Article
Medicine, Research & Experimental
Georg Karl Ludwig Burghardt, Mandy Cuevas, Rumi Sekine, Thomas Hummel
Summary: This study compared nasal trigeminal sensitivity in patients with allergic rhinitis (AR), chronic rhinosinusitis with nasal polyps (CRSwNP), and healthy controls (HC). The results showed that AR patients had increased sensitivity to trigeminal stimuli, while CRSwNP patients had decreased sensitivity.
Article
Immunology
Li Li, Yuanding Zhang, Hong Liu, Tianqi Wang, Junxin Li, Xin Wang
Summary: This Mendelian Randomization (MR) study aims to evaluate the causal relationships between 41 inflammatory cytokines and the incidence of Allergic Rhinitis (AR), Chronic Rhinosinusitis (CRS), and Nasal Polyps (NP). The results showed that elevated levels of MIP-1 alpha and TNF-alpha were associated with an increased risk of AR, while elevated levels of IL-2 were associated with an increased susceptibility to NP. Furthermore, increased levels of circulating PDGF-BB were linked to a reduced risk of NP. However, there was no positive association found between levels of inflammatory cytokines and the incidence of CRS.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, Research & Experimental
Patrick El Khoury, Walid Abou Hamad, Michel G. Khalaf, Christopher El Hadi, Ralph Assily, Simon Rassi, Nadim Khoueir
Summary: This study aimed to compare the effectiveness of intranasal ipratropium bromide (INIB) to a placebo in reducing nasal symptoms, particularly rhinorrhea, and enhancing quality of life in non-allergic rhinitis patients. The results showed that INIB nasal spray significantly reduced the severity and duration of rhinorrhea and improved the quality of life compared to the placebo.
Article
Otorhinolaryngology
Weigang Gan, Fengjuan Yang, Juan Meng, Feng Liu, Shixi Liu, Junming Xian
Summary: The microbiome of the nasal cavity and its contribution to nasal mucosal disease have been poorly understood. This study used molecular methods to characterize the microbiome and found that certain microbial populations were significantly different in allergic rhinitis and chronic rhinosinusitis, suggesting a role of microbial dysbiosis in the pathogenesis of nasal mucosal inflammation.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Review
Otorhinolaryngology
Rachel A. Schusteff, Margaret A. Chervinko, Sharmilee M. Nyenhuis, Victoria S. Lee
Summary: This study examined the use of ecological momentary assessment (EMA) in allergic rhinitis (AR) and chronic rhinosinusitis (CRS). It found that there have been few studies using EMA in AR and no studies in CRS. EMA has the potential to capture real-time data and provide a better understanding of the relationship between environmental triggers and symptoms, guiding treatment decisions.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2022)
Article
Otorhinolaryngology
Aysegul Tuna, Burak M. Tas, Gokben Basaran Kankilic, Furkan M. Kocak, Ziya Sencan, Ela Comert, Nuray Bayar Muluk, Birguel Kacmaz, Serdar Gul, Eftal Boeke
Summary: This study investigated the relationship between microplastics, a global health and environmental issue, and allergic rhinitis. The findings showed that allergic rhinitis patients had significantly higher levels of microplastics in their nasal lavage fluids compared to the control group.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yara Zoabi, Francesca Levi-Schaffer, Ron Eliashar
Summary: Allergic rhinitis is a common nasal disorder affecting up to 30% of adults. Mast cells play a crucial role in allergic inflammation and are involved in the development of symptoms. This review provides a comprehensive summary of mast cells' involvement in allergic rhinitis and the modulation of mast cells by current and emerging therapies.
Article
Otorhinolaryngology
Jean Kim, Darryn W. Waugh, Benjamin F. Zaitchik, Amber Luong, Regan Bergmark, Kent Lam, Lauren Roland, Joshua Levy, Jivianne T. Lee, Do-Yeon Cho, Murugappan Ramanathan Jr, Fuad Baroody, Mas Takashima, Daniel O'Brien, Sandra Y. Lin, Stephanie Joe, Mohamad R. Chaaban, Anna Butrymowicz, Stephanie Smith, Warren Mullings
Summary: Climate change has a negative impact on our environment, leading to an increased morbidity of rhinologic diseases. A systematic approach is needed to improve healthcare infrastructure and funding, and promote diverse scientific collaboration to address these healthcare needs.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2023)
Article
Otorhinolaryngology
Qiqi Luo, Siyi Zhou, Bo Yuan, Zeli Feng, Guolin Tan, Honghui Liu
Summary: This study analyzed blood parameter differences between patients with allergic rhinitis (AR) and nonallergic rhinitis (NAR), with or without chronic rhinosinusitis (CRS). The results showed that blood eosinophil count and proportion may be good diagnostic predictors of allergic-like rhinitis, but they cannot distinguish between AR and NAR. However, these indicators may be more effective in predicting allergic-like rhinitis with CRSwNP.
CLINICAL OTOLARYNGOLOGY
(2023)
Article
Otorhinolaryngology
V. Backer, K. Aanaes, S. Hansen, J. Petersen, C. von Buchwald
Summary: The researchers aimed to design a standardized test for the awareness of global airway diseases by developing a global airways questionnaire using a mix of clinical knowledge and data-driven methods. The questionnaire included three domains: allergic rhinitis, chronic rhinosinusitis, and asthma sub-factors.
Article
Respiratory System
Ayse Fusun Kalpaklioglu, Ayse Baccioglu, Sumeyra Alan Yalim
Summary: The study compared serum leptin levels between AR and NAR patients, finding similar levels but significantly higher in obese AR patients. Leptin levels correlated with female gender, older age, and high BMI, with younger age and high leptin levels being independent predictors for AR diagnosis.
CLINICAL RESPIRATORY JOURNAL
(2021)
Article
Otorhinolaryngology
Min-Seok Rha, Hyung-Ju Cho, Joo-Heon Yoon, Chang-Hoon Kim
Summary: This study found a significant association between the use of electronic cigarettes (ECs) and the prevalence of chronic rhinosinusitis (CRS) and allergic rhinitis (AR) in adults.
Article
Environmental Sciences
Mahdi Ghaemi Asl, Muhammad Mahdi Rashidi, Aviral Kumar Tiwari, Chi-Chuan Lee, David Roubaud
Summary: This research examines the dynamics of dependence and causality between the S&P Kensho Clean Energy (CE) and Cleantech (CT) indices and two green bond indices, as well as four Islamic bond indices. The study finds that the dependence of CE and CT on Sukuk and green bond indices strengthens in the long and medium term, particularly in normal or bearish market conditions. AA- and A-rated Sukuk indices and Green Bond Select (GBS) indices exhibit stronger dependence with CE and CT compared to other instruments. Furthermore, causality is predominantly observed from Sukuk and bond indices to CT and CE in the frequency domain.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Review
Immunology
Harsha H. Kariyawasam, Louisa K. James
Summary: This article discusses the role of B cells in upper airway diseases, focusing on allergic rhinitis and chronic rhinosinusitis with nasal polyps. Despite the increasing understanding of B-cell dysfunction in these diseases, there is a lack of specific studies on B cells in relation to sinonasal infection and mucosal inflammation. Further research is needed to explore how respiratory inflammation and impaired B-cell function contribute to immune dysregulation in these conditions.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2021)
Review
Otorhinolaryngology
Nadim Khoueir, Michel G. Khalaf, Ralph Assily, Simon Rassi, Walid Abou Hamad
Summary: This systematic review and meta-analysis examined the effects of intranasal antihistamines (INAH) on idiopathic rhinitis (IR). The study found that INAH had a beneficial effect on improving nasal symptoms compared to placebo. No significant difference in efficacy was observed between different types of INAH. The most commonly reported adverse event was bitter taste sensation.
Article
Otorhinolaryngology
Umit Taskin, Timur Batmaz, Mehmet Erdil, Salih Aydin, Kadir Yucebas
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2017)
Article
Allergy
Ismet Bulut, Zeynep F. Ozseker, Abdurrahman Coskun, Mustafa Serteser, Ibrahim Unsal
Article
Otorhinolaryngology
Sahin Ogreden, Sedat Ruzgar, Hasan Deniz Tansuker, Umit Taskin, Yalcin Alimoglu, Salih Aydin, Mehmet Faruk Oktay, Ugur Izol
BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY
(2018)
Article
Allergy
Arzu Yorgancioglu, Ferda Oner Erkekol, Dilsad Mungan, Munevver Erdinc, Bilun Gemicioglu, Zeynep Ferhan Ozseker, Papatya Bayrak Degirmenci, Sibel Nayci, Aykut Cilli, Fusun Erdenen, Cengiz Kirmaz, Dane Ediger, Arzu Didem Yalcin, Suna Buyukozturk, Sami Ozturk, Mustafa Gulec, Sacide Rana Isik, Ali Fuat Kalyoncu, Ozlem Goksel, Omur Aydin, Yavuz Havlucu, Idilhan Baloglu Ar, Ahmet Erdogdu
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2018)
Article
Allergy
Muge Olgac, Semra Dolek Guler, Semra Demir, Derya Unal, Belkis Ertek, Z. Ferhan Ozseker, Bahauddin Colakoglu, Halim Issever, Raif Coskun, Asli Gelincik, F. Canan Alatli, Suna Buyukozturk
Summary: Paucigranulocytic asthma (PGA) is the most common phenotype of stable asthma, characterized by predominant macrophages in sputum. PGA patients have a lower uncontrolled asthma ratio and lower FEV1 reversibility compared to other phenotypes.
ALLERGY AND ASTHMA PROCEEDINGS
(2021)
Article
Allergy
Sengul Beyaz, Yagmur Ersoy, Ela Bicki, Tumay Ak, Onur Erk Taparli, Ismet Bulut, Erdogan Gurgen, Zeynep Ferhan Ozseker
Summary: Anxiety and depression are prevalent in patients with drug hypersensitivity, leading to a significant decrease in their quality of life. Self-administered psychological questionnaires are useful in assessing and managing the psychological status of patients. Therefore, psychological support is critical in reducing the negative outcomes of hypersensitivity reactions in patients.
ALLERGY AND ASTHMA PROCEEDINGS
(2022)
Review
Allergy
Zeynep Ferhan Ozseker, Kurtulus Aksu, Levent Cem Mutlu, Pinar Mutlu, Can Ozturk
Summary: This article reviews the current knowledge on practice patterns in real-life management of mild asthma and highlights the recent updates in asthma treatment by The Global Initiative for Asthma (GINA). The study suggests a shift from short-acting beta 2-agonists (SABA)-only therapy to the use of symptom-driven low-dose inhaled corticosteroids (ICS)-formoterol combinations in mild asthma. The new recommendations aim to guide clinicians for the best clinical practice in applying these new treatment paradigms.
CURRENT ALLERGY AND ASTHMA REPORTS
(2022)
Article
Respiratory System
Sengul Beyaz, Emircan Erecan, Pinar Mutlu, Zeynep Ferhan Ozseker
Summary: The impact of biologic therapies on the course of SARS-CoV-2 infection and the outcome of COVID-19 for severe asthmatics were evaluated in this study. It was found that the rate of COVID-19 infection was higher in severe asthma patients receiving biologics, but treatment with biologics may have protection against severe COVID-19 and mortality. Further studies are needed to investigate the role of biologic agents in viral infections, especially SARS-CoV-2.
EURASIAN JOURNAL OF PULMONOLOGY
(2022)
Meeting Abstract
Immunology
Muge Olgac, Semra Dolek Guler, Semra Demir, Derya Unal, Belkis Ertek, Zeynep Ferhan Ozseker, Bahauddin Colakoglu, Halim Issever, Raif Coskun, Asli Gelincik, Fatma Canan Alatli, Suna Buyukozturk
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Bilun Gemicioglu, Arzu Didem Yalcin, Yavuz Havlucu, Gul Karakaya, Levent Ozdemir, Metin Keren, Sevim Bavbek, Dane Ediger, Ipek Kivilcim Oguzulgen, Zeynep Ferhan Ozseker, Arzu Yorgancioglu
Summary: The study on pregnant asthmatic patients receiving omalizumab treatment in our country showed that it appeared to be safe for both the patients and their infants, with no congenital anomalies detected and a low occurrence of low birth weight and prematurity in infants.
TURKISH JOURNAL OF MEDICAL SCIENCES
(2021)
Meeting Abstract
Critical Care Medicine
B. Gemicioglu, A. D. Yalcin, G. Karakaya, L. Ozdemir, M. Keren, A. A. Yorgancioglu, D. Ediger, S. Bavbek, Y. Havlucu, I. Oguzulgen, Z. F. Ozseker
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
Review
Respiratory System
Zeynep Ferhan Ozseker
EURASIAN JOURNAL OF PULMONOLOGY
(2020)
Article
Respiratory System
Cuneyt Tetikkurt, Zeynep Ferhan Ozseker, Fatma Gulsum Karakas
MONALDI ARCHIVES FOR CHEST DISEASE
(2019)
Meeting Abstract
Allergy
Y. Hacioglu, C. Kulahci, F. Ozseker
Meeting Abstract
Allergy
C. Kulahci, Y. Hacioglu, F. Ozseker