Review
Clinical Neurology
Sweety Trivedi, Ambar Chakravarty
Summary: This review discusses the neurological complications of dengue virus infection and their underlying mechanisms. It covers the recognition of different serotypes of dengue virus and their epidemiology, as well as the expanded dengue syndrome involving the central nervous system. The neurotropic virus can directly invade the CNS and cause neural injury, as well as trigger immune-mediated neurological sequelae. Various neurological syndromes can result from CNS or peripheral nervous system involvement. It is important to recognize and promptly treat these neurological manifestations, as some can be fatal.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2022)
Review
Emergency Medicine
Xiaoxia Liu, Kun Han, Xiaoxiong Lu
Summary: Unilateral paralysis is a concerning symptom that can be caused by various conditions such as stroke, Todd's paralysis, myelopathy, and peripheral neuropathy. Hypokalemic paralysis (HP) is a neuromuscular disorder characterized by muscle weakness due to hypokalemia. Unilateral paralysis in HP is rare, and delayed diagnosis and treatment can be life-threatening.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Review
Medicine, General & Internal
Jitendra Singh, Anju Dinkar, Nilesh Kumar, Kailash Kumar
Summary: Hypothyroidism can have unusual presentations, such as recurrent hypokalemic paralysis, which is a rare initial symptom. We report the case details and clinical outcomes of two individuals with this presentation. Immediate potassium correction and thyroxine supplementation were effective in their recovery.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2023)
Article
Clinical Neurology
Alberto Vogrig, Sergio Muniz-Castrillo, Antonio Farina, Jerome Honnorat, Bastien Joubert
Summary: Neurological immune-related adverse events (n-irAEs) are rare but severe complications, with a mortality and morbidity burden for the small percentage of patients who develop severe forms. The diagnosis of n-irAEs is challenging and requires a tailored approach based on the presentation, clinical history, and known specificities. Various patterns of n-irAEs are emerging with distinct clinical, immunological, and prognostic characteristics.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Valeria A. Sansone, Nicholas E. Johnson, Michael G. Hanna, Emma Ciafaloni, Jeffrey M. Statland, Perry B. Shieh, Fredric Cohen, Robert C. Griggs
Summary: Long-term use of dichlorphenamide showed good efficacy and safety in patients with primary periodic paralysis. Common adverse events included paresthesia and cognition-related events, which were manageable in most patients.
Article
Clinical Neurology
Zhi Zhang, Banghui Xiao
Summary: Hypokalemic periodic paralysis (HPP) is a group of diseases characterized by intermittent paralysis of skeletal muscle and hypokalemia. It can be caused by gene variants or secondary to other conditions such as thyrotoxicosis. We present a rare case of HPP combined with hyperthyroidism caused by a SCNA4A gene variant, emphasizing the importance of awareness and accurate diagnosis.
FRONTIERS IN NEUROLOGY
(2023)
Article
Infectious Diseases
Hannah K. Hopkins, Elizabeth M. Traverse, Kelli L. Barr
Summary: Dengue virus (DENV) infection can lead to parkinsonism, characterized by symptoms such as tremor, bradykinesia, instability, and rigidity. Research has found that clinically diagnosed DENV parkinsonism patients are more likely to be male and exhibit expressionless face, speech issues, and lymphocytosis. Suspected cases are more likely to be diagnosed with encephalitis and exhibit tremors, thrombocytopenia, and low hemoglobin.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Medicine, General & Internal
Abu Baker Khan, Muhammad Asfandiyar Ali, Saeed Ur Rehman, Umar Siddiqe, Saad Ahmad
Summary: Dengue fever is a globally prevalent, mosquito-borne viral disease that can cause various symptoms, including fever, flu-like symptoms, and circulatory failure. Although classified as a non-neurotropic virus, dengue fever can also impact the nervous system and lead to conditions such as myositis, Guillain-Barre syndrome, or hypokalemic paralysis. A case study of a young pregnant female with dengue-associated hypokalemic paralysis demonstrated the importance of promptly recognizing and treating neurological complications of dengue fever, especially in areas where the disease is prevalent.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Neurosciences
Thomas O. Krag, Sonja Holm-Yildiz, Nanna Witting, John Vissing
Summary: Hypokalemic periodic paralysis is a rare disorder caused by gene variants, associated with vacuolar myopathy. Patients may experience periodic paralysis and permanent weakness, with disrupted autophagic processing contributing to vacuole formation.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Clinical Neurology
Atul Pandey, Rajesh Verma, Amita Jain, Shantanu Prakash, Ravindra Kumar Garg, Hardeep Singh Malhotra, Praveen Kumar Sharma, Neeraj Kumar, Ravi Uniyal, Sweta Pandey, Imran Rizvi
Summary: The study found that neurological manifestations of dengue virus infection are associated with DENV-1 and DENV-2, rather than the previously reported DENV-2 and DENV-3. DENV-2 is more commonly associated with hypokalemic paralysis in neurological complications. However, there is no significant association between serotypes and outcomes or mortality rates.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Evgenii P. Nuzhnyi, Alina S. Arestova, Alexey V. Rossokhin, Anna O. Protopopova, Nataliya Yu Abramycheva, Natalia A. Suponeva, Sergey N. Illarioshkin
Summary: This study reports a case of HypoKPP associated with a previously unreported mutation in the CACNA1S gene. Molecular modeling suggests that the mutation may affect the activation process of calcium channels.
FRONTIERS IN NEUROLOGY
(2023)
Review
Urology & Nephrology
Haw-Ting Tai, Po-Tsang Lee, Shih-Hsiang Ou
Summary: This case study discusses a patient with hypokalemic periodic paralysis (HPP) who experienced acute muscle weakness and hypokalemia following a dexamethasone injection, highlighting the potential role of steroids as a precipitating factor in HPP.
Article
Multidisciplinary Sciences
Jeth WeiQuan Chng, Tamilsalvan Parvathi, Junxiong Pang
Summary: This study compared the knowledge, attitudes, and practices scores between dengue sustained hotspots (SHS) and non-sustained hotspots (NSHS), and identified factors associated with dengue prevention among SHS residents in Singapore. The findings showed that there were no significant differences in the mean scores for knowledge, attitudes, and practices between SHS and NSHS. However, certain factors such as age, ethnicity, education level, housing type, and healthcare-seeking behavior were associated with SHS and may influence the risk of dengue transmission in residential areas.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Mohsin Nazir, Malika Hameed, Rizwana Shehzad
Summary: Thyrotoxic hypokalemic periodic paralysis is a rare but life-threatening complication of hyperthyroidism, typically seen in males but can also occur in females without a prior history of thyroid disease. Diagnosis requires recognition of the diverse etiologies, and treatment involves nonselective beta-blockade and potassium replacement, with cure achievable once euthyroidism is achieved.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Immunology
Yun Liu, Hanwen Tong, Fei He, Yu Zhai, Chao Wu, Jun Wang, Chenxiao Jiang
Summary: A single-center retrospective study found that a prolonged high-dose IVIG treatment is beneficial for the 28-day prognosis in SFTS patients with neurological complications. The study analyzed survival curves and conducted multivariate Cox regression analysis to show a significant association between IVIG dosage and duration and the risk of death.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Clinical Neurology
Ravindra Kumar Garg, Vimal Kumar Paliwal, Ankit Gupta
Summary: This review examines the clinical, neuroimaging, treatment, and prognostic aspects of spinal cord disorders associated with the SARS-CoV-2 virus. Various manifestations of COVID-19-related spinal cord disorders have been reported, but treatment outcomes have generally been unsatisfactory, requiring long-term rehabilitation.
JOURNAL OF SPINAL CORD MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Kaushal Kishor Agrawal, Pooran Chand, Saumyendra Vikram Singh, Neetu Singh, Prashant Gupta, Ravindra Kumar Garg, Akhilanand Chaurasia, Mohd Anwar, Anil Kumar
Summary: This study investigated the association between single-nucleotide polymorphisms and early crestal bone loss around dental implants. The results showed that individuals with interleukin-1B-511 AA and interleukin-6-572 GG genotypes were more susceptible to early bone loss. This has significant implications for bone development and health around dental implants.
JOURNAL OF PROSTHETIC DENTISTRY
(2023)
Article
Clinical Neurology
Manish Ramesh Patil, Imran Rizvi, Ravindra Kumar Garg, Hardeep Singh Malhotra, Neeraj Kumar, Ravi Uniyal, Shweta Pandey, Rajesh Verma, Praveen Kumar Sharma
Summary: Approximately 15.3% of patients with tuberculous meningitis needed re-hospitalization, with paradoxical neurological deterioration being the main reason. Re-hospitalization had an adverse impact on prognosis.
ACTA NEUROLOGICA BELGICA
(2023)
Article
Dermatology
Himanshu Dandu, Manish Kumar, Hardeep Singh Malhotra, Naveen Kumar, Neeraj Kumar, Prashant Gupta, Bipin Puri, Geeta Yadav
Summary: This study investigated the characteristics of T-cells in mucormycosis patients and found that T-cell immune dysfunction is more severe in non-COVID patients, indicating a continuous activation followed by extreme exhaustion state.
Article
Public, Environmental & Occupational Health
Kinzang Wangda, Neeraj Kumar, Ravindra Kumar Garg, Hardeep Singh Malhotra, Imran Rizvi, Ravi Uniyal, Shweta Pandey, Kiran Preet Malhotra, Rajesh Verma, Praveen Kumar Sharma, Anit Parihar, Amita Jain
Summary: Disseminated neurocysticercosis was found in patients with multiple neurocysticercosis brain lesions. Treatment with albendazole resulted in a significant reduction in neurocysticercosis lesions throughout the body.
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
(2023)
Letter
Clinical Neurology
Rohit Anand, Shweta Pandey, Ravindra Kumar Garg, Hardeep Singh Malhotra, Shrikant Shrivastava, Sujita Kumar Kar, Sumit Rungta, Rajesh Verma, Praveen Kumar Sharma, Neeraj Kumar, Ravi Uniyal, Imran Rizvi
Summary: This study aimed to investigate the phenomenology, predictors of reversibility, and impact on the quality of life of drug-induced movement disorders (DIMDs). The results showed that drug-induced Parkinsonism (DIP) was the most common and often reversible DIMD, while levosulpiride was notorious for causing DIMD in the elderly.
Article
Virology
Vijayaragavan Vijayavarman, Hardeep S. S. Malhotra, Imran Rizvi, Neeraj Kumar, Shweta Pandey, Mili Jain, Wahid Ali, Vinay Suresh, Ravindra K. K. Garg, Amita Jain, Rajesh Verma, Praveen Sharma, Ravi Uniyal
Summary: Subacute sclerosing panencephalitis (SSPE) is a chronic progressive neurological condition caused by a defective measles virus. This study aimed to analyze the pattern of immune dysregulation in SSPE patients and assess the correlation between measured immunological variables and disability/death at 6 months.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Clinical Neurology
Ravindra Kumar Garg, Vimal Paliwal, Imran Rizvi, Shweta Pandey, Ravi Uniyal, Smriti Agrawal, Richa Khanna
Summary: This systematic review focuses on the maternal and foetal outcomes among pregnant women with subacute sclerosing panencephalitis (SSPE). The study found that SSPE in pregnancy usually has devastating consequences, but the majority of foetuses can survive. SSPE is often missed as it mimics eclampsia. Universal early childhood measles vaccination is the only way to fight this menace.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Ravi Uniyal, Shweta Pandey, Neeraj Kumar, Ravindra Kumar Garg, Hardeep Singh Malhotra, Imran Rizvi, Adarsh Tripathi
Summary: There is a bidirectional and complex interplay between psychiatric comorbidities and migraine. This study aimed to investigate the impact of psychogenic non-epileptic seizures (PNES) on migraine. The results showed that patients with migraine and PNES had higher headache frequency and mental stress was the most common trigger for headaches.
JOURNAL OF NEUROSCIENCES IN RURAL PRACTICE
(2023)
Article
Cell Biology
Sanjeev Kumar Yadav, Abhishek Jauhari, Nishant Singh, Anuj Pandey, Sana Sarkar, Shweta Pandey, Ravindra K. Garg, Devendra Parmar, Sanjay Yadav
Summary: Parkinson's disease is a neurodegenerative disorder caused by the destruction of dopaminergic neurons. Currently, diagnosis is based on clinical signs and symptoms, but these become visible only after a significant degeneration of neurons. Therefore, understanding the cellular and molecular degeneration process and identifying new biomarkers are crucial for effective management of the disease.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Clinical Neurology
Ravi Uniyal, Ravindra Kumar Garg, Hardeep Singh Malhotra, Neeraj Kumar, Shweta Pandey, Imran Rizvi, Amita Jain, Nidhi Tejan, Rupesh Singh Kirar
Summary: We present a case of a 37-year-old man with visual loss and visual hallucinations. He also had seizures. Examination showed no perception of light rays and disc oedema with peripapillary small haemorrhages. MRI revealed abnormalities in white and gray matter, and CSF examination showed the presence of anti-measles IgG antibodies. This case highlights the importance of considering SSPE in the differential diagnosis of acute vision loss in measles-endemic regions.
NEURO-OPHTHALMOLOGY
(2023)
Review
Clinical Neurology
Ravindra Kumar Garg, Vimal Paliwal, Shweta Pandey, Ravi Uniyal, Kaushal Kishore Agrawal
Summary: In this systematic review, the etiological spectrum of multiple ring-enhancing lesions of the brain was evaluated. It was found that immunocompromised patients were more likely to be caused by Toxoplasma gondii infections and CNS lymphoma, while immunocompetent patients were more commonly associated with Mycobacterium tuberculosis infection and immune-related demyelinating disorders.
NEUROLOGICAL SCIENCES
(2023)
Review
Public, Environmental & Occupational Health
Ravindra Kumar Garg, Ravi Uniyal, Shweta Pandey, Nidhi Tejan, Imran Rizvi, Praveen Kumar Sharma, Neeraj Kumar, Hardeep Singh Malhotra
Summary: This systematic review provides evidence of CNS involvement in leprosy, based on autopsy findings, neuroimaging, CSF analysis and neurophysiological studies.
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
(2023)
Meeting Abstract
Hematology
Geeta Yadav, Himanshu Dandu, Hardeep Singh Malhotra, Shailendra Prasad Verma, Wahid Ali
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2023)