Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 54, Issue 6, Pages 1885-1887Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201410213
Keywords
amino acids; asymmetric synthesis; hydrogenation; regioselectivity; rhodium
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Funding
- Wuhan University [203273463]
- 111 Project of the Ministry of Education of China
- National Natural Science Foundation of China [21372179, 21432007, 21402145]
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An efficient and highly regio- and enantioselective catalytic asymmetric hydrogenation of ,-dienamido esters to ,-unsaturated amido esters has been achieved using Rh/TangPhos as the catalyst. A series of ,-unsaturated amido acids were furnished in excellent yields with up to 99% ee. This effective methodology was applied in the asymmetric synthesis of key intermediate of Ramipril, an ACE inhibitor.
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