PTG protein depletion rescues malin-deficient Lafora disease in mouse

Inhibiting glycogen synthesis prevents lafora disease in a mouse model

(2013) Bartholomew A Pederson et al.   ANNALS OF NEUROLOGY

Hyperphosphorylation of Glucosyl C6 Carbons and Altered Structure of Glycogen in the Neurodegenerative Epilepsy Lafora Disease

(2013) Felix Nitschke et al.   Cell Metabolism

Neuronatin-mediated Aberrant Calcium Signaling and Endoplasmic Reticulum Stress Underlie Neuropathology in Lafora Disease

(2013) Jaiprakash Sharma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deleterious effects of neuronal accumulation of glycogen in flies and mice

(2012) Jordi Duran et al.   EMBO Molecular Medicine

Increased Laforin and Laforin Binding to Glycogen Underlie Lafora Body Formation in Malin-deficient Lafora Disease

(2012) Erica Tiberia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Malin Regulates Wnt Signaling Pathway through Degradation of Dishevelled2

(2012) Jaiprakash Sharma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lafora disease E3 ubiquitin ligase malin is recruited to the processing bodies and regulates the microRNA-mediated gene silencing process via the decapping enzyme Dcp1a

(2012) Sweta Singh et al.   RNA Biology

Neurodegeneration and functional impairments associated with glycogen synthase accumulation in a mouse model of Lafora disease

(2011) Jordi Valles-Ortega et al.   EMBO Molecular Medicine

Lafora bodies and neurological defects in malin-deficient mice correlate with impaired autophagy

(2011) Olga Criado et al.   HUMAN MOLECULAR GENETICS

Lafora disease ubiquitin ligase malin promotes proteasomal degradation of neuronatin and regulates glycogen synthesis

(2011) Jaiprakash Sharma et al.   NEUROBIOLOGY OF DISEASE

PTG Depletion Removes Lafora Bodies and Rescues the Fatal Epilepsy of Lafora Disease

(2011) Julie Turnbull et al.   PLoS Genetics

Glycogen hyperphosphorylation underlies lafora body formation

(2010) Julie Turnbull et al.   ANNALS OF NEUROLOGY

Inhibition of glycogen biosynthesis via mTORC1 suppression as an adjunct therapy for Pompe disease

(2010) Karen M. Ashe et al.   MOLECULAR GENETICS AND METABOLISM

Abnormal Metabolism of Glycogen Phosphate as a Cause for Lafora Disease

(2008) Vincent S. Tagliabracci et al.   JOURNAL OF BIOLOGICAL CHEMISTRY