Review
Medicine, General & Internal
Chiara Lazzeri, Manuela Bonizzoli, Simona Di Valvasone, Adriano Peris
Summary: Uncontrolled donation after circulatory death (uDCD) lungs have shown promising results in Europe and North America. However, existing experiences and protocols are not uniform, particularly in lung maintenance methods, definition of warm ischemic time (WIT), and the use of ex vivo perfusion. In situ lung cooling may be superior but challenging, while protective ventilation is simpler and feasible. Although scarce, preliminary results of lung transplants after protective ventilation are promising.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Santosh Nagaraju, Rachel Savilla, Myla Moore, Alice Jones, Joseph Africa
Summary: Approximately 25% of deceased donors in the United States come from donation after circulatory death (DCD) setting. Successful transplant outcomes have been reported in Europe using established protocols and devices to reduce ischemic damage and maintain circulation before organ retrieval. In this study, we report the successful transplantation of kidneys from uncontrolled DCD (uDCD) donors without the use of perfusion, with prolonged warm ischemia time (rWIT), and all recipients showed improved renal function after transplant.
CLINICAL TRANSPLANTATION
(2023)
Article
Surgery
Christopher M. Bobba, Bryan A. Whitson, Matthew C. Henn, Nahush A. Mokadam, Brian C. Keller, Justin Rosenheck, Asvin M. Ganapathi
Summary: The use of lungs donated after circulatory death (DCD) has increased, with similar survival rates compared to lungs donated after brain death (DBD). This supports further utilization of DCD lungs in transplantation, expanding the donor pool.
TRANSPLANT INTERNATIONAL
(2022)
Article
Immunology
Shih-Ning Then, Dominique E. Martin, Andrew McGee, Dale Gardiner, Nadia El Moslemani
Summary: This article examines the importance of premortem interventions (PMIs) in organ donation and focuses on the ethical and legal issues surrounding their use. It argues that reforms are needed in many countries to provide legal certainty and ensure that the goals and preferences of potential donors are considered in the decision-making process.
Article
Surgery
Anji E. Wall, Amy Fiedler, Seth Karp, Ashish Shah, Giuliano Testa
Summary: This article discusses the ethical issues of thoracic normothermic regional perfusion (TA-NRP) as a method for in-situ organ preservation in donation after circulatory determination of death (DCD) procedures. The authors argue that TA-NRP DCD meets ethical standards and describe its potential benefits. Finally, the authors call for support and advancement of TA-NRP DCD procedures by professional organizations.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Ethics
Emil J. Nielsen Busch, Marius T. Mjaaland
Summary: The vital status of patients involved in cDCD is a controversial topic in bioethical literature. This article argues that both opponents and proponents of cDCD protocols often misunderstand the moral implications of the dead donor rule. The authors contend that the rule does not require an assessment of a donor's vital status, but rather whether the procurement of organs in cDCD causes the donor's death. They further argue that commonly practiced cDCD protocols do not violate the dead donor rule as the donation process does not cause the donor's death.
AMERICAN JOURNAL OF BIOETHICS
(2023)
Article
Surgery
Jennie H. Kwon, Walker M. Blanding, Khaled Shorbaji, Joseph R. Scalea, Barry C. Gibney, Prabhakar K. Baliga, Arman Kilic
Summary: Organ donation after circulatory death (DCD) expands access to transplantation and improves waitlist outcomes for liver and heart transplant candidates. However, DCD transplant carries increased mortality risk for kidney, liver, and lung recipients.
Article
Surgery
Armaun D. Rouhi, Rashikh A. Choudhury, Gerard D. Hoeltzel, Kas Prins, Dor Yoeli, Hunter B. Moore, Noel N. Williams, Kristoffel R. Dumon, Trevor L. Nydam
Summary: Compared to controlled donation after cardiac death (cDCD), uncontrolled DCD (uDCD) kidney transplantation is an underutilized resource in the US. However, it is unclear whether long-term allograft outcomes following uDCD are inferior to cDCD transplantation. The study found that although initial allograft outcomes were inferior following uDCD, long-term durability of uDCD kidney allografts is on par with cDCD transplantation.
AMERICAN JOURNAL OF SURGERY
(2023)
Review
Immunology
Amy Lewis, Angeliki Koukoura, Georgios-Ioannis Tsianos, Athanasios Apostolos Gargavanis, Anne Ahlmann Nielsen, Efstathios Vassiliadis
Summary: Organ donation and transplantation is the best clinical solution for end-stage organ failure, but challenges such as organ shortage, religious and ethical concerns exist. Addressing these issues requires a multifaceted approach including increasing the potential donor pool, improving consent rates, and enhancing organ allocation.
TRANSPLANTATION REVIEWS
(2021)
Article
Surgery
Shuji Okahara, Gregory Snell, Mark McDonald, Rohit D'Costa, Helen Opdam, David Pilcher, Bronwyn Levvey
Summary: The use of DCD donors has increased lung transplant activity, but a significant percentage do not successfully convert to donation due to various factors. Factors like ICU stay length, brain damage severity, and vasopressin use are related to successful conversion to actual donation. CART modeling can help identify DCD donor candidates with low probability of progression.
TRANSPLANT INTERNATIONAL
(2021)
Article
Immunology
Angela Kotsopoulos, Piet Vos, Marloes Witjes, Meint Volbeda, Hildegard Franke, Jelle Epker, Hans Sonneveld, Koen Simons, Ewald Bronkhorst, Ruud Mullers, Nichon Jansen, Hans van der Hoeven, Wilson F. Abdo
Summary: This study aimed to develop prediction models for circulatory death within 1 or 2 hours after withdrawal of life-sustaining treatment in controlled donation after circulatory death (cDCD) donors. The models were developed using LASSO regression and machine learning-artificial intelligence analysis, and their predictive ability was externally validated. The results showed that the models had a reasonable ability to predict circulatory death.
Article
Cardiac & Cardiovascular Systems
Jason Thomas, Qiudong Chen, Amy Roach, Stanley Wolfe, Asishana A. Osho, Vinay Sundaram, Steven A. Wisel, Dominick Megna, Dominic Emerson, Lawrence Czer, Fardad Esmailian, Joanna Chikwe, Irene Kim, Pedro Catarino
Summary: The utilization and outcomes of concurrently procured DCD livers and kidneys were evaluated in this study. It was found that in-situ thoracoabdominal normothermic regional perfusion was associated with increased utilization of DCD livers and a lower incidence of delayed graft function in concurrently procured DCD kidneys.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
Qiudong Chen, Dominic Emerson, Dominick Megna, Asishana Osho, Amy Roach, Joshua Chan, Georgina Rowe, George Gill, Fardad Esmailian, Joanna Chikwe, Natalia Egorova, James K. Kirklin, Jon Kobashigawa, Pedro Catarino
Summary: Heart transplantation with donation after circulatory death donors has comparable short-term survival to donation after brain death transplants, and broader implementation could increase donor organ availability.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Surgery
Anji E. Wall, Rehma Shabbir, Sneha Chebrolu, Erin Vines, Chad Trahan, Patricia Niles, Giuliano Testa
Summary: This study investigates the variability in DCD hospital policies and recommends a national effort to achieve consistency and clarity in these policies.
AMERICAN JOURNAL OF SURGERY
(2022)
Article
Surgery
Marian Urban, Anthony W. Castleberry, Nicholas W. Markin, Megan M. Chacon, Heather M. Strah, John Y. Um, David Berkheim, Shaheed Merani, Aleem Siddique
Summary: Lung transplantation from donors after circulatory death is now seen as a viable alternative to traditional brain death donation. The emergence of TA-NRP as a technique for cardiac allograft procurement from circulatory death cases allows for in situ organ assessment, potentially impacting lung allograft quality. However, successful cases of transplantation using this method have been reported.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Public, Environmental & Occupational Health
David C. Lee, Ta'Loria Young, Christian A. Koziatek, Christopher J. Shim, Marcela Osorio, Andrew J. Vinson, Joseph E. Ravenell, Stephen P. Wall
PREVENTING CHRONIC DISEASE
(2019)
Article
Surgery
Brendan Parent, Arthur Caplan, Luis Angel, Zachary Kon, Nancy Dubler, Lewis Goldfrank, Jacob Lindner, Stephen P. Wall
AMERICAN JOURNAL OF TRANSPLANTATION
(2020)
Article
Public, Environmental & Occupational Health
Charles J. DiMaggio, Marko Bukur, Stephen P. Wall, Spiros G. Frangos, Andy Y. Wen
Article
Surgery
Brendan Parent, Nader Moazami, Stephen Wall, Julius Carillo, Zachary Kon, Deane Smith, B. Corbett Walsh, Arthur Caplan
AMERICAN JOURNAL OF TRANSPLANTATION
(2020)
Letter
Medicine, General & Internal
Stephen P. Wall, Brendan Parent, Arthur Caplan
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2020)
Article
Emergency Medicine
Kevin G. Munjal, Siri Shastry, Hugh Chapin, Nadir Tan, Anjali Misra, Eric Greenberg, Benjamin Traisman, Rose Kleiman, George Loo, Corita Grudzen, Kevin Chason, Lynne D. Richardson
JOURNAL OF EMERGENCY MEDICINE
(2020)
Letter
Surgery
Thomas M. Egan, Stephen Wall, Lewis Goldfrank, John J. Requard
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Public, Environmental & Occupational Health
Azizi A. Seixas, Iredia M. Olaye, Stephen P. Wall, Pat Dunn
Summary: The COVID-19 pandemic has brought to light inefficiencies and deficiencies in chronic disease management in the US, with digital health and telemedicine solutions offering potential solutions but facing limitations. It is suggested to gamify these solutions through a pantheoretical framework for optimal results.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Public, Environmental & Occupational Health
Stephen P. Wall, Patricio Castillo, Francine Shuchat Shaw, Elizabeth Norman, Natalia Martinez-Lopez, Mairyn Lopez-Rios, Hehidy Paulino, Bruce Homer, Jan L. Plass, Joseph E. Ravenell
Summary: This study aimed to investigate the impact of medical videos and storylines on deceased organ donor registration among clients in Latinx-owned barbershops and beauty salons. Results demonstrated that medical footage, sad, or unresolved storylines did not significantly affect registration and changes in organ donation willingness.
HEALTH EDUCATION & BEHAVIOR
(2022)
Article
Communication
Stephen P. Wall, Patricio Castillo, Francine Shuchat-Shaw, Elizabeth Norman, David Brown, Natalia Martinez-Lopez, Mairyn Lopez-Rios, Azizi A. Seixas, Jan L. Plass, Joseph E. Ravenell
Summary: This study evaluated the impact of different types of videos on organ donor registration among black men and found that targeted or tailored videos can increase the willingness stage of change for organ donation. However, they were not effective in encouraging registration.
JOURNAL OF HEALTH COMMUNICATION
(2022)
Article
Clinical Neurology
Teresa Gerhalter, Anna M. Chen, Seena Dehkharghani, Rosemary Peralta, Fatemeh Adlparvar, James S. Babb, Tamara Bushnik, Jonathan M. Silver, Brian S. Im, Stephen P. Wall, Ryan Brown, Steven H. Baete, Ivan I. Kirov, Guillaume Madelin
Summary: The study found that while there were significant differences in sodium concentration and anisotropy in specific regions, overall patients had lower sodium concentrations compared to controls. Linear regression analysis showed significantly lower global sodium concentrations in patients, with the strongest correlation found between global grey matter sodium concentration and patient outcomes. This suggests that sodium imaging may be a non-invasive and sensitive method for assessing outcomes in mild traumatic brain injury.
BRAIN COMMUNICATIONS
(2021)
Article
Emergency Medicine
Aaron Arredondo, Chinwe Ogedegbe, Jerome R. Hoffman, Lewis R. Goldfrank, Stephen P. Wall, Teresa Y. Smith
ACADEMIC EMERGENCY MEDICINE
(2020)
Article
Marine & Freshwater Biology
Scott A. Gorenstein, Michael L. Castellano, Eric S. Slone, Brian Gillette, Helen Liu, Cindy Alsamarraie, Alan M. Jacobson, Stephen P. Wall, Samrachana Adhikari, Jordan L. Swartz, Jenica J. S. McMullen, Marcela Osorio, Christian A. Koziatek, David C. Lee
UNDERSEA AND HYPERBARIC MEDICINE
(2020)
Article
Ergonomics
Jessica B. Cicchino, Melissa L. McCarthy, Craig D. Newgard, Stephen P. Wall, Charles J. DiMaggio, Paige E. Kulie, Brittany N. Arnold, David S. Zuby
ACCIDENT ANALYSIS AND PREVENTION
(2020)
Article
Emergency Medicine
Mark X. Cicero, Travis Whitfill, Barbara Walsh, Maria Carmen G. Diaz, Grace M. Arteaga, Daniel J. Scherzer, Scott A. Goldberg, Manu Madhok, Angela Bowen, Geno Paesano, Michael Redlener, Kevin Munjal, Marc Auerbach
PREHOSPITAL EMERGENCY CARE
(2019)