Article
Oncology
Maria Kyrgiou, Anna-Barbara Moscicki
Summary: The microbiome in the female reproductive tract plays a crucial role in maintaining health and homeostasis. Imbalances in the genital tract microbiome and specific bacteria and cytokines may contribute to the development of HPV infection and cervical intra-epithelial neoplasia, leading to cervical cancer.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Oncology
Mingjun Ma, Jingfen Zhu, Yongbin Yang, Xiaoyun Wang, Yubiao Jin, Jiawen Zhang, Sufang Wu
Summary: Human papillomavirus (HPV) infection is the main cause of female precancerous lesions and cervical cancer. The development and application of HPV prophylactic vaccines have been recognized as a major effective intervention for the control of cervical lesions. This retrospective study investigated the clinical features and risk factors of non-9-valent vaccine covered HPV subtypes in cervical lesions. The findings provide valuable information for optimizing cervical cancer prevention in the post-vaccine era.
Article
Oncology
Smita Joshi, Richard Muwonge, Vinay Kulkarni, Mahesh Mandolkar, Eric Lucas, Sanjay Pujari, Rengaswamy Sankaranarayanan, Partha Basu
Summary: This study provides updated incidence rates of cervical intraepithelial neoplasia (CIN) among women living with HIV (WHIV), and examines disease outcomes and HPV status among women treated for CIN. The study found that women who cleared HPV infection had a significantly increased risk of incident CIN 2 or worse lesions, while those with persistent HPV infection had an even higher risk of such lesions. The study also highlights the importance of long-term surveillance and the possibility of extending screening intervals among HPV negative women.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Medicine, General & Internal
Flavia M. Correa, Arn Migowski, Liz M. De Almeida, Marcelo A. Soares
Summary: This review discusses the current strategies in Brazil for screening, treatment, and prevention (HPV vaccination) against cervical cancer, highlighting the country's large public health system and the disparities in access to healthcare. It also explores the potential integration of newer technologies to eliminate cervical cancer.
FRONTIERS IN MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Barbara Gardella, Marianna Francesca Pasquali, Marco La Verde, Stefano Cianci, Marco Torella, Mattia Dominoni
Summary: This study reviewed the interaction between vaginal microbiota, cervical intraepithelial neoplasia (CIN), and the immune response. While some studies struggle to demonstrate the correlation between vaginal microbiota and HPV-related lesions, there is significant evidence suggesting changes in vaginal microbiota in HPV-positive women. The presence of new bacteria, pathway deregulation, and cytokine overexpression are strongly associated with the progression of cervical dysplasia and chronic inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Qiaoli Zheng, Xianzhen Chen, Rui Han, Jiang Zhu, Hui Wang, Lingjing Chen, Yinjing Song, Luxia Chen, Hao Cheng, Na Jin
Summary: The HPV58 E7 protein is highly expressed in both cervical cancer and CIN tissues. Combined with p16 and Ki-67 immunohistochemistry, the HPV58 E7 IHC may be sensitive and specific for evaluating HPV-driven cervical cancer and pre-cancerous lesions.
Article
Medicine, General & Internal
Sarah J. Bowden, Triada Doulgeraki, Emmanouil Bouras, Georgios Markozannes, Antonios Athanasiou, Harriet Grout-Smith, Konstantinos S. Kechagias, Laura Burney Ellis, Verena Zuber, Marc Chadeau-Hyam, James M. Flanagan, Konstantinos K. Tsilidis, Ilkka Kalliala, Maria Kyrgiou
Summary: Persistent HPV infection is necessary but not sufficient for cervical cancer. Behavioral, environmental, or comorbid exposures may affect the development of cervical cancer. However, the validity of the observational studies describing these associations is still unclear.
Article
Oncology
Giorgio Bogani, Francesco Sopracordevole, Violante Di Donato, Andrea Ciavattini, Alessandro Ghelardi, Salvatore Lopez, Tommaso Simoncini, Francesco Plotti, Jvan Casarin, Maurizio Serati, Ciro Pinelli, Gaetano Valenti, Alice Bergamini, Barbara Gardella, Andrea Dell'acqua, Ermelinda Monti, Paolo Vercellini, Margherita Fischetti, Giovanni D'ippolito, Lorenzo Aguzzoli, Vincenzo D. Mandato, Paola Carunchio, Gabriele Carlinfante, Luca Giannella, Cono Scaffa, Francesca Falcone, Chiara Borghi, Antonino Ditto, Mario Malzoni, Andrea Giannini, Maria Giovanna Salerno, Viola Liberale, Biagio Contino, Cristina Donfrancesco, Michele Desiato, Anna Myriam Perrone, Giulia Dondi, Pierandrea De Iaco, Valentina Chiappa, Simone Ferrero, Giuseppe Sarpietro, Maria G. Matarazzo, Antonio Cianci, Sara Bosio, Simona Ruisi, Rocco Guerrisi, Claudia Brusadelli, Lavinia Mosca, Antonio Simone Lagana, Raffaele Tinelli, Mauro Signorelli, Rosa De Vincenzo, Gian Franco Zannoni, Gabriella Ferrandina, Sara Lovati, Marco Petrillo, Salvatore Dessole, Annunziata Carlea, Fulvio Zullo, Roberto Angioli, Stefano Greggi, Arsenio Spinillo, Fabio Ghezzi, Nicola Colacurci, Ludovico Muzii, Pierluigi Benedetti Panici, Giovanni Scambia, Francesco Raspagliesi
Summary: This study evaluated the outcomes of high-risk (HR) HPV-positive and -negative women with high-grade cervical dysplasia. It found that HR-HPV-positive patients had a higher risk of recurrence at 5 years compared to HR-HPV-negative patients. Further prospective studies are needed to corroborate these findings.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Obstetrics & Gynecology
M. Kyrgiou, S. J. Bowden, A. Athanasiou, M. Paraskevaidi, K. Kechagias, A. Zikopoulos, V Terzidou, P. Martin-Hirsch, M. Arbyn, P. Bennett, E. Paraskevaidis
Summary: Treating CIN may increase the risk of preterm birth, caution is needed when making treatment decisions. Treatment should be conducted effectively to optimize disease clearance and minimize recurrence risk.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2021)
Review
Immunology
Asami Yagi, Yutaka Ueda, Mamoru Kakuda, Satoshi Nakagawa, Kosuke Hiramatsu, Ai Miyoshi, Eiji Kobayashi, Toshihiro Kimura, Megumi Kurosawa, Manako Yamaguchi, Sosuke Adachi, Risa Kudo, Masayuki Sekine, Yukio Suzuki, Akiko Sukegawa, Sayaka Ikeda, Etsuko Miyagi, Takayuki Enomoto, Tadashi Kimura
Summary: Despite the widely accepted national immunization program for HPV vaccination in Japan, the suspension of government recommendation due to adverse events led to a drastic drop in vaccination rates. Even with the introduction of a new vaccine, Japanese mothers remain hesitant, and it is crucial for educational and medical institutions to work harder in informing parents and children about the benefits of HPV vaccines.
Article
Engineering, Biomedical
Liming Zhang, Kun Wang, Yuheng Huang, Hui Zhang, Long Zhou, Ang Li, Yunyan Sun
Summary: A novel HPV nanovaccine combining nanotechnology and photodynamic therapy was constructed, which could effectively inhibit the progression of cervical cancer and was experimentally demonstrated in a mouse model.
Editorial Material
Medicine, General & Internal
Eileen E. Reynolds, Amy Weinstein, Huma Farid, Howard Libman
Summary: Successful cervical cytology screening programs and human papillomavirus immunization have reduced the incidence of cervical cancer. Guidelines from the American Cancer Society and the U.S. Preventive Services Task Force differ on the recommended age and methods for cervical cancer screening.
ANNALS OF INTERNAL MEDICINE
(2022)
Article
Oncology
Jacqueline M. Mix, Mona Saraiya, Trevor D. Thompson, Troy D. Querec, April Greek, Thomas C. Tucker, Edward S. Peters, Charles F. Lynch, Brenda Y. Hernandez, Glenn Copeland, Marc T. Goodman, Elizabeth R. Unger
Summary: The study compared HPV prevalence among high-grade cervical precancers and invasive cervical cancers before and after HPV vaccine availability. No significant reduction in vaccine-type prevalence was observed between the two studies, likely due to low HPV vaccination coverage among women in the postvaccine study. Monitoring HPV-type prevalence through population-based strategies remains important for evaluating the impact of the HPV vaccine.
Article
Public, Environmental & Occupational Health
Jiao Pei, Ting Shu, Chenyao Wu, Mandi Li, Minghan Xu, Min Jiang, Cairong Zhu
Summary: This study evaluated the early effect of the HPV vaccine on cervical cancer and found that the incidence of cervical cancer increased in age groups not receiving the vaccine while remained stable in vaccinated age groups.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Obstetrics & Gynecology
Agustina Guacimara Gomez de la Rosa, Alfonso Quesada Lopez-Fe, Monica Vilar Chesa, Alejandro Ferrer Machin, Antonio Gimeno Gil, Armando Molina Bethancourt, Miguel Angel Garcia Bello, Lina Inmaculada Perez-Mendez
Summary: The study demonstrated the efficacy of HPV vaccination in reducing recurrence risk after conization for high-grade cervical neoplasia. It recommended closer and longer follow-up for nonvaccinated women and provided a 4-year prognosis for patients undergoing conization for high-grade cervical lesions.
JOURNAL OF LOWER GENITAL TRACT DISEASE
(2021)
Article
Immunology
Irene Man, Simopekka Vanska, Matti Lehtinen, Johannes A. Bogaards
Summary: The study indicates that type replacement after HPV vaccination is influenced by the balance between cross-immunity and cross-protection, with the latter being crucial to prevent type replacement. Monitoring of nonvaccine-type prevalence is essential for gauging the population-level impacts of HPV vaccination.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Simopekka Vanska, Tapio Luostarinen, Camilla Lagheden, Carina Eklund, Sara Nordqvist Kleppe, Bengt Andrae, Par Sparen, Karin Sundstrom, Matti Lehtinen, Joakim Dillner
Summary: The study analyzed HPV genotyping data from Sweden between 2002 and 2011 to estimate age-specific cervical cancer incidence by HPV type and the impact of removing different types of HPV. The results showed that after eliminating vaccine-protected HPV types, very few cases of cervical cancer will be left, especially among fertile, reproductive-age women.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Immunology
Hanna Kann, Matti Lehtinen, Tiina Eriksson, Helja-Marja Surcel, Joakim Dillner, Helena Faust
Summary: The study demonstrates that cross-reactive antibodies can still be detected 12 years after HPV vaccination. Women with high levels of anti-HPV16 antibodies and recipients of the bivalent vaccine show higher rates of cross-reactive seropositivity.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Joseph E. Tota, Frank Struyf, Allan Hildesheim, Paula Gonzalez, Martin Ryser, Rolando Herrero, John Schussler, Naveen Karkada, Ana Cecilia Rodriguez, Nicolas Folschweiller, Carolina Porras, Mark Schiffman, John T. Schiller, Wim Quint, Aimee R. Kreimer, Matti Lehtinen, Cosette M. Wheeler, Joshua N. Sampson
Summary: Clinical trial data and real-world evidence suggest that the AS04-adjuvanted vaccine targeting human papillomavirus types 16 and 18 provides nearly 90% protection against cervical intraepithelial neoplasia grade 3 or higher among women vaccinated before sexual debut. This high efficacy is not fully explained by cross-protection, and although the vaccine does not affect clearance of prevalent infections, it may accelerate clearance of newly acquired infections. However, pooled data from 2 large-scale randomized controlled trials did not show a significant effect in expediting clearance of incident infections.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Claudia Robles, Laia Bruni, Amelia Acera, Joan Carles Riera, Laia Prats, Mario Poljak, Jana Mlakar, Anja Ostrbenk Valencak, Tiina Eriksson, Matti Lehtinen, Karolina Louvanto, Maria Hortlund, Joakim Dillner, Mette T. Faber, Christian Munk, Susanne K. Kjaer, Karl Ulrich Petry, Agnieszka Denecke, Lan Xu, Marc Arbyn, Louise Cadman, Jack Cuzick, Veronique Dalstein, Christine Clavel, Silvia de Sanjose, F. Xavier Bosch
Summary: The study found that acceptance and completion of the human papillomavirus vaccination program in adult women largely depended on recruitment method, national vaccination program coverage, and personal relationship status. Knowledge of the benefits and safety of the vaccine may be crucial in expanding the target age for vaccination.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2021)
Article
Obstetrics & Gynecology
Maria Pekkola, Minna Tikkanen, Mika Gissler, Mikko Loukovaara, Jorma Paavonen, Vedran Stefanovic
Summary: This study found that women with stillbirth were more likely to undergo labor induction and less likely to have cesarean sections compared to women with live birth. They also had shorter duration of labor but higher risk for postpartum interventions and bleeding complications.
JOURNAL OF PERINATAL MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Tuomas Lehtinen, K. Miriam Elfstrom, Antti Makitie, Mari Nygard, Simopekka Vanska, Michael Pawlita, Joakim Dillner, Tim Waterboer, Matti Lehtinen
Summary: The incidence of HPV-associated OPSCC has tripled among middle-aged males in four high income Nordic countries over the past 30 years. Implementing school-based prophylactic HPV vaccination for early adolescent boys and girls is expected to decrease the incidence and eventually eliminate these types of cancers. However, there are still approximately 50 birth cohorts born in 1995 or earlier that would benefit from screening for HPV-associated OPSCC.
PREVENTIVE MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Ilkka Kalliala, Tiina Eriksson, Karoliina Aro, Mari Hokkanen, Matti Lehtinen, Mika Gissler, Pekka Nieminen
Summary: The study found that the rates of preterm birth, especially early preterm birth, were lower among women who received HPV vaccination, indicating that prophylactic HPV vaccination may help reduce preterm birth rates.
PREVENTIVE MEDICINE
(2021)
Review
Medicine, General & Internal
Gilbert Donders, Peter Greenhouse, Francesca Donders, Ulrike Engel, Jorma Paavonen, Werner Mendling
Summary: There has been a rising incidence of invasive group A streptococcal (GAS) disease in postpartum women in the past 30 years, with severe infections like toxic shock syndrome and necrotizing fasciitis posing life-threatening risks. Despite treatment efforts, mortality rates remain high, accounting for a significant number of postpartum deaths globally. Pregnant and postpartum women have a significantly increased risk of GAS disease, yet many cases go undiagnosed, leading to preventable deaths.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Jorma Paavonen, Renee Turzanski Fortner, Matti Lehtinen, Annika Idahl
Summary: The link between Chlamydia trachomatis, pelvic inflammatory disease (PID), and epithelial ovarian cancer (EOC) may be relatively weak, but biologically plausible, requiring further investigation in future studies.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Immunology
Jorma Paavonen, David A. Eschenbach
Summary: The article discusses the pathogenesis, clinical characteristics, educational significance, and the importance of future research and clinical trials on localized provoked vulvodynia (LPV) causing dyspareunia among reproductive aged women.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Infectious Diseases
Filipe Colaro Mariz, Penelope Gray, Noemi Render, Tiina Eriksson, Hanna Kann, Dan Apter, Jorma Paavonen, Emma Pajunen, Kristina M. Prager, Peter Sehr, Helja-Marja Surcel, Tim Waterboer, Martin Mueller, Michael Pawlita, Matti Lehtinen
Summary: This study tracked the data from two international HPV vaccine trials in Finland, and found that HPV vaccine-induced antibodies can last up to 12 years after vaccination. Significant differences were observed in the neutralising antibody efficacy and cross-neutralising antibody efficacy between quadrivalent and bivalent vaccine recipients, which correlated with vaccine efficacy.
LANCET INFECTIOUS DISEASES
(2021)
Article
Obstetrics & Gynecology
Maria Pekkola, Minna Tikkanen, Mikko Loukovaara, Jorma Paavonen, Vedran Stefanovic
Summary: This study aimed to assess parents' satisfaction with the care and support they received during a stillbirth. A questionnaire survey was conducted at Helsinki University Hospital, and the results showed that parents generally felt well supported during delivery and were satisfied with the time holding their newborn. However, there was room for improvement in social worker counseling and support after discharge. Further training of healthcare professionals and other professionals involved in stillbirth aftercare is needed.
JOURNAL OF PERINATAL MEDICINE
(2022)
Review
Immunology
Gilbert Donders, Istvan Oszkar Sziller, Jorma Paavonen, Phillip Hay, Francesco de Seta, Jean Marc Bohbot, Jan Kotarski, Jordi Antoni Vives, Bela Szabo, Ramona Cepuliene, Werner Mendling
Summary: Recurrent vulvovaginal candidosis (RVVC) is a chronic and difficult to treat vaginal infection caused by Candida species. Fluconazole resistance and the rising prevalence of non-albicans Candida species pose challenges in treatment. Innovative strategies and research into new drugs and the impact of RVVC on patients' quality of life and sex life are needed.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Oncology
Tiina Holster, Elina Urpilainen, Jorma Paavonen, Ulla Puistola, Mirja Puolakkainen
Summary: This study explored the role of C. trachomatis infection in epithelial ovarian cancer (EOC) by analyzing antibody responses to chlamydial TroA, HtrA, and MOMP. The results showed that women with these antibodies were more likely to have a complete response to the first-line treatment.
ANTICANCER RESEARCH
(2023)
