals. It found that patient characteristics such as age and comorbidity status, as well as hospital characteristics, were associated with receiving physical therapy. There was also significant variability in the number and frequency of visits, and costs, between hospitals.
JOURNAL OF HOSPITAL MEDICINE
(2023)
Article
Medicine, General & Internal
Marina Latif, Ning Guo, Larisa G. Tereshchenko, Michael B. Rothberg
Summary: This study investigates the association between hospital spending and patient outcomes for community-acquired pneumonia. The results show that increased hospital spending is not associated with lower mortality rates. Lower diagnostic costs are linked to lower overall costs of care, suggesting that judicious use of diagnostic testing may reduce costs without affecting patient outcomes.
JOURNAL OF HOSPITAL MEDICINE
(2023)
Article
Medicine, General & Internal
Daniel L. Young, Joshua K. Johnson, Ning Guo, Larisa G. Tereshchenko, Maylyn Martinez, Michael B. Rothberg
Summary: This study examined the relationship between physical therapy visit frequency and discharge disposition among hospitalized pneumonia patients. It found that patients who received more frequent physical therapy were more likely to be discharged home rather than to postacute care.
JOURNAL OF HOSPITAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Abhishek Deshpande, Ramara Walker, Rebecca Schulte, Andrea M. Pallotta, Larisa G. Tereshchenko, Bo Hu, Sameer S. Kadri, Michael Klompas, Michael B. Rothberg
Summary: This study aims to determine if identifying the etiological agent early and pharmacist-led de-escalation can safely reduce the use of extended-spectrum antibiotics in patients with community-acquired pneumonia. The study will be conducted through a randomized controlled trial across 12 hospitals and will enroll over 12,000 patients to evaluate the effects of these approaches on patient outcomes and healthcare costs.
Article
Medicine, General & Internal
Akram Khan, Ryan D. Clay, Asha Singh, Chitra Lal, Larisa G. Tereshchenko
Summary: Patients with pre-existing cardiac disease and high risk of obstructive sleep apnea (OSA) have increased burden of non-sustained ventricular tachycardia (NSVT).
MEDICINA-LITHUANIA
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
William Jon Young, Patricia B. Munroe, Larisa Tereshchenko
EUROPEAN JOURNAL OF HUMAN GENETICS
(2022)