Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 54, Issue 5, Pages 1481-1484Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201409795
Keywords
analytical chemistry; hyperpolarization; NMR spectroscopy; SABRE; trace analysis
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Funding
- European Union
- province of Gelderland through the EFRO Ultrasense NMR project
- province of Overijssel through the EFRO Ultrasense NMR project
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Signal amplification by reversible exchange (SABRE) is an emerging nuclear spin hyperpolarization technique that strongly enhances NMR signals of small molecules in solution. However, such signal enhancements have never been exploited for concentration determination, as the efficiency of SABRE can strongly vary between different substrates or even between nuclear spins in the same molecule. The first application of SABRE for the quantitative analysis of a complex mixture is now reported. Despite the inherent complexity of the system under investigation, which involves thousands of competing binding equilibria, analytes at concentrations in the low micromolar range could be quantified from single-scan SABRE spectra using a standard-addition approach.
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