Review
Oncology
Yiting Li, Zile Chen, Shu Nie, Zhouwei Wu
Summary: Dermatofibrosarcoma protuberans is a rare skin cancer with high recurrence and low metastasis. Atrophic dermatofibrosarcoma protuberans is a rare variant often misdiagnosed as benign lesions. Early identification and understanding of these variants can improve prognosis.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Juan Bai, Bin Liu, Taoming Liu, Jianjun Qiao, Hong Fang
Summary: DFSP is a rare soft tissue sarcoma with histopathological variations, early identification can help prevent recurrence.
FRONTIERS IN ONCOLOGY
(2021)
Article
Dermatology
Anber Mahboob, Claire Turgeon, Syeda Qasim, Arif Usmani
Summary: Dermatofibrosarcoma protuberans (DFSP) is a rare and locally aggressive spindle cell tumor that occurs in the dermis and has low metastatic potential. Atrophic DFSP is a rare form that affects young adults and is similar to DFSP histologically. The current management strategy involves surgical excision and long-term follow-up. Our case is exceptionally rare due to the presence of eosinophilic infiltration.
Article
Dermatology
Gauri Panse, Emily Reisenbichler, Matija Snuderl, Wei-Lien Wang, William Laskin, George Jour
Summary: This case report describes a 31-year-old female with a 1.5 cm pigmented nodule on the scalp, diagnosed as lipofibromatosis-like neural tumor (LPF-NT) based on histopathological and immunohistochemical findings. LPF-NT tumors have a distinct immunoprofile and can be differentiated from pigmented dermatofibrosarcoma protuberans, lipofibromatosis, low-grade malignant peripheral nerve sheath tumor, and spindle cell/desmoplastic melanoma. The LMNA-NTRK1 fusion gene serves as both a diagnostic and therapeutic biomarker for LPF-NT.
JOURNAL OF CUTANEOUS PATHOLOGY
(2021)
Article
Dermatology
Qiuyu Yu, Yueqian Zhu, Renjun Huang, Yan Li, Linyi Song, Xiaoping Zhang, Mengxiao Tang, Qinghua Gu, Ping Li, Naihui Zhou, Yonggang Li
Summary: This study found that DCE-HR-MRI is valuable for the diagnosis and differential diagnosis of DFSP, and can help determine treatment options to improve patient prognosis.
SKIN RESEARCH AND TECHNOLOGY
(2022)
Article
Medicine, General & Internal
Fedele Lembo, Liberato Roberto Cecchino, Domenico Parisi, Aurelio Portincasa
Summary: This case report presents a new approach for reconstructive treatment of the lumbar area after wide excision of DFSP in a young obese woman, using a new type of acellular dermal matrix (ADM). The method involves wide local excision and the use of an artificial bilaminar dermal template, resulting in excellent surgical outcomes without the need for postoperative radiotherapy.
JOURNAL OF MEDICAL CASE REPORTS
(2021)
Article
Cell Biology
Oliver J. Culley, Blaise Louis, Christina Philippeos, Benedicte Oules, Matthieu Tihy, Joe M. Segal, Della Hyliands, Gail Jenkins, Ranjit K. Bhogal, Richard C. Siow, Fiona M. Watt
Summary: Although human dermis contains distinct fibroblast subpopulations, the functional heterogeneity of fibroblast lines from different donors is under-appreciated. We have identified IGF1 and WNT4 as candidate mediators of two distinct dermal functions: myofibroblast formation and epidermal maintenance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Erica L. Riedesel, Edward J. Richer, Susan D. Taylor, Ting Tao, Marie -Helene Gagnon, Kiery A. Braithwaite, Adina L. Alazraki, Geetika Khanna
Summary: When a pediatric hepatic cystic lesion is identified at imaging, the differential diagnosis may be broad, including developmental, infectious, neoplastic, and posttraumatic or iatrogenic causes. The location of a cystic lesion and its number, size, composition, and relationship to the biliary system are features that help in narrowing the differential diagnosis.
