Article
Multidisciplinary Sciences
Elissa L. Newport, Anna Seydell-Greenwald, Barbara Landau, Peter E. Turkeltaub, Catherine E. Chambers, Kelly C. Martin, Rebecca Rennert, Margot Giannetti, Alexander W. Dromerick, Rebecca N. Ichord, Jessica L. Carpenter, Madison M. Berl, William D. Gaillard
Summary: The mature human brain is lateralized for language, with the left hemisphere primarily responsible for sentence processing and the right hemisphere primarily responsible for processing suprasegmental aspects of language. It has been hypothesized that there is plasticity for language in early life, allowing young children to acquire language in other cortical regions when LH areas are damaged. This reorganization is highly constrained, with sentence processing almost always occurring in the right hemisphere frontotemporal regions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Daniel L. Barabasi, Taliesin Beynon, Adam Katona, Nicolas Perez-Nieves
Summary: This paper introduces neurodevelopmental considerations into the framework of machine learning, simulating the evolutionary selection process in brain development by updating the connection rules of neurons to improve task fitness. Experimental results show that this model not only provides high accuracy in machine learning but also compresses the parameter count, and it can select simple circuits from metalearning tasks to provide stable and adaptive performance. By introducing neurodevelopmental considerations, we not only model the emergence of innate behaviors but also define a discovery process for structures that promote complex computations.
NATURE COMMUNICATIONS
(2023)
Article
Neurosciences
Wei Wen, Gina G. Turrigiano
Summary: Homeostatic plasticity in neural circuits can be modulated differently at various developmental stages, with excitatory synaptic scaling and intrinsic homeostatic plasticity being induced during critical periods but only excitatory synaptic scaling persisting into adulthood. This suggests that distinct sets of homeostatic plasticity mechanisms are recruited based on the needs of the developing neural circuit.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Adonis Yiannakas, Sailendrakumar Kolatt Chandran, Haneen Kayyal, Nathaniel Gould, Mohammad Khamaisy, Kobi Rosenblum
Summary: Memory retrieval is a fundamental ability for organisms to utilize acquired information, with the anterior insula playing a critical role in associative memory retrieval related to conditioned taste aversion. The activation of parvalbumin interneurons in the anterior insula is essential for the coherent retrieval of aversive memories.
Article
Neurosciences
Ipek Akol, Evgenia Kalogeraki, Justyna Pielecka-Fortuna, Merle Fricke, Siegrid Loewel
Summary: The extracellular matrix (ECM) plays a crucial role in neuronal network development and plasticity. Proteolytic cleavage of ECM and cell surface proteins is important for regulating plasticity. MMP2 and MMP9 are enzymes involved in proteolysis and their activity is critical for adult visual plasticity.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Rashad Yusifov, Anja Tippmann, Jochen F. Staiger, Oliver M. Schlueter, Siegrid Loewel
Summary: Key periods in brain development, known as Critical periods, are crucial for synaptic connection refinement. A protein called PSD-95 plays a major role in the maturation of synapses. Impaired PSD-95 function affects spine dynamics, leading to altered structural plasticity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
Jiahua Xu, Mircea Ariel Schoenfeld, Paolo M. Rossini, Turgut Tatlisumak, Andreas Nuernberger, Andrea Antal, Huiguang He, Ying Gao, Bernhard A. Sabel
Summary: After occipital stroke, functional connectivity network (FCN) undergoes reorganization, which can be both adaptive and maladaptive. In the intact occipital region, the FCN structure becomes more regular and may lead to spatiotemporal visual impairments in the intact visual field. In other brain regions, FCN reorganization may be adaptive and help compensate for the loss of vision.
BRAIN CONNECTIVITY
(2022)
Article
Neurosciences
Binliang Tang, Kailin Li, Yuan Cheng, Guimin Zhang, Pengying An, Yutian Sun, Yue Fang, Hui Liu, Yang Shen, Yifan Zhang, Ye Shan, Etienne De Villers-Sidani, Xiaoming Zhou
Summary: Exposure to BPA during development affects auditory cortical processing and auditory discrimination, particularly in the temporal domain.
NEUROSCIENCE BULLETIN
(2022)
Article
Neurosciences
Shang Feng, Zhichang Cui, Zhengqi Han, Hongjian Li, Hongbo Yu
Summary: This study explores the contribution of neural plasticity to the saliency detection of temporally distributed visual streams. The results show that neuronal responses are potentiated when the probability of a biased orientation is slightly higher than others, and suppressed when the probability becomes much higher. This bidirectional plasticity is induced by the competition between excitatory and inhibitory components of V1 neuronal receptive field.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Clinical Neurology
Michael Christian Leitner, Anja-Maria Ladek, Florian Hutzler, Herbert Reitsamer, Stefan Hawelka
Summary: A study on 16 stroke patients showed that bright light stimulation at the border of the blind field did not lead to visual field improvement, indicating that the effectiveness of Restitution Training is questionable.
FRONTIERS IN NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Daniel Severin, Su Z. Hong, Seung-Eon Roh, Shiyong Huang, Jiechao Zhou, Michelle C. D. Bridi, Ingie Hong, Sachiko Murase, Sarah Robertson, Rebecca P. Haberman, Richard L. Huganir, Michela Gallagher, Elizabeth M. Quinlan, Paul Worley, Alfredo Kirkwood
Summary: The study found that monocular deprivation in the layer 2/3 of mouse visual cortex triggers a unique binary form of circuit plasticity, which is transient, local, and lasts only 1 day. This loss of local connections is contingent on a reduction of the protein neuropentraxin2 and is absolutely necessary for ocular dominance plasticity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biology
Junshi Lu, Lu Luo, Qian Wang, Fang Fang, Nihong Chen
Summary: The recall of learned temporal sequences through a visual cue is an important form of neural plasticity, observed in awake human visual cortex with neural reactivation in the downstream receptive field. After repeated exposure to a moving dot, a flash of the dot triggers neural reactivation in the receptive field along the motion path, with faster estimated traveling speed than real motion activation.
SCIENCE CHINA-LIFE SCIENCES
(2021)
Article
Neurosciences
Alina Rojas Albert, Winifried Backhaus, Jose A. Graterol Perez, Hanna Braass, Gerhard Schoen, Chi-Un Choe, Jan Feldheim, Marlene Boenstrup, Bastian Cheng, Goetz Thomalla, Christian Gerloff, Robert Schulz
Summary: Imaging studies have shown that the contralesional cortices are involved in recovery after motor stroke. Analyzing cortical thickness can capture changes in cortical anatomy that are related to recovery and treatment gains. This study investigates whether cortical thickness obtained in the acute phase after stroke can explain outcome variability. The results suggest that the baseline cortical anatomy of selected contralesional cortices can explain outcome variability after severe stroke, contributing to the concept of structural brain reserve for promoting recovery.
Editorial Material
Biochemistry & Molecular Biology
Carola I. Radulescu, Samuel J. Barnes
Summary: A new study looks into the neural-circuit and synaptic processes that facilitate the transition from general to specific aversive memory formation. The research identifies a critical role played by homeostatic synaptic down-scaling in shaping the specificity of associative memory.
Review
Clinical Neurology
Daniel S. Marin-Medina, Paula A. Arenas-Vargas, Juan C. Arias-Botero, Manuela Gomez-Vasquez, Manuel F. Jaramillo-Lopez, Jorge M. Gaspar-Toro
Summary: After a stroke, neural plasticity mechanisms can be activated for significant recovery. Rehabilitation therapies aim to restore tissue and reorganize neural connections. New technologies such as brain-computer interfaces, robot-assisted and virtual reality therapies, brain stimulation, and cell therapies have emerged as promising options for better functional outcomes.
NEUROLOGICAL SCIENCES
(2023)
Article
Education, Scientific Disciplines
Abdullah Ben Awadh, Jill Clark, Gavin Clowry, Iain D. Keenan
Summary: The study suggests that using visualization table-based thoracic cross-sections, digital models, and a 3D printed heart for learning can enhance student understanding of cross-sectional anatomy. It also found that clinical imaging is more challenging for students compared to surface anatomy and gross anatomy. Further research is needed to explore the implications of these findings on implementing multimodal cross-sectional anatomy learning approaches in medical curricula.
ANATOMICAL SCIENCES EDUCATION
(2022)
Article
Multidisciplinary Sciences
Dan J. Hayman, Tamara Modebadze, Sarah Charlton, Kat Cheung, Jamie Soul, Hua Lin, Yao Hao, Colin G. Miles, Dimitra Tsompani, Robert M. Jackson, Michael D. Briggs, Katarzyna A. Pirog, Ian M. Clark, Matt J. Barter, Gavin J. Clowry, Fiona E. N. LeBeau, David A. Young
Summary: MicroRNAs play important roles in downregulating gene expression, with miR-324 specifically targeting thousands of RNA transcripts in the brain, potentially influencing neurological pathways.
SCIENTIFIC REPORTS
(2021)
Review
Psychology, Developmental
Phillip Antony Harniess, Deanna Gibbs, Jeff Bezemer, Anna Purna Basu
Summary: The study highlights the importance of parental engagement strategies in early intervention programs for infants at high risk of cerebral palsy. Constructive parent reasoning mechanisms and intervention co-design are key components in achieving successful parental engagement. Effective parent connection, involvement, and investment within early intervention programs for infants with CP rely on sensitively designed strategies centered on relational quality between parent, infant, and therapist.
CHILD CARE HEALTH AND DEVELOPMENT
(2022)
Editorial Material
Clinical Neurology
Anna P. Basu
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2022)
Article
Anatomy & Morphology
Ayman Alzu'bi, Niveditha Sankar, Moira Crosier, Janet Kerwin, Gavin J. Clowry
Summary: Several strategies have recently been introduced to improve the practicality of multiple immunolabeling and RNA in situ hybridization protocols. In this work, we describe the highly sensitive and specific methods of using TSA and RNAScope in situ hybridization for evaluating protein and RNA expression in fetal brain tissue.
JOURNAL OF ANATOMY
(2022)
Letter
Pediatrics
Dhinesh Baskaran, Chris Gale, Sena Jawad, Kayleigh Oughham, Ki Pang, Anna Purna Basu
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2023)
Editorial Material
Clinical Neurology
Gavin Clowry
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2022)
Article
Engineering, Biomedical
B. Zaaimi, M. Turnbull, A. Hazra, Y. Wang, C. Gandara, F. McLeod, E. E. McDermott, E. Escobedo-Cousin, A. Shah Idil, R. G. Bailey, S. Tardio, A. Patel, N. Ponon, J. Gausden, D. Walsh, F. Hutchings, M. Kaiser, M. O. Cunningham, G. J. Clowry, F. E. N. LeBeau, T. G. Constandinou, S. N. Baker, N. Donaldson, P. Degenaar, A. O'Neill, A. J. Trevelyan, A. Jackson
Summary: Closed-loop optogenetic stimulation with excitatory opsins enables precise manipulation of neural dynamics in brain slices and non-human primates, with potential therapeutic applications in humans.
NATURE BIOMEDICAL ENGINEERING
(2023)
Editorial Material
Clinical Neurology
Anna Basu, Kathleen Friel, Bolajoko Olusanya, Mijna Hadders-Algra
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2023)
Editorial Material
Clinical Neurology
Anna Basu
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2023)
Editorial Material
Clinical Neurology
Ana Basu, Kathleen Friel, Bolajoko Olusanya, Mijna Hadders-Algra
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2023)
Article
Rehabilitation
Phillip Antony Harniess, Anna Purna Basu, Jeff Bezemer, Deanna Gibbs
Summary: The purpose of this study is to understand how parents perceive their engagement experience in early intervention over time. The findings show that parents' perspectives of their engagement in early intervention change according to critical circumstances such as neonatal trauma, CP diagnosis, and the child's response to intervention. This theorizing has implications for early intervention therapists in engaging with families and partnering with parents to support healthier parental transition and improved infant outcomes.
DISABILITY AND REHABILITATION
(2023)
Article
Pharmacology & Pharmacy
A. Alzu'bi, M. S. Al Zoubi, G. T. Abdelhady, B. Al-Trad, S. Omari, M. Abualarjah, W. El-Huneidi, D. R. Alzu'bi, J. M. Bani-Issa, G. J. Clowry
Summary: This study found that exposure to nicotine during pregnancy can lead to decreased fetal growth and weight, as well as reduced placental size. This is accompanied by increased apoptosis within the placenta, while the expression of angiogenic factors remains unchanged.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Review
Clinical Neurology
Rebecca Caesar, Paul B. Colditz, Giovanni Cioni, Roslyn N. Boyd
Summary: In infants born very preterm, only the GMA and HINE tools used at 6 months or younger corrected age have shown predictive validity for cognitive and motor delays at 24 months corrected age.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2021)
Article
Pediatrics
Roberta Milone, Claudia Cesario, Marina Goldoni, Rosa Pasquariello, Caterina Fusilli, Agnese Giovannetti, Sabrina Giglio, Antonio Novelli, Viviana Caputo, Giovanni Cioni, Tommaso Mazza, Agatino Battaglia, Laura Bernardini, Roberta Battini
Summary: This study evaluated the relationship between neurodevelopmental disorders, brain anomalies, and copy number variations, showing that the detection rates of brain anomalies and CMA are related to the types of patients with IDD, ASD, and/or EPI. CMA detection rate was significantly higher in patients with brain anomalies, suggesting its potential usefulness in these cases.
JOURNAL OF PEDIATRIC GENETICS
(2021)
