Journal
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
Volume 64, Issue 11, Pages 570-577Publisher
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2014.996706
Keywords
Doxorubicin; magnetic mesoporous silica nanoparticles; nanocarrier; PEGylated polyvinyl pyridine; pH-responsive
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In the present work a pH responsive drug nanocarrier based on magnetic mesoporous silica nanoparticles (MMSN) and polyethylene glycol-co-polyvinyl pyridine (PEG-co-PVP) was prepared. The core-shell nanocarrier was formed due to electrostatic interaction between protonated polyvinyl pyridine and surface modified MMSN with carboxylate groups. This carrier was used for pH-controllable doxorubicin release. The maximum release was occurred at pH 5.5 (pH of endosomes). This carrier was characterized by Fourier transform infrared spectroscopy, thermogravimetric analysis, UV-Vis spectrophotometer, scanning electron microscope, and high-resolution transmission electron microscope techniques. Also the zeta potential value and dynamic light scattering were measured. All characterizations confirmed the core-shell structure of the drug nanocarrier. [GRAPHICS] .
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