Article
Medicine, General & Internal
Alison Halliday, Richard Bulbulia, Leo H. Bonati, Johanna Chester, Andrea Cradduck-Bamford, Richard Peto, Hongchao Pan
Summary: The international multicentre randomised trial ACST-2 compared the effects of CAS and CEA for asymptomatic patients with severe stenosis, showing that the long-term effects of these two procedures on fatal or disabling stroke are comparable.
Article
Clinical Neurology
Yunlu Tao, Yang Hua, Lingyun Jia, Liqun Jiao, Beibei Liu
Summary: Factors influencing residual stenosis after carotid artery stenting include closed-loop stents, irregular plaques, and plaques with calcification as independent risk factors, while a high radial expansion rate of stents acts as a protective factor. The incidence of restenosis is higher in the group with residual stenosis compared to the group without residual stenosis after 1-year follow-up.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Francis J. Jareczek, Mary Beth Farrell, Erik B. Lehman, Cathy Sila, John B. Terry, David Sacks, Paul Kalapos, Scott D. Simon, Kevin M. Cockroft
Summary: This study compared the measurements of carotid artery stenosis by real-world physicians to those measured by independent expert reviewers. The results showed that real-world operators tend to overestimate the degree of carotid artery stenosis.
Article
Multidisciplinary Sciences
Yaxuan Sun, Yongxia Ding, Kun Meng, Bin Han, Jing Wang, Yan Han
Summary: This study found that carotid artery endarterectomy (CEA) and carotid artery stenting (CAS) resulted in similar outcomes for patients with contralateral carotid occlusion (CCO), with the risk of death being lower for patients treated with CEA. Further high-level evidence is needed to confirm these results.
Article
Clinical Neurology
Francesco Squizzato, Michele Piazza, Edoardo Forcella, Elda Chiara Colacchio, Marny Fedrigo, Annalisa Angelini, Franco Grego, Michele Antonello
Summary: This study compared the quantity of embolized material captured by filters during carotid artery stenting using different stent designs. The use of micromesh stents was associated with a lower embolization rate and embolic filter debris load, especially in patients with hypoechogenic and long plaques and preoperative evidence of asymptomatic ischemic cerebral lesion.
Article
Medicine, General & Internal
Magdalena Piegza, Izabela Jaworska, Jacek Piegza, Kamil Bujak, Pawel Debski, Aleksandra Leksowska, Piotr Gorczyca, Mariusz Gasior, Robert Pudlo
Summary: This study confirms the effectiveness of carotid artery stenting in improving cognitive function, particularly in the areas of psychomotor speed, visuospatial episodic memory, and executive function.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Clinical Neurology
Jie Wang, Xuesong Bai, Tao Wang, Adam A. Dmytriw, Aman B. Patel, Liqun Jiao
Summary: The study found that carotid artery stenting (CAS) and carotid endarterectomy (CEA) have comparable perioperative and long-term composite outcomes in treating asymptomatic carotid artery stenosis, but CAS may have a higher risk of any stroke and nondisabling stroke during the perioperative period.
Article
Multidisciplinary Sciences
Dat Tin Nguyen, Boldizsar Voko, Balazs Bence Nyaradi, Tamas Munkacsi, Akos Berczi, Zoltan Voko, Edit Dosa
Summary: This study evaluated the long-term outcomes of carotid endarterectomy (CEA) and carotid artery stenting (CAS) in patients who underwent both procedures on different sides. The results showed a higher risk of restenosis for CEA compared to CAS.
Article
Radiology, Nuclear Medicine & Medical Imaging
Davide Colombi, Flavio Cesare Bodini, Nicola Morelli, Corrado Ciatti, Pietro Maniscalco, Emanuele Michieletti
Summary: This study aimed to identify predictors of multiwire technique (MWT) use in carotid artery stenting (CAS). The results showed that aortic arch type II or III, carotid plaque stenosis > 79% of the lumen, or absence of heavy concentric calcifications were independent predictors for MWT use during CAS. These features should be considered in CAS planning as indicators of vascular stiffness and higher procedure complexity.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Article
Medicine, General & Internal
Hui-Li Gao, Bing-Sha Han, Kun Zhang, Zi-Liang Wang, Bu-Lang Gao, Tian-Xiao Li, Liang-Fu Zhu
Summary: The effect of carotid artery stenting compared with medication alone on cognitive impairment in patients with severe symptomatic carotid artery stenosis was investigated. The study showed that carotid artery stenting significantly improved cognitive impairment and neurological function compared with medication alone.
Article
Surgery
Paola Batarseh, Michael Parides, Matthew Carnevale, Jeffrey Indes, Evan Lipsitz, Issam Koleilat
Summary: Limited data are available to guide the choice of intervention for patients with radiation-induced carotid stenosis (RICS). The purpose of the present study was to evaluate patients who had undergone these carotid artery interventions for RICS and the associated outcomes. Results showed that RICS patients treated by TCAR in the SVS VQI had the lowest risk.
JOURNAL OF VASCULAR SURGERY
(2022)
Article
Clinical Neurology
You-Min Fan, Han-Yang Liu, Yu-Yang Xue
Summary: This study retrospectively analyzed 6 patients who underwent mechanical thrombectomy for carotid stent thrombosis (CST) and found that this treatment method resulted in satisfactory clinical outcomes. Further prospective and randomized studies are needed to validate its safety and efficacy.
FRONTIERS IN NEUROLOGY
(2023)
Article
Surgery
Yoel Solomon, Rens R. B. Varkevisser, Nicholas J. Swerdlow, Chun Li, Patric Liang, Jeffrey J. Siracuse, Gert J. de Borst, Marc L. Schermerhorn
Summary: This study investigated the perioperative outcomes based on preprocedural symptom status of TFCAS, finding that patients with recent stroke had a significantly higher rate of in-hospital stroke/death compared to other patients, while asymptomatic patients had the lowest risk. The results support further symptom stratification by the degree of presenting neurologic injury in preoperative risk assessment.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Clinical Neurology
Yoichi Miura, Hideki Kanamaru, Ryuta Yasuda, Naoki Toma, Hidenori Suzuki
Summary: This study found that nonfasting serum triglyceride (TG) levels may be an effective marker to predict carotid restenosis after carotid endarterectomy (CEA) or carotid artery stenting (CAS), and could be a new therapeutic target to prevent restenosis after revascularization procedures.
WORLD NEUROSURGERY
(2021)
Review
Surgery
Zeling Guo, Chenshu Liu, Kan Huang, Nan Yu, Meixiu Peng, Benjamin W. Starnes, Warren B. Chow, Zilun Li, Wayne W. Zhang
Summary: This study compared the outcomes of rCAS and CEA in ISR patients, finding similar short- and midterm results in terms of stroke, death, and surgery-related complications.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Uwe Zeymer, Vusal Ahmadli, Steffen Schneider, Karl Werdan, Michael Weber, Sven Hohenstein, Gerhard Hindricks, Steffen Desch, Andreas Bollmann, Holger Thiele
Summary: This study aimed to comprehensively describe hospital admissions and in-hospital mortality during the first wave of the COVID-19 pandemic in all German federal states. The results showed a significant reduction in admissions for NSTEMI and STEMI, while the quality of in-hospital care and in-hospital mortality were not affected.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Immunology
Norman Mangner, Vassili Panagides, David del Val, Mohamed Abdel-Wahab, Lisa Crusius, Eric Durand, Nikolaj Ihlemann, Marina Urena, Costanza Pellegrini, Francesco Giannini, Tomasz Gasior, Wojtek Wojakowski, Martin Landt, Vincent Auffret, Jan-Malte Sinning, Asim N. Cheema, Luis Nombela-Franco, Chekrallah Chamandi, Francisco Campelo-Parada, Erika Munoz-Garcia, Howard C. Herrmann, Luca Testa, Won-Keun Kim, Helene Eltchaninoff, Lars Sondergaard, Dominique Himbert, Oliver Husser, Azeem Latib, Herve Le Breton, Clement Servoz, Philippe Gervais, Melanie Cote, Holger Thiele, David Holzhey, Axel Linke, Josep Rodes-Cabau
Summary: In transcatheter aortic valve related infective endocarditis (IE), absent echocardiographic signs of IE were associated with the same prognosis as evident echocardiographic signs, highlighting the need for early treatment initiation in high-risk patients presenting with positive blood cultures and symptoms of infection after TAVI.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Andrea Scotti, Augustin Coisne, Maurizio Taramasso, Juan F. Granada, Sebastian Ludwig, Josep Rodes-Cabau, Philipp Lurz, Jorg Hausleiter, Neil Fam, Susheel K. Kodali, Joel Rosiene, Ari Feinberg, Alberto Pozzoli, Hannes Alessandrini, Luigi Biasco, Eric Brochet, Paolo Denti, Rodrigo Estevez-Loureiro, Christian Frerker, Edwin C. Ho, Vanessa Monivas, Georg Nickenig, Fabien Praz, Rishi Puri, Horst Sievert, Gilbert H. L. Tang, Martin Andreas, Ralph Stephan Von Bardeleben, Karl-Philipp Rommel, Guillem Muntane-Carol, Mara Gavazzoni, Daniel Braun, Benedikt Koell, Daniel Kalbacher, Kim A. Connelly, Jean-Michel Juliard, Claudia Harr, Giovanni Pedrazzini, Giulio Russo, Francois Philippon, Joachim Schofer, Holger Thiele, Matthias Unterhuber, Dominique Himbert, Marina Urena Alcazar, Mirjam G. Wild, Stephan Windecker, Ulrich Jorde, Francesco Maisano, Martin B. Leon, Rebecca T. Hahn, Azeem Latib
Summary: This study aimed to investigate the impact of sex on treatment outcomes in patients with significant tricuspid regurgitation (TR) undergoing transcatheter tricuspid valve intervention (TTVI). The results showed no significant differences between women and men in terms of 1-year survival, heart failure hospitalization, functional status, and severity of TR after TTVI. Multivariable Cox-regression analysis with inverse probability of treatment weighting (IPTW) demonstrated that TTVI was associated with improved 1-year survival compared to medical therapy alone in both women and men.
EUROPEAN HEART JOURNAL
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Holger Thiele, Steffen Desch, Anne Freund
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Sean Fitzgerald, Maria Rubini Gimenez, Abdelhakim Allali, Ralph Toelg, Dmitriy S. Sulimov, Volker Geist, Adnan Kastrati, Holger Thiele, Gert Richardt, Mohamed Abdel-Wahab
Summary: This study investigated the sex-specific characteristics and outcomes of patients with calcified coronary arteries in the Prepare-CALC trial. The results showed that rotational atherectomy was superior to modified balloon therapy in men, while both strategies had similar success rates in women. There were no significant differences in complications between sexes or treatment strategies.
INTERVENTIONAL CARDIOLOGY-REVIEWS RESEARCH RESOURCES
(2023)
Article
Biochemistry & Molecular Biology
Petra Buettner, Julia Boettner, Knut Krohn, Ronny Baber, Uwe Platzbecker, Michael Cross, Steffen Desch, Holger Thiele, Sabine Steiner, Dierk Scheinert, Klaus H. Metzeler, Daniela Branzan
Summary: In this pilot study, it was found that clonal hematopoiesis (CH)-associated mutations can be detected in both peripheral blood cells and tissues associated with atherosclerosis, suggesting a potential impact on disease physiology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Leonardo De Luca, Raffaella Mistrulli, Riccardo Scirpa, Holger Thiele, Giuseppe De Luca
Summary: Despite improvements in therapies, the outcomes for patients with acute myocardial infarction (AMI) and cardiogenic shock (CS) remain poor. CS occurs in 3-15% of AMI cases, with high mortality rates. Limited evidence-based knowledge and nonuniform management lead to underutilization or overutilization of treatment options. This article aims to provide a critical overview of the literature on CS management, summarizing recent evidence on revascularization strategies, pharmacological treatments, and mechanical circulatory support (MCS) use.
JOURNAL OF CLINICAL MEDICINE
(2023)
Letter
Cardiac & Cardiovascular Systems
Alexander Jobs, Collet Jean-Philippe, Holger Thiele
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
(2023)
Review
Biochemistry & Molecular Biology
Hamza El Hadi, Anne Freund, Steffen Desch, Holger Thiele, Nicolas Majunke
Summary: Cardiomyopathies are a diverse group of heart muscle disorders with potentially fatal consequences such as arrhythmias and heart failure. They are a leading cause of heart transplantation worldwide. Recent advancements in understanding the molecular basis and diagnostic evaluation have paved the way for targeted therapies. However, further research is needed to improve risk assessment and prevention strategies for sudden cardiac death.
Article
Cardiac & Cardiovascular Systems
Jonas Lanz, Helge Moellmann, Won-Keun Kim, Christof Burgdorf, Axel Linke, Simon Redwood, Michael Hilker, Michael Joner, Holger Thiele, Lars Conzelmann, Lenard Conradi, Sebastian Kerber, Christian Thilo, Stefan Toggweiler, Bernard Prendergast, Oliver Husser, Stefan Stortecky, Sarah Deckarm, Arnaud Kuenzi, Dik Heg, Thomas Walther, Stephan Windecker, Thomas Pilgrim
Summary: In the SCOPE I trial, transcatheter aortic valve implantation with the ACURATE neo device did not meet noninferiority compared to the SAPIEN 3 device at 30 days due to higher rates of valve regurgitation and kidney injury. However, after 3 years, there were no significant differences in clinical outcomes or bioprosthetic valve failure between the two devices.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Medicine, General & Internal
Holger Thiele, Uwe Zeymer, Ibrahim Akin, Michael Behnes, Tienush Rassaf, Amir Abbas Mahabadi, Ralf Lehmann, Ingo Eitel, Tobias Graf, Tim Seidler, Andreas Schuster, Carsten Skurk, Daniel Duerschmied, Peter Clemmensen, Marcus Hennersdorf, Stephan Fichtlscherer, Ingo Voigt, Melchior Seyfarth, Stefan John, Sebastian Ewen, Axel Linke, Eike Tigges, Peter Nordbeck, Leonhard Bruch, Christian Jung, Jutta Franz, Philipp Lauten, Tomaz Goslar, Hans-Josef Feistritzer, Janine Poess, Eva Kirchhof, Taoufik Ouarrak, Steffen Schneider, Steffen Desch, Anne Freund, ECLS-SHOCK Investigators
Summary: In patients with acute myocardial infarction complicated by cardiogenic shock, early extracorporeal life support (ECLS) combined with standard medical treatment did not reduce mortality.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Maximilian von Roeder, Mauritius Maeder, Vincent Wahl, Mitsunobu Kitamura, Johannes Rotta Detto Loria, Oliver Dumpies, Karl-Philipp Rommel, Karl-Patrik Kresoja, Stephan Blazek, Ines Richter, Nicolas Majunke, Steffen Desch, Holger Thiele, Philipp Lurz, Mohamed Abdel-Wahab
Summary: This study investigated the prognostic value and clinical utility of left atrial reservoir strain (LARS) in patients undergoing transcatheter aortic valve replacement (TAVR) for aortic stenosis (AS). The results showed that impaired LARS was independently associated with worse outcomes, and LARS assessment allowed for reliable prediction in patients where conventional echocardiographic assessment was unavailable.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Sebastian Rosch, Karl-Philipp Rommel, Stephan Blazek, Karl-Patrik Kresoja, Anne Schoeber, Maximilian von Roeder, Steffen Desch, Holger Thiele, Philipp Lurz, Karl Fengler
Summary: This study pooled data from two previous studies on endovascular ultrasound-based renal denervation (uRDN) and found that uRDN effectively lowered blood pressure for up to 24 months after treatment, with low rates of adverse events.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Andreas Rueck, Won-Keun Kim, Mohamed Abdel-Wahab, Holger Thiele, Tanja K. Rudolph, Alexander Wolf, Jan Martin Wambach, Ole De Backer, Lars Sondergaard, Christian Hengstenberg, Mika Laine, Hirokazu Miyashita, Henrik Bjursten, Matthias Goetberg, Costanza Pellegrini, Stefan Toggweiler, Joanna J. Wykrzykowska, Osama Soliman, Nawzad Saleh, Christopher U. Meduri
Summary: This study aimed to evaluate the safety and efficacy of ACURATE neo2 in transcatheter aortic valve implantation in Europe. The results showed favorable postoperative hemodynamics and clinical outcomes, as well as a low rate of postoperative pacemaker implantation.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Medicine, General & Internal
Johannes Rotta detto Loria, Steffen Desch, Janine Poess, Katharina Kirsch, Holger Thiele, Marcus Sandri
Summary: This systematic review provides a comprehensive evaluation of the clinical application of percutaneous left atrial appendage occlusion (LAAO) in patients with atrial fibrillation (AF) over the past two decades, including anatomical features, patient selection, procedural planning and execution, complications, medical treatment following the procedure, and contemporary outcome data.
JOURNAL OF CLINICAL MEDICINE
(2023)
