Article
Psychology, Developmental
Peiyu Chen, Ana Baylin, Joyce Lee, Galit Levi Dunietz, Alejandra Cantoral, Martha Maria Tellez Rojo, Karen E. Peterson, Erica C. Jansen
Summary: The study examined the relationship between sleep duration, timing, and insulin resistance in Mexican adolescents. Shorter sleep duration and later sleep timing were both independently associated with higher insulin resistance, particularly among girls.
JOURNAL OF ADOLESCENT HEALTH
(2021)
Article
Public, Environmental & Occupational Health
Aurelija Podlipskyte, Nijole Kazukauskiene, Giedrius Varoneckas, Narseta Mickuviene
Summary: This study investigates the association between insulin resistance and cardiovascular risk factors and sleep complaints over a 10-year follow-up period. The results show that insulin resistance is significantly associated with increased obesity, metabolic syndrome, diabetes, elevated fasting glucose levels, triglyceridemia, and sleep problems.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Clinical Neurology
Kelvin Pengyuan Zhang, Miatta Buxton, Yanelli Rodriguez-Carmona, Karen E. Peterson, Yun Liu, Helen J. Burgess, Alejandra Cantoral, Martha Maria Tellez-Rojo, Libni A. Torres-Olascoaga, Laura Arboleda-Merino, Erica C. Jansen
Summary: This study evaluated the association between sleep duration, timing, and variability, and inflammatory cytokines in Mexico City adolescents. The results showed that later timing, shorter duration, and inconsistency of sleep were related to higher levels of inflammatory biomarkers.
Article
Clinical Neurology
Olga E. Titova, Eva Lindberg, Solve Elmstahl, Lars Lind, Christian Benedict
Summary: A Swedish study found that self-reported sleep characteristics may vary across seasons, with individuals surveyed in summer more likely to report short sleep duration, those in winter less likely to report early awakenings, and those in spring less likely to report difficulties in falling asleep and disturbed sleep.
JOURNAL OF SLEEP RESEARCH
(2022)
Article
Multidisciplinary Sciences
Ivy C. Mason, Daniela Grimaldi, Kathryn J. Reid, Chloe D. Warlick, Roneil G. Malkani, Sabra M. Abbott, Phyllis C. Zee
Summary: This study found that exposure to light during nighttime sleep can negatively affect glucose homeostasis the following morning, potentially through reduced sleep quality, melatonin suppression, or activation of the sympathetic nervous system (SNS) during sleep.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Psychology, Clinical
Emma L. M. Clark, Lauren D. Gulley, Mark A. Prince, Milena Casamassima, Natalia Sanchez, Virginia Jimenez, Sarah A. Johnson, Reagan L. Miller, Isabella Conte, Jill L. Kaar, Stacey L. Simon, Christopher Melby, Rachel G. Lucas-Thompson, Lauren B. Shomaker
Summary: The study suggests that sleep difficulties play a role in the connection between depression and insulin resistance in adolescents at risk of excess weight gain. Additionally, dispositional mindfulness may moderate the associations among depression, sleep, and insulin resistance.
JOURNAL OF BEHAVIORAL MEDICINE
(2021)
Article
Psychiatry
Li-Hua Lin, Wen-Qi Xu, Shi-Bin Wang, Qing Hu, Ping Zhang, Jia-Hao Huang, Yun-Fei Ke, Kai-Rong Ding, Cai-Lan Hou, Fu-Jun Jia
Summary: A U-shaped association was found between sleep duration and subjective cognitive complaints (SCCs) in Chinese elderly, with the least association observed at 8 hours of sleep. Both longer and shorter sleep durations than 8 hours were linked to worse SCCs.
Article
Multidisciplinary Sciences
Hwa-Yen Chiu, Kun-Ta Chou, Kang-Cheng Su, Fang-Chi Lin, Yung-Yang Liu, Tsu-Hui Shiao, Yuh-Min Chen
Summary: This study investigated the proportion of young adults with obstructive sleep apnea (OSA) and sleep-related complaints in a sleep center over a period of 17 years. The results showed that young adults constituted a significant portion of individuals undergoing polysomnography (PSG) and confirmed OSA cases, with a relatively constant proportion over time. Young adults with OSA were found to be sleepier, have a higher body mass index, and engage more in smoking and alcohol consumption. They also reported more snoring and daytime sleepiness. Furthermore, they exhibited higher levels of apnea-hypopnea index and experienced more hypoxemia during sleep compared to other age groups. The study highlights the importance of recognizing OSA in young adults and the need for tailored treatment plans.
SCIENTIFIC REPORTS
(2022)
Article
Rheumatology
Clara Malattia, Lorenzo Chiarella, Miriam Sansone, Angela Pistorio, Claudio Lavarello, Manuela Carpaneto, Raffaele Ferri, Angelo Ravelli, Lino Nobili
Summary: This study investigates sleep quality in juvenile fibromyalgia syndrome (JFS) and its impact on the global burden of the disease. The results show that patients with JFS have longer sleep period time, increased wake after sleep onset, and lower N3 distribution index compared to healthy peers. Subjective poor sleep quality is related to widespread pain, symptom severity, depressive symptoms, fatigue, and symptom severity upon awakening. Sleep complaints are a key characteristic of JFS and have significant effects on pain and depression.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Multidisciplinary Sciences
Alexander Q. Vining, Charles L. Nunn, David R. Samson
Summary: Experimental study at the Duke Lemur Center in North Carolina, USA, showed that enhancing softness or insulation of the sleep-site could increase daily sleep times of lemurs, while the effect of sleep-site impoverishment was minimal. Factors such as surface area or stability did not have a significant impact on lemur sleep quality.
Article
Medicine, General & Internal
Hisashi Adachi, Akiko Matsumura, Mika Enomoto, Ako Fukami, Nagisa Morikawa, Yume Nohara, Maki Yamamoto, Hiromi Sato, Tatsuyuki Kakuma, Yoshihiro Fukumoto
Summary: This study found a J-shaped relationship between sleep duration and the risk of insulin resistance in a general Japanese population.
Review
Biochemistry & Molecular Biology
Kanagavalli Ramasubbu, Gnanasambandan Ramanathan, Ganesh Venkatraman, V. Devi Rajeswari
Summary: Lifestyle modification can lead to various health issues related to sleep, including inflammation, immunity, neurodegeneration, cognitive decline, memory impairment, neuroplasticity, and insulin resistance. Sleep significantly affects brain and memory formation, toxin excretion, hormonal function, metabolism, and motor and cognitive functions. Sleep restriction associated with insulin resistance interferes with insulin signaling pathway, neurotransmission, inflammatory pathways, and neuronal plasticity. This review discusses the evidence suggesting the relationship between sleep, neurodegeneration, and insulin resistance, and explores the role of hormones in these conditions.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Nutrition & Dietetics
Marriam Ali, Sirimon Reutrakul, Gregory Petersen, Kristen L. Knutson
Summary: The timing of eating is associated with metabolic health, with earlier eating start time being associated with lower fasting glucose and estimated insulin resistance. This suggests that meal timing is an important characteristic of dietary patterns that can affect metabolism.
Article
Pediatrics
Douglas M. Teti, Corey J. Whitesell, Jacqueline A. Mogle, Brian Crosby, Orfeu M. Buxton, Karen L. Bierman, David M. Almeida
Summary: This study examined the relationship between child sleep duration and various outcomes, such as socioemotional development, learning engagement, executive functioning, and academic performance. The results showed that establishing healthy nighttime sleep habits and consistently sleeping for ten hours or more per night before starting kindergarten was associated with better outcomes in these domains.
Article
Clinical Neurology
Francisco G. Vital-Lopez, Thomas J. Balkin, Jaques Reifman
Summary: The study developed and validated mathematical models predicting sleep latency and duration, providing insights on the impact of small shifts in sleep onset timing on sleep duration. The models showed low prediction errors and can be applied to enhance performance, safety, and sustainability in civilian and military operations.
Article
Family Studies
Mari Laakso, Ase Fagerlund, Anu-Katriina Pesonen, Rejane A. O. Figueiredo, Johan G. Eriksson
Summary: This current study used experience sampling to examine the change in daily positive and negative emotions of students participating in the Flourishing Students program. The findings suggest that the program has a positive effect on reducing negative emotions and increasing positive emotions in students.
JOURNAL OF EARLY ADOLESCENCE
(2023)
Article
Endocrinology & Metabolism
Jessica Edstorp, Yuxia Wei, Emma Ahlqvist, Lars Alfredsson, Valdemar Grill, Leif Groop, Bahareh Rasouli, Elin P. Sorgjerd, Per M. Thorsby, Tiinamaija Tuomi, Bjorn O. Asvold, Sofia Carlsson
Summary: The study reveals that smoking and snus use are associated with a higher risk of LADA and type 2 diabetes, and smoking acts synergistically with HLA high-risk genotypes in the development of LADA.
Article
Nutrition & Dietetics
Maryann Regina Rolands, Jia Ying Toh, Ray Sugianto, Wen Lun Yuan, Yung Seng Lee, Kok Hian Tan, Fabian Yap, Keith M. Godfrey, Johan G. Eriksson, Yap-Seng Chong, Klazine Van der Horst, Mary Foong-Fong Chong
Summary: The study aims to develop and evaluate a dietary quality index for preschool-aged children in Singapore. The results show that the diet quality of preschool-aged children is generally low, with some excessive intake. Children with mothers of Malay ethnicity, low income, low education level, and shared primary caregiver responsibilities tend to have lower DQI-5 scores.
JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS
(2023)
Article
Psychiatry
Mia D. Eriksson, Johan G. Eriksson, Paivi Korhonen, Hannu Koponen, Minna K. Salonen, Tuija M. Mikkola, Eero Kajantie, Niko S. Wasenius, Mikaela von Bonsdorff, Hannu Kautiainen, Merja K. Laine
Summary: Individuals with depression, specifically melancholic subtype, have a higher risk of mortality compared to non-depressed individuals. The underlying pathophysiological differences between depressive subtypes may contribute to this phenomenon.
ACTA PSYCHIATRICA SCANDINAVICA
(2023)
Article
Biochemistry & Molecular Biology
Tuomo Kiiskinen, Pyry Helkkula, Kristi Krebs, Juha Karjalainen, Elmo Saarentaus, Nina Mars, Arto Lehisto, Wei Zhou, Mattia Cordioli, Sakari Jukarainen, Joel T. Ramo, Juha Mehtonen, Kumar Veerapen, Markus Rasanen, Sanni Ruotsalainen, Mutaamba Maasha, Teemu Niiranen, Tiinamaija Tuomi, Veikko Salomaa, Mitja Kurki, Matti Pirinen, Aarno Palotie, Mark Daly, Andrea Ganna, Aki S. Havulinna, Lili Milani, Samuli Ripatti
Summary: A new analysis of large biobanks reveals genetic variants associated with changes in medication for cardiometabolic diseases and presents polygenic scores of medication-use behavior. The study used data from the Finnish nationwide drug purchase registry and performed genome-wide association analyses to identify loci associated with medication use in hyperlipidemia, hypertension, and type 2 diabetes. The findings demonstrate the potential for medication-based strategies to identify cardiometabolic risk loci and provide genome-wide tools for preventing cardiovascular diseases.
Article
Multidisciplinary Sciences
Suvi Alenius, Eero Kajantie, Reijo Sund, Markku Nurhonen, Peija Haaramo, Pieta Nasanen-Gilmore, Sakari Lemola, Katri Raikkonen, Daniel D. Schnitzlein, Dieter Wolke, Mika Gissler, Petteri Hovi
Summary: Attendance in special education is more common among individuals born preterm. However, the minor differences in school grades according to gestational age do not translate into educational differences in young adulthood.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Jessica Edstorp, Emma Ahlqvist, Lars Alfredsson, Dina Mansour Aly, Valdemar Grill, Bahareh Rasouli, Elin P. Sorgjerd, Tiinamaija Tuomi, Bjorn O. Asvold, Sofia Carlsson
Summary: This study found that smoking and Swedish smokeless tobacco are associated with latent autoimmune diabetes in adults and type 2 diabetes. Furthermore, genetic susceptibility to type 2 diabetes, insulin resistance, and insulin secretion worsen these associations.
Article
Endocrinology & Metabolism
Minna Harsunen, Jani Haukka, Valma Harjutsalo, Nina Mars, Anna Syreeni, Taina Harkonen, Annemari Karajaemaki, Jorma Ilonen, Mikael Knip, Niina Sandholm, Paivi Johanna Miettinen, Per-Henrik Groop, Tiinamaija Tuomi
Summary: Contrary to the presumption that type 1 diabetes leads to an absolute insulin deficiency, this study found that many individuals with type 1 diabetes still have circulating C-peptide years after diagnosis. The study also identified the correlation between age at diagnosis and decline in C-peptide secretion, as well as the association between polygenic risk scores, clinical factors, and random serum C-peptide concentrations.
LANCET DIABETES & ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Marco Bucci, Patricia Iozzo, Harri Merisaari, Ville Huovinen, Heta Lipponen, Katri Raikkonen, Riitta Parkkola, Minna Salonen, Samuel Sandboge, Johan Gunnar Eriksson, Lauri Nummenmaa, Pirjo Nuutila
Summary: This study aimed to investigate the effects of maternal obesity on brain structure and metabolism in frail women and their reversibility in response to exercise. The results showed that offspring of lean/normal-weight mothers had higher white matter density compared to offspring of obese/overweight mothers. Exercise intervention resulted in an increase in white matter density, with a greater effect observed in offspring of lean/normal-weight mothers. These findings suggest that exercise has an impact on brain morphology and cognition in elderly frail women.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Samuel Sandboge, Katri Raikkonen, Marius Lahti-Pulkkinen, Helena Hauta-alus, Elisa Holmlund-Suila, Polina Girchenko, Eero Kajantie, Outi Makitie, Sture Andersson, Kati Heinonen
Summary: This study found that high-dose (1200 IU) vitamin D-3 supplementation during the first 2 years reduced the risk of internalizing problems in children aged 6 to 8 years, especially in those with lower maternal vitamin D-3 levels.
Article
Multidisciplinary Sciences
Om Prakash Dwivedi, Karina Barreiro, Annemari Karajamaki, Erkka Valo, Anil K. Giri, Rashmi B. Prasad, Rishi Das Roy, Lena M. Thorn, Antti Rannikko, Harry Holthoefer, Kim M. Gooding, Steven Sourbron, Denis Delic, Maria F. Gomez, Per-Henrik Groop, Tiinamaija Tuomi, Carol Forsblom, Leif Groop, Maija Puhka
Summary: By genome-wide sequencing of 200 urinary extracellular vesicle (uEV) mRNA samples from clinical studies, we identified potential candidate biomarkers and mechanisms for studying diabetic kidney disease (DKD) in Type 1 diabetes (T1D), which were validated in both Type 1 and 2 diabetes. The sequencing results revealed over 10,000 mRNAs with similarity to the kidney transcriptome. Thirteen upregulated genes predominantly expressed in proximal tubules, correlated with hyperglycemia and involved in cellular/oxidative stress homeostasis were found in T1D DKD groups. We constructed a transcriptional stress score based on six of these genes (GPX3, NOX4, MSRB, MSRA, HRSP12, and CRYAB), which reflected long-term decline of kidney function and could identify individuals with early decline even in normoalbuminuric patients.
Article
Endocrinology & Metabolism
Yuxia Wei, Katharina Herzog, Emma Ahlqvist, Tomas Andersson, Thomas Nystrom, Yiqiang Zhan, Tiinamaija Tuomi, Sofia Carlsson
Summary: Despite having fewer metabolic risk factors than type 2 diabetes, latent autoimmune diabetes in adults (LADA) has equal to higher risks of death, cardiovascular diseases (CVDs), and retinopathy. Poorer glycemic control, particularly in LADAhigh, highlights the need for improved LADA management.
Article
Genetics & Heredity
Karina Barreiro, Om Prakash Dwivedi, Antti Rannikko, Harry Holthoefer, Tiinamaija Tuomi, Per-Henrik Groop, Maija Puhka
Summary: Urinary extracellular vesicles (uEV) contain non-invasive RNA biomarkers for genitourinary tract diseases. This study aimed to assess the effects of preanalytical variables on uEV isolates and discover stable reference mRNAs. The researchers analyzed various sequencing datasets and found that urine storage temperature and isolation workflow affected kidney-RNAs, while ultracentrifugation captured DKD-linked miRNAs. They also identified 11 stable mRNAs across the datasets. These findings highlight the importance of considering preanalytical choices in uEV biomarker studies.
Article
Psychology, Developmental
Anna Lahdepuro, Marius Lahti-Pulkkinen, Polina Girchenko, Pia M. Villa, Kati Heinonen, Jari Lahti, Riikka Pyhala, Hannele Laivuori, Eero Kajantie, Katri Raikkonen
Summary: Positive maternal mental health during pregnancy has a positive impact on children's psychiatric problems. This study found that higher positive maternal mental health scores during pregnancy were associated with lower total psychiatric problem scores in both early and late childhood.
DEVELOPMENT AND PSYCHOPATHOLOGY
(2023)
Article
Medicine, Research & Experimental
Jaakko Leinonen, Nina Mars, Leevi Lehtonen, Ari Ahola-Olli, Sanni Ruotsalainen, Terho Lehtimaki, Mika Kahonen, Olli Raitakari, Terhi Piltonen, Mark Daly, Tiinamaija Tuomi, Samuli Ripatti, Matti Pirinen, Taru Tukiainen
Summary: This study examines the relationship between testosterone levels and human health. The analysis of genetic and health registry data reveals that while testosterone levels are associated with various health characteristics, the causality of these associations is debated. The study shows that testosterone levels are intricately tied to metabolic health but lack of evidence for causality is found in most associations. However, genetically predicted testosterone levels do affect many sex-specific traits.
COMMUNICATIONS MEDICINE
(2023)
