Journal
ANNALS OF NONINVASIVE ELECTROCARDIOLOGY
Volume 14, Issue -, Pages S30-S34Publisher
WILEY-BLACKWELL PUBLISHING, INC
DOI: 10.1111/j.1542-474X.2008.00262.x
Keywords
QT; Holter; 12-lead; beat-to-beat; moxifloxacin
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Background: Concern for drug-induced QT prolongation has caused significant investment in QT measurement to safety-test new compounds. Manual methods are expensive and time-consuming. Reliable automatic methods would be highly desirable. Methods: Twelve-lead Holter recordings were annotated beat-to-beat by an automatic algorithm for global QRS onset and T offset. T offset was established from the time of peak T downslope plus a rate-dependent offset, analogous to the tangent method, wherein T offset is determined by extrapolating the T downslope to an intersection with the baseline. Results and Conclusions: Variances of the beat-to-beat QT measurements were in the range 2.5-3.4 ms over three distinct databases, including a large heart failure database. Application to a moxifloxacin/placebo control database of 29 subjects showed excellent results. Ann Noninvasive Electrocardiol 2009;14(Suppl. 1):S30-S34.
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