Improving Physical Properties via CH Oxidation: Chemical and Enzymatic Approaches

A Simple Litmus Test for Aldehyde Oxidase Metabolism of Heteroarenes

(2014) Fionn O’Hara et al.   JOURNAL OF MEDICINAL CHEMISTRY

Iridium-Catalyzed Regioselective Silylation of Secondary Alkyl C–H Bonds for the Synthesis of 1,3-Diols

(2014) Bijie Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Clinical development success rates for investigational drugs

(2014) Michael Hay et al.   NATURE BIOTECHNOLOGY

Enhanced Reactivity in Dioxirane C–H Oxidations via Strain Release: A Computational and Experimental Study

(2013) Lufeng Zou et al.   JOURNAL OF ORGANIC CHEMISTRY

Complementation of Biotransformations with Chemical C–H Oxidation: Copper-Catalyzed Oxidation of Tertiary Amines in Complex Pharmaceuticals

(2013) Julien Genovino et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

14-Step Synthesis of (+)-Ingenol from (+)-3-Carene

(2013) L. Jorgensen et al.   SCIENCE

Strategic Redox Relay Enables A Scalable Synthesis of Ouabagenin, A Bioactive Cardenolide

(2013) H. Renata et al.   SCIENCE

Catalytic functionalization of unactivated primary C–H bonds directed by an alcohol

(2012) Eric M. Simmons et al.   NATURE

Electron-Rich CpIr(biphenyl-2,2′-diyl) Complexes with π-Accepting Carbon Donor Ligands

(2012) Jonathan Graeupner et al.   ORGANOMETALLICS

A partial synthesis of 23-hydroxybetulonic acid and 23-hydroxybetulinic acid starting from betulinic acid

(2012) Fei Sun et al.   JOURNAL OF CHEMICAL RESEARCH

Innate and Guided C–H Functionalization Logic

(2011) Tobias Brückl et al.   ACCOUNTS OF CHEMICAL RESEARCH

Improving Drug Candidates by Design: A Focus on Physicochemical Properties As a Means of Improving Compound Disposition and Safety

(2011) Nicholas A. Meanwell   CHEMICAL RESEARCH IN TOXICOLOGY

Synthesis and anti-leishmanial activity of heterocyclic betulin derivatives

(2010) Sami Alakurtti et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Ruthenium-Catalyzed Hydroxylation of Unactivated Tertiary C−H Bonds

(2010) Eric McNeill et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dissolution Rate and Apparent Solubility of Poorly Soluble Drugs in Biorelevant Dissolution Media

(2010) Jonas H. Fagerberg et al.   MOLECULAR PHARMACEUTICS

Strain Release in CH Bond Activation?

(2009) Ke Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Novel semisynthetic derivatives of betulin and betulinic acid with cytotoxic activity

(2009) Rita C. Santos et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Total synthesis of eudesmane terpenes by site-selective C–H oxidations

(2009) Ke Chen et al.   NATURE