Rational Design of Modular Polyketide Synthases: Morphing the Aureothin Pathway into a Luteoreticulin Assembly Line

Multifactorial Control of Iteration Events in a Modular Polyketide Assembly Line

(2013) Benjamin Busch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Minimally Invasive Mutagenesis Gives Rise to a Biosynthetic Polyketide Library

(2012) Susanna Kushnir et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Convergent Asymmetric Synthesis of (+)-Aureothin Employing an Oxygenase-Mediated Resolution Step

(2012) Matthias Henrot et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pyran Formation by an Atypical CYP-Mediated Four-Electron Oxygenation-Cyclization Cascade in an Engineered Aureothin Pathway

(2012) Martin Richter et al.   CHEMBIOCHEM

Combinatorial biosynthesis of polyketides—a perspective

(2012) Fong T Wong et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Interchenar Retrotransfer of Aureothin Intermediates in an Iterative Polyketide Synthase Module

(2012) Benjamin Busch et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rational Domain Swaps Decipher Programming in Fungal Highly Reducing Polyketide Synthases and Resurrect an Extinct Metabolite

(2011) Katja M. Fisch et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural Fine-Tuning of a Multifunctional Cytochrome P450 Monooxygenase

(2011) Georg Zocher et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Genomics-inspired discovery of natural products

(2010) Jaclyn M Winter et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Exploiting Enzymatic Promiscuity to Engineer a Focused Library of Highly Selective Antifungal and Antiproliferative Aureothin Analogues

(2010) Martina Werneburg et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Biosynthetic Logic of Polyketide Diversity

(2009) Christian Hertweck   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Revisiting the modularity of modular polyketide synthases

(2009) Chaitan Khosla et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Evolution of metabolic diversity in polyketide-derived pyrones: Using the non-colinear aureothin assembly line as a model system

(2009) Benjamin Busch et al.   PHYTOCHEMISTRY

Sequential Asymmetric Polyketide Heterocyclization Catalyzed by a Single Cytochrome P450 Monooxygenase (AurH)

(2008) Martin E. A. Richter et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Genome Mining for Novel Natural Product Discovery

(2008) Gregory L. Challis   JOURNAL OF MEDICINAL CHEMISTRY

Increasing Complexity of a Diterpene Synthase Reaction with a Single Residue Switch

(2008) Dana Morrone et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Orchestration of Discoid Polyketide Cyclization in the Resistomycin Pathway

(2008) Kathrin Fritzsche et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection

(2008) TuAnh Nguyen et al.   NATURE BIOTECHNOLOGY

Evolution of polyketide synthases in bacteria

(2008) C. P. Ridley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA