ST101 induces a novel 17kDa APP cleavage that precludes Aβ generation in vivo

A Novel Cognitive Enhancer, ZSET1446/ST101, Promotes Hippocampal Neurogenesis and Ameliorates Depressive Behavior in Olfactory Bulbectomized Mice

(2010) N. Shioda et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

α-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Aβ generation

(2009) Sebastian Jäger et al.   JOURNAL OF NEUROCHEMISTRY

Nicotinamide Restores Cognition in Alzheimer's Disease Transgenic Mice via a Mechanism Involving Sirtuin Inhibition and Selective Reduction of Thr231-Phosphotau

(2008) K. N. Green et al.   JOURNAL OF NEUROSCIENCE

Spiro[imidazo[1,2-a]pyridine-3,2-indan]-2(3H)-one (ZSET1446/ST101) Treatment Rescues Olfactory Bulbectomy-Induced Memory Impairment by Activating Ca2+/Calmodulin Kinase II and Protein Kinase C in Mouse Hippocampus

(2008) F. Han et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

β-Secretase as a therapeutic target for Alzheimer’s disease

(2008) Arun K. Ghosh et al.   Neurotherapeutics