Article
Agriculture, Dairy & Animal Science
Daniel Polasik, Jacek Golinczak, Witold Proskura, Arkadiusz Terman, Andrzej Dybus
Summary: The study aimed to detect polymorphisms in the THRSP gene and analyze their impact on fatty acid composition in milk of Jersey and Holstein-Friesian cattle. A significant association between the analyzed SNP and fatty acid content in milk was found, suggesting its potential as a marker for milk quality improvement. Variants of the THRSP gene may play a role in the de novo synthesis of fatty acids in lactating mammary glands, with differing activity levels.
Article
Biotechnology & Applied Microbiology
Xiao-Meng Hu, Junbo Zhang, Wen-Yang Ding, Xiao Liang, Rong Wan, Sergey Dobretsov, Jin-Long Yang
Summary: The inactivation of the tesA gene in Pseudoalteromonas marina increased the c-di-GMP content, reduced fatty acid content, weakened motility, and enhanced biofilm formation, resulting in a significant decrease in mussel larval metamorphosis rate. Addition of extracted fatty acids from P. marina to the Delta tesA biofilms promoted biofilm-inducing capacity, indicating a regulation of bacterial biofilm composition by tesA gene.
Article
Agriculture, Dairy & Animal Science
David Gamarra, Noelia Aldai, Aisaku Arakawa, Marian M. Pancorbo, Masaaki Taniguchi
Summary: This study revealed that the SL genotype of the 84 bp-indel in the SREBP1 gene is associated with higher content of polyunsaturated fatty acids in backfat, especially in the Pirenaica breed. However, the gene expression level of SREBP1 is not influenced by the genotypes of the 84 bp-indel.
ANIMAL SCIENCE JOURNAL
(2021)
Article
Biotechnology & Applied Microbiology
Kathryn Mains, Jackson Peoples, Jerome M. Fox
Summary: This study shows that adjusting enzyme concentration in fatty acid synthesis can significantly affect the type and yield of products, with the specific impact depending on environmental conditions and the concentrations of other enzyme components.
METABOLIC ENGINEERING
(2022)
Article
Agriculture, Dairy & Animal Science
Frances A. Arend, Gordon K. Murdoch, Matt E. Doumit, Gwinyai E. Chibisa
Summary: This study evaluated the effects of feeding a high amount of grape pomace to finishing cattle and found that it can enhance both the sensory quality and the health value of beef lipids.
Article
Biochemistry & Molecular Biology
Tahreer Mohammed Al-Thuwaini, Mohammed Baqur Sahib Al-Shuhaib
Summary: This study investigated the association between variations in the SCD gene and fatty acid composition in Awassi sheep. The TA genotype was found to result in increased intramuscular fat and monounsaturated fatty acids compared to the TT genotype. Breeding for the TA genotype can be used to produce meat that is more favorable for human consumption.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Ji Su Yang, Naeun Yoon, Mingyu Kong, Byung Hwa Jung, Hyunbeom Lee, Jinyoung Park
Summary: While attempts were made to inhibit cancer cell growth by combining FASN and USP14 inhibitors, there were no synergistic effects on cancer cell death compared to FASN inhibitor alone. Surprisingly, the USP14 inhibitor IU1 did not significantly affect FASN levels in cancer cells, and metabolite changes in IU1-treated cells differed significantly from those in cells treated with the FASN inhibitor Fasnall.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Li-Ping Peng, Qing Hao, Si-Qi Men, Xi-Ruo Wang, Wen-Yuan Huang, Ning-Ning Tong, Mo Chen, Zheng-An Liu, Xiao-Feng Ma, Qing-Yan Shu
Summary: The study identified a CHS homolog gene in Paeonia ostii, showing the highest expression in developing seeds. In vitro assays confirmed the enzymatic activity of PoCHS protein, with optimal pH and reaction temperature. Ectopic over-expression of PoCHS in Arabidopsis up-regulated genes related to seed development, glycolysis, and fatty acid biosynthesis, resulting in increased unsaturated fatty acid content in transgenic seeds.
PHYSIOLOGIA PLANTARUM
(2021)
Article
Agriculture, Dairy & Animal Science
Keiichi Inoue, Motohide Nishio, Noriaki Shoji, Hiroyuki Hirooka
Summary: This study explores the effects of pedigree information on imprinting variances in Japanese Black cattle for carcass traits and fatty acid composition. It was found that using the sire-maternal grandsire model can be useful for estimating imprinting variance under certain conditions, and that maternal gametic effects on beef marbling score should be considered in breeding programs for Japanese Black cattle to avoid selection bias caused by imprinting effects.
JOURNAL OF ANIMAL BREEDING AND GENETICS
(2021)
Article
Agriculture, Dairy & Animal Science
Carlo Corino, Francesco Vizzarri, Sabrina Ratti, Mirco Pellizzer, Raffaella Rossi
Summary: This study evaluates the effect of adding omega-3 fatty acids (FA) lipid supplement to beef diet on the nutritional characteristics of Longissimus lumborum (LL) muscle. The results show that the supplement improves the fatty acid profile and decreases cholesterol content of the meat, enhancing consumer health.
Article
Biotechnology & Applied Microbiology
Feifei Xin, Meng Gao, Yufei Chang, Wenrui Dang, Ruixue Wang, Hongjuan Yuan, Zhike Xie, Yanlei Zhao, Yuanda Song, Chunchi Rong, Huaiyuan Zhang
Summary: The ACOT8 enzyme in Mucor circinelloides plays a crucial role in fatty acid metabolism. Three genes were examined and found to increase total fatty acid content but had no significant impact on fatty acid composition.
FERMENTATION-BASEL
(2023)
Article
Food Science & Technology
Yong Geum Shin, Dhanushka Rathnayake, Hong Seok Mun, Muhammad Ammar Dilawar, Sreynak Pov, Chul Ju Yang
Summary: This study found that supplementation of stevioside and organic selenium in the diet of Hanwoo cattle can improve body weight, weight gain, carcass crude protein content, reduce drip loss and shear force, enhance redness in meat, and improve the polyunsaturated fatty acid content while delaying lipid oxidation during storage. Although there was a trend of decrease in microbial count, it was not significant, and all sensory attributes were enhanced with the supplementation.
Article
Biochemistry & Molecular Biology
John E. Cronan
Summary: FadR is a transcription factor in E. coli that regulates fatty acid metabolism in response to environmental fatty acids. It represses fatty acid degradation genes and activates fatty acid synthesis genes. Overproduction of FadR increases fatty acid yields but may have negative effects on cell physiology.
MOLECULAR MICROBIOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Wenyu Zhang, Ming Yang, Wanlu Li, Lin Zhou, Yaoyao Shen, Shu-Ping Wang, Jin-Ming Gao, Hou-Wen Lin, Jianzhao Qi, Yongjun Zhou
Summary: This study discovered antitumor oxazole-containing compounds and identified the enzyme pathways involved in their biosynthesis. The production of these compounds was found to be correlated with specific biosynthetic pathways and can be generated by a unique enzyme called Cong-TE. Biochemical analysis showed that Cong-TE has broad substrate compatibility. This work provides a prospect for environmentally friendly synthesis of valuable oxazole-containing esters.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Jialiang Wang, Zixin Deng, Jingdan Liang, Zhijun Wang
Summary: Iterative type I polyketide synthases (iPKSs) are megaenzymes that synthesize complex natural products with diverse bioactivities. The programmed patterns of domain combinations during the synthetic cycle of iPKSs strongly influence the complexity of the resulting natural products. This article reviews the structural enzymology of iPKSs, focusing on individual domain structures and their representative programming activities.
NATURAL PRODUCT REPORTS
(2023)
Article
Evolutionary Biology
Andrea Talenti, Francesca Bertolini, Jamie Williams, Muhammad Moaeen-ud-Din, Stefano Frattini, Beatrice Coizet, Giulio Pagnacco, James Reecy, Max F. Rothschild, Paola Crepaldi
JOURNAL OF HEREDITY
(2018)
Article
Biotechnology & Applied Microbiology
Gabriella B. Oliveira, Luciana C. A. Regitano, Aline S. M. Cesar, James M. Reecy, Karina Y. Degaki, Mirele D. Poleti, Andrezza M. Felicio, James E. Koltes, Luiz L. Coutinho
Article
Biotechnology & Applied Microbiology
Gabriel Costa Monteiro Moreira, Clarissa Boschiero, Aline Silva Mello Cesar, James M. Reecy, Thais Fernanda Godoy, Priscila Anchieta Trevisoli, Mauricio E. Cantao, Monica Correa Ledur, Adriana Mercia Guaratini Ibelli, Jane de Oliveira Peixoto, Ana Silvia Alves Meira Tavares Moura, Dorian Garrick, Luiz Lehmann Coutinho
Article
Biotechnology & Applied Microbiology
Aline S. M. Cesar, Luciana C. A. Regitano, James M. Reecy, Mirele D. Poleti, Priscila S. N. Oliveira, Gabriella B. de Oliveira, Gabriel C. M. Moreira, Mauricio A. Mudadu, Polyana C. Tizioto, James E. Koltes, Elyn Fritz-Waters, Luke Kramer, Dorian Garrick, Hamid Beiki, Ludwig Geistlinger, Gerson B. Mourao, Adhemar Zerlotini, Luiz L. Coutinho
Article
Immunology
Hamid Beiki, Abbas Pakdel, Ardeshir Nejati Javaremi, Ali Masoudi-Nejad, James M. Reecy
Article
Genetics & Heredity
Aniek C. Bouwman, Hans D. Daetwyler, Amanda J. Chamberlain, Carla Hurtado Ponce, Mehdi Sargolzaei, Flavio S. Schenkel, Goutam Sahana, Armelle Govignon-Gion, Simon Boitard, Marlies Dolezal, Hubert Pausch, Rasmus F. Brondum, Phil J. Bowman, Bo Thomsen, Bernt Guldbrandtsen, Mogens S. Lund, Bertrand Servin, Dorian J. Garrick, James Reecy, Johanna Vilkki, Alessandro Bagnato, Min Wang, Jesse L. Hoff, Robert D. Schnabel, Jeremy F. Taylor, Anna A. E. Vinkhuyzen, Frank Panitz, Christian Bendixen, Lars-Erik Holm, Birgit Gredler, Chris Hoze, Mekki Boussaha, Marie-Pierre Sanchez, Dominique Rocha, Aurelien Capitan, Thierry Tribout, Anne Barbat, Pascal Croiseau, Cord Drogemuller, Vidhya Jagannathan, Christy Vander Jagt, John J. Crowley, Anna Bieber, Deirdre C. Purfield, Donagh P. Berry, Reiner Emmerling, Kay-Uwe Goetz, Mirjam Frischknecht, Ingolf Russ, Johann Soelkner, Curtis P. Van Tassell, Ruedi Fries, Paul Stothard, Roel F. Veerkamp, Didier Boichard, Mike E. Goddard, Ben J. Hayes
Article
Multidisciplinary Sciences
Somayeh Sharifi, Abbas Pakdel, Mansour Ebrahimi, James M. Reecy, Samaneh Fazeli Farsani, Esmaeil Ebrahimie
Article
Mathematical & Computational Biology
Lisa Harper, Jacqueline Campbell, Ethalinda K. S. Cannon, Sook Jung, Monica Poelchau, Ramona Walls, Carson Andorf, Elizabeth Arnaud, Tanya Z. Berardini, Clayton Birkett, Steve Cannon, James Carson, Bradford Condon, Laurel Cooper, Nathan Dunn, Christine G. Elsik, Andrew Farmer, Stephen P. Ficklin, David Grant, Emily Grau, Nic Herndon, Zhi-Liang Hu, Jodi Humann, Pankaj Jaiswal, Clement Jonquet, Marie-Angelique Laporte, Pierre Larmande, Gerard Lazo, Fiona McCarthy, Naama Menda, Christopher J. Mungall, Monica C. Munoz-Torres, Sushma Naithani, Rex Nelson, Daureen Nesdill, Carissa Park, James Reecy, Leonore Reiser, Lacey-Anne Sanderson, Taner Z. Sen, Margaret Staton, Sabarinath Subramaniam, Marcela Karey Tello-Ruiz, Victor Unda, Deepak Unni, Liya Wang, Doreen Ware, Jill Wegrzyn, Jason Williams, Margaret Woodhouse, Jing Yu, Doreen Main
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION
(2018)
Article
Multidisciplinary Sciences
Gabriel Costa Monteiro Moreira, Clarissa Boschiero, Aline Silva Mello Cesar, James M. Reecy, Thais Fernanda Godoy, Fabio Pertille, Monica Correa Ledur, Ana Silvia Alves Meira Tavares Moura, Dorian J. Garrick, Luiz Lehmann Coutinho
SCIENTIFIC REPORTS
(2018)
Article
Genetics & Heredity
L. M. Kramer, M. S. Mayes, E. D. Downey, R. G. Tait, A. Woolums, C. Chase, J. M. Reecy
Article
Biochemistry & Molecular Biology
Zhi-Liang Hu, Carissa A. Park, James M. Reecy
NUCLEIC ACIDS RESEARCH
(2019)
Article
Biotechnology & Applied Microbiology
H. Beiki, H. Liu, J. Huang, N. Manchanda, D. Nonneman, T. P. L. Smith, J. M. Reecy, C. K. Tuggle
Article
Agriculture, Dairy & Animal Science
Simara Larissa Fanalli, Bruna Pereira Martins da Silva, Julia Dezen Gomes, Vivian Vezzoni de Almeida, Felipe Andre Oliveira Freitas, Gabriel Costa Monteiro Moreira, Barbara Silva-Vignato, Juliana Afonso, James Reecy, James Koltes, Dawn Koltes, Luciana Correia de Almeida Regitano, Dorian John Garrick, Julio Cesar de Carvalho Balieiro, Ariana Nascimento Meira, Luciana Freitas, Luiz Lehmann Coutinho, Heidge Fukumasu, Gerson Barreto Mourao, Severino Matias de Alencar, Albino Luchiari Filho, Aline Silva Mello Cesar
Summary: This study analyzed the transcriptome profiles of skeletal muscle and liver samples from pigs fed diets with different levels of soybean oil. The findings showed that the diet affected the fatty acid composition in tissues and led to differential expression of genes related to lipid oxidation, metabolic diseases, and inflammation.
Article
Genetics & Heredity
Simara Larissa Fanalli, Bruna Pereira Martins da Silva, Julia Dezen Gomes, Vivian Vezzoni de Almeida, Gabriel Costa Monteiro Moreira, Barbara Silva-Vignato, Juliana Afonso, Felipe Andre Oliveira Freitas, James Mark Reecy, James Eugene Koltes, Dawn Koltes, Dorian Garrick, Luciana Correia de Almeida Regitano, Julio Cesar de Carvalho Balieiro, Gerson Barreto Mourao, Luiz Lehmann Coutinho, Heidge Fukumasu, Mirele Daiana Poleti, Severino Matias de Alencar, Albino Luchiari Filho, Aline Silva Mello Cesar
Summary: This study evaluated the impact of different lipid sources on gene expression in porcine skeletal muscle tissue using RNA-Seq, and identified differentially expressed genes involved in metabolic pathways and biological processes. Addition of fish oil in pig diets resulted in intramuscular lipid with a higher composition of certain fatty acids. Blood parameters showed lower cholesterol and HDL content in the fish oil group compared to the other two groups. Enrichment analysis revealed differentially expressed genes related to lipid metabolism, metabolic diseases, and inflammation, as well as specific gene functions and altered blood parameters in each group.
FUNCTIONAL & INTEGRATIVE GENOMICS
(2023)
Article
Mathematical & Computational Biology
Zhi-Liang Hu, Carissa A. Park, James M. Reecy
Summary: A precise description of traits is crucial in genetics and genomics studies. Despite previous standardization efforts, capturing trait nomenclature granularity remains a challenge. However, by using trait modifiers and qualifiers to extend livestock trait ontologies, the management and curation of trait information have been streamlined.
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION
(2023)
