4.7 Article

Refinement of a quantitative gene locus on equine chromosome 16 responsible for osteochondrosis in Hanoverian warmblood horses

Journal

ANIMAL
Volume 3, Issue 9, Pages 1224-1231

Publisher

CAMBRIDGE UNIV PRESS
DOI: 10.1017/S1751731109004765

Keywords

horse; osteochondrosis; QTL; fine-mapping

Ask authors/readers for more resources

Osteochondrosis (OC) is an inherited developmental disease in young horses most frequently observed in thoroughbreds, trotters, warmblood and coldblood horses. Quantitative trait loci (QTL) for equine OC have been identified in Hanoverian warmblood horses employing a whole genome scan with microsatellites. A QTL on ECA16 reached the genome-wide significance level for hock osteochondrosis dissecans (OCD). The aim of this study was to refine this QTL on ECA16 using an extended marker set of 34 newly developed microsatellites and 15 single nucleotide polymorphisms (SNPs). We used the same 14 paternal half-sib groups as in the above-mentioned whole genome scan. The QTL for OCD in hock joints on ECA16 could be delimited at an interval between 17.60 and 45.18 Mb using multipoint non-parametric linkage analyses. In addition, six microsatellites and one SNP were significantly associated with hock OCD in the QTL region between 24.26 and 42.41 Mb. Furthermore, our analysis revealed a second QTL for fetlock OC between 6.55 and 24.26 Mb on ECA16. This report is a further step towards unravelling the genes underlying QTL for equine OC and towards the development of a marker test for OC in Hanoverian warmblood horses.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Editorial Material Agriculture, Dairy & Animal Science

Segregation of the hereditary thrombopathia-associated polymorphism in polled German Fleckvieh cattle

Ina Zerbin, Julia Metzger, Claudia Dierks, Ottmar Distl

ANIMAL GENETICS (2015)

Article Gastroenterology & Hepatology

Functional variants in the sucrase-isomaltase gene associate with increased risk of irritable bowel syndrome

Maria Henstrom, Lena Diekmann, Ferdinando Bonfiglio, Fatemeh Hadizadeh, Eva-Maria Kuech, Maren von Koeckritz-Blickwede, Louise B. Thingholm, Tenghao Zheng, Ghazaleh Assadi, Claudia Dierks, Martin Heine, Ute Philipp, Ottmar Distl, Mary E. Money, Meriem Belheouane, Femke-Anouska Heinsen, Joseph Rafter, Gerardo Nardone, Rosario Cuomo, Paolo Usai-Satta, Francesca Galeazzi, Matteo Neri, Susanna Walter, Magnus Simren, Pontus Karling, Bodil Ohlsson, Peter T. Schmidt, Greger Lindberg, Aldona Dlugosz, Lars Agreus, Anna Andreasson, Emeran Mayer, John F. Baines, Lars Engstrand, Piero Portincasa, Massimo Bellini, Vincenzo Stanghellini, Giovanni Barbara, Lin Chang, Michael Camilleri, Andre Franke, Hassan Y. Naim, Mauro D'Amato

Article Agriculture, Dairy & Animal Science

Monochorial diamniotic dizygotic twins in a German Shepherd Dog: A case report

C. Urhausen, K. Wolf, A. Beineke, C. Dierks, M. Schmicke, A. Einspanier, A. R. Guenzel-Apel

REPRODUCTION IN DOMESTIC ANIMALS (2017)

Article Veterinary Sciences

Suspected X-linked facial dysmorphia and growth retardation in related Labrador retriever puppies

C. Dierks, H. Hoffmann, F. Heinrich, M. Hellige, M. Hewicker-Trautwein, O. Distl

VETERINARY JOURNAL (2017)

Article Agriculture, Dairy & Animal Science

Allelic heterogeneity of FGF5 mutations causes the long-hair phenotype in dogs

C. Dierks, S. Moemke, U. Philipp, O. Distl

ANIMAL GENETICS (2013)

Editorial Material Agriculture, Dairy & Animal Science

Elimination of keratin 71 as candidate for hairlessness in Don Sphynx cats

C. Dierks, S. Lehner, U. Philipp, O. Distl

ANIMAL GENETICS (2013)

Editorial Material Agriculture, Dairy & Animal Science

A novel myostatin mutation in double-muscled German Gelbvieh

C. Dierks, J. Eder, S. Glatzer, S. Lehner, O. Distl

ANIMAL GENETICS (2015)

Article Multidisciplinary Sciences

A Single Nucleotide Polymorphism within the Interferon Gamma Receptor 2 Gene Perfectly Coincides with Polledness in Holstein Cattle

Sabrina Glatzer, Nina Johanna Merten, Claudia Dierks, Anne Woehlke, Ute Philipp, Ottmar Distl

PLOS ONE (2013)

Article Multidisciplinary Sciences

Two-Exon Skipping within MLPH Is Associated with Coat Color Dilution in Rabbits

Stefanie Lehner, Marion Gaehle, Claudia Dierks, Ricarda Stelter, Jonathan Gerber, Ralph Brehm, Ottmar Distl

PLOS ONE (2013)

Article Multidisciplinary Sciences

Genome-Wide Association Study Identifies Phospholipase C zeta 1 (PLCz1) as a Stallion Fertility Locus in Hanoverian Warmblood Horses

Rahel Schrimpf, Claudia Dierks, Gunilla Martinsson, Harald Sieme, Ottmar Distl

PLOS ONE (2014)

Letter Veterinary Sciences

Trial of a novel diet for epilepsy in dogs

Judith Eckardt, Susanne Kluth, Claudia Dierks, Ute Philipp, Ottmar Distl

VETERINARY RECORD (2013)

Article Genetics & Heredity

A recessive lethal chondrodysplasia in a miniature zebu family results from an insertion affecting the chondroitin sulfat domain of aggrecan

Ann-Kathrin Struck, Claudia Dierks, Marina Braun, Maren Hellige, Anna Wagner, Bernd Oelmaier, Andreas Beineke, Julia Metzger, Ottmar Distl

BMC GENETICS (2018)

Article Agriculture, Dairy & Animal Science

Genome-wide association analysis for lethal brachycephalic-like facial dysmorphia in Labrador Retrievers

D. Vasiliadis, C. Dierks, H. Hoffmann, M. Hellige, M. Hewicker-Trautwein, J. Metzger, O. Distl

ANIMAL GENETICS (2020)

Article Andrology

Testicular yolk sac tumor and impaired spermatogenesis in a Holstein Friesian calf

Lia Schindewolffs, Claudia Dierks, Maike Heppelmann, Marion Gaehle, Marion Piechotta, Andreas Beineke, Ralph Brehm, Ottmar Distl

SYSTEMS BIOLOGY IN REPRODUCTIVE MEDICINE (2015)

Article Veterinary Sciences

Elevated testosterone levels in a racing horse due to an XY testicular disorder of sexual development

Claudia Dierks, Harald Sieme, Marion Piechotta, Stephanie Lehner, Jan Carlos Merkt, Hubert Uphaus, Erich Klug, Ottmar Distl

BERLINER UND MUNCHENER TIERARZTLICHE WOCHENSCHRIFT (2015)

No Data Available