Article
Endocrinology & Metabolism
Xueqi Yan, Aiqing Zhu, Yexing Li, Ziyi Yang, Yuteng Wang, Li Liu, Wei Liu, Dan Liu, Fenghua Li, Juan Du, Fang Cheng, Xueying Gao, Junli Zhao
Summary: In recent years, the right 2D:4D digit ratio has been considered as a marker for prenatal testosterone exposure. There is an ongoing debate whether the ratio is reduced in the right hand of Polycystic Ovary Syndrome (PCOS) women compared to non-PCOS women. This study systematically measured various digit ratios and found significant differences, particularly in the left hand 2D ratios, suggesting that digit ratios can serve as anatomical markers of prenatal testosterone exposure and potentially of PCOS diagnosis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Pharmacology & Pharmacy
Congshun Ma, Qianru Xiang, Ge Song, Xuefei Wang
Summary: Polycystic ovary syndrome (PCOS) is a reproductive endocrine disease with no specific drug treatment. Quercetin (QUR), a flavonoid, has potential therapeutic effects for PCOS patients. However, the mechanisms of QUR in PCOS patients remain unclear.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, Research & Experimental
Si-wei Zhang, Jing Zhou, Hans-Jurgen Gober, Wing Ting Leung, Ling Wang
Summary: PCOS is a common disorder in women of reproductive age, affecting their physiology and metabolism, and often leading to metabolic syndrome and insulin resistance; Berberine can intervene in the development of PCOS in multiple ways, including alleviating insulin resistance, reducing androgen levels, regulating lipid metabolism, and reducing inflammation.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Endocrinology & Metabolism
Kexin Wang, Yanhua Li
Summary: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age. The etiologies of this syndrome are complex and involve prenatal factors, genetic variation, epigenetic mechanisms, unhealthy lifestyles, and environmental toxins. This review examines the molecular mechanisms underlying PCOS pathogenesis at the level of signaling pathways and discusses potential therapies including exosome therapy, gene therapy, and drugs based on traditional Chinese medicine and natural compounds.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Daniel A. Dumesic, Ayli Tulberg, Karen L. Leung, Samantha C. Fisch, Tristan R. Grogan, David H. Abbott, Rajanigandha Naik, Gregorio D. Chazenbalk
Summary: In vitro differentiation of adipose stem cells into adipocytes in SC abdominal fat may predict insulin sensitivity in vivo in normal-weight women with PCOS, suggesting a potential role for hyperandrogenism in metabolic thrift. PCOS patients exhibited higher androgen levels, adipose-IR, and android fat percentage, while their adipocyte differentiation and gene expression in vitro were negatively correlated with adipose-IR and serum free testosterone but positively correlated with insulin sensitivity.
FERTILITY AND STERILITY
(2021)
Article
Reproductive Biology
Zaixin Guo, Xiaohan Chen, Penghui Feng, Qi Yu
Summary: In DHEA-induced PCOS mice, rapamycin exacerbated reproductive imbalance characterized by elevated testosterone levels and suppressed steroid synthesis.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Obstetrics & Gynecology
Sofia Persson, Evangelia Elenis, Sahruh Turkmen, Michael S. Kramer, Eu-Leong Yong, Inger Sundstrom Poromaa
Summary: This study found that polycystic ovary syndrome is an independent risk factor for type 2 diabetes, regardless of BMI adjustment. Women with the hyperandrogenic PCOS phenotype face a higher risk of type 2 diabetes than those with the normoandrogenic PCOS phenotype.
FERTILITY AND STERILITY
(2021)
Review
Biochemistry & Molecular Biology
Dejana Rakic, Vladimir Jakovljevic, Nikola Jovic, Marija Bicanin Ilic, Aleksandra Dimitrijevic, Tatjana Vulovic, Petar Arsenijevic, Jasmina Sretenovic, Maja Nikolic, Vladimir Petrovich Fisenko, Stefani Bolevich, Gala Zarkovic, Jovana Joksimovic Jovic
Summary: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age, and it has specific cardiometabolic properties. The presence of metabolic disorders in PCOS emphasizes the importance of regulating glycemic status. Sodium-glucose cotransporter type 2 inhibitors (SGLT-2is) have potential advantages in managing PCOS by improving glucose metabolism, reducing fat tissue, lowering blood pressure, reducing oxidative stress and inflammation, and protecting the cardiovascular system.
Article
Endocrinology & Metabolism
Frank Gonzalez, Robert Considine, Ola A. Abdelhadi, Jiaping Xue, Anthony J. Acton
Summary: In PCOS, saturated fat intake triggers proatherogenic inflammation pathways, independent of obesity. This effect is more pronounced in PCOS combined with obesity compared to obesity alone. Abdominal adiposity and hyperandrogenism may contribute to perpetuating proatherogenic inflammation.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Review
Cell Biology
Yi-Ru Tsai, Yen-Nung Liao, Hong-Yo Kang
Summary: Polycystic ovary syndrome (PCOS) is a common gynecological and endocrine disorder that affects the reproductive health of women. This article provides an overview of the latest cellular approaches used to study the pathophysiology of PCOS through in vitro cell models. It discusses abnormalities in folliculogenesis and explores potential treatments and underlying mechanisms, aiming to enhance our understanding of PCOS at a cellular level.
Article
Endocrinology & Metabolism
Yuanyuan Peng, Hongyue Yang, Jiahui Song, Di Feng, Zhijing Na, Hongyu Jiang, Yaxin Meng, Bei Shi, Da Li
Summary: This study analyzed the association between leptin and polycystic ovary syndrome (PCOS). The results showed that serum leptin levels were significantly higher in patients with PCOS and were associated with multiple metabolic markers. Combined detection of leptin and anti-Mullerian hormone (AMH) had high accuracy in diagnosing PCOS.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Hosna Mohammad Sadeghi, Ida Adeli, Daniela Calina, Anca Oana Docea, Taraneh Mousavi, Marzieh Daniali, Shekoufeh Nikfar, Aristidis Tsatsakis, Mohammad Abdollahi
Summary: PCOS is an endocrine-gynecology disorder affecting women of childbearing age, with incomplete understanding of its etiology and pathophysiology. Lifestyle modifications and alternative medicines are the preferred first-line therapy, and certain medications have shown potential for repurposing in PCOS. Further research and well-designed clinical trials are needed, as the current evidence is limited.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
Marina A. Skiba, Robin J. Bell, Dilinie Herbert, Alejandra Martinez Garcia, Rakibul M. Islam, Susan R. Davis
Summary: Despite applying stringent criteria for the diagnosis of PCOS in a non-healthcare seeking community-based sample, there remains a risk of diagnostic uncertainty in identifying women with PCOS.
HUMAN REPRODUCTION
(2021)
Article
Biochemistry & Molecular Biology
Emmi Rotgers, Barbara Nicol, Karina Rodriguez, Saniya Rattan, Jodi A. Flaws, Humphrey Hung-Chang Yao
Summary: The study found that overexpression of NR5A1 in female mice leads to reproductive dysfunction and metabolic imbalance, resulting in premature infertility. These results provide a new model for studying not only the molecular actions of NR5A1, but also the crosstalk between endocrine, reproductive, and metabolic systems.
Article
Immunology
Yi Zhai, Yanli Pang
Summary: PCOS is a common disorder related to endocrine/reproductive/metabolic systems, and it is associated with low-grade chronic inflammation. Patients with PCOS have higher levels of inflammatory cells and factors, as well as lower levels of anti-inflammatory cytokines. This systemic inflammation is thought to interact with obesity, insulin resistance, and hyperandrogenism.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Obstetrics & Gynecology
M. Peigne, S. Catteau-Jonard, G. Robin, A. Dumont, P. Pigny, D. Dewailly
HUMAN REPRODUCTION
(2018)
Article
Endocrinology & Metabolism
Sophie Catteau-Jonard, Anne Brunel, Agathe Dumont, Geoffroy Robin, Pascal Pigny, Didier Dewailly
ANNALES D ENDOCRINOLOGIE
(2019)
Article
Obstetrics & Gynecology
Sarah Desongnis, Geoffroy Robin, Didier Dewailly, Pascal Pigny, Sophie Catteau-Jonard
Summary: This study found that serum AMH <8 pmol/L before the age of 36 may increase the risk of POI, especially for women with irregular cycles. Regular follow-up is necessary for these women.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2021)
Editorial Material
Obstetrics & Gynecology
Didier Dewailly
FERTILITY AND STERILITY
(2021)
Editorial Material
Obstetrics & Gynecology
Didier Dewailly
FERTILITY AND STERILITY
(2021)
Review
Biochemistry & Molecular Biology
Simona Dinicola, Vittorio Unfer, Fabio Facchinetti, Christophe O. Soulage, Nicholas D. Greene, Mariano Bizzarri, Antonio Simone Lagana, Shiao-Yng Chan, Arturo Bevilacqua, Lali Pkhaladze, Salvatore Benvenga, Annarita Stringaro, Daniele Barbaro, Marialuisa Appetecchia, Cesare Aragona, Maria Salome Bezerra Espinola, Tonino Cantelmi, Pietro Cavalli, Tony T. Chiu, Andrew J. Copp, Rosario D'Anna, Didier Dewailly, Cherubino Di Lorenzo, Evanthia Diamanti-Kandarakis, Imelda Hernandez Marin, Moshe Hod, Zdravko Kamenov, Eleni Kandaraki, Giovanni Monastra, Mario Montanino Oliva, John E. Nestler, Maurizio Nordio, Ali C. Ozay, Olga Papalou, Giuseppina Porcaro, Nikos Prapas, Scott Roseff, Monica Vazquez-Levin, Ivana Vucenik, Artur Wdowiak
Summary: Myo-inositol and D-chiro-inositol are natural compounds with beneficial effects on gynecological and endocrinological diseases. They act as effective alternatives to insulin sensitizers, influencing steroidogenesis and the balance of androgens and estrogens. Ongoing research aims to uncover new roles and mechanisms for tailored inositol therapy in various medical areas.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Obstetrics & Gynecology
Virginie Simon, Geoffroy Robin, Christine Decanter, Didier Dewailly, Sophie Catteau-Jonard, Anne-Laure Barbotin, Pauline Plouvier
Summary: This study evaluated the impact of endometrial preparation on FET outcomes in anovulatory PCOS patients. Results showed that early pregnancy rates, miscarriage rates, and live birth rates were similar between stimulated and artificial cycles. In conclusion, the type of endometrial preparation does not influence FET outcomes, specifically regarding the miscarriage rate, in anovulatory PCOS women.
JOURNAL OF GYNECOLOGY OBSTETRICS AND HUMAN REPRODUCTION
(2022)
Letter
Obstetrics & Gynecology
Daniel Mayrhofer, Didier Dewailly, Marlene Hager, Rodrig Marculescu, Klara Beitl, Johannes Ott
FERTILITY AND STERILITY
(2022)
Article
Endocrinology & Metabolism
Sarah Makolle, Sophie Catteau-Jonard, Geoffroy Robin, Didier Dewailly
Summary: The study aimed to investigate the association between serum LH levels in women with FHA and PCOM and BMI, serum insulin, and AMH levels using a larger population of FHA. The results showed that 42% of the FHA population had PCOM, and the PCOM+ group had significantly higher BMI and serum AMH levels and significantly lower serum FSH levels compared to the other group. LH was positively correlated with fasting insulin and AMH in the PCOM+ group only, but not with BMI.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
M. Peigne, V Simon, P. Pigny, N. E. H. Mimouni, C. Martin, D. Dewailly, S. Catteau-Jonard, P. Giacobini
Summary: This study investigated the changes in serum concentration of total and cleaved anti-Muullerian hormone (AMH) molecular forms and androgens in women with and without PCOS before and throughout pregnancy. The results showed that women with PCOS had higher levels of total and cleaved AMH compared to controls from preconception to the third trimester of pregnancy, and higher levels of testosterone and androstenedione during pregnancy.
HUMAN REPRODUCTION
(2023)
Review
Medicine, General & Internal
Stefan Ghobrial, Johannes Ott, Johanna Steininger, Didier Dewailly, Gerhard Prager
Summary: Polycystic ovary syndrome (PCOS), the most common endocrine disorder in women of reproductive age, is associated with obesity. The most effective method to achieve and maintain long-term weight loss is by the Roux-en-Y gastric bypass (RYGB). RYGB leads to adequate weight loss and reduction in BMI in obese PCOS patients, as well as improvements in testosterone levels, hirsutism, and cycle irregularities. However, more comprehensive studies are needed to evaluate fertility outcomes in this patient population.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Obstetrics & Gynecology
Maeliss Peigne, Valerie Bernard, Laura Dijols, Helene Creux, Geoffroy Robin, Claude Hocke, Michael Grynberg, Didier Dewailly, Charlotte Sonigo
Summary: This study conducted a systematic review and meta-analysis to evaluate whether serum anti-Mullerian hormone (AMH) level can predict the cumulative live birth (CLB) rate after assisted reproductive technology (ART) or in women trying to conceive naturally. The results showed a positive relation between serum AMH level and CLB after IVF/ICSI, but there is a lack of data for IUI or natural conception without ART.
HUMAN REPRODUCTION
(2023)
Article
Medicine, General & Internal
Lucie Huyghe, Camille Robin, Agathe Dumont, Christine Decanter, Maeva Kyheng, Didier Dewailly, Sophie Catteau-Jonard, Geoffroy Robin
Summary: The objective of this study was to identify clinical, biological, and ultrasound factors that may predict resistance to 50 mg/day of CC in the first cycle of treatment for women with anovulatory PCOS. The study found that higher levels of AMH and lower levels of SHBG were significantly associated with resistance to 50 mg/day of CC. However, no satisfactory thresholds have been established for predicting resistance to 50 mg CC.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Sarah Eskenazi, Anne Bachelot, Justine Hugon-Rodin, Genevieve Plu-Bureau, Anne Gompel, Sophie Catteau-Jonard, Denise Molina-Gomes, Didier Dewailly, Catherine Dode, Sophie Christin-Maitre, Philippe Touraine
Summary: POI is often idiopathic, with a study finding that 38% of patients had genetic abnormalities detected through NGS analysis. NOBOX variants were the most common, and no significant differences were observed in family history, ethnic origin, age at onset, primary amenorrhea, or secondary menstrual disturbances between different genotypes.
JOURNAL OF THE ENDOCRINE SOCIETY
(2021)
Article
Obstetrics & Gynecology
Clemence Delcour, Geoffroy Robin, Jacques Young, Didier Dewailly
CLINICAL MEDICINE INSIGHTS-REPRODUCTIVE HEALTH
(2019)
