Article
Nutrition & Dietetics
Jule Filler, Ricarda von Kruechten, Nina Wawro, Lisa Maier, Roberto Lorbeer, Johanna Nattenmueller, Barbara Thorand, Fabian Bamberg, Annette Peters, Christopher L. Schlett, Jakob Linseisen, Susanne Rospleszcz
Summary: Iron-related disorders of the liver can result in serious health conditions, such as liver cirrhosis. This study aimed to assess the association between habitual diet and liver iron content (LIC) in 303 participants. The results showed that there are sex-specific associations of dietary intake with LIC, with alcohol, fiber, and potassium playing a considerable role in liver iron metabolism.
Article
Nutrition & Dietetics
Limin Wu, Haibo Si, Yi Zeng, Yuangang Wu, Mingyang Li, Yuan Liu, Bin Shen
Summary: Iron intake is associated with the progression of knee osteoarthritis in a U-shaped manner, with optimal intake range of 10.9-23.3 mg/day. Both excessive and deficient iron intake increase the risk of knee osteoarthritis progression.
Article
Endocrinology & Metabolism
Ruiyue Qiu, Kristina Alikhanyan, Nadine Volk, Oriana Marques, Christina Mertens, Anand Ruban Agarvas, Sanjana Singh, Rainer Pepperkok, Sandro Altamura, Martina U. Muckenthaler
Summary: The study focuses on the relationship between iron metabolism and type 2 diabetes mellitus (T2DM). It demonstrates that iron accumulation in hepatocytes, observed in a subset of T2DM patients, is associated with the repression of the iron exporter ferroportin. Insulin resistance and treatment with palmitate and/or insulin can influence the transcription and post-transcriptional regulation of ferroportin.
MOLECULAR METABOLISM
(2022)
Article
Nutrition & Dietetics
Efrem Davila Ferreira, Mariko Hatta, Yasunaga Takeda, Chika Horikawa, Mizuki Takeuchi, Noriko Kato, Hiroki Yokoyama, Yoshio Kurihara, Koichi Iwasaki, Kazuya Fujihara, Hiroshi Maegawa, Hirohito Sone
Summary: This study aimed to investigate the relationship between dietary iron intake and obesity, assessed by BMI, after controlling for nutrient intake and food groups. The results showed that higher iron intake was positively associated with obesity in individuals aged 30 to 54 years. Furthermore, multivariate analysis using food groups as opposed to nutrients revealed a positive trend for obesity in the younger age group after adjustment for lifestyle factors, energy intake, and bean and vegetable intake. However, in all participants, an inverse association was observed between iron intake and obesity after adjusting for vegetable intake.
Article
Immunology
Sulafa Elhassan, Fran Dong, Teresa Buckner, Randi K. Johnson, Jennifer A. Seifert, Patrick M. Carry, Lauren Vanderlinden, Kathleen Waugh, Marian Rewers, Jill M. Norris
Summary: Studies have shown that iron intake may be associated with the risk of developing type 1 diabetes. This study found that individuals with high iron intake had a lower risk of developing type 1 diabetes compared to those with moderate iron intake.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Neurosciences
Tingli Guo, Ye Yu, Wenhui Yan, Meng Zhang, Xinyao Yi, Na Liu, Xin Cui, Xiaotong Wei, Yuzhuo Sun, Zhuanzhuan Wang, Jia Shang, Wei Cui, Lina Chen
Summary: Type 2 diabetes mellitus (T2DM) is associated with cognitive dysfunction, but the role of erythropoietin (EPO) in T2DM-associated cognitive dysfunction is unclear. This study found that EPO improved cognitive impairments in diabetic mice by reducing blood glucose and ameliorating hippocampal damage. EPO also decreased iron overload and inhibited ferroptosis.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yemin Zhang, Lu Li, Xinyu Yang, Changhua Wang
Summary: Iron overload is associated with insulin resistance and iron overload cardiomyopathy. The study found that iron overload has an impact on brown adipose tissue (BAT) and contributes to the onset of cardiomyopathy. RNA-Seq analysis and exosome coculture technology were used to reveal this process and provide new therapeutic strategies for the treatment of cardiomyopathy.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Jiedong Ma, Hongqi Zhang, Yufei Chen, Xiaojin Liu, Jiamin Tian, Wei Shen
Summary: This article summarizes the role of iron overload and ferroptosis in macrophages in the development of AS from the perspective of iron metabolism, highlighting their significant contribution to AS progression.
Review
Cell Biology
Xiaomin Wang, Ye Li, Li Han, Jie Li, Cun Liu, Changgang Sun
Summary: Iron overload is a high risk factor for many diseases, while flavonoids have been found to affect iron status and may act as potential complementary therapies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Simon Grootendorst, Jonathan de Wilde, Birgit van Dooijeweert, Annelies van Vuren, Wouter van Solinge, Roger Schutgens, Richard van Wijk, Marije Bartels
Summary: Rare hereditary anemias (RHA) are characterized by impaired red blood cell production or decreased survival, often leading to disturbances in iron metabolism and erythropoiesis, resulting in iron overload or exacerbation of chronic anemia. Iron overload is a significant issue in both transfusion-dependent and non-transfusion-dependent patients with RHA, suggesting common defects in erythroid development linked to intrinsic iron metabolism defects. Key regulators involved in the interaction between iron and erythropoiesis are discussed in the context of RHA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Artur Slomka, Monika Lecka, Jan Styczynski
Summary: This systematic review provides an overview of observational studies on the association between hepcidin and acute leukemia (AL) or hematopoietic cell transplantation (HCT). The review highlights the need for more extensive research as iron metabolism disturbances are common in AL and HCT, and hepcidin seems to play a significant role in their modulation.
Article
Multidisciplinary Sciences
Cornelia Knaak, Friederike S. Schuster, Peter Nyvlt, Patrick Heeren, Claudia Spies, Thomas Schenk, Paul La Rosee, Gritta Janka, Frank M. Brunkhorst, Gunnar Lachmann
Summary: This study found that transfusions, hemodialysis, and ECLS did not impact ferritin increases in critically ill patients. Changes in aspartate aminotransferase and sequential organ failure assessment score were identified as factors influencing ferritin change, with SOFA platelet count being associated with ferritin change in subgroups of SOFA score.
Review
Nutrition & Dietetics
Marcin Delijewski, Aleksandra Barton, Beata Maksym, Natalia Pawlas
Summary: Iron is a crucial transition metal in physiological processes, but it can also be toxic due to its involvement in free radical formation. Impaired iron metabolism leads to iron deficiency, anemia, and iron overload, with different prevalences in transplant patients. Limited knowledge exists on iron metabolism in lung graft recipients and donors, complicated further by the potential impact of drugs. This overview highlights the importance of understanding iron turnover in transplant patients and assessing drug effects on iron metabolism for perioperative treatment in transplantology.
Article
Radiology, Nuclear Medicine & Medical Imaging
Michaela Plaikner, Lukas Lanser, Christian Kremser, Guenter Weiss, Benjamin Henninger
Summary: The study compares the measurement of splenic and pancreatic iron content using a commercial 3D-Dixon sequence (qDixon) and an established fat-saturated R2* relaxometry method (ME-GRE). The results show good concordance between the two methods, with the qDixon sequence proving to be a reliable tool for non-invasive evaluation of iron content in the spleen and pancreas.
EUROPEAN RADIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Mahdi Aalikhani, Ensie Taheri, Masoumeh Khalili
Summary: Vanillin, a natural antioxidant compound, has been found to have better iron chelation efficacy than deferoxamine. It reduces iron content, enhances the activity of antioxidant enzymes, and decreases lipid peroxidation caused by iron overload.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Respiratory System
Carla Colombo, Gianfranco Alicandro, Mark Oliver, Peter J. Lewindon, Grant A. Ramm, Chee Y. Ooi, Federico Alghisi, Nataliya Kashirskaya, Elena Kondratyeva, Fabiola Corti, Rita Padoan, Irina Asherova, Helen Evans, Isabelle de Monestrol, Birgitta Strandvik, Anders Lindblad
Summary: This study evaluated the difference in the incidence of severe liver disease between cystic fibrosis centers that routinely prescribe ursodeoxycholic acid (UDCA) and those that do not. The results showed that CF patients followed-up in UDCA-prescribing centers did not have a lower incidence of portal hypertension (PH) compared to those followed in centers not prescribing UDCA.
JOURNAL OF CYSTIC FIBROSIS
(2022)
Review
Biochemistry & Molecular Biology
Sheridan L. Helman, Jie Zhou, Brie K. Fuqua, Yan Lu, James F. Collins, Huijun Chen, Christopher D. Vulpe, Gregory J. Anderson, David M. Frazer
Summary: The mammalian multicopper ferroxidases (MCFs), including ceruloplasmin, hephaestin, and zyklopen, play crucial roles in maintaining iron homeostasis in the body. They function in oxidizing, releasing, and absorbing iron ions, and have various physiological functions in different tissues. Apart from their iron-related roles, they also have other physiological functions, although many of them are not well-defined.
Article
Cell Biology
Sahar Keshvari, Berit Genz, Ngari Teakle, Melanie Caruso, Michelle F. Cestari, Omkar L. Patkar, Brian W. C. Tse, Kamil A. Sokolowski, Hilmar Ebersbach, Julia Jascur, Kelli P. A. MacDonald, Gregory Miller, Grant A. Ramm, Allison R. Pettit, Andrew D. Clouston, Elizabeth E. Powell, David A. Hume, Katharine M. Irvine
Summary: Resident and recruited macrophages play a crucial role in the development and proliferation of the liver. Previously, the use of a macrophage colony stimulating factor (CSF1)-Fc fusion protein has been shown to promote hepatocyte proliferation and repair in acute hepatic injury in mice. In this study, the impact of CSF1-Fc on the resolution of advanced fibrosis and liver regeneration was investigated using a toxin-induced model of chronic liver injury and fibrosis in mice. The findings suggest that CSF1-dependent macrophages contribute to both the initiation and resolution of fibrotic injury, and that CSF1-Fc has therapeutic potential in the treatment of human liver disease.
DISEASE MODELS & MECHANISMS
(2022)
Article
Respiratory System
Marilisa Baldissera, Peter J. Lewindon, Louise E. Ramm, Gunter F. Hartel, Rita Mattiello, Grant A. Ramm
Summary: This study assessed the impact of liver disease on the survival of children with cystic fibrosis. The results showed that advanced cystic fibrosis-associated liver disease (CFLD) was associated with decreased survival, especially in females with cystic fibrosis.
JOURNAL OF CYSTIC FIBROSIS
(2022)
Article
Respiratory System
Diego A. Calvopina, Peter J. Lewindon, Louise E. Ramm, Charlton Noble, Gunter F. Hartel, Daniel H. Leung, Grant A. Ramm
Summary: This study investigated the use of gamma-glutamyl transpeptidase-to-platelet ratio (GPR) as a non-invasive biomarker for detecting liver disease and fibrosis severity in children with CF-associated liver disease (CFLD). The results showed that GPR is a useful diagnostic tool for detecting the presence of CFLD, assessing fibrosis severity, and predicting complications of liver disease.
JOURNAL OF CYSTIC FIBROSIS
(2022)
Article
Immunology
James C. Barton, J. Clayborn Barton, Luigi F. Bertoli
Summary: This study retrospectively evaluated immunoglobulin levels in women with IgG subclass deficiency (IgGSD) who were treated with hydroxychloroquine (HCQ) for systemic lupus erythematosus (SLE), Sjogren syndrome (SS), or rheumatoid arthritis (RA). The results showed that HCQ therapy was not associated with significantly lower IgG, IgG subclass, IgA, or IgM levels in women with IgGSD. However, women with combined subnormal IgG1/IgG3 who took HCQ had higher levels of IgG2.
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
(2022)
Article
Parasitology
Jack P. Carson, Mark W. Robinson, Grant A. Ramm, Geoffrey N. Gobert
Summary: Sm16 is a protein released by Schistosoma mansoni that modulates inflammatory responses in host cells. This study suggests a potential role for Sm16 in combating fibrotic liver disease.
EXPERIMENTAL PARASITOLOGY
(2022)
Article
Biochemistry & Molecular Biology
James C. Barton, Howard W. Wiener, Ronald T. Acton
Summary: This study estimated the proportion of West African Black ancestry in African Americans using allele frequencies of iron-related genes, showing that the average proportion of West African Black ancestry in African Americans is 87.8%.
GENETIC TESTING AND MOLECULAR BIOMARKERS
(2022)
Article
Medicine, General & Internal
Lauren Andersson, Lawrie W. Powell, Louise E. Ramm, Grant A. Ramm, John K. Olynyk
Summary: This study conducted a retrospective analysis of 112 HFE hemochromatosis patients and found that arthritis is strongly associated with advanced hepatic fibrosis. (This study conducted a retrospective analysis of 112 HFE hemochromatosis patients and found that arthritis is strongly associated with advanced hepatic fibrosis.)
MAYO CLINIC PROCEEDINGS
(2022)
Article
Respiratory System
Carla Colombo, Grant A. Ramm, Anders Lindblad, Fabiola Corti, Luigi Porcaro, Federico Alghisi, Irina Asherova, Helen Evans, Nataliya Kashirskaya, Elena Kondratyeva, Peter J. Lewindon, Isabelle de Monestrol, Mark Oliver, Chee Y. Ooi, Rita Padoan, Sahana Shankar, Gianfranco Alicandro
Summary: Cystic-fibrosis-related liver disease (CFLD) is a variable phenotype of CF. CFTR modulator therapies, elexacaftor, tezacaftor, and ivacaftor (ETI), and ivacaftor (IVA), are available for CF patients. Genetic eligibility evaluation showed that 13% of patients without CFLD and 11% of patients with severe CFLD are not eligible for ETI or IVA therapy. Ineligible patients cannot benefit from these new treatments.
JOURNAL OF CYSTIC FIBROSIS
(2023)
Editorial Material
Gastroenterology & Hepatology
Darrell H. G. Crawford, Grant A. Ramm, Kim R. Bridle, Amanda J. Nicoll, Martin B. Delatycki, John K. Olynyk
HEPATOLOGY INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Shruti Sakhuja, Heather M. Staples, Charles G. Minard, Louise E. Ramm, Peter J. Lewindon, Grant A. Ramm, Daniel H. Leung
Summary: This study aimed to evaluate the clinical utility of lung function and liver biomarkers assessed years prior to liver biopsy-proven CFLD in predicting the risk of severe fibrosis development. The findings suggest that mild-moderate pulmonary dysfunction and higher liver biomarker indices at baseline may be associated with faster progression of CFLD.
LIVER INTERNATIONAL
(2023)
Article
Oncology
N. Dianah B. Abu Bakar, Rodrigo Carlessi, Jully Gogoi-Tiwari, Julia Kohn-Gaone, Vincent Williams, Marco Falasca, John K. Olynyk, Grant A. Ramm, Janina E. E. Tirnitz-Parker
Summary: The TWEAK/Fn14 signalling pathway plays a crucial role in tissue injury and regeneration, and its involvement in pancreatic injury and cancer is not well understood. This study demonstrates that TWEAK/Fn14 signalling is important in the establishment and progression of chronic pancreatitis, increasing the risk of pancreatic cancer. The findings suggest the TWEAK/Fn14 pathway as a potential therapeutic target.
Article
Genetics & Heredity
James C. Barton, J. Clayborn Barton, Ronald T. Acton
Summary: This study aimed to evaluate the height of white adults with hemochromatosis. The results showed that there was no association between HFE genotype and height in men, while women with the p.C282Y/p.C282Y genotype had a greater height. No independent association was found between HFE genotype and height in both men and women.
MOLECULAR GENETICS & GENOMIC MEDICINE
(2023)
Article
Medicine, General & Internal
James C. Barton, Barrett P. Cary, Robert M. Frederickson
Summary: This article reports a case of a 71-year-old woman who was diagnosed with polycythemia rubra vera and asymptomatic sporadic bilateral renal angiomyolipomas. Phlebotomy and hydroxyurea were used for the treatment of polycythemia rubra vera, while surveillance was conducted for the renal angiomyolipomas.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Gastroenterology & Hepatology
Fakhar Ali Qazi Arisar, Rhea Varghese, Shiyi Chen, Wei Xu, Markus Selzner, Ian Mcgilvray, Blayne Sayed, Trevor Reichman, Chaya Shwaartz, Mark Cattral, Anand Ghanekar, Gonzalo Sapisochin, Elmar Jaeckel, Cynthia Tsien, Nazia Selzner, Leslie Lilly, Mamatha Bhat
Summary: Recurrent cirrhosis complicates a significant percentage of liver transplants and may require re-transplantation. This study examined the trajectories of relisted versus primary listed patients on the waitlist and assessed their overall survival and cumulative incidence of transplant.
ANNALS OF HEPATOLOGY
(2024)
Article
Gastroenterology & Hepatology
Helena Hernandez-Evole, Natalia Jimenez-Esquivel, Elisa Pose, Ram on Bataller
Summary: Alcohol is the leading cause of preventable morbidity and mortality worldwide, and the most frequent cause of liver disease. Alcohol-associated liver disease has a complex pathogenesis, with unknown precise mechanisms. Currently, there are no targeted therapies to interfere with the disease's progression, making alcohol abstinence the most effective measure to improve prognosis in patients with this disease.
ANNALS OF HEPATOLOGY
(2024)
Letter
Gastroenterology & Hepatology
Alexander M. Sy
ANNALS OF HEPATOLOGY
(2024)
Letter
Gastroenterology & Hepatology
Eric David Ornos, Janus P. Ong
ANNALS OF HEPATOLOGY
(2024)
Review
Gastroenterology & Hepatology
Lauren Loeb, Jason Lewis, Zhongwei Peng, Michael G. Heckman, Raouf Nakhleh, Andrew P. Keaveny
Summary: Congenital hepatic fibrosis (CHF) is a rare condition characterized by biliary tract changes and liver fibrosis. This study reviewed the medical records of 24 adult patients with CHF and found that renal cysts, splenomegaly, and a cirrhotic-appearing liver were the most common imaging findings. The most common liver-related complications were cholangitis, varices, and hepatic encephalopathy. Liver transplantation may be required for patients with decompensated disease.
ANNALS OF HEPATOLOGY
(2024)
