Journal
ANGIOLOGY
Volume 62, Issue 7, Pages 523-534Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0003319711401012
Keywords
peroxisome proliferator-activated receptors alpha; atherosclerosis; peroxisome proliferator-activated receptors gamma; atherosclerotic plaque
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Funding
- Ministry of Science, Republic of Serbia [173033, 172001]
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The peroxisome proliferator-activated receptors (PPARs) represent the family of 3 nuclear receptor isoforms-PPAR alpha, -gamma, and -delta/beta, which are encoded by different genes. As lipid sensors, they are primarily involved in regulation of lipid metabolism and subsequently in inflammation and atherosclerosis. Atherosclerosis considers accumulation of the cells and extracellular matrix in the vessel wall leading to the formation of atherosclerotic plaque, atherothrombosis, and other vascular complications. Besides existence of natural ligands for PPARs, their more potent synthetic ligands are fibrates and thiazolidindiones. Future investigations should now focus on the mechanisms of PPARs activation, which might present new approaches involved in the antiatherosclerotic effects revealed in this review. In addition, in this review we are presenting latest data from recent performed clinical studies which have focus on novel approach to PPARs agonists as potential therapeutic agents in the treatment of complex disease such as atherosclerosis.
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