Improving the API dissolution rate during pharmaceutical hot-melt extrusion I: Effect of the API particle size, and the co-rotating, twin-screw extruder screw configuration on the API dissolution rate

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Title
Improving the API dissolution rate during pharmaceutical hot-melt extrusion I: Effect of the API particle size, and the co-rotating, twin-screw extruder screw configuration on the API dissolution rate
Authors
Keywords
Hot-melt extrusion, Particle size, Screw configuration, Dissolution rate, Flowability, Amorphous solid dispersions
Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 478, Issue 1, Pages 103-112
Publisher
Elsevier BV
Online
2014-11-17
DOI
10.1016/j.ijpharm.2014.11.024

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