Identification and In Silico Analysis of Novel von Hippel-Lindau (VHL) Gene Variants from a Large Population

Performance of protein stability predictors

(2010) Sofia Khan et al.   HUMAN MUTATION

Adding structural information to the von Hippel-Lindau (VHL) tumor suppressor interaction network

(2009) E. Leonardi et al.   FEBS LETTERS

Alu-Alurecombination underlies the vast majority of largeVHLgermline deletions: Molecular characterization and genotype-phenotype correlations in VHL patients

(2009) Gerlind Franke et al.   HUMAN MUTATION

Pathogenic or not? And if so, then how? Studying the effects of missense mutations using bioinformatics methods

(2009) Janita Thusberg et al.   HUMAN MUTATION

VHLMutations Linked to Type 2C von Hippel-Lindau Disease Cause Extensive Structural Perturbations in pVHL

(2009) Katja Knauth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Beyond the Knudson’s hypothesis in von Hippel–Lindau (VHL) disease—proposing vitronectin as a “gene modifier”

(2009) Francesco Turturro   JOURNAL OF MOLECULAR MEDICINE-JMM

VHL Type 2B gene mutation moderates HIF dosage in vitro and in vivo

(2009) C M Lee et al.   ONCOGENE

The von Hippel-Lindau protein sensitizes renal carcinoma cells to apoptotic stimuli through stabilization of BIMEL

(2009) Y Guo et al.   ONCOGENE

Structural bioinformatics mutation analysis reveals genotype-phenotype correlations in von Hippel-Lindau disease and suggests molecular mechanisms of tumorigenesis

(2009) Julia R. Forman et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

The Mechanism of Ubiquitination in the Cullin-RING E3 Ligase Machinery: Conformational Control of Substrate Orientation

(2009) Jin Liu et al.   PLoS Computational Biology

Accurate prediction of stability changes in protein mutants by combining machine learning with structure based computational mutagenesis

(2008) M. Masso et al.   BIOINFORMATICS

A three-state prediction of single point mutations on protein stability changes

(2008) Emidio Capriotti et al.   BMC BIOINFORMATICS

Allosteric effects in the marginally stable von Hippel-Lindau tumor suppressor protein and allostery-based rescue mutant design

(2008) J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pre-mRNA splicing aberrations and cancer

(2007) Christopher et al.   Frontiers in Bioscience-Landmark