Article
Emergency Medicine
Jennifer E. Lee, Sean M. Bryant
Summary: Angiotensin converting enzyme inhibitor-induced angioedema is typically easily recognizable, but unilateral angioedema is infrequently reported and rare.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Genetics & Heredity
Carina M. Mathey, Carlo Maj, Annika B. Scheer, Julia Fazaal, Bettina Wedi, Dorothea Wieczorek, Philipp M. Amann, Harald Loffler, Lukas Koch, Clemens Schoffl, Heinrich Dickel, Nomun Ganjuur, Thorsten Hornung, Susann Forkel, Jens Greve, Gerda Wurpts, Par Hallberg, Anette Bygum, Christian Von Buchwald, Malgorzata Karawajczyk, Michael Steffens, Julia Stingl, Per Hoffmann, Stefanie Heilmann-Heimbach, Elisabeth Mangold, Kerstin U. Ludwig, Eva R. Rasmussen, Mia Wadelius, Bernhardt Sachs, Markus M. Nothen, Andreas J. Forstner
Summary: This study investigated the possible association between ACEi/ARB-induced angioedema and HAE genes through molecular genetic screening. The results suggest that HAE-associated mutations are, at best, a rare cause of ACEi/ARB-induced angioedema, and there was no significant association found between ACEi/ARB-induced angioedema and other variants in the investigated genes.
FRONTIERS IN GENETICS
(2022)
Article
Emergency Medicine
Steven Rosenbaum, R. Gentry Wilkerson, Michael E. Winters, Gary M. Vilke, Marie Yung Chen
Summary: Angioedema induced by ACE inhibitors is a complex complication that may lead to airway compromise. The optimal treatment remains uncertain, with discontinuation of ACE inhibitors being the primary focus of management.
JOURNAL OF EMERGENCY MEDICINE
(2021)
Letter
Allergy
Aude Belbezier, Melanie Arnaud, Isabelle Boccon-Gibod, Fabien Pelletier, Chloe McAvoy, Delphine Gobert, Olivier Fain, Aurelie Du-Thanh, David Launay, Julien Lupo, Laurence Bouillet
Summary: Acute attacks may occur during the convalescent phase of COVID-19, especially in patients with a history of frequent attacks, but it is unclear whether these acute attacks are specifically triggered by COVID-19.
CLINICAL AND EXPERIMENTAL ALLERGY
(2021)
Article
Medicine, General & Internal
Zs. Polai, Zs. Balla, N. Andrasi, K. V. Kohalmi, Gy. Temesszentandrasi, Sz. Benedek, L. Varga, H. Farkas
Summary: The study evaluated clinical follow-up results of 17 patients with C1-INH-AAE, finding that the patients had an average age of 61 years and 33% of them experienced AE attacks provoked by ACE inhibitors. The majority of patients experienced attacks involving the skin, upper airways, tongue/lip, with most having an underlying condition.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Allergy
Zsuzsanna Balla, Zsuzsanna Zsilinszky, Zsofia Polai, Noemi Andrasi, Kinga Viktoria Kohalmi, Dorottya Csuka, Lilian Varga, Henriette Farkas
Summary: This study evaluated the results of complement testing in patients experiencing angioedema while taking angiotensin-converting enzyme inhibitors. The findings revealed that most initial angioedema episodes in the 149 patients occurred in the face, lips, and tongue. The diagnosis of acquired angioedema related to angiotensin-converting enzyme inhibitors is closely linked to the use of these medications.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Pharmacology & Pharmacy
Taikang Yao, Zhenchao Wu, Zilu Wang, Liting Chen, Beibei Liu, Ming Lu, Ning Shen
Summary: Observational studies and meta-analyses have shown a positive correlation between the use of angiotensin-converting enzyme inhibitors (ACEIs) and lung cancer. The study used Mendelian randomization to verify the associations between ACE inhibition, ACEI-induced cough, and the risk of lung cancer. The results indicate a significant relationship between ACE inhibition and the development of lung cancer, as well as a higher risk of lung cancer for Europeans with ACEI-induced cough.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Nicolas Simon, Alexis Bocquet, Isabelle Boccon-Gibod, Laurence Bouillet
Summary: This study retrospectively examined the clinical features of AE episodes prompting a call on the CREAK hotline and found that mast cell induced angioedema patients had a higher history of hives, while ACEi-AAE mainly affected the tongue and larynx. The hotline provided rapid AE expertise and helped educate physicians in the management of angioedema.
Article
Pharmacology & Pharmacy
Steven D. Brooks, Rachel L. Smith, Aline S. Moreira, Hans C. Ackerman
Summary: Lisinopril increases ACE2 expression in tissues relevant to COVID-19, while adding losartan prevents the lisinopril-induced increase. A sex difference was observed with higher ACE2 levels in the kidneys of male mice.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Filipa Gouveia, Antoni Camins, Miren Ettcheto, Joana Bicker, Amilcar Falcao, M. Teresa Cruz, Ana Fortuna
Summary: Alzheimer's disease (AD) is a neurodegenerative disease that is characterized by Tau hyperphosphorylation and A beta deposits. Recent scientific evidence suggests that age-related vascular alterations and cardiovascular risk factors play a role in the development of AD. Drugs targeting the Renin Angiotensin System (RAS) have the potential to delay AD development due to their effects on brain RAS. The ACE 1/Ang II/AT1R axis in AD is believed to have detrimental effects, while the alternative axis ACE 1/Ang II/AT2R; ACE 2/Ang (1 7)/MasR; Ang IV/AT4R (IRAP) seems to have beneficial effects on memory and cognition. Retrospective studies and pre-clinical studies support the therapeutic potential of RAS drugs for AD.
AGEING RESEARCH REVIEWS
(2022)
Article
Pharmacology & Pharmacy
Whitley J. Whitehead, Jennifer Meyer Reid
Summary: Lisinopril-induced angioedema (LIA) cases within the Veterans Health Administration are significantly underreported, leading to an overestimation of the risk. Due to the substantial underreporting, the true risk of LIA may be four times higher than official figures suggest.
ANNALS OF PHARMACOTHERAPY
(2022)
Article
Clinical Neurology
Malik Nassan, Iyas Daghlas, Ignazio S. Piras, Emily Rogalski, Lianne M. Reus, Yolande Pijnenburg, Leah K. Cuddy, Richa Saxena, M-Marsel Mesulam, Matt Huentelman
Summary: This study used genetic approaches to find that angiotensin-converting enzyme (ACE) inhibition is associated with Alzheimer's disease and frontotemporal dementia, but not with Lewy body dementia or vascular dementia. These results provide evidence for further research on the neurocognitive effects of ACE inhibition.
ALZHEIMERS & DEMENTIA
(2023)
Article
Pharmacology & Pharmacy
Kung-Ming Laio, Chuan-Wei Shen, Yun-Hui Huang, Chun-Hui Lu, Hsuan-Lin Lai, Chung-Yu Chen
Summary: The prescription pattern and effectiveness of antihypertensive drugs in surgical patients with aortic dissection were investigated. The study found that no specific type of antihypertensive drug was associated with a better outcome in patients with type A aortic dissection, while the use of beta-blockers and calcium channel blockers (CCBs) was related to a significantly lower risk of the composite outcome in patients with type B aortic dissection.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ilaria Caputo, Brasilina Caroccia, Ilaria Frasson, Elena Poggio, Stefania Zamberlan, Margherita Morpurgo, Teresa M. Seccia, Tito Cali, Marisa Brini, Sara N. Richter, Gian Paolo Rossi
Summary: Blockers of the renin-angiotensin system (RAS) can increase the expression of ACE2, the cellular receptor of SARS-CoV-2, and thus increase the risk of COVID-19. This study found that angiotensin II (Ang II) significantly increased the levels of ACE2 expression by acting on the angiotensin type 1 receptor, resulting in enhanced viral entry into cells. However, the blockade of ACE-1-mediated Ang II formation and ACE2-mediated Ang II conversion did not have any effect. Therefore, increased production of Ang II in patients with an activated RAS may lead to a greater spread of COVID-19 infection in lung cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Rheumatology
Tomoaki Ida, Kei Ikeda, Hiroyuki Ohbe, Kaito Nakamura, Hiroki Furuya, Taro Iwamoto, Shunsuke Furuta, Yoshihisa Miyamoto, Mikio Nakajima, Yusuke Sasabuchi, Hiroki Matsui, Hideo Yasunaga, Hiroshi Nakajima
Summary: This retrospective cohort study evaluated the effectiveness of early initiation of ACE inhibitor in patients with SRC. The results showed that early ACEi treatment was associated with a lower composite outcome of in-hospital mortality or haemodialysis dependence at discharge. Further prospective studies are needed to confirm these findings.
Article
Pediatrics
Giulia M. Martone, Heather K. Lehman, Todd C. Rideout, Divya Choudhary, Claire E. Cameron, Emily Oken, Sheryl L. Rifas-Shiman, Carlos A. Camargo, Diane R. Gold, Xiaozhong Wen
Summary: The study found that children who had delayed introduction of eggs after 12 months had a significantly higher risk of egg allergy at 2 years and the risk persisted into early adolescence at 12 years. This suggests that introducing eggs before 12 months could help prevent egg allergy.
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2023)
Article
Critical Care Medicine
Brandon-R. Bedell, Krislyn-M. Boggs, Janice-A. Espinola, Ashley-F. Sullivan, Kohei Hasegawa, Margaret Samuels-Kalow, Kori -S. Zachrison, Carlos-A. Camargo Jr
Summary: There are discrepancies between trauma center certifications in the U.S., with many states maintaining unique certification systems. This study investigates the similarity between the national trauma certification program established by the American College of Surgeons (ACS) and state certifications, and creates a unified national trauma center database.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2023)
Article
Nutrition & Dietetics
Raphaelle Varraso, Orianne Dumas, Fred K. Tabung, Krislyn M. Boggs, Teresa T. Fung, Frank Hu, Edward Giovannucci, Frank E. Speizer, Walter C. Willett, Carlos A. Camargo
Summary: This study aimed to determine if adherence to a healthful plant-based diet is associated with a lower risk of COPD, while adherence to an unhealthful plant-based diet is associated with a higher risk of COPD. Findings showed that participants with the highest hPDI score had a 46% lower risk of COPD, while those with the highest uPDI score had a 39% higher risk of COPD.
Article
Allergy
Rachel L. Miller, Holly Schuh, Aruna Chandran, Izzuddin M. Aris, Casper Bendixsen, Jeffrey Blossom, Carrie Breton, Carlos A. Camargo Jr, Glorisa Canino, Kecia N. Carroll, Sarah Commodore, Jose F. Cordero, Dana M. Dabelea, Assiamira Ferrara, Rebecca C. Fry, Jody M. Ganiban, James E. Gern, Frank D. Gilliland, Diane R. Gold, Rima Habre, Marion E. Hare, Robyn N. Harte, Tina Hartert, Kohei Hasegawa, Gurjit K. Khurana Hershey, Daniel J. Jackson, Christine Joseph, Jean M. Kerver, Haejin Kim, Augusto A. Litonjua, Carmen J. Marsit, Cindy McEvoy, Eneida A. Mendonca, Paul E. Moore, Flory L. Nkoy, Thomas G. O'Connor, Emily Oken, Dennis Ownby, Matthew Perzanowski, Katherine Rivera-Spoljaric, Patrick H. Ryan, Anne Marie Singh, Joseph B. Stanford, Rosalind J. Wright, Robert O. Wright, Antonella Zanobetti, Edward Zoratti, Christine C. Johnson
Summary: This study found that the incidence rates of asthma with recurrent exacerbations (ARE) are influenced by time, geography, age, race and ethnicity, sex, and parental history. Children aged 2-4 years, Hispanic Black and non-Hispanic Black children, and those with a parental history of asthma had the highest rates of ARE.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Immunology
Michihito Kyo, Zhaozhong Zhu, Ryohei Shibata, Michimasa Fujiogi, Jonathan M. Mansbach, Carlos A. Camargo, Kohei Hasegawa
Summary: This study identified specific nasopharyngeal lipids that can differentiate between respiratory syncytial virus (RSV) and rhinovirus (RV) bronchiolitis in infants. These lipids, including phosphatidylcholine (18:2/18:2), dihydroceramide (16:0), and eicosapentaenoic acid, are also associated with the severity of bronchiolitis.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Obstetrics & Gynecology
Steven J. Ondersma, Amii M. Kress, Annemarie Stroustrup, Robert D. Annett, Lyndsay A. Avalos, Maria Talavera-Barber, Patricia A. Brennan, Carlos A. Camargo, Elisabeth Conradt, Anne L. Dunlop, Amy J. Elliott, Monique M. Hedderson, Ximin Li, Monica McGrath, Ruby H. N. Nguyen, Grier P. Page, Sheela Sathyanarayana, Barry Lester
JOURNAL OF PERINATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Heidi Makrinioti, Zhaozhong Zhu, Carlos A. Camargo, Valentina Fainardi, Kohei Hasegawa, Andrew Bush, Sejal Saglani
Summary: Obesity-related asthma in childhood is a heterogeneous phenotype, with prevalence increasing. Observational studies have found that early-life obesity or weight gain are risk factors for childhood asthma development, and the reverse association is also described. Obese children with asthma have poorer symptom control and more asthma attacks compared to non-obese children with asthma. Clinical trials have found that some obese children with asthma do not respond well to usual treatment.
Letter
Medicine, General & Internal
Christopher L. Bennett, Krislyn M. Boggs, Cameron J. Gettel, Wendy W. Sun, Arjun K. Venkatesh, Carlos A. Camargo
Article
Emergency Medicine
Son H. McLaren, Ying Shelly Qi, Janice A. Espinola, Jonathan M. Mansbach, Peter S. Dayan, Carlos A. Camargo
Summary: This article aims to identify characteristics associated with mild bronchiolitis in infants <= 90 days old. The results show that older age (61-90 days), adequate oral intake, and oxygen saturation >= 94% are factors associated with mild bronchiolitis.
JOURNAL OF THE AMERICAN COLLEGE OF EMERGENCY PHYSICIANS OPEN
(2023)
Article
Emergency Medicine
Scott A. Goldberg, Emma Chadwick, Supriya Makam, Hridaya J. Shah, Michelle B. Bass, Mohammad A. Hasdianda, Gregory Peters, Carlos A. Camargo Jr, Rebecca E. Cash
Summary: Since the publication of the National EMS Research Agenda in 2001, there has been an increase in EMS-specific research and NIH-funded grants. EMS-related publications have tripled and the number of funded EMS research grants has nearly quintupled in the United States over the past 20 years.
ANNALS OF EMERGENCY MEDICINE
(2023)
Article
Medical Informatics
Jeffrey A. Kline, Brian Reed, Alex Frost, Naomi Alanis, Meylakh Barshay, Andrew Melzer, James W. Galbraith, Alicia Budd, Amber Winn, Eugene Pun, Carlos A. Camargo Jr
Summary: This study describes the development and operation of a national network dedicated to surveillance of acute respiratory infections in emergency departments, providing a valuable public health resource for monitoring the epidemiology, viral causes, and outcomes of ED patients with ARIs.
BMC MEDICAL INFORMATICS AND DECISION MAKING
(2023)
Article
Virology
Yury A. Bochkov, Mark Devries, Kaitlin Tetreault, Ronald Gangnon, Sujin Lee, Leonard B. Bacharier, William W. Busse, Carlos A. Camargo, Timothy Choi, Robyn Cohen, Ramyani De, Gregory P. DeMuri, Anne M. Fitzpatrick, Peter J. Gergen, Kristine Grindle, Rebecca Gruchalla, Tina Hartert, Kohei Hasegawa, Gurjit K. Khurana Hershey, Patrick Holt, Kiara Homil, Tuomas Jartti, Meyer Kattan, Carolyn Kercsmar, Haejin Kim, Ingrid A. Laing, Peter N. Le Souef, Andrew H. Liu, David T. Mauger, Tressa Pappas, Shilpa J. Patel, Wanda Phipatanakul, Jacqueline Pongracic, Christine Seroogy, Peter D. Sly, Christopher Tisler, Ellen R. Wald, Robert Wood, Robert F. Lemanske, Daniel J. Jackson, James E. Gern
Summary: This study examined cross-neutralization reactions and antibody duration of rhinovirus type A (RV-A) and type C (RV-C). The results showed limited cross-neutralization reactions between the two types, which are limited to genetically similar strains. However, the duration of antibody response during childhood is similar for both types.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Multidisciplinary Sciences
Christopher L. Bennett, Allan S. Detsky, Carson E. Clay, Janice A. Espinola, Julie Parsonnet, Carlos A. Camargo
Summary: This study found that emergency departments (EDs) in HIV priority jurisdictions in the United States serve populations emphasized in HIV-related efforts, such as Black or African American or Hispanic or Latino populations, as well as communities with higher proportions uninsured and living in poverty, and higher rates of chlamydia, gonorrhea, and syphilis. EDs with teaching hospital affiliations had the highest visit volumes and steady growth. The findings suggest that geographically targeted screening in EDs with a teaching hospital affiliation could efficiently reach vulnerable populations and reduce the burden of undiagnosed HIV in the US.
Article
Cardiac & Cardiovascular Systems
Geneva D. Mehta, Anna Chen Arroyo, Zhaozhong Zhu, Janice A. Espinola, Jonathan M. Mansbach, Kohei Hasegawa, Carlos A. Camargo Jr
Summary: The history of severe bronchiolitis in infancy is associated with decreased lung function at the age of 6, potentially increasing the risk of chronic respiratory illnesses in the future.
RESPIRATORY MEDICINE
(2023)
Article
Health Care Sciences & Services
Kori S. Zachrison, Rebecca E. Cash, Krislyn M. Boggs, Emily M. Hayden, Ashley F. Sullivan, Carlos A. Camargo Jr
Summary: This study aimed to examine the use of telehealth by US emergency departments (EDs) during COVID-19 and whether existing telehealth infrastructure or increased system integration were associated with increased likelihood of use. The results showed that telehealth use by US EDs in 2020 exceeded expectations and preexisting telehealth infrastructure was associated with increased innovation in its use.
TELEMEDICINE AND E-HEALTH
(2023)