Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 53, Issue 36, Pages 9603-9607Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201405035
Keywords
asymmetric synthesis; cooperative effects; carbenes
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Funding
- NIH [R01-GM073072]
- Northwestern University
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A convergent and efficient transition-metal-free catalytic synthesis of 2-aryl-indoles has been developed. The interception of a highly reactive and transient aza-ortho-quinone methide by an acyl anion equivalent generated through N-hetereocyclic carbene catalysis is central to this successful strategy. High yields and a wide scope as well as the streamlined synthesis of a kinase inhibitor are reported.
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