Article
Chemistry, Medicinal
Gang Xing, Zhengxing Zhi, Ce Yi, Jitian Zou, Xuefeng Jing, Anthony Yiu-Ho Woo, Bin Lin, Li Pan, Yuyang Zhang, Maosheng Cheng
Summary: A group of 8-hydroxyquinolin-2(1H)-one analogues were designed and synthesized, among which compounds B05 and C08 were identified as potent and selective beta(2) agonists. They exhibited partial beta(2)-agonist activities in cells and showed rapid smooth muscle relaxation and long duration of action, suggesting their potential applicability in chronic respiratory diseases.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Medicine, General & Internal
Angela Klain, Cristiana Indolfi, Giulio Dinardo, Marcella Contieri, Fabio Decimo, Michele Miraglia Del Giudice
Summary: Exercise-induced bronchoconstriction (EIB) is a transient airflow obstruction that can limit physical activities and sports in children. By taking appropriate precautions and medication, routine exercise is extremely safe for children.
FRONTIERS IN MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Francesco De Pascali, Michael Ippolito, Emily Wolfe, Konstantin E. Komolov, Nathan Hopfinger, Douglas Lemenze, Nicholas Kim, Roger S. Armen, Steven S. An, Charles P. Scott, Jeffrey L. Benovic
Summary: This study identified several G(s)-biased agonists that relieve airflow obstruction by activating G(s) signaling pathway through β(2)-adrenoceptor. These biased compounds showed minimal β-arrestin-mediated effects and induced minimal desensitization of the receptor in primary HASM cells. These findings may have implications for the treatment of asthma and the development of safer drugs.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Cell Biology
Jonas H. Olesen, Jon Herskind, Katja K. Pedersen, Kristian Overgaard
Summary: Elevated extracellular K+ concentration can enhance muscle force, while salbutamol further potentiates force in fast-twitch muscles but not in slow-twitch muscles already potentiated by moderately elevated K+ concentration. Lactic acid, 9-AC, and increased temperature do not exert significant effects on muscles exposed to moderate elevations of K+ concentration.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Allergy
Liza Bronner Murrison, Xiaomeng Ren, Kristina Preusse, Hua He, John Kroner, Xiaoting Chen, Seth Jenkins, Elisabet Johansson, Jocelyn M. Biagini, Matthew T. Weirauch, Raphael Kopan, Lisa J. Martin, Gurjit K. Khurana Hershey
Summary: This study found that the combined effects of TSLP genotype and TSLP expression play a role in modulating childhood asthma. Increased TSLP mRNA expression is associated with increased asthma risk, while circulating TSLP is not associated with asthma.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Sport Sciences
Morten Hostrup, Erik S. H. Hansen, Soren M. Rasmussen, Soren Jessen, Vibeke Backer
Summary: Athletes often suffer from lower airway dysfunction, including asthma and exercise-induced bronchoconstriction (EIB), which affects more than half of the athletes in certain sports, especially endurance sports. Early diagnosis and proper management are crucial as untreated or poorly managed asthma and EIB can negatively impact performance and lead to airway damage. However, with advancements in treatment strategies, athletes with asthma and EIB can still compete at a high level. It is important for practitioners and athletes to adhere to general guidelines and anti-doping regulations to avoid unintentionally exceeding dosage limits.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Article
Respiratory System
Jose Angelo Rizzo, Laienne Carla Barbosa de Barros Albuquerque, Decio Medeiros, Claudio Gonsalves de Albuquerque, Edil de Albuquerque Rodrigues Filho, Marcos Andre de Moura Santos, Steve Hunter, Nadia Gaua, Marco Aurelio Valois de Correia Junior
Summary: This study evaluated the association between achieved ventilation rates during a challenge and EIB-compatible response in young asthma patients, and found that the achieved ventilation rates did not seem to have a significant correlation with EIB-compatible response.
Article
Environmental Sciences
Carlo De Pieri, Michele Arigliani, Maria Pia Francescato, Maurizio Droli, Michael Vidoni, Ilaria Liguoro, Maria Elena Ferrari, Paola Cogo, Mario Canciano Canciani
Summary: The study found that a one-week climate therapy in the mountains improved bronchial hyperreactivity and cardiorespiratory endurance in asthmatic children, helping to reduce the incidence of exercise-induced bronchoconstriction.
Review
Medicine, Research & Experimental
Daniel Enrique Rodriguez Bauza, Patricia Silveyra
Summary: Asthma is a chronic inflammatory lung disease that affects approximately 7.7% of the US population. Sex differences in the prevalence, incidence, and severity of asthma have been widely described, with higher rates in boys before puberty and a reversed pattern in adults. Asthma is often associated with atopy and can be worsened by environmental stimuli and/or exercise.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Article
Respiratory System
Malvika Kaul, Karen Turner, Israel Rubinstein
Summary: The study investigated the occurrence of post-bronchodilator paradoxical bronchospasm in spirometry test results of veterans with COPD or asthma. Among the identified cases, majority of patients were African American males with an average age of 67 years, most of whom used inhaled beta(2)-adrenergic agonists.
RESPIRATORY MEDICINE AND RESEARCH
(2021)
Article
Allergy
Maiju Malmberg, L. Pekka Malmberg, Anna S. Pelkonen, Mika J. Makela, Anne Kotaniemi-Syrjanen
Summary: The study evaluated the impact of body mass index on exercise performance and respiratory symptoms in 7- to 16-year-old children. Results showed that greater ISO-BMI and overweight were associated with poorer exercise performance and respiratory symptoms, but not with EIB or wheeze during exercise challenge.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Article
Pediatrics
Marco Aurelio de Valois Correia Junior, Edil de Albuquerque Rodrigues Filho, Ricardo Cesar Espinhara Tenorio, Claudio Goncalves de Albuquerque, Laienne Carla Barbosa, Polyanna Guerra Chaves Quirino, Emanuel Sarinho, Decio Medeiros, Jose Angelo Rizzo
Summary: Impulse oscillometry parameters are inversely correlated with forced expiratory volume in the first second (FEV1) and can be used as diagnostic indicators for exercise-induced bronchoconstriction (EIB). However, caution should be taken when interpreting and using the results.
PEDIATRIC PULMONOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Abdolhamid Esmaeeli, Zahra Keshavarz, Firoozeh Dehdar, Majid Assadi, Mohammad Seyedabadi
Summary: In this study, the effects of carvedilol, metoprolol and propranolol on cisplatin-induced nephrotoxicity in an animal model were investigated. The researchers found that carvedilol and high-dose propranolol may offer potential therapeutic benefits in cisplatin-induced nephrotoxicity.
DRUG AND CHEMICAL TOXICOLOGY
(2022)
Article
Allergy
Jose Angelo Rizzo, Edil de Albuquerque Rodrigues Filho, Adriana Velozo Goncalves, Laienne Carla Barbosa De Barros Albuquerque, Eduardo Martins de Albuquerque, Claudio Goncalves de Albuquerque, Anderson Henrique Souza de Almeida, Decio Medeiros Peixoto, Marco Aurelio de Valois Correia Junior
Summary: This study evaluated the short-term test-retest agreement and reproducibility of FEV1 changes after EVH in asthmatic patients aged 10-20 years. The results suggest that more than one EVH test should be performed in children and young adolescents with asthma to exclude EIB and minimize misdiagnosis and mistreatment.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Article
Respiratory System
Yechan Kim, Vincent Hou, Ryan D. Huff, Jennifer A. Aguiar, Spencer Revill, Nicholas Tiessen, Quynh Cao, Matthew S. Miller, Mark D. Inman, Kjetil Ask, Andrew C. Doxey, Jeremy A. Hirota
Summary: The study suggests that modulating intracellular cAMP levels by inhibiting phosphodiesterase 4 (PDE4) or blocking ATP Binding Cassette Transporter C4 (ABCC4) can enhance the efficacy of LABA/GCS therapy in asthma when challenged with viral stimuli.
RESPIRATORY RESEARCH
(2021)
