Review
Critical Care Medicine
Hitasha Rupani, Brian D. Kent
Summary: Asthma is a common disease with lower airway inflammation and airflow limitation. Measurement of fractional exhaled nitric oxide (FENO) can quickly assess the degree of lower airway inflammation and aid in the diagnosis, treatment guidance, and selection of appropriate biologic therapy for asthma.
Article
Biochemistry & Molecular Biology
Megan Pophal, Zachary W. Grimmett, Clara Chu, Seunghee Margevicius, Thomas Raffay, Kristie Ross, Anjum Jafri, Olivia Giddings, Jonathan S. Stamler, Benjamin Gaston, James D. Reynolds
Summary: The study suggests that F-ENO could reflect airway S-nitrosothiol concentrations and serve as a biomarker for asthma. Inhalational challenge with GSNO resulted in increased F-ENO, indicating a potential non-invasive test for monitoring airway GSNO breakdown.
Article
Pediatrics
Kamil Baranski, Jan Eugeniusz Zejda
Summary: This study aimed to assess the accuracy of Fractional Exhaled Nitric Oxide (FeNO) in identifying children with asthma. The results showed that FeNO had the best diagnostic accuracy for isolated asthma without any coexisting respiratory or allergic disease.
Review
Biochemistry & Molecular Biology
Tommaso Pianigiani, Lorenzo Alderighi, Martina Meocci, Maddalena Messina, Beatrice Perea, Simona Luzzi, Laura Bergantini, Miriana D'Alessandro, Rosa Metella Refini, Elena Bargagli, Paolo Cameli
Summary: Through a systematic review of published articles, it was found that FeNO plays an important role as a biomarker in severe asthmatic patients undergoing biologic treatment. Higher baseline FeNO levels are associated with better clinical control and lower exacerbation rates. FeNO during biologic treatment can help predict clinical worsening and differentiate eosinophilic from non-eosinophilic exacerbations.
Article
Biotechnology & Applied Microbiology
Sabina Galiniak, Marta Rachel
Summary: The study aimed to measure FeNO concentration in asthmatic patients in Poland, finding a significant correlation between FeNO concentration and asthma symptom control in patients with and without allergic rhinitis.
Article
Medicine, General & Internal
Natasa Karamarkovic Lazarusic, Eugenija Kasap Basioli, Ena Tolic, Martina Dokoza, Gordana Pavlisa
Summary: This study evaluated the diagnostic accuracy of fractional exhaled nitric oxide (FeNO) in mild asthma and found that FeNO has insufficient sensitivity and specificity in this condition.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pediatrics
Liang-Mei Lin, Yu-Jun Chang, Kuender D. Yang, Ching-Hsiung Lin, Jien-Wen Chien, Jun-Kai Kao, Ming-Sheng Lee, Tsay- Chiang, Ching-Yuang Lin, Yi-Giien Tsai
Summary: This study aimed to investigate the utility of IOS and FeNO for assessing childhood asthma control in terms of small airway dysfunction and airway inflammation.
FRONTIERS IN PEDIATRICS
(2022)
Article
Allergy
J. A. Buendia, R. Acuna-Cordero, C. E. Rodriguez-Martinez
Summary: This study evaluated the budget impact of asthma management using FeNO monitoring in Colombia. The findings showed that adopting FeNO for routine management in patients with persistent asthma could lead to cost savings for the Colombian National Health System.
JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Environmental Sciences
N. Ji, M. Fang, A. Baptista, C. Cepeda, M. Greenberg, I. Colon Mincey, P. Ohman-Strickland, F. Haynes, N. Fiedler, H. M. Kipen, R. J. Laumbach
Summary: Exposure to traffic-related air pollution was associated with increased levels of airway inflammation and decreased levels of DNA methylation in the promoter regions of the NOS3 gene in children with asthma. The strongest associations were found between FeNO and BC at lag 0-6 h, as well as between methylation at positions 1 and 2 in NOS3 and BC at lag 13-24 h and lag 0-24 h, respectively. Associations weakened at longer lag periods.
ENVIRONMENTAL HEALTH
(2021)
Article
Medicine, General & Internal
Leonard B. Bacharier, Jorge F. Maspero, Constance H. Katelaris, Alessandro G. Fiocchi, Remi Gagnon, Ines de Mir, Neal Jain, Lawrence D. Sher, X. Mao, D. Liu, Yi Zhang, Asif H. Khan, Upender Kapoor, Faisal A. Khokhar, Paul J. Rowe, Yamo Deniz, Marcella Ruddy, Elizabeth Laws, Naimish Patel, David M. Weinreich, George D. Yancopoulos, Nikhil Amin, Leda P. Mannent, David J. Lederer, Megan Hardin
Summary: This study showed that among children aged 6 to 11 with uncontrolled moderate-to-severe asthma, those who received add-on dupilumab had fewer asthma exacerbations, better lung function and asthma control compared to those who received placebo.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Respiratory System
Francesca Bertolini, Andrea E. Sprio, Andrea Baroso, Elisa Riccardi, Stefano Pizzimenti, Vitina Carriero, Elisa Arrigo, Antonino Di Stefano, Fabio L. M. Ricciardolo
Summary: This study stratified asthma patients based on their exhaled nitric oxide (FENO) levels and identified specific clinical features and predictors for different FENO levels. The findings have important implications for tailoring treatment and improving outcomes in asthmatic patients.
Review
Pharmacology & Pharmacy
Beatrice Ragnoli, Alessandro Radaeli, Patrizia Pochetti, Stefano Kette, Jaymin Morjaria, Mario Malerba
Summary: Exhaled nitric oxide (NO) production can be measured in exhaled air as a non-invasive tool to monitor inflammatory pathways in asthma and other respiratory conditions. It has shown to be useful in asthma diagnosis, treatment evaluation, phenotyping severe asthma patients, and predicting response to biologic treatments.
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
(2023)
Article
Medicine, General & Internal
Bruna Cuoco Provenzano, Thiago Prudente Bartholo, Kennedy Martins Kirk, Mario Fritsch Neves, Marcelo Ribeiro-Alves, Ana Paula Ramos Barreto, Nadja Polisseni Graca, Paulo Roberto Chauvet Coelho, Claudia Henrique da Costa, Rogerio Rufino
Summary: Nitric oxide (NO) is produced by eosinophilic metabolism and its increase is linked with bronchial remodeling and airway hyperresponsiveness. Fractional exhaled NO (FENO) is used as a marker for eosinophilic inflammation in patients with asthma. This study found that both positive and negative bronchodilation (BD) response groups showed an increase in eosinophil count and FENO values as asthma severity increased. The correlations between FENO and eosinophils, as well as FENO values and BD+, were significant. Measuring FENO levels may help identify patients with positive BD.
Article
Pediatrics
Ying Lou, Qiuping Ke, Huailiang Cui, Ying Shang, Chengsheng Yang
Summary: This study found that cytokine levels in the BALF of children with asthma were significantly elevated, correlated with FeNO, and can be used to evaluate airway inflammation in children with asthma.
TRANSLATIONAL PEDIATRICS
(2021)
Review
Allergy
Fahad Alahmadi, Adam Peel, Brian Keevil, Rob Niven, Stephen J. Fowler
Summary: Although corticosteroid treatment is effective in controlling asthma, poor adherence undermines its efficacy. Studies have used blood prednisolone levels and FeNO as markers for adherence to oral and inhaled corticosteroids, but further research is needed to assess the impact of dose and timing on blood levels and explore FeNO suppression testing in prospective studies.
CLINICAL AND EXPERIMENTAL ALLERGY
(2021)
Article
Allergy
Saliha Esenboga, Aysegul Akarsu, Melike Ocak, Pinar Gur Cetinkaya, Umit Murat Sahiner, Bulent Enis Sekerel, Ozge Soyer
Summary: This study aimed to evaluate the characteristics, safety, and efficacy of rapid drug desensitization (RDD) in children with hypersensitivity reactions (HSRs), as well as the management of breakthrough reactions. The results demonstrated the safety and efficacy of RDD in childhood, offering a first-line treatment option for children with chronic diseases and HSRs.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Dermatology
Handan Bezirganoglu, Ebru Arik Yilmaz, Umit M. Sahiner, Ozge Soyer, Bulent E. Sekerel, Ozlem Teksam, Betul Buyuktiryaki, Cansin Sackesen
Summary: This study aimed to investigate the possible and exact triggers of urticaria in children admitted to the pediatric emergency department (PED). The study found that infections were the most common triggers of urticaria in children admitted to the PED, and severe urticaria led to more frequent readmissions.
PEDIATRIC DERMATOLOGY
(2022)
Article
Pediatrics
Elif Soyak Aytekin, Umit M. Sahiner, Sevda Tuten Dal, Hilal Unsal, Ozan Hakverdi, Berna Oguz, Yasemin Ozsurekci, Bulent E. Sekerel, Ozge Soyer
Summary: This study investigated the course and consequences of SARS-CoV-2 infection in children with asthma. It found that COVID-19 infection leads to dysfunction of the small airways in asthmatic children, and obesity is an independent risk factor for a decrease in FEF25-75.
PEDIATRIC PULMONOLOGY
(2022)
Article
Allergy
Millie Nguyen Basu, Charlotte G. Mortz, Tina Kold Jensen, Torben Barington, Kate Lykke Lambertsen, Susanne Halken
Summary: The clinical and molecular characteristics of an AD+asthma phenotype were investigated and compared with AD, asthma, and control groups. The study found an increased number of IgE sensitizations and elevated levels of Pro-Th-2 cytokines in the AD+asthma group. NMF levels were decreased in AD. These findings suggest potential biomarkers and provide insights into the pathogenesis of AD+asthma.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Article
Allergy
Aysegul Akarsu, Ceyda Oksel Karakus, Melike Ocak, Nihan Oral, Eyup Bilgi, Umit Murat Sahiner, Ozge Soyer, Bulent Enis Sekerel
Summary: The study identified three distinct phenotypes in patients with food allergies using latent class analysis. Compared to the single food allergy cluster, the multiple food allergy clusters had higher prevalence of atopic dermatitis, and cluster 1 had the highest rates of allergic rhinitis and allergic asthma, as well as the lowest rate of complete food allergy tolerance.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2023)
Article
Allergy
Murat Turk, Ragip Ertas, Umit Murat Sahiner, Pavel Kolkhir, Bulent Enis Sekerel, Ozge Soyer, Atil Avci, Mustafa Atasoy, Kemal Ozyurt, Yekta Turk, Engin Zeydan, Marcus Maurer
Summary: This study identified that the complete response to standard-dose and higher than standard-dose antihistamine treatments in patients with CSU can be predicted based on CSU disease activity assessed by UAS. This finding is important for disease management, cost reduction, and time-saving.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2023)
Article
Pediatrics
Halime Nayir Buyuksahin, Deniz Dogru, Nagehan Emiralioglu, Dilber Ademhan Tural, Beste Ozsezen, Birce Sunman, Ismail Guzelkas, Didem Alboga, Sevtap Arikan-Akdagli, Zeynep Saribas, Dolunay Gulmez, Alpaslan Alp, Guelsen Hazirolan, Ozge Soyer, Bulent Enis Sekerel, Gozde Inam, Ilim Irmak, Ebru Damadoglu, Fuat Kalyoncu, Ebru Yalcin, Ugur Ozcelik, Nural Kiper
Summary: The study aimed to determine the clinical phenotypes caused by Aspergillus spp. in patients with cystic fibrosis using laboratory and immunologic parameters, and to compare the Aspergillus phenotypes in terms of pulmonary function tests. The results showed that although Aspergillus isolation in patients with cystic fibrosis was not associated with decreased lung function, a further decline was seen in the allergic bronchopulmonary aspergillosis subgroup, and frequent pulmonary exacerbations occurred during the 1-year follow-up.
PEDIATRIC PULMONOLOGY
(2023)
Article
Biochemical Research Methods
Tutku Soyer, Esra Birben, Servet Melike Akinci, Gulnur Gollu, Ozlem Boybeyi Turer, Ozge Soyer, Murat Cakmak, Bulent Enis Sekerel, Feridun Cahit Tanyel
Summary: Bullous lung diseases may lead to primary spontaneous pneumothorax (PSP) in children. The expression of miRNA-24 in the exhaled breath of children with bullous lung disease and PSP is significantly reduced. Close monitoring is recommended for children with PSP, especially those with bullous disease.
JOURNAL OF BREATH RESEARCH
(2023)
Article
Allergy
Elif Soyak Aytekin, Ozge Soyer, Umit Murat Sahiner, Sandra Wieser, Christian Lupinek, Bulent Enis Sekerel
CLINICAL AND EXPERIMENTAL ALLERGY
(2023)
Review
Nutrition & Dietetics
Mattia Giovannini, Burcin Beken, Betul Buyuktiryaki, Simona Barni, Giulia Liccioli, Lucrezia Sarti, Lorenzo Lodi, Matteo Pontone, Irene Bartha, Francesca Mori, Cansin Sackesen, George du Toit, Andreas L. Lopata, Antonella Muraro
Summary: Shellfish, a key component of a healthy diet, can also cause allergic reactions. These reactions can be immunological or non-immunological in nature. Immunological reactions involve IgE-mediated allergic reactions, while non-immunological reactions include toxic reactions and food intolerance. Understanding the molecular features of shellfish allergens can improve diagnosis and immunotherapy for shellfish allergy.
Article
Allergy
Dilara Kocacik Uygun, Betul Karaatmaca, Erdem Topal, Mustafa Arga, Ozlem Sancakli, Dilek Ozcan, Mahir Igde, Sukru Cekic, Gulbin Bingol, Betul Buyuktiryaki, Cansin Sackesen, Alihan Sursal, Fatih Ozdener, Aysen Bingol
Summary: This study aimed to determine the factors, including COVID-19, affecting formula compliance in CMPA patients. The results showed that increased breastfeeding duration, increased daily formula intake, and the addition of sweeteners had a negative impact on formula compliance. Meanwhile, the pandemic did not significantly affect the formula adherence of CMPA patients.
FRONTIERS IN ALLERGY
(2023)
Article
Pediatrics
Hilal uensal, Sevda Tueten Dal, Uemit Murat Sahiner, Oezge Soyer, Buelent Enis Sekerel
Summary: This study reviewed 102 children aged 3-18 years with persistent IgE-mediated hen's egg allergy. The results showed that 90.2% of patients had multiple food allergies, with the most common co-allergies being tree nuts, cow's milk, and seeds. The study also found that baked egg and heated egg yolk were more likely to be tolerated by patients.
TURKISH JOURNAL OF PEDIATRICS
(2023)
Article
Pediatrics
Fatma Tuncer, Umit Murat Sahiner, Melike Ocak, Hilal Unsal, Ozge Soyer, Bulent E. Sekerel, Esra Birben
Summary: The study revealed that expression levels of miRNAs varied according to the type of allergic diseases and the presence of allergens. miR-181a and miR-125b could be candidate biomarkers for allergic rhinitis, while miR-206 might be suitable for non-atopic asthmatics and perennial allergic rhinitis.
TURKISH JOURNAL OF PEDIATRICS
(2022)
Meeting Abstract
Allergy
Moshe Ben-Shoshan, Bulent Enis Sekerel, Petra Staubach-Renz, Montserrat Alvaro-Lozano, Marcus Maurer, Anton Drollmann, Andrzej Bienczak, Miriam Porter, Tian Liu, Alis Burciu, Thomas Severin
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)