Risk in complex genetics: “All models are wrong but some are useful”

Strengthening the Reporting of Genetic Risk Prediction Studies: The GRIPS Statement

(2013) A. Cecile J.W. Janssens   ANNALS OF INTERNAL MEDICINE

The mystery of missing heritability: Genetic interactions create phantom heritability

(2012) O. Zuk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Estimating Missing Heritability for Disease from Genome-wide Association Studies

(2011) Sang Hong Lee et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Rare variants in the CYP27B1 gene are associated with multiple sclerosis

(2011) Sreeram V. Ramagopalan et al.   ANNALS OF NEUROLOGY

Smoking and two human leukocyte antigen genes interact to increase the risk for multiple sclerosis

(2011) Anna Karin Hedström et al.   BRAIN

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

(2011) David M Evans et al.   NATURE GENETICS

Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

(2011) Mariely DeJesus-Hernandez et al.   NEURON

Synthetic Associations Are Unlikely to Account for Many Common Disease Genome-Wide Association Signals

(2011) Carl A. Anderson et al.   PLOS BIOLOGY

Aggregation of multiple sclerosis genetic risk variants in multiple and single case families

(2010) Pierre-Antoine Gourraud et al.   ANNALS OF NEUROLOGY

Rare Variants Create Synthetic Genome-Wide Associations

(2010) Samuel P. Dickson et al.   PLOS BIOLOGY

What role for genetics in the prediction of multiple sclerosis?

(2009) Stephen Sawcer et al.   ANNALS OF NEUROLOGY

Predicting human height by Victorian and genomic methods

(2009) Yurii S Aulchenko et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Twin studies and the heritability of MS: a conclusion

(2009) CH Hawkes et al.   Multiple Sclerosis Journal

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Beyond odds ratios — communicating disease risk based on genetic profiles

(2009) Peter Kraft et al.   NATURE REVIEWS GENETICS

Rare Variants of IFIH1, a Gene Implicated in Antiviral Responses, Protect Against Type 1 Diabetes

(2009) S. Nejentsev et al.   SCIENCE

Prediction and Interaction in Complex Disease Genetics: Experience in Type 1 Diabetes

(2009) David G. Clayton   PLoS Genetics

Genome-wide association studies for complex traits: consensus, uncertainty and challenges

(2008) Mark I. McCarthy et al.   NATURE REVIEWS GENETICS

Risk for multiple sclerosis in relatives and spouses of patients diagnosed with autoimmune and related conditions

(2008) Kari Hemminki et al.   NEUROGENETICS

Polygenes, Risk Prediction, and Targeted Prevention of Breast Cancer

(2008) Paul D.P. Pharoah et al.   NEW ENGLAND JOURNAL OF MEDICINE