Journal
ANNALS OF DERMATOLOGY
Volume 21, Issue 1, Pages 60-62Publisher
KOREAN DERMATOLOGICAL ASSOC
DOI: 10.5021/ad.2009.21.1.60
Keywords
Aggravation; Crohn's disease; Psoriasis; TNF-alpha blocker
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As more rheumatologists and dermatologists have begun to use biological agents such as TNF-alpha blocker, they have confronted an unexpected complication: psoriasis was paradoxically aggravated or induced by the TNF-alpha blocker. Although it is not a common complication of TNF-alpha blocker, this aggravation may be more common than previously thought. To our knowledge, most reports about TNF-alpha blocker-induced psoriasis have been limited to western countries while only a few cases have been reported in Korea and Japan. In addition, new onset of pustular psoriasis by TNF-alpha blocker has been reported more commonly than worsening of preexisting psoriasis. Now we report a patient whose preexisting psoriasis vulgaris was aggravated repeatedly after using the TNF-alpha blocker, infliximab, to control Crohn's disease, which is a rare rheumatologic disease in Korea. (Ann Dermatol (Seoul) 21(1) 60 similar to 62, 2009)
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