Journal
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
Volume 64, Issue 17, Pages 919-926Publisher
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2015.1030662
Keywords
Bone tissue engineering; differentiation of mesenchymal stem cell; in situ forming hydrogel; light cure; methacrylated chondroitin sulfate
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Funding
- Iran National Science Foundation [91052984]
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In this research, tissue engineered hydrogels consist of chondroitin sulfate and hydroxyapatite capable of light curing and cell encapsulation were prepared. Chemical and physical characteristics were analyzed by FTIR spectroscopy, compressive strength and water uptake measurements. Observations with fluorescence microscopy as well as MTT viability assay revealed no toxicity for encapsulated cells. Moreover, alkaline phosphatase activity, calcium deposition, and gene expression analysis were determined to prove the osteogenic potential of the prepared hydrogel. In conclusion, this in situ forming hydrogel can be utilized as filler for bone deficiencies as well as carrier for cell encapsulation and osteogenic differentiation.
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