Review
Biochemistry & Molecular Biology
Xing-An Wang, Ju-Pi Li, Kang-Hsi Wu, Shun-Fa Yang, Yu-Hua Chao
Summary: Aplastic anemia is a rare but life-threatening disease characterized by low blood cell count and reduced cellularity in the bone marrow. Mesenchymal stem cell dysfunction is believed to play a role in the development of the disease. This review provides a comprehensive understanding of the involvement of mesenchymal stem cells in acquired idiopathic aplastic anemia and discusses their clinical application. The pathophysiology of the disease, properties of mesenchymal stem cells, and results of mesenchymal stem cell therapy in animal models are also described. The authors anticipate that more patients with aplastic anemia can benefit from mesenchymal stem cell therapy in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Ju -Pi Li, Kang-Hsi Wu, Wan-Ru Chao, Yi-Ju Lee, Shun-Fa Yang, Yu-Hua Chao
Summary: Immune-mediated hematopoietic destruction plays a major role in idiopathic severe aplastic anemia. Mesenchymal stem cells (MSCs) have important immunomodulatory functions in the bone marrow niche. Dysfunction of MSCs is believed to be a major cause of immunological changes in SAA bone marrow.
Review
Biochemistry & Molecular Biology
Antonio G. Solimando, Carmen Palumbo, Mary Victoria Pragnell, Max Bittrich, Antonella Argentiero, Markus Krebs
Summary: In recent years, it has become evident that bone marrow failures and myeloid malignancy predisposition syndromes have a wide range of phenotypes. Diagnosis of these diseases should be considered in patients with unexplained hematopoiesis defects. Treatment of hypocellular bone marrow failure remains challenging. Exogenous stressors, immune defects, and constitutional genetic defects contribute to disease progression. Understanding the diverse phenotypes of inherited and acquired bone marrow failures and predispositions to myeloid malignancies is crucial. Exploring the pathomechanisms of bone marrow failure may lead to the discovery of new therapeutic and diagnostic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Hong Yu, Yang Zhao, Xiaofeng Pan, Chunyan Liu, Rong Fu
Summary: The expression of Pfn1 in BM mDCs of SAA patients increased and was positively correlated with cytokine levels, potentially impacting the function of mDCs in SAA. Profilin 1 may be involved in the immunopathogenesis of SAA.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Khaled Atmar, Adam J. Tulling, Arjan C. Lankester, Marije Bartels, Frans J. Smiers, Mirjam van der Burg, Alexander B. Mohseny
Summary: This review evaluates the in vitro functional properties of MSCs derived from AA patients compared to healthy controls. The results suggest that AA-MSCs have decreased proliferation potential, increased adipogenic differentiation, decreased osteogenic differentiation, reduced immunosuppressive capacity, and impaired hematopoietic support compared to healthy controls.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Albert K. Park, Anem Waheed, Deborah A. Forst, Hanny Al-Samkari
Summary: Temozolomide-induced aplastic anemia (TIAA) is a rare but challenging complication. In this retrospective study of 34 patients with central nervous system malignancies, TIAA had a rapid onset and resulted in varying outcomes, with some patients achieving hematologic recovery and others experiencing severe complications and even death.
Article
Genetics & Heredity
Tonglin Hu, Yanna Zhao, Xiaoling Yu, Ruilan Gao, Liming Yin
Summary: This study used single-cell transcriptomic sequencing to reveal the transcriptomic landscape of hematopoiesis in AA patients, and identified the aberrance of B cells as a factor contributing to hematopoiesis failure. These findings provide valuable insights and potential targets for the treatment of AA.
FRONTIERS IN GENETICS
(2022)
Review
Oncology
Momen Nassani, Riad El Fakih, Jakob Passweg, Simone Cesaro, Hazzaa Alzahrani, Ali Alahmari, Carmem Bonfim, Raheel Iftikhar, Amal Albeihany, Constantijn Halkes, Syed Osman Ahmed, Carlo Dufour, Mahmoud Aljurf
Summary: Bone marrow failure syndromes are a diverse group of diseases that can now be better classified and treated with the help of advanced diagnostic tools and sequencing techniques. Androgens, a historical group of drugs, have been used for decades to stimulate hematopoiesis and treat bone marrow failure. However, with the availability of more effective treatment options, androgens are now less commonly used. Nonetheless, they can still be considered for bone marrow failure patients who cannot receive standard therapy. This article reviews the use of androgens in bone marrow failure patients and provides recommendations for their optimal use in the current therapeutic landscape.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Hongchen Liu, Xiaoli Zheng, Chengtao Zhang, Jiajun Xie, Beibei Gao, Jing Shao, Yan Yang, Hengxiang Wang, Jinsong Yan
Summary: The study demonstrated the efficacy of haploidentical bone marrow transplantation (haplo-BMT) for patients with severe aplastic anemia II (SAA-II), achieving a 3-year overall survival and disease-free survival rate of 86.4% +/- 0.73%. This indicates that haplo-BMT could be considered as an alternative treatment strategy for SAA-II patients lacking HLA-matched donors.
FRONTIERS OF MEDICINE
(2021)
Article
Oncology
Eleni Gavriilaki, Athanasios Tragiannidis, Maria Papathanasiou, Sotiria Besikli, Paraskevi Karvouni, Vassiliki Douka, Eleni Paphianou, Emmanuel Hatzipantelis, Giorgos Papaioannou, Anastasia Athanasiadou, Anastasia Marvaki, Alkistis-Kira Panteliadou, Anna Vardi, Ioannis Batsis, Antonia Syrigou, Despina Mallouri, Chrysavgi Lalayanni, Ioanna Sakellari
Summary: This study aims to investigate the efficiency and safety of therapeutic methods for aplastic anemia and paroxysmal nocturnal hemoglobinuria. The study found that novel treatments are changing the field of BMF syndromes, but further research is needed to personalize algorithms.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Hui Li, Dexiao Kong, Yi Zhao, Xia Liu, Fang Xiao, Xiaoyan Li, Jianting Hu, Yingjie Chen, Shengli Li, Baozhu Wang, Yuan Chen, Yang Jiang, Xiaoli Liu, Xiumei Feng, Yanan Guo, Xiaoli Feng, Jing Ren, Fang Wang, Ying Han, William Donelan, Lijun Yang, Dawei Xu, Dongqi Tang, Chengyun Zheng
Summary: This study investigates the therapeutic effect of irisin in an AA mouse model. The results show that irisin plays a role in the pathogenesis of AA and can protect HPSC through stimulation of proliferation and regulation of mitochondria function, providing evidence for the application of irisin in AA therapy.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell & Tissue Engineering
Chuan He, Chao Yang, Qiang Zeng, Zhigang Liu, Fangfang Wang, Qiang Chen, Ting Liu
Summary: Umbilical cord-derived MSCs cultured in different media showed the general characteristics of MSCs. HGF, ANG-1, and TGF-beta 1 secretion by MSCs in the MCL was higher than in the other media, while PGE2 secretion was lower in the MCL. MSCs in the MCL inhibited IFN-gamma and TNF-alpha more effectively. MSC treatment promoted recovery of peripheral blood cells, increased Treg ratio and VEGF level, and significantly improved bone marrow.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Cell Biology
Maria Florencia Tellechea, Flavia S. Donaires, Vinicius S. de Carvalho, Barbara A. Santana, Fernanda B. da Silva, Raissa S. Tristao, Lilian F. Moreira, Aline F. de Souza, Yordanka M. Armenteros, Lygia Pereira, Rodrigo T. Calado
Summary: This study used iPSCs to model immune aplastic anemia and found that the differentiation potential of hematopoietic cells in this disease is significantly reduced, suggesting that specific epigenetic changes in HSPCs caused by immune attack may limit cell proliferation and differentiation.
CELL DEATH & DISEASE
(2022)
Review
Immunology
Yanjing Huang, Mengdi Zhu, Zhuo Liu, Runan Hu, Fan Li, Yufan Song, Yuli Geng, Wenwen Ma, Kunkun Song, Mingmin Zhang
Summary: Premature ovarian failure is a common female reproductive disorder characterized by early menopause, increased gonadotropin levels, and estrogen deficiency. The use of bone marrow mesenchymal stem cells may offer potential for restoring ovarian function and fertility in POF patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Mohammad A. Gholampour, Saeid Abroun, Rienk Nieuwland, Seyed J. Mowla, Sara Soudi
Summary: The study showed that treatment with hypoxic MSC-EVs and normoxic MSC-EVs significantly prolonged the survival rate, increased platelet counts, and ameliorated BM hypoplasia in a mouse model of AA. The effects of MSC-EVs were mediated by T cell suppression and inhibition of interferon-gamma and tumor necrosis factor-alpha production. Additionally, there was an association between reduced pro-inflammatory cytokine levels and decreased splenocyte viability in vitro.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Chiao-Wen Lin, Yi-Tzu Chen, Hsieh-Hsun Ho, Pei-Shan Hsieh, Yi-Wei Kuo, Jia-Hung Lin, Cheng-Ruei Liu, Yu-Fen Huang, Ching-Wei Chen, Chen-Hung Hsu, Wen-Yang Lin, Shun-Fa Yang
Summary: The study showed that oral probiotic lozenges significantly increased the population of Lactobacillus in the oral cavity and exhibited antibacterial activity within two weeks. IgA levels, Lactobacillus and Bifidobacterium abundances in the oral cavity were significantly increased in the experimental groups, leading to reduced plaque formation. Most participants experienced improved oral health and intestinal symptoms.
Editorial Material
Otorhinolaryngology
Pei-Hsuan Wu, Chia-Yi Lee, Jing-Yang Huang, Shun-Fa Yang, Cheng-Ping Shih
Summary: Low gestational age, low birth weight, and a long disease course are significantly correlated with late-onset SNHL in patients with cCMV infection.
CLINICAL OTOLARYNGOLOGY
(2022)
Article
Environmental Sciences
Cheng-Chen Huang, Chun-Wen Su, Po-Hui Wang, Yen-Ting Lu, Yu-Ting Ho, Shun-Fa Yang, Chung-Han Hsin, Chiao-Wen Lin
Summary: This study found that dihydromyricetin (DHM) inhibited the migration and invasion of nasopharyngeal carcinoma (NPC) cells by suppressing the expression of matrix metalloproteinases-2 (MMP-2) via down regulating the extracellular signal-regulated kinase 1 and 2 (ERK1/2) signaling pathway.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Ophthalmology
Chia-Chen Lin, Chia-Yi Lee, Jing-Yang Huang, Sheng-Min Hsu, Jia-Horung Hung, Shun-Fa Yang
Summary: This study provides an in-depth analysis of the trends in DR, DME, and related comorbidities in patients with T2DM. It shows that the prevalence and incidence of DR and PDR decreased over time, while the prevalence and incidence of DME increased. Additionally, the percentage of patients with hyperlipidaemia increased in all forms of DR, while the percentage of patients with ESRD increased only in DME.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Immunology
Yia-Ting Li, Yao-Chen Wang, Shun-Fa Yang, Yat-Yin Law, Bei-Hao Shiu, Te-An Chen, Shih-Chi Wu, Min-Chi Lu
Summary: This study aimed to identify the risk factors of invasive Candida infection (ICI) in surgical critically ill peptic ulcer patients. The results indicated that blood lactate level measured at hospital admission could be a predictor of ICI, and patients with liver cirrhosis and higher Sequential Organ Failure Assessment (SOFA) score had poor outcomes.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2022)
Article
Pediatrics
Yu-Jung Chang, Grace Hao, Anpin Ni, Thomas Layton, Jing-Yang Huang, Shun-Fa Yang, Shiuan-Chih Chen
Summary: This study aims to evaluate guidelines for initiating oral feeding in preterm infants and finds that using the Taiwan version of Preterm Oral Feeding Readiness Assessment Scale (TW-POFRAS) in clinical decision-making can help preterm infants to start oral feeding at the appropriate time. For most preterm infants, they can smoothly consume at least 5 mL of milk in one meal and proceed to consume a full day of meals within a week. The average length of stay in the hospital is typically one month, except for infants with a birth weight less than 1,500 g or a gestational age less than 32 weeks.
PEDIATRICS AND NEONATOLOGY
(2022)
Article
Plant Sciences
Chien-Feng Huang, Tung-Wei Hung, Shun-Fa Yang, Yi-Lun Tsai, Jen-Te Yang, Chia-Liang Lin, Yi-Hsien Hsieh
Summary: The study found that asiatic acid (AA) can inhibit the metastatic properties of renal cell carcinoma (RCC) cells by suppressing the p-ERK/p-p38MAPK axis and down-regulating MMP-15 expression. These findings are important for exploring AA as a potential anti-metastatic agent for RCC.
Article
Oncology
Hsueh-Ju Lu, Chih-Yu Peng, Hsien-Chun Tseng, Chung-Han Hsin, Chun-Yi Chuang, Chun-Chia Chen, Wei-Shiou Huang, Yu-Wei Chiu, Shun-Fa Yang
Summary: This study retrospectively analyzed 262 patients with OCSCC and divided them into resectable and unresectable groups. The study found that salvage surgery had an impact on the survival of OCSCC patients and established a scoring model to predict life expectancy after salvage surgery.
Article
Multidisciplinary Sciences
Shih-Ching Lo, Kevin Sheng-Kai Ma, Yen-Ru Li, Zi-Yue Li, Cheng-Hung Lin, Hsing-Chun Lin, Shun-Fa Yang
Summary: There is an association between nutritional provision and successful weaning from ventilators, suggesting that adequate nutrition support may increase the chances of successful extubation in patients.
SCIENTIFIC REPORTS
(2022)
Article
Environmental Sciences
Ming-Hong Hsieh, Yi-Liang Wu, Thomas Chang-Yao Tsao, Yi-Wen Huang, Jian-Cheng Lin, Chia-Yi Lee, Ming-Ju Hsieh, Shun-Fa Yang
Summary: The study aimed to evaluate the combined effect of GAS5 SNP and EGFR phenotypes on the clinicopathological characteristics of lung adenocarcinoma. The results showed that GAS5 SNP rs145204276 variant was associated with tumor stage, lymph node metastasis, and distal metastases in patients with EGFR wild type lung adenocarcinoma.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Chung-Yuan Lee, Yung-Chuan Ho, Chiao-Wen Lin, Min-Chieh Hsin, Po-Hui Wang, Ya-Cheng Tang, Shun-Fa Yang, Yi-Hsuan Hsiao
Summary: The synthetic curcumin analog, EF-24, has been shown to have enhanced bioavailability and stronger anti-inflammatory and anti-cancer activity compared to curcumin. This study investigated the effects of EF-24 on TPA-induced cellular migration of cervical cancer and found that EF-24 significantly reduced cellular migration and invasion. Further analysis revealed that EF-24 modulated MMP-9 expression by inhibiting the phosphorylation of the p38 signaling pathway. These findings suggest that EF-24 may have potential as a chemopreventive agent for cervical cancer.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Ophthalmology
Hsiang-Wen Chien, Chia-Yi Lee, Jing-Yang Huang, Hung-Chi Chen, Kai Wang, Shun-Fa Yang
Summary: This study, using the National Health Insurance Research Database of Taiwan, found a relationship between congenital cytomegalovirus (CMV) infection and late-onset keratitis. Severe congenital CMV infection was found to be significantly correlated with late-onset keratitis in individuals with congenital CMV infection.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Xing-An Wang, Ju-Pi Li, Kang-Hsi Wu, Shun-Fa Yang, Yu-Hua Chao
Summary: Aplastic anemia is a rare but life-threatening disease characterized by low blood cell count and reduced cellularity in the bone marrow. Mesenchymal stem cell dysfunction is believed to play a role in the development of the disease. This review provides a comprehensive understanding of the involvement of mesenchymal stem cells in acquired idiopathic aplastic anemia and discusses their clinical application. The pathophysiology of the disease, properties of mesenchymal stem cells, and results of mesenchymal stem cell therapy in animal models are also described. The authors anticipate that more patients with aplastic anemia can benefit from mesenchymal stem cell therapy in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pediatrics
Yi-Sheng Chang, Chang-Wei Li, Ling Chen, Xing-An Wang, Maw-Sheng Lee, Yu-Hua Chao
Summary: The development of the gut microbiome during early life has long-term effects on health. This study analyzed the microbiota profile of the first-pass meconium in healthy neonates and found a similar composition, with Pseudomonas being the most abundant genus. The diversity of the microbial communities in the first-pass meconium was extremely poor. Primigravidae babies had a higher diversity index, and the Bacteroidales order was a biomarker for their meconium. Delivery mode, maternal antibiotic treatment, rupture of membranes, and birth weight did not affect the diversity index.
Article
Multidisciplinary Sciences
Kevin Chih-Yang Huang, Tao-Wei Ke, Jia-Yi Chen, Wei-Ze Hong, Shu-Fen Chiang, Chia-Ying Lai, Tsung-Wei Chen, Pei-Chen Yang, Liang-Chi Chen, Ji-An Liang, William Tzu-Liang Chen, K. S. Clifford Chao
Summary: This study found that patients with colorectal cancer who carry the TLR1-N248S polymorphism may have a higher risk of distant metastasis and poorer response to adjuvant chemotherapy. Defective TLR1 affects dendritic cell maturation and immune cell infiltration, while TLR1/2 agonists enhance the efficacy of chemotherapy and increase tumor-infiltrating immune cells.
SCIENTIFIC REPORTS
(2023)