Review
Health Care Sciences & Services
Ting-Yen Chen, Yu-Chi Su, Yu-Ching Lin, Yao-Hong Guo
Summary: This study conducted a systematic review and meta-analysis to evaluate the effectiveness of botulinum neurotoxin (BoNT) in treating obstetric brachial plexus injury. The findings revealed that BoNT treatment significantly improved passive range of motion of the shoulder external rotation and active range of motion of elbow extension. However, the improvement in shoulder abduction, active elbow flexion, and muscle power did not reach statistical significance. Age did not significantly affect the treatment outcomes. The study emphasizes the need for further research with larger sample sizes and randomized controlled trials to determine the effectiveness of BoNT in obstetric brachial plexus injury patients.
Review
Clinical Neurology
Haijun Li, Jinxiu Chen, Juehan Wang, Tianfang Zhang, Zuobing Chen
Summary: Brachial plexus injury (BPI) is a serious peripheral nerve injury that leads to severe and persistent impairments of the upper limb. The demand for rehabilitation treatment after BPI is increasing due to the relatively mature early diagnosis and surgical technique. Rehabilitation intervention can benefit different stages of recovery, but the treatment methods vary due to the complexity of the brachial plexus. This article explores the potential contributions of various methods to BPI rehabilitation and provides a concise overview of beneficial interventions, forming clear rehabilitation processes based on different periods and populations.
FRONTIERS IN NEUROLOGY
(2023)
Article
Pediatrics
Murat Danisman, Abdulsamet Emet, Ismail Aykut Kocyigit, Ercan Hassa, Akin Uzumcugil
Summary: The study aimed to determine the differences in the length of the affected extremity in patients with obstetric brachial plexus palsy (OBPP). They evaluated the humerus, ulna, radius, 2nd metacarpal, and 5th metacarpal lengths in 45 patients aged 6 months to 18 years. Statistically significant differences were found in the change rates of affected/healthy humerus, radius, 2nd metacarpal, and 5th metacarpal lengths according to age and Narakas classification. There were also differences in the affected/healthy change rates of ulna, radius, and 5th metacarpal lengths based on secondary surgeries.
Review
Orthopedics
Willem Pondaag, Martijn J. A. Malessy
Summary: The majority of children with obstetric brachial plexus injury show some degree of spontaneous recovery, but randomized trials evaluating the effectiveness of nerve repair surgery have not been conducted. Experts agree that nerve reconstruction is necessary when spontaneous recovery is absent or severely delayed at specific time points.
JOURNAL OF HAND SURGERY-EUROPEAN VOLUME
(2021)
Article
Orthopedics
Tim Hems
Summary: A prospective database study was conducted to investigate the severity and progression of elbow and forearm contractures in patients with obstetric brachial plexus injury. The study found that the degree of fixed flexion in the elbow was related to the patient's group, and poorer active shoulder abduction was a significant risk factor for severe contractures. As the injury severity increased, both active and passive pronation and supination tended to decrease. These findings provide valuable insights for the treatment of obstetric brachial plexus injury.
JOURNAL OF HAND SURGERY-EUROPEAN VOLUME
(2022)
Article
Clinical Neurology
Mariano Socolovsky, Karina Barillaro, Gonzalo Bonilla, Gilda Di Masi, Martijn Malessy
Summary: This study investigates the levels of disconnection and reconnection in nerve transfers for brachial plexus injuries. A novel plasticity grading scale was developed and used to assess the volitional control achieved. The study found that only approximately 20% of patients achieved complete control over the reinnervated muscle.
JOURNAL OF NEUROSURGERY
(2023)
Article
Behavioral Sciences
Zeyu Cai, Gaowei Lei, Jie Li, Yundong Shen, Yudong Gu, Juntao Feng, Wendong Xu
Summary: Contralateral C7 nerve transfer can aid in motor and sensory recovery in TBPI, but synchronous sensation often persists postoperatively. Central plasticity may play a role in sensory recovery, with sensory functioning of the injured hand dominated by its ipsilateral SI and overlapping with the intact hand's representative area.
BRAIN AND BEHAVIOR
(2021)
Review
Health Care Sciences & Services
Amaranta De Miguel-Rubio, Alvaro Alba-Rueda, Elena Maria Millan-Salguero, M. Dolores De Miguel-Rubio, Jose A. Moral-Munoz, David Lucena-Anton
Summary: This systematic review found insufficient evidence to support the efficacy of VR therapy for upper limb rehabilitation outcomes in patients with OBP. However, scientific literature suggests that VR technologies have several advantages for rehabilitation, such as enhancing motivation and providing direct feedback. Further research is needed to fully understand the potential of VR technologies for therapeutic approaches in patients with OBP.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Review
Obstetrics & Gynecology
Shireen Jaufuraully, Anjana Lakshmi Narasimhan, Daniel Stott, George Attilakos, Dimitrios Siassakos
Summary: This study aimed to aggregate cases of obstetric brachial plexus injury (BPI) after cesarean section (CS) and identify risk factors for BPI. The findings showed that 53% of BPI cases after CS had risk factors related to challenging fetal handling/manipulation prior to delivery, maternal/fetal concerns, and difficulties in accessing the fetus due to obesity or adhesions.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Medicine, General & Internal
Qun Lao, Yuzhu Jia, Kaiyu Zhao, Kun Liu, Jianju Feng
Summary: This study investigated the diagnostic value of high-resolution MRI based on 3D-STIR SPACE sequence for brachial plexus injury in infants and young children. The results showed that this technique accurately identified the injured nerve and characterized related pathological alterations, making it a valuable tool for screening and monitoring of brachial plexus injury.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Margareta Mollberg, Linnea Ladfors, Christina Strombeck, Helen Elden, Lars Ladfors
Summary: Despite an increase in risk factors such as shoulder dystocia, the incidence of obstetric brachial plexus palsy in infants delivered vaginally in a cephalic presentation decreased between 1997 and 2019.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Orthopedics
Dafang Zhang, George S. M. Dyer, Rohit Garg
Summary: Nearly half of traumatic BPI patients evaluated at 2 tertiary referral centers in a large metropolitan area in the United States presented in a delayed time frame. Both modifiable and nonmodifiable associations with delayed referral were identified, with factors such as the hospital to which the patient was referred, Medicare insurance, and motorcycle accident as the mechanism of injury being associated with delayed referral.
JOURNAL OF HAND SURGERY-AMERICAN VOLUME
(2021)
Article
Medicine, General & Internal
Zinon Kokkalis, Spyridon Papagiannis, Antonis Kouzelis, George Diamantakis, Andreas Panagopoulos
Summary: Traumatic brachial plexus injuries are increasing worldwide, requiring thorough evaluation through physical examination and various tests. Bilateral brachial plexus injuries are extremely rare, and we report a rare case of a 19-year-old male who sustained bilateral brachial plexus injuries after a motorbike accident, achieving good recovery through surgery and conservative treatment.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Clinical Neurology
Ailin Liu, Xiaotian Jia, Li Zhang, Xiaoyun Huang, Weimin Chen, Lin Chen
Summary: This study compared the diagnostic performance of preoperative ultrasound and electrophysiology study in assessing traumatic brachial plexus root injury. The results showed that preoperative ultrasound had higher sensitivity, specificity, positive predictive value, negative predictive value, and accuracy than electrophysiology study. When ultrasound was combined with electrophysiology study, the sensitivity and specificity were significantly higher.
FRONTIERS IN NEUROLOGY
(2023)
Article
Critical Care Medicine
Emmanuel P. Estrella, Nina T. Castillo-Carandang, Cynthia P. Cordero, Noel R. Juban
Summary: This study evaluated 126 adult patients with traumatic brachial plexus injuries and found that elbow flexion recovery, pain, and duration of the injury were significantly associated with functional disability scores.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2021)
Article
Clinical Neurology
Jean-Christophe Corvol, Jean-Philippe Azulay, Bjorn Bosse, Yves Dauvilliers, Luc Defebvre, Fabian Klostermann, Norbert Kovacs, David Maltete, William G. Ondo, Rajesh Pahwa, Werner Rein, Stephane Thobois, Martin Valis, Aleksandar Videnovic, Olivier Rascol
Summary: The study of THN102 in PD patients with EDS showed that the 200/2 dose demonstrated efficacy and good tolerability, supporting further development. On the other hand, the 200/18 dose did not show significant improvement.
MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
Reka A. Horvath, Zsofia Suto, Balazs Cseke, Daniel Schranz, Gergely Darnai, Norbert Kovacs, Imre Janszky, Jozsef Janszky
Summary: This study aimed to assess the prevalence of epilepsy among COVID-related deaths and found that epilepsy was more common among COVID-19 patients who died under the age of 50.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2022)
Article
Neurosciences
Norbert Kovacs, Lars Bergmann, Marieta Anca-Herschkovitsch, Esther Cubo, Thomas L. Davis, Robert Iansek, Mustafa S. Siddiqui, Mihaela Simu, David G. Standaert, K. Ray Chaudhuri, Paul Bourgeois, Tianming Gao, Pavnit Kukreja, Francesco E. Pontieri, Jason Aldred
Summary: Motor and non-motor symptoms of Parkinson's disease have an impact on health-related quality of life (HRQoL), and improvements in HRQoL are correlated with improvements in non-motor symptoms and sleep. LCIG treatment can improve HRQoL.
JOURNAL OF PARKINSONS DISEASE
(2022)
Article
Clinical Neurology
Katina Aleksovska, Teia Kobulashvili, Joao Costa, Georg Zimmermann, Karen Ritchie, Carola Reinhard, Luca Vignatelli, Alessandra Fanciulli, Maxwel Damian, Lucia Pavlakova, Jean-Marc Burgunder, Svetlana Kopishinskaya, Martin Rakusa, Norbert Kovacs, Fusun Ferda Erdogan, Lori Renna Linton, Massimiliano Copetti, Costanza Lamperti, Serenella Servidei, Theresina Evangelista, Segolene Ayme, Davide Pareyson, Johann Sellner, Christian Krarup, Marianne de Visser, Peter van den Bergh, Antonio Toscano, Holm Graessner, Thomas Berger, Claudio Bassetti, Marie Vidailhet, Eugene Trinka, Guenther Deuschl, Antonio Federico, Maurizio A. Leone
Summary: This article introduces the impact of rare diseases on patients and the existing problems within the European Union. It also provides recommendations and methods for developing and reporting high-quality clinical practice guidelines (CPGs) for rare neurological diseases (RNDs). Through a consensus procedure, 63 final items were identified. These recommendations provide solutions to the specific issues of RNDs and are considered as a starting point for further harmonization and improving the quality of CPGs.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Geriatrics & Gerontology
Daniel Pham, Beata Polgar, Tunde Toth, Adel Jungling, Norbert Kovacs, Istvan Balas, Endre Pal, Dora Szabo, Balazs Daniel Fulop, Dora Reglodi, Zalan Szanto, Robert Herczeg, Attila Gyenesei, Andrea Tamas
Summary: The study found that PACAP levels were significantly decreased in PD patients without DBS therapy and in the akinetic-rigid subtype. However, there were no significant correlations between PACAP levels and other clinical parameters. The results suggest that monitoring PACAP alterations in PD patients could improve therapeutic interventions and provide a clearer prognosis for the disease.
Article
Clinical Neurology
Norbert Kovacs, Jozsef Szasz, Lydia Vela-Desojo, Per Svenningsson, Samira Femia, Juan Carlos Parra, Olga Sanchez-Solino, Lars Bergmann, Tanya Gurevich, Alfonso Fasano
Summary: This study compared motor and nonmotor outcomes in APD patients receiving 24-hour versus 16-hour LCIG treatment. The results showed reductions in off time, dyskinesia, and prevalence of most symptoms in both treatment groups. Significant differences were found in freezing of gait, urinary symptoms, and cognitive impairment between the two groups.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Multidisciplinary Sciences
Dalma Tenyi, Tamas Tenyi, Gyorgyi Csabi, Sara Jeges, Beata Bone, Katalin Lorincz, Norbert Kovacs, Jozsef Janszky
Summary: This study aimed to investigate the occurrence and distribution of minor physical anomalies (MPAs) in adult epilepsy patients. The results showed that MPAs were more common in epilepsy patients and were positively associated with antiepileptic drug therapy resistance. This finding contributes to the understanding of the neurodevelopmental etiology of epilepsy and provides a basis for early non-pharmacological treatment.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Liesanne M. Centen, David Pinter, Martje E. van Egmond, Holm Graessner, Norbert Kovacs, Anne Koy, Belen Perez-Duenas, Carola Reinhard, Marina A. J. Tijssen, Sylvia Boesch
Summary: This study evaluated the current state of dystonia management in Europe and found that accessibility was only considered "satisfactory" in nearly half of the surveyed countries, with over half of the countries facing challenging access to genetic and neurophysiological testing. Main oral medications and botulinum toxin were available in all countries, but deep brain stimulation (DBS) was easily accessible in only one-third of the countries. For pediatric dystonia, over half of the countries had experts and specific training available.
JOURNAL OF NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
David Pinter, Evelyn Jardahazi, Jozsef Janszky, Norbert Kovacs
Summary: Teleprogramming for deep brain stimulation (DBS) can reduce travel and financial burdens for patients, especially during special situations like the COVID-19 pandemic. Research shows a significant decrease in the number of in-person visits during the pandemic.
SCIENTIFIC REPORTS
(2022)
Article
Psychiatry
Diana Kuperczko, Peter Kenyeres, Gergely Darnai, Norbert Kovacs, Jozsef Janszky
Summary: This study investigated 24 cases of deaths related to playing video games, most of which involved young males aged between 11 and 40. The majority of cases occurred in Southeast Asia, with 12 deaths happening in internet cafes. Prolonged gaming sessions, dehydration, and other factors like sleep deprivation and stress contributed to the deaths.
Article
Clinical Neurology
Fran Borovecki, Romana Perkovic, Norbert Kovacs, Peter A. A. LeWitt, Monika Rudzinska Bar, Regina Katzenschlager
Summary: In advanced Parkinson's disease, motor and non-motor symptoms worsen and become harder to treat. When oral therapy is insufficient in controlling motor complications, device-aided treatments, such as infusion therapies and deep brain stimulation, should be considered. These treatments should be provided according to guidelines and treatment standards, and ensuring availability and education for patients and physicians is crucial.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Meeting Abstract
Clinical Neurology
G. Deuschl, R. Schuurman, G. Loret, N. Kovacs, M. Blazquez Estrada, F. Clement, J. Il Lee, L. Chen, R. Jain
MOVEMENT DISORDERS
(2022)
Meeting Abstract
Clinical Neurology
N. Kovacs, M. Simu, O. Sanchez Solino, J. Parra, J. Alcazar, S. Snedecor, V. Fung
MOVEMENT DISORDERS
(2022)
Meeting Abstract
Clinical Neurology
K. Chaudhuri, N. Kovacs, F. Pontieri, J. Aldred, P. Bourgeois, T. Davis, E. Cubo, M. Anca-Herschkovitsch, R. Iansek, M. Siddiqui, M. Simu, L. Bergmann, P. Kukreja, O. Ladhani, J. Jia, D. Standaert
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Meeting Abstract
Clinical Neurology
E. Freire Alvarez, P. Vanni, E. Kurca, L. Lopez Manzanares, N. Kovacs, C. Spanaki, T. Gao, L. Bergmann, O. Sanchez-Solino, L. Barbato
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
