Article
Cardiac & Cardiovascular Systems
Meng Wang, Derick R. R. Peterson, Eleonora Pagan, Vincenzo Bagnardi, Andrea Mazzanti, Scott McNitt, David Q. Q. Rich, Christopher L. L. Seplaki, Valentina Kutyifa, Bronislava Polonsky, Alon Barsheshet, Deni Kukavica, Spencer Rosero, Ilan Goldenberg, Silvia Priori, Wojciech Zareba
Summary: This study developed two risk prediction algorithms for assessing the 5-year absolute risk of life-threatening arrhythmic events in LQTS patients, aiding in clinical decision making.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Haoyang Lu, Wen Ding, Hui Xiao, Manyu Dai, Yangcheng Xue, Zhuoran Jia, Jie Guo, Mengzuo Wu, Bing Shen, Ren Zhao
Summary: In this study, we report a missense mutation P441L in the C-terminus of KCNQ1 gene, which leads to a severe LQT1 phenotype in a 37-year-old female patient. Variant P441L shows reduced membrane trafficking and interaction with KCNQ1-KCNE1, resulting in potassium efflux disorder and eventually causing LQT1.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Kathryn E. Waddell-Smith, Alexandra A. Chaptynova, Jian Li, Jackie R. Crawford, Halina Hinds, Jonathan R. Skinner
Summary: This study found that the average repolarization length recorded by Holter, particularly mRTPc, better reflects the status and clinical risk of LQTS than the initial 12-lead QTc. mRTPc showed higher sensitivity and specificity for genotype positive status and the risk of cardiac arrest compared to 12-lead QTc.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)
Article
Physiology
Dafni Charisopoulou, George Koulaouzidis, Annika Rydberg, Michael Y. Henein
Summary: Patients with inherited long QT syndrome (LQTS) exhibit a reversed longitudinal relaxation sequence, which worsens during exercise, particularly in those with previous cardiac events.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Tibor Hornyik, Marina Rieder, Alessandro Castiglione, Peter Major, Istvan Baczko, Michael Brunner, Gideon Koren, Katja E. Odening
Summary: To study human cardiac diseases and develop treatment strategies, complex interactions of cardiac cells on multiple levels need to be considered. While mice are commonly used in cardiac research, differences in function and composition limit their translatability; rabbits, with closer resemblance to human hearts, are suitable as models. Different methodological approaches for generating transgenic rabbits and their utility in understanding disease mechanisms and treatment options are discussed.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Doo-Hwan Kim, Young-Kug Kim, Tae-Yong Ha, Shin Hwang, Wooil Kim, Hyun-Jung Koo, Dong-Hyun Yang, Joon-Won Kang, Sung-Gyu Lee
Summary: The study evaluated the association between CTCA and long-term MACEs within 5 years after living donor liver transplantation (LDLT), finding that a combination of a coronary artery calcium score (CACS) of >400 and obstructive coronary artery disease (CAD) may be associated with long-term MACEs.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Sami Viskin, Ehud Chorin, Arie Lorin Schwartz, Piotr Kukla, Raphael Rosso
Summary: Cardiac memory is an interesting electrocardiographic phenomenon where T waves become abnormal in the opposite direction of wide QRS complex, and normalize at a later stage. Reduction of repolarizing potassium currents during cardiac memory may lead to prolonged QT syndrome and ventricular arrhythmias.
Article
Radiology, Nuclear Medicine & Medical Imaging
Thais Pinheiro Lima, Antonildes N. N. Assuncao, Marcio Sommer Bittencourt, Gabriela Liberato, Armin Arbab-Zadeh, Joao A. C. Lima, Carlos Eduardo Rochitte
Summary: This study evaluated the long-term prognosis of coronary CTA scores for cardiovascular events in symptomatic patients with suspected CAD. The results showed that coronary CTA scores based on plaque burden and characteristics can provide long-term prognostic information, especially the distribution of non-calcified plaques is associated with increased cardiovascular risk for late events.
EUROPEAN RADIOLOGY
(2023)
Article
Medicine, Research & Experimental
Fatemeh Mahboobifard, Maryam Rahmati, Atrin Niknam, Ehsan Rojhani, Amir Abbas Momenan, Fereidoun Azizi, Fahimeh Ramezani Tehrani
Summary: This study explored the impact of Polycystic Ovary Syndrome (PCOS) on the risk of developing cardiovascular disease (CVD), and found that PCOS status did not increase the risk of silent coronary artery disease (CAD). However, women with a history of silent CAD had a higher incidence of CVD events. PCOS status independently reduced the incidence of CVD, regardless of silent CAD or traditional risk factors.
ARCHIVES OF MEDICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
William A. Agudelo, Sebastian Ramiro Gil-Quinones, Alejandra Fonseca, Alvaro Arenas, Laura Castro, Diana Carolina Sierra-Diaz, Manuel A. Patarroyo, Paul Laissue, Carlos F. Suarez, Rodrigo Cabrera
Summary: Congenital long QT syndrome (LQTS) is a cardiac channelopathy characterized by prolonged QT interval and T-wave abnormalities, often caused by mutations in genes such as KCNQ1, KCNH2, and SCN5A. This study aimed to investigate the structural impact of compound mutations on potassium channels in severe LQTS phenotypes using molecular dynamic simulations. The findings suggest that mutant channels show moderate changes in energy and mobility, potentially influencing K+ ion flow and differentiating from wild-type channels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cardiac & Cardiovascular Systems
Christian Krijger Juarez, Ahmad S. Amin, Joost A. Offerhaus, Connie R. Bezzina, Bastiaan J. Boukens
Summary: Abnormal cardiac repolarization is the underlying cause of life-threatening arrhythmias in various congenital and acquired cardiac diseases. Dysfunction of ion channels involved in repolarization at the cellular level often leads to the repolarization abnormality. Understanding the genetic and electrophysiological basis of repolarization provides insights into cardiac repolarization and may contribute to improved patient-specific management in the future.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2023)
Review
Medicine, General & Internal
Ana Gabaldon-Perez, Victor Marcos-Garces, Jose Gavara, Cesar Rios-Navarro, Gema Minana, Antoni Bayes-Genis, Oliver Husser, Juan Sanchis, Julio Nunez, Francisco Javier Chorro, Vicente Bodi
Summary: The development of coronary revascularization techniques has been crucial in reducing mortality rates in acute coronary syndrome, but controversial in extending life expectancy in patients with chronic coronary syndrome.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Hui-Hui Liu, Ye-Xuan Cao, Jing-Lu Jin, Yuan-Lin Guo, Cheng-Gang Zhu, Na-Qiong Wu, Ying Gao, Rui-Xia Xu, Qian Dong, Ming-Hua Zheng, Jian-Jun Li
Summary: This study showed a significant association between MAFLD and the risk of MACEs in patients with CCS, with patients with MAFLD having a higher risk of MACEs compared to controls. The relationship remained consistent regardless of meeting NAFLD criteria, highlighting the utility of MAFLD criteria in clinical practice.
HEPATOLOGY INTERNATIONAL
(2021)
Review
Medicine, General & Internal
Francesco Giallauria, Anna Di Lorenzo, Elio Venturini, Mario Pacileo, Antonello D'Andrea, Umberto Garofalo, Felice De Lucia, Crescenzo Testa, Gianluigi Cuomo, Gabriella Iannuzzo, Marco Gentile, Cinzia Nugara, Filippo M. Sarullo, Nastasia Marinus, Dominique Hansen, Carlo Vigorito
Summary: The worldwide population aging leads to an increase in geriatric syndromes, with advanced standard of care driving the incidence of acute coronary syndrome in the elderly. Aging is a risk factor for frailty and cardiovascular disease, with shared pathophysiological mechanisms between the two conditions. Early identification of frail elderly patients with ACS is crucial for developing personalized care plans and secondary prevention strategies.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Maria Emfietzoglou, Michail C. Mavrogiannis, Athanasios Samaras, Georgios P. Rampidis, George Giannakoulas, Polydoros N. Kampaktsis
Summary: Cardiac computed tomography is a non-invasive diagnostic test that provides qualitative and quantitative assessment of coronary artery disease. Recent research focuses on using it to predict cardiovascular risk using endothelial shear stress and pericoronary fat attenuation index.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Natasja M. S. de Groot, Dipen Shah, Patrick M. Boyle, Elad Anter, Gari D. Clifford, Isabel Deisenhofer, Thomas Deneke, Pascal van Dessel, Olaf Doessel, Polychronis Dilaveris, Frank R. Heinzel, Suraj Kapa, Pier D. Lambiase, Joost Lumens, Pyotr G. Platonov, Tachapong Ngarmukos, Juan Pablo Martinez, Alejandro Olaya Sanchez, Yoshihide Takahashi, Bruno P. Valdigem, Alle-Jan Van der Veen, Kevin Vernooy, Ruben Casado-Arroyo, Tom De Potter, Borislav Dinov, Jedrzej Kosiuk, Dominik Linz, Lis Neubeck, Emma Svennberg, Young-Hoon Kim, Elaine Wan, Nestor Lopez-Cabanillas, Emanuela T. Locati, Peter Macfarlane
Summary: This article provides a critical appraisal of signal recording and processing technologies applied for atrial fibrillation mapping and detection. Current technologies have limitations and are mainly restricted to specific applications. It highlights the importance of improving signal processing and anticipates future enhancements and automation.
Article
Cardiac & Cardiovascular Systems
Shipeng Dang, Ru-Xing Wang, Christian Jons, Peter Karl Jacobsen, Steen Pehrson, Xu Chen
Summary: AS linear ablation using robotic magnetic navigation is an effective and safe strategy for PMAFL ablation.
JOURNAL OF INTERVENTIONAL CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Robert D. Anderson, Jairo Rodriguez Padilla, Christian Joens, Stephane Masse, Abhishek Bhaskaran, Karl Magtibay, Ahmed Niri, John Asta, Patrick Lai, Mohammed Ali Azam, Edward Vigmond, Kumaraswamy Nanthakumar
Summary: Conventional unipolar electrogram characteristics lack specificity in predicting intramural arrhythmic sources, but novel endocardial-epicardial mapping surface indices can determine the depth of arrhythmic foci.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Andrea Ghiroldi, Giuseppe Ciconte, Pasquale Creo, Adriana Tarantino, Dario Melgari, Sara D'Imperio, Marco Piccoli, Federica Cirillo, Emanuele Micaglio, Michelle M. Monasky, Anthony Frosio, Emanuela T. Locati, Gabriele Vicedomini, Ilaria Rivolta, Carlo Pappone, Luigi Anastasia
Summary: Brugada Syndrome (BrS) is a genetic arrhythmogenic disorder associated with mutations in genes affecting the sodium channel NaV1.5. This study investigated the involvement of sialylation, a post-translational modification, in BrS. The researchers found significant alterations in gene expression and protein sialylation in BrS patients, which were associated with the clinical phenotype of the disease. Furthermore, protein desialylation was found to reduce sodium current. These findings suggest that dysregulation of sialylation may play a role in BrS and could potentially be used as a biomarker for the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Carlo Pappone, Giuseppe Ciconte, Luigi Anastasia, Fiorenzo Gaita, Edward Grant, Emanuele Micaglio, Emanuela T. Locati, Zarko Calovic, Gabriele Vicedomini, Vincenzo Santinelli
Summary: This study investigates the electroanatomical arrhythmogenic substrate in high-risk LQTS patients and finds that abnormal electrical activities in the epicardium of the right ventricle contribute to malignant ventricular arrhythmia. Catheter ablation successfully eliminates these abnormalities and prevents recurrences.
Article
Cardiac & Cardiovascular Systems
Anna F. Thomsen, Christian Jons, Reza Jabbari, Mia R. Jacobsen, Niels Kjaer Stampe, Jawad H. Butt, Niels Thue Olsen, Henning Kelbaek, Christian Torp-Pedersen, Emil L. Fosbol, Frants Pedersen, Lars Kober, Thomas Engstrom, Peter Karl Jacobsen
Summary: Incomplete revascularization (ICR) in ST-segment elevation myocardial infarction (STEMI) patients compared with complete revascularization (CR) is associated with an increased risk of new-onset arrhythmia and all-cause mortality in the long-term phase.
Article
Cardiac & Cardiovascular Systems
Anna F. Thomsen, Litten Bertelsen, Christian Jons, Reza Jabbari, Jacob Lonborg, Kasper Kyhl, Christoffer Goransson, Lars Nepper-Christensen, Kiril Atharovski, Kathrine Ekstrom, Hans-Henrik Tilsted, Frants Pedersen, Lars Kober, Thomas Engstrom, Niels Vejlstrup, Peter Karl Jacobsen
Summary: This study aimed to evaluate if scar core mass, border zone (BZ) mass, and BZ channels are risk markers for subsequent ventricular arrhythmia (VA) in ST-segment elevation myocardial infarction (STEMI) patients. The results showed that increased BZ mass and presence of BZ channels were associated with higher risk of VA in STEMI patients.
Article
Cardiac & Cardiovascular Systems
Jairo Rodriguez Padilla, Robert D. Anderson, Christian Joens, Stephane Masse, Abhishek Bhaskaran, Ahmed Niri, Patrick Lai, Mohammed Ali Azam, Geoffrey Lee, Edward Vigmond, Kumaraswamy Nanthakumar
Summary: This study compared the accuracy of two-dimensional (2D) and three-dimensional (3D) conduction velocity (CV) algorithms in heart models, and examined the influence of mapping resolution on the results. The findings showed that 2D CV was significantly higher than 3D CV, and increased as the resolution decreased.
Article
Cardiac & Cardiovascular Systems
Sam Aiyad Ali, Mads Ersboll, Naja Emborg Vinding, Jawad Haider Butt, Rasmus Rorth, Christian Selmer, Lucas Malta Westergaard, Ulrik Madvig Mogensen, Peter E. Weeke, Christian Jons, Finn Gustafsson, Emil Fosbol, Lars Kober, Soren Lund Kristensen
Summary: The incidence of thyroid dysfunction is around 5% in patients initiating amiodarone treatment, with a slightly higher incidence in those with heart failure. There is a dose-response relationship between the accumulated dose of amiodarone and the cumulative incidence of thyroid dysfunction.
Article
Cardiac & Cardiovascular Systems
Camilla H. B. Jespersen, Johanna Kroll, Priya Bhardwaj, Bo Gregers Winkel, Peter Karl Jacobsen, Christian Jons, Jens Haarbo, Jens Kristensen, Jens Brock Johansen, Berit T. Philbert, Sam Riahi, Christian Torp-Pedersen, Lars Kober, Jacob Tfelt-Hansen, Peter E. Weeke
Summary: This study aimed to investigate the association between a diagnosis of Brugada syndrome (BrS) and symptomatic disease presentation with new-onset depression or anxiety and all-cause mortality. The results showed that symptomatic BrS disease manifestation was significantly associated with new-onset depression or anxiety, while the overall mortality rate in these patients was low.
Article
Cardiac & Cardiovascular Systems
Camilla H. B. Jespersen, Johanna Kroll, Priya Bhardwaj, Carl Johann Hansen, Jesper Svane, Bo G. G. Winkel, Christian Jons, Peter Karl Jacobsen, Jens Haarbo, Jens Cosedis Nielsen, Jens Brock Johansen, Berit T. T. Philbert, Sam Riahi, Christian Torp-Pedersen, Lars Kober, Jacob Tfelt Hansen, Peter E. E. Weeke
Summary: One in 3 patients with Brugada syndrome were treated with a nonrecommended drug after diagnosis. Factors associated with nonrecommended drug use include gender, psychiatric disease, and prior use of nonrecommended BrS drugs. More awareness of nonrecommended drug use among BrS patients is needed.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Lia Crotti, Carla Spazzolini, Mette Nyegaard, Michael T. Overgaard, Maria-Christina Kotta, Federica Dagradi, Luca Sala, Takeshi Aiba, Mark D. Ayers, Anwar Baban, Julien Barc, Cheyenne M. Beach, Elijah R. Behr, J. Martijn Bos, Marina Cerrone, Peter Covi, Bettina Cuneo, Isabelle Denjoy, Birgit Donner, Adrienne Elbert, Hakan Eliasson, Susan P. Etheridge, Megumi Fukuyama, Francesca Girolami, Robert Hamilton, Minoru Horie, Maria Iascone, Juan Jimenez Jaimez, Henrik Kjaerulf Jensen, Prince J. Kannankeril, Juan P. Kaski, Naomasa Makita, Carmen Munoz-Esparza, Hans H. Odland, Seiko Ohno, John Papagiannis, Alessandra Pia Porretta, Christopher Prandstetter, Vincent Probst, Tomas Robyns, Eric Rosenthal, Ferran Roses-Noguer, Nicole Sekarski, Anoop Singh, Georgia Spentzou, Fridrike Stute, Jacob Tfelt-Hansen, Jan Till, Kathryn E. Tobert, Jeffrey M. Vinocur, Gregory Webster, Arthur A. M. Wilde, Cordula M. Wolf, Michael J. Ackerman, Peter J. Schwartz
Summary: The International Calmodulinopathy Registry (ICalmR) is an international collaborative study that aims to understand the clinical manifestations and molecular mechanisms of calmodulinopathy caused by CALM gene mutations. The registry has enrolled 140 patients, mainly presenting with CALM-LQTS and CALM-CPVT, with some patients also exhibiting neurological symptoms. The study shows a reduced frequency and severity of cardiac events in recent years.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Hillah Saffi, Ulrik Winslow, Tharsika Sakthivel, Emma Vinther Hojgaard, Jesper Linde, Berit Philbert, Michael Vinther, Christian Jons, Henning Bundgaard, Niels Risum
Summary: The study aimed to evaluate if the magnitude of global constructive work (GCW) was associated with the occurrence of ventricular arrhythmias in patients after cardiac resynchronization therapy (CRT). The results showed that patients with a GCW below the median level had a five-fold increased risk of ventricular arrhythmias.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Ljuba Bacharova, Philippe Chevalier, Bulent Gorenek, Christian Jons, Yi-Gang Li, Emanuela T. Locati, Maren Maanja, Andres Ricardo Perez-Riera, Pyotr G. Platonov, Antonio Luiz Pinho Ribeiro, Douglas Schocken, Elsayed Z. Soliman, Jana Svehlikova, Larisa G. Tereshchenko, Martin Ugander, Niraj Varma, Zaklyazminskaya Elena, Takanori Ikeda
Summary: The electrocardiographic diagnosis of left ventricular hypertrophy (LVH) is based on QRS voltage criteria, but the low sensitivity of these criteria has been observed. A new paradigm is proposed, emphasizing the role of electrophysiological background in interpreting QRS changes.
ANNALS OF NONINVASIVE ELECTROCARDIOLOGY
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Carola Rutigliani, Giuseppe Ciconte, Emanuele Micaglio, Michelle Monasky, Sara Benedetti, Giorgio Nevio Casari, Emanuela Teresina Locati, Carlo Pappone
EUROPEAN JOURNAL OF HUMAN GENETICS
(2022)