Article
Biochemistry & Molecular Biology
Thi Van Nguyen, Chau Tuan Vo, Van Minh Vo, Cong Thuy Tram Nguyen, Thi My Pham, Chun Hua Piao, Yan Jing Fan, Ok Hee Chai, Thi Tho Bui
Summary: The plant extract from Phaeanthus vietnamensis BaN, a medicinal plant in Vietnam, has shown potential anti-inflammatory and anti-asthmatic effects. It can improve asthma symptoms, balance Th1/Th2 ratio, reduce inflammation and oxidative stress, and help restore lung function.
Article
Allergy
Stephanie Musiol, Carla P. Harris, Ruth Karlina, Johanna M. Gostner, Birgit Rathkolb, Benjamin Schnautz, Evelyn Schneider, Lisa Mair, Ernesto Elorduy Vergara, Claudia Flexeder, Sibylle Koletzko, Carl-Peter Bauer, Tamara Schikowski, Dietrich Berdel, Andrea von Berg, Gunda Herberth, Jan Rozman, Martin Hrabe de Angelis, Marie Standl, Carsten B. Schmidt-Weber, Siegfried Ussar, Francesca Alessandrini
Summary: This study investigated the association between starch, sucrose, and fat in relation to allergic sensitization and asthma prevalence in humans, as well as their underlying mechanisms using mouse models. The findings suggest that high consumption of digestible carbohydrates is associated with an increased prevalence of asthma in humans and aggravated lung allergic inflammation in mice, involving oxidative stress-related mechanisms.
Review
Biochemistry & Molecular Biology
Efthymia Theofani, Georgina Xanthou
Summary: Autophagy is a crucial self-degradative process in cells that plays a key role in cellular renovation, physiology, and homeostasis. It can be triggered by factors such as starvation, pathogens, and stress, and is important in immune response regulation. Dysregulation of autophagy processes, either impaired or overactive, can contribute to the pathogenesis of various diseases, including infections and cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Tongqian Wu, Lan Ma, Xiaoqian Jin, Jingjing He, Ke Chen, Dingshan Zhang, Rui Yuan, Jun Yang, Qin Zhong, Haiyan Zhou, Zou Xiang, Yu Fang
Summary: The study demonstrated that S100A4 plays a critical role in regulating mast cell activation and allergic responses. S100A4(-/-) mice showed reduced symptoms in allergic models, indicating that S100A4 is required for mast cell activation and may be involved in the regulation of allergic diseases through this mechanism.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Xinxing Zhang, Yu Ma, Yanyu He, Wenjing Gu, Yongdong Yan, Wei Ji, Li Huang, Yuqing Wang, Chuangli Hao, Gang Li, Zhengrong Chen
Summary: The overexpression of Foxp2 gene can attenuate allergic asthma by inhibiting Th9 cell differentiation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Acharya Balkrishna, Siva Kumar Solleti, Hoshiyar Singh, Rani Singh, Kunal Bhattacharya, Anurag Varshney
Summary: This study validated the anti-inflammatory and anti-asthmatic properties of the traditional metallic medicine MS in a mouse model of asthma and LPS stimulated human cells. The results showed that MS can alleviate asthma symptoms and reduce inflammation by regulating cellular, biochemical, and molecular processes.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shanshan Xu, Nan Wang, Dandan Yan, Yingjie Zhong
Summary: The study found that PE can alleviate asthma caused by obesity. In both mouse and cell experiments, PE can reduce airway inflammation and oxidative damage, as well as reduce body weight and inflammation levels in obese asthmatic mice.
MOLECULAR IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Stanislawa Bazan-Socha, Krzysztof Wojcik, Magdalena Olchawa, Tadeusz Sarna, Jakub Pieta, Bogdan Jakiela, Jerzy Soja, Krzysztof Okon, Jacek Zarychta, Lech Zareba, Michal Stojak, Daniel P. Potaczek, Jan G. Bazan, Magdalena Celinska-Lowenhoff
Summary: The study found that there is increased systemic oxidative stress in asthma, which is associated with decreased lung function and elevated inflammatory markers. However, there is no correlation between oxidative stress and the severity of asthma or airway remodeling. Proper disease control can help reduce oxidative stress.
Article
Plant Sciences
Wen-Chung Huang, Tse-Hung Huang, Kuo-Wei Yeh, Ya-Ling Chen, Szu-Chuan Shen, Chian-Jiun Liou
Summary: The study showed that ginsenoside Rg3 significantly reduced airway inflammation, oxidative stress, and airway hyperresponsiveness in asthmatic mice, as well as decreased eosinophil infiltration. In tracheal epithelial cells, ginsenoside Rg3 also reduced inflammatory responses and oxidative stress.
JOURNAL OF GINSENG RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Teodora-Irina Adam-Bonci, Eduard-Alexandru Bonci, Alina-Elena Parvu, Andrei-Ioan Herdean, Augustin Mot, Marian Taulescu, Andrei Ungur, Raluca-Maria Pop, Corina Bocsan, Alexandru Irimie
Summary: The study showed that oral vitamin D supplementation can reduce oxidative forces and increase antioxidant capacity, while also exhibiting anti-inflammatory effects to protect against acute airway inflammation related to oxidative stress processes induced by ovalbumin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Wenxian Ma, Qiaoyan Jin, Haiqin Guo, Xinpeng Han, Lingbin Xu, Shemin Lu, Changgui Wu
Summary: This study demonstrates that metformin can alleviate airway inflammation and remodeling in an OVA-induced chronic asthmatic model. The protective effects of metformin may be associated with the restoration of AMPKα activity and decreased asthma-related angiogenesis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Je-Oh Lim, Se-Jin Lee, Woong-Il Kim, So-Won Pak, Changjong Moon, In-Sik Shin, Jeong-Doo Heo, Je-Won Ko, Jong-Choon Kim
Summary: The study found that TiO(2)NPs caused pulmonary toxicity and exacerbated asthma development by exacerbating inflammatory response and activating the TXNIP-apoptosis pathway. Additionally, TiO(2)NPs treated cells showed increased inflammatory factors and elevated TXNIP signaling. TXNIP knockdown in airway epithelial cells significantly decreased pathophysiological changes induced by TiO2NP treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jin-Hwa Kim, Jeong-Won Kim, Chang-Yeop Kim, Ji-Soo Jeong, Je-Oh Lim, Je-Won Ko, Tae-Won Kim
Summary: This study evaluated the therapeutic effects of Korean red ginseng (KRG) on allergic asthma and found that it can reduce airway hyperresponsiveness, reactive oxygen species (ROS) production, and inflammatory cell infiltration. KRG also decreased the levels of pro-inflammatory factors and showed potential in alleviating asthma.
Article
Endocrinology & Metabolism
Jack T. Womble, Mark D. Ihrie, Victoria L. McQuade, Akhil Hegde, Matthew S. McCravy, Sanat Phatak, Robert M. Tighe, Loretta G. Que, David D'Alessio, Julia K. L. Walker, Jennifer L. Ingram
Summary: Asthma is a chronic airway inflammatory disease, and patients with comorbid obesity may experience resistance to currently available therapeutics. Bariatric surgery has been shown to improve asthma control and airway hyperresponsiveness, but the underlying mechanisms are still unclear.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Engineering, Environmental
Chan Lu, Faming Wang, Qin Liu, Miaomiao Deng, Xu Yang, Ping Ma
Summary: This study investigates the potential toxicological mechanisms of allergic asthma caused by exposure to nitrogen dioxide (NO2) in mice. The results show that NO2 exposure aggravates lung inflammation and airway remodeling in asthmatic mice, as well as promotes airway hyperresponsiveness and inflammatory cytokine production. The imbalance of Th1/Th2 cell differentiation plays a key role in the inflammatory response of asthma under NO2 exposure.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Allergy
Hyouk-Soo Kwon, Tae-Bum Kim, Yoon Su Lee, Seung-Hwan Jeong, Yun-Jeong Bae, Keun-Ai Moon, Bo-Ram Bang, Hee-Bom Moon, You Sook Cho
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2014)
Article
Immunology
Kwangwon Hong, Youngmin Lee, Siyoung Lee, Sungnoh Hong, Suyoung Bae, Jaewoo Hong, Jida Choi, Hyunjhung Jhun, Areum Kwak, Eunsom Kim, Seunghyun Jo, Taebong Kang, You Sook Cho, Yong-Gil Kim, Soohyun Kim
IMMUNOLOGIC RESEARCH
(2013)
Article
Cell Biology
So Yong Kim, Keun-Ai Moon, Hee-Yeon Jo, Sookyung Jeong, Seung-Han Seon, Eunyu Jung, You Sook Cho, Eunyoung Chun, Ki-Young Lee
IMMUNOLOGY AND CELL BIOLOGY
(2012)
Letter
Rheumatology
Ji-Beom Kim, Sujeong Kim, Taehoon Lee, Yoon Su Lee, You Sook Cho, Hee-Bom Moon, Yong-Gil Kim, Tae-Bum Kim
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
(2013)
Letter
Allergy
Sun-Young Yoon, Seung Hee Baek, Sujeong Kim, Yoon Su Lee, Taehoon Lee, Yun-Jeong Bae, Hyouk-Soo Kwon, Jin Won Huh, Sang-Bum Hong, You Sook Cho, Sail Chun, Chae-Man Lim, Younsuck Koh, Hee-Bom Moon, Tae-Bum Kim
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2013)
Article
Dermatology
Taehoon Lee, Yoon Su Lee, Sun-Young Yoon, Sujeong Kim, Yun-Jeong Bae, Hyouk-Soo Kwon, You Sook Cho, Hee-Bom Moon, Tae-Bum Kim
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2013)
Article
Respiratory System
An Soo Jang, Hyouk-Soo Kwon, You Sook Cho, Yun Jeong Bae, Tae Bum Kim, Jong Sook Park, Sung Woo Park, Soo-Taek Uh, Jae-Sung Choi, Yong-Hoon Kim, Hyeon-Kyu Hwang, Hee-Bom Moon, Choon Sik Park
Article
Multidisciplinary Sciences
Yun-Jeong Bae, Ye Won Hwang, Sun-young Yoon, Sujeong Kim, Taehoon Lee, Yoon Su Lee, Hyouk-Soo Kwon, You Sook Cho, Myung Jin Shin, Hee-Bom Moon, Tae-Bum Kim
Article
Multidisciplinary Sciences
Sujeong Kim, Seunghee Baek, Bomi Shin, Sun-young Yoon, So Young Park, Taehoon Lee, Yoon Su Lee, Yun-Jeong Bae, Hyouk Soo Kwon, You Sook Cho, Hee-Bom Moon, Tae-Bum Kim
Article
Multidisciplinary Sciences
So Young Park, Seunghee Baek, Sujeong Kim, Sun-young Yoon, Hyouk-Soo Kwon, Yoon-Seok Chang, You Sook Cho, An-Soo Jang, Jung Won Park, Dong-Ho Nahm, Ho-Joo Yoon, Sang-Heon Cho, Young-Joo Cho, ByoungWhui Choi, Hee-Bom Moon, Tae-Bum Kim
Article
Cardiac & Cardiovascular Systems
Ji-Yong Moon, Sang-Heon Kim, Tae-Bum Kim, Sae-Hoon Kim, Yoon-Seok Chang, Jae Hyun Lee, You Sook Cho, Jung Won Park, An-Soo Jang, Choon-Sik Park, Dong-Ho Nahm, Young-Joo Cho, Sang-Heon Cho, Byoung-Whui Choi, Hee-Bom Moon, Ho Joo Yoon
RESPIRATORY MEDICINE
(2013)
Article
Allergy
An-Soo Jang, Sang-Heon Kim, Tae-Bum Kim, Heung-Woo Park, Sae-Hoon Kim, Yoon-Seok Chang, Jae Hyun Lee, You Sook Cho, Jung Won Park, Dong-Ho Nahm, Young-Joo Cho, Sang-Heon Cho, Ho Joo Yoon, Byoung-Whui Choi, Hee-Bom Moon, Choon-Sik Park
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
(2013)
Article
Allergy
Sujeong Kim, Sun-Young Yoon, So Young Park, Hyouk-Soo Kwon, You Sook Cho, Hee-Bom Moon, Tae-Bum Kim
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
(2013)
Article
Allergy
Bomi Shin, So Young Park, Sun-Young Yoon, Eun-Hye Shin, Young-Joo Yang, Hyung-Jin Cho, Il-Young Jang, Dong-Uk Kang, Tae-Bum Kim, You Sook Cho, Hee-Bom Moon, Hyouk-Soo Kwon
ALLERGY ASTHMA & RESPIRATORY DISEASE
(2013)
Article
Allergy
Jin Yong Kim, Sang Yong Om, Sun-Young Yoon, Tae-Bum Kim, You Sook Cho, Hee-Bom Moon, Hyouk-Soo Kwon
ALLERGY ASTHMA & RESPIRATORY DISEASE
(2013)