Journal
AMERICAN JOURNAL OF SURGERY
Volume 209, Issue 1, Pages 187-193Publisher
EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
DOI: 10.1016/j.amjsurg.2014.02.015
Keywords
Liver resection; Liver transplantation; Recurrence; Tumor marker; Inflammation
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BACKGROUND: We investigated whether a preoperative scoring system (the CRP-AFP Score [CAS]'') based on the serum levels of C-reactive protein and alpha-fetoprotein would predict outcome in patients undergoing hepatectomy for hepatocellular carcinoma. METHODS: The CAS was defined as follows: patients with an elevated level of both C-reactive protein (>.3 mg/dL) and alpha-fetoprotein (>20 ng/mL) were assigned a score of 2, and patients showing one or none of these abnormalities were assigned a score of 1 or 0, respectively. RESULTS: A total of 349 patients were identified. Pathologic findings, in terms of tumor size, histologic grade, vascular invasion, intrahepatic metastasis, and recurrence rate, worsened as the CAS increased. CAS 2 patients had a poorer 5-year overall survival than CAS 0 or 1 patients (32.2% vs 59.7% vs 49.2%, respectively; P < .001). CONCLUSIONS: The CAS is an informative scoring system that can predict outcome in patients with hepatocellular carcinoma after hepatectomy. (C) 2015 Elsevier Inc. All rights reserved.
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