Article
Biotechnology & Applied Microbiology
Zihao Zhang, Haian Zhong, Shudai Lin, Li Liang, Shaopan Ye, Zhenqiang Xu, Congliang Ji, Zhe Zhang, Dexiang Zhang, Xiquan Zhang
Summary: The study found significant associations between multiple SNPs in the genomic regions of the AMY1A gene and traits such as feed intake efficiency, growth traits, and carcass characteristics in chickens. Haplotypes based on specific SNPs in AMY1A were also found to be significantly associated with important traits like daily gain and abdominal fat. This research provides substantial evidence for the potential impact of AMY1A polymorphisms on chicken breeding programs.
Article
Multidisciplinary Sciences
Ezequiel Jorge-Smeding, Sergio Polakof, Muriel Bonnet, Stephanie Durand, Delphine Centeno, Melanie Petera, Sebastien Taussat, Gonzalo Cantalapiedra-Hijar
Summary: This study investigated plasma biomarkers and metabolic pathways related to residual feed intake (RFI) in Charolais heifers, finding that plasma concentrations of IGF-1 and back fat depth were associated with RFI. However, there were no changes in other plasma concentrations. Metabolic pathway analysis revealed that branched chain amino acid metabolism was significantly impacted by RFI. These findings confirm previous research in male beef cattle and suggest that changes in branched-chain amino acids metabolism and body composition are biological mechanisms related to RFI.
Article
Genetics & Heredity
Ao Qi, Jianyu Yan, Yu Yang, Jia Tang, Wenxiu Ru, Xiaojun Jiang, Chuzhao Lei, Xiuzhu Sun, Hong Chen
Summary: This study found that four polymorphic loci of ASB-3 gene were associated with growth traits in cattle breeds. The results suggest that ASB-3 may be an important candidate gene, and these four SNPs can be used for molecular marker-assisted selection of beef cattle breeds.
Article
Genetics & Heredity
Chaoyun Yang, Liyun Han, Peng Li, Yanling Ding, Yun Zhu, Zengwen Huang, Xingang Dan, Yuangang Shi, Xiaolong Kang
Summary: This study utilized RNA sequencing to identify key genes and functional pathways contributing to variance in cattle RFI phenotypes, uncovering differentially expressed genes and key genes related to metabolism, oxidative phosphorylation, and feed intake behavior. The findings suggest specific biological functions of the duodenum in regulating feed intake and provide insights into potential pathways and key genes involved in feed efficiency regulation in beef cattle.
FRONTIERS IN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Xiwen Zeng, Weimin Wang, Deyin Zhang, Xiaolong Li, Yukun Zhang, Yuan Zhao, Liming Zhao, Jianghui Wang, Dan Xu, Jiangbo Cheng, Wenxin Li, Bubo Zhou, Changchun Lin, Xiaobin Yang, Rui Zhai, Zongwu Ma, Jia Liu, Panpan Cui, Xiuxiu Weng, Weiwei Wu, Xiaoxue Zhang, Wenxin Zheng
Summary: In this study, the expression levels of the BANK1 gene and its polymorphism were investigated in Hu sheep using qRT-PCR, Sanger sequencing, and KASPar methods. The results revealed that the BANK1 gene was extensively expressed in multiple tissues, with significantly higher expression in lymph tissue. Additionally, a polymorphism locus, g.93888 A > T, in intron 4 of the BANK1 gene was found to be significantly associated with feed efficiency traits.
DNA AND CELL BIOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Ziyi Pan, Xuewen Li, Dongsheng Wu, Xingyong Chen, Cheng Zhang, Sihua Jin, Zhaoyu Geng
Summary: This study investigated the effect of the RXRA gene on duck preadipocytes and identified a significant relationship between RXRA mutation and duck feed efficiency. The findings suggest that RXRA promotes fat accumulation in duck preadipocytes and provides molecular markers for breeding efficient ducks.
Article
Agriculture, Dairy & Animal Science
G. Manafiazar, C. Fitzsimmons, M. Zhou, J. A. Basarab, V. S. Baron, L. McKeown, L. L. Guan
Summary: This study investigated the diversity of fecal methanogen profiles among efficient and inefficient beef heifers and found that fecal methanogen profiles may be used to predict methane emissions in cattle.
Article
Multidisciplinary Sciences
Chaoyun Yang, Zengwen Huang, Cuili Pan, Shuzhe Wang
Summary: This study identified critical signatures and biological processes associated with feed efficiency in beef cattle by analyzing liver transcriptome data. Differences in feed efficiency between Angus and Charolais cattle were found to be related to substance metabolism, energy metabolism, and gene transcription. The study also identified five key candidate genes associated with hepatic lipid metabolism.
Article
Agriculture, Dairy & Animal Science
Jigme Dorji, Iona M. MacLeod, Amanda J. Chamberlain, Christy J. Vander Jagt, Phuong N. Ho, Majid Khansefid, Brett A. Mason, Claire P. Prowse-Wilkins, Leah C. Marett, William J. Wales, Benjamin G. Cocks, Jennie E. Pryce, Hans D. Daetwyler
Summary: The study found that animals with high RFI require more energy to achieve weight gain or milk production compared to animals with low RFI. Differential expression of MiP genes between H_RFI and L_RFI groups suggests a link between cellular energy demand and feed efficiency differences in dairy cattle.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Genetics & Heredity
Robert N. Vaughn, Kelli J. Kochan, Aline K. Torres, Min Du, David G. Riley, Clare A. Gill, Andy D. Herring, James O. Sanders, Penny K. Riggs
Summary: The study revealed a relationship between the expression of the ACTN3 gene in skeletal muscle and feed efficiency in crossbred steers. The inefficient group showed higher expression of ACTN3 and a maternal effect was observed in ACTN3 inheritance. Additionally, a significant breed effect was found in other genes related to feed efficiency, suggesting a possible link between muscle fiber type ratio and feed efficiency.
FRONTIERS IN GENETICS
(2022)
Article
Agriculture, Dairy & Animal Science
Ales Knoll, Michaela Nesvadbova, Tomas Urban
Summary: NREP gene plays a critical role in muscle transformation in pigs, with higher expression levels in Czech Large White pigs compared to wild boars and positive associations with meat-related traits, suggesting its potential as a marker for selection in improving pork production.
JOURNAL OF ANIMAL BREEDING AND GENETICS
(2022)
Article
Multidisciplinary Sciences
Eun Hee Hong, Hoseok Yeom, Hyo Seon Yu, Jong Eun Park, Yong Un Shin, So-Young Bang, Heeyoon Cho
Summary: This study analyzed the association between the genetic profile of patients with diabetic macular edema (DME) and their response to intravitreal anti-VEGF injection. Several genes were found to be associated with treatment response, including DIRC3, SLCO3A1, and RAB2A. Pathway analysis revealed a connection between RAB2A and CREB5 with AMPK signaling related to VEGF. These genetic biomarkers can provide insights into patient response and guide therapeutic strategies.
SCIENTIFIC REPORTS
(2022)
Article
Agriculture, Dairy & Animal Science
Peng Wan, Xueyao Yang, Yulian Li, Bizhi Huang, Cuicui Cai
Summary: A new missense mutation in the bovine SDK1 gene was found in native Chinese cattle breeds, with the mutant allele frequency decreasing from southern to northern cattle groups, while the wild-type allele frequency showed an opposite pattern, consistent with the distribution of indicine and taurine cattle in China. This suggests that the bovine SDK1 gene may be a candidate gene associated with disease resistance in Chinese cattle.
ANIMAL BIOTECHNOLOGY
(2021)
Article
Fisheries
Catarina Basto-Silva, Paula Enes, Aires Oliva-Teles, Encarnacion Capilla, Ines Guerreiro
Summary: This study evaluated the effects of dietary protein/carbohydrate ratio and feeding frequency on the growth, metabolism, and economic efficiency of gilthead seabream juveniles. The results showed that feeding a diet with a protein/carbohydrate ratio of 40%/20% twice a day was the most suitable strategy, as it improved fish growth and economic efficiency.
Review
Agriculture, Dairy & Animal Science
Sang Weon Na, Le Luo Guan
Summary: This review discusses the relationship between rumen microbiota and cattle feed efficiency, emphasizing the importance of rumen epithelium and epimural microbiota in feed efficiency.
Article
Evolutionary Biology
Michael P. Heaton, Timothy P. L. Smith, Derek M. Bickhart, Brian L. Vander Ley, Larry A. Kuehn, Jonas Oppenheimer, Wade R. Shafer, Fred T. Schuetze, Brad Stroud, Jennifer C. McClure, Jennifer P. Barfield, Harvey D. Blackburn, Theodore S. Kalbfleisch, Kimberly M. Davenport, Kristen L. Kuhn, Richard E. Green, Beth Shapiro, Benjamin D. Rosen
Summary: Genomics research has increasingly acknowledged the limitation of single reference genomes and turned to pangenome representations, with the Bovine Pangenome Consortium aiming to assemble genomes from over 600 recognized cattle breeds to capture the broadest genetic diversity. This study presents a complete single haplotype assembly for a Simmental cow, a triple-purpose breed known for its fast growth and beef yields, suggesting promising continuity and completeness comparable to the best Bos taurus reference assemblies.
JOURNAL OF HEREDITY
(2021)
Article
Evolutionary Biology
Jonas Oppenheimer, Benjamin D. Rosen, Michael P. Heaton, Brian L. Vander Ley, Wade R. Shafer, Fred T. Schuetze, Brad Stroud, Larry A. Kuehn, Jennifer C. McClure, Jennifer P. Barfield, Harvey D. Blackburn, Theodore S. Kalbfleisch, Derek M. Bickhart, Kimberly M. Davenport, Kristen L. Kuhn, Richard E. Green, Beth Shapiro, Timothy P. L. Smith
Summary: This study focuses on sequencing and assembling the genome of the American plains bison, which provides a highly contiguous genome and serves as a new tool for researching the evolutionary history of this iconic species and managing bison populations.
JOURNAL OF HEREDITY
(2021)
Article
Agriculture, Dairy & Animal Science
Andre Mauric F. Ribeiro, Leticia P. Sanglard, Warren M. Snelling, R. Mark Thallman, Larry A. Kuehn, Matthew L. Spangler
Summary: This study analyzed a crossbred beef population to estimate the genetic relationship, heterosis, and breed effects between mature cow weight (MWT) and body condition score (BCS). The results showed that MWT and BCS are moderately genetically correlated and would respond favorably to selection. Breed differences and heterotic effects can be used in multibreed genetic evaluations for cow maintenance energy requirements.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Sophie C. Walsh, Jeremy R. Miles, Brittney N. Keel, Lea A. Rempel, Elane C. Wright-Johnson, Amanda K. Lindholm-Perry, William T. Oliver, Angela K. Pannier
Summary: This study identified transcriptome differences and highlighted the importance of gene regulation during the morphological transitions of spherical, ovoid, and tubular porcine blastocysts. The analysis revealed the involvement of lipid signaling and membrane/ECM remodeling in this rapid morphological change.
MOLECULAR REPRODUCTION AND DEVELOPMENT
(2022)
Article
Agriculture, Dairy & Animal Science
Leticia P. Sanglard, Larry A. Kuehn, Warren M. Snelling, Matthew L. Spangler
Summary: This study investigated the genetic and non-genetic factors associated with mitochondrial DNA copy number (mtDNA CN) in a beef cattle population, revealing that a significant portion of mtDNA CN variation is under genetic control, while non-genetic factors such as tissue type, age, and sex also play a significant role in influencing mtDNA CN.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Genetics & Heredity
Matthew S. Crouse, Joel S. Caton, Kate J. Claycombe-Larson, Wellison J. S. Diniz, Amanda K. Lindholm-Perry, Lawrence P. Reynolds, Carl R. Dahlen, Pawel P. Borowicz, Alison K. Ward
Summary: Epigenetic modifiers are crucial for early embryonic development, with roles as methyl donors and cofactors in methylation reactions. Supplementation of multiple epigenetic modifiers in ruminants can enhance cell growth, mitochondrial function, and DNA methylation, potentially improving growth parameters beyond control treated cells.
FRONTIERS IN GENETICS
(2022)
Article
Multidisciplinary Sciences
Wellison J. S. Diniz, Matthew S. Crouse, Joel S. Caton, Kate J. Claycombe-Larson, Amanda K. Lindholm-Perry, Lawrence P. Reynolds, Carl R. Dahlen, Pawel P. Borowicz, Alison K. Ward
Summary: Fetal programming, established early in life through epigenetic mechanisms, can be influenced by micronutrients acting as epigenetic modifiers (EM). This study provides a genome-wide DNA methylation dataset of bovine embryonic fibroblast cells exposed to different supplementation levels of glucose and EM. The findings offer valuable information on putative candidate genes responsive to DNA methylation due to EM supplementation.
Article
Agriculture, Dairy & Animal Science
El Hamidi Hay, Sajjad Toghiani, Andrew J. Roberts, Tiago Paim, Larry Alexander Kuehn, Harvey D. Blackburn
Summary: Genomic composition of composite breeds is not stable across generations and the Tarentaise breed contributes useful attributes as a progenitor beef cattle breed in a cool semi-arid environment.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Amanda K. Lindholm-Perry, Allison M. Meyer, Rebecca J. Kern-Lunbery, Hannah C. Cunningham-Hollinger, Taran H. Funk, Brittney N. Keel
Summary: This study conducted a meta-analysis of the ruminal transcriptome of two unrelated populations of cattle to identify genes involved in feed efficiency. A total of 83 differentially expressed genes were identified, some of which have been previously identified in other studies on feed efficiency. These genes may serve as more robust indicators of feed efficiency.
Article
Agriculture, Dairy & Animal Science
Leticia P. Sanglard, Warren M. Snelling, Larry A. Kuehn, R. Mark Thallman, Harvey C. Freetly, Tommy L. Wheeler, Steven D. Shackelford, D. Andy King, Matthew L. Spangler
Summary: This study investigated the relationship between mitochondrial DNA copy number (mtDNA CN) and growth and carcass traits in a composite beef cattle population. The results showed that mtDNA CN was associated with birth weight and weaning weight, but there was no association between mtDNA SNP, haplogroups, or types with growth and carcass traits. The genetic correlation estimates of mtDNA CN with growth and carcass traits were mostly negative and ranged from low to moderate. Overall, mtDNA CN could be potentially used as a genetic indicator for growth in beef cattle.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Andrew D. Lakamp, Cashley M. Ahlberg, Kristi Allwardt, Ashely Broocks, Kelsey Bruno, Levi Mcphillips, Alexandra Taylor, Clint R. Krehbiel, Michelle S. Calvo-Lorenzo, Chris Richards, Sara E. Place, Udaya Desilva, Larry A. Kuehn, Robert L. Weaber, Jennifer M. Bormann, Megan M. Rolf
Summary: Predicted methane traits are heritable and easy to calculate, making them potential candidates for selecting animals with low methane production. Using a mathematical model to predict methane production can overcome the difficulties and expenses of direct measurement, and animals can be ranked similarly regardless of the model used. A genome-wide association study identified significant loci and genes related to predicted methane production, including oxidoreductase activity and collagen production.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
John W. Keele, Tara G. McDaneld, Larry A. Kuehn
Summary: The genetic evaluation of seedstock cattle could benefit from commercial data, but the hidden relationships between the commercial and seedstock sectors pose a challenge. Single nucleotide polymorphism genotypes can reveal these relationships, but the cost of genotyping can be prohibitive. Pooling DNA is a cost-effective strategy to capture commercial data, but inexact pool formation can complicate interpretation.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Elizabeth A. Dressler, William Shaffer, Kelsey Bruno, Clint R. Krehbiel, Michelle Calvo-Lorenzo, Chris J. Richards, Sara E. Place, Udaya DeSilva, Larry A. Kuehn, Robert L. Weaber, Jennifer M. Bormann, Megan M. Rolf
Summary: This study evaluated novel phenotypes related to feed and water intake behaviors and estimated their heritabilities, variance components, and genetic and phenotypic correlations. Understanding the importance of feed and water intake is crucial for cattle production as it impacts producer profitability and sustainability. While previous studies have focused on feed and water intake, the associated feeding and drinking behaviors are relatively unknown and lack standardized phenotypes. This study assessed five behaviors of feed and water intake using individual animal records and identified significant single nucleotide polymorphisms for these behaviors.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Amanda K. Lindholm-Perry, Larry A. Kuehn, James E. Wells, Lea A. Rempel, Carol G. Chitko-McKown, Brittney N. Keel, William T. Oliver
Summary: This study aimed to investigate the association between hematology parameters in pigs and feed efficiency metrics. Platelet count, lymphocyte count, neutrophil, RBC counts, hemoglobin, hematocrit, and changes in these parameters were found to be correlated with average daily gain and average daily feed intake. Changes in RBC measurements, particularly hematocrit, were identified as potentially useful measurements to supplement feed efficiency phenotypes in swine.
TRANSLATIONAL ANIMAL SCIENCE
(2021)
Meeting Abstract
Agriculture, Dairy & Animal Science
Madison T. Henniger, Lea A. Rempel, William T. Oliver, Jeremy R. Miles, Amanda Lindholm-Perry, Phillip R. Myer
JOURNAL OF ANIMAL SCIENCE
(2021)