Article
Chemistry, Multidisciplinary
Lisa Hecker, Wenyu Wang, Ioanna Mela, Saeed Fathi, Chetan Poudel, Giancarlo Soavi, Yan Yan Shery Huang, Clemens F. Kaminski
Summary: The study presents a method for assembling amyloid-polymer hybrid fibers using core-shell electrospinning with microconfinement. It demonstrates that microscale confinement is crucial for guiding the assembly of amyloids.
Article
Biophysics
Avigail Baruch-Leshem, Corinne Chevallard, Frederic Gobeaux, Patrick Guenoun, Jean Daillant, Philippe Fontaine, Michel Goldmann, Ariel Kushmaro, Hanna Rapaport
Summary: The order of the catalytic triad residues along amphiphilic beta-strands affects both assembly structures and catalytic activity. The amphiphilic peptide ESH achieved the highest catalytic efficiency at a concentration of 250 μM.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Yunlong Zhang, Donglei Yang, Pengfei Wang, Yonggang Ke
Summary: Structural DNA nanotechnology enables the fabrication of designer nanoscale artificial architectures. In this study, we developed a molecular assembly system where DNA tiles can assemble into tubes and then large one-dimensional DNA bundles. By incorporating a cohesive link into the tiles, we induced intertube binding and successfully formed DNA bundles with micrometer-length and nanometer-width, whose assembly was collectively determined by cationic strength and linker designs. Moreover, programmable spatial features and compositions of multicomponent DNA bundles were realized. Lastly, dynamic capability was implemented to achieve reversible reconfigurations among tile, tube, and bundles. This assembly strategy expands the toolbox of DNA nanotechnology and has broad applications in materials science, synthetic biology, biomedical science, and beyond.
Article
Chemistry, Multidisciplinary
Chongyang Wu, Hongyue Zhang, Nan Kong, Bihan Wu, Xinhui Lin, Huaimin Wang
Summary: Chirality correction, asymmetry, ring-chain tautomerism, and hierarchical assemblies are fundamental phenomena in nature that affect the functions of proteins and other supermolecules. A designed alternating D,L peptide was used to recreate and validate the chirality inversion prior to cyclization. The resulting asymmetrical cyclic peptide with a 4-imidazolidinone ring provides a platform to study tautomerism, thermostability, and assembly of nanostructures.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Physical
Li Zhang, Ming Deng, Yu Duan, Xin Wen, Yuqian Jiang, Hejin Jiang, Yuqiang Ma, Minghua Liu
Summary: The study found that tree-shaped fractal patterns could be self-assembled from Fmoc-Glu and ZnTPyP, composed of nanorod aggregate arranged in a spiral fractal way. The formation and growth of initial nucleon led to the fractal patterns, and the spiral packing and their branches were closely related to the absolute configuration of Fmoc-Glu.
Article
Chemistry, Multidisciplinary
Ana Margarida Goncalves Carvalho Dias, Ines Pimentel Moreira, Iana Lychko, Catia Lopes Soares, Arianna Nurrito, Armenio Jorge Moura Barbosa, Viviane Lutz-Bueno, Raffaele Mezzenga, Ana Luisa Carvalho, Ana Sofia Pina, Ana Cecilia Afonso Roque
Summary: This study investigates the molecular self-assembly mechanism of a protopeptide sequence. The results demonstrate that the protopeptide can assemble into supramolecular hydrogels under different environmental cues, and the prepared protopeptide films exhibit optical activity.
FRONTIERS IN CHEMISTRY
(2023)
Article
Biochemical Research Methods
Jui-Wen Chang, Rajan Deepan Chakravarthy, Nien-Tzu Chu, Jyun-Cheng Liu, Mei-Yu Yeh, Hsin-Chieh Lin
Summary: We have developed a new peptide-based urchin-shaped structure by self-assembly of tetraphenylethylenediserine (TPE-SS). The self-assembly process resulted in the formation of nanobelts, which further transformed into urchin-like microstructures with nanosized spines. The hydrogelator containing TPE moiety showed aggregation-induced emission characteristics and had the lowest molecular weight among TPE-capped hydrogelators with beta-sheet-like structures. This new design strategy has potential applications in generating three-dimensional self-assembled microstructures and multifunctional biomaterials.
BIOCONJUGATE CHEMISTRY
(2023)
Editorial Material
Physics, Multidisciplinary
Susan Kempinger
Summary: Advancements in precision lithography and measurement have enabled the observation and control of magnetic phase transition in kagome artificial spin ice, potentially leading to the development of new technological devices.
Article
Biotechnology & Applied Microbiology
Baoshan Li, Junyi Song, Ting Mao, Ling Zeng, Zonghuang Ye, Biru Hu
Summary: Barnacles adhere to solid surfaces by secreting protein adhesives. In this study, a functional motif of a barnacle protein was identified to have unique self-assembly and wet-binding characteristics. The presence of cysteines and disulfide bonds was found to play a crucial role in the self-assembly and wet binding of the protein.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Ashley K. Nguyen, Thomas G. Molley, Egi Kardia, Sylvia Ganda, Sudip Chakraborty, Sharon L. Wong, Juanfang Ruan, Bethany E. Yee, Jitendra Mata, Abhishek Vijayan, Naresh Kumar, Richard D. Tilley, Shafagh A. Waters, Kristopher A. Kilian
Summary: This article reports the discovery of a short peptide based on the tryptophan zipper motif, which shows multiscale hierarchical ordering and displays antimicrobial and self-healing properties. It can be used for cell delivery and bioprinting, and has important implications for supramolecular assembly of soft materials in biotechnology and medicine.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Sumit Roy, Venkata Sai Sreyas Adury, Anish Rao, Soumendu Roy, Arnab Mukherjee, Pramod P. Pillai
Summary: This study reports the design of a multifunctional bioplasmonic network through the long-range self-assembly ability of ATP in the presence of cations and gold nanoparticles. The coordination of ATP-Ca2+ helps regulate the electrostatic interaction, transforming an uncontrolled precipitation into a kinetically controlled aggregation process. Additionally, ATP and AuNP retain their inherent properties in the multifunctional bioplasmonic network, and the electrostatically directed self-assembly process is applicable to different nucleotide-nanoparticle systems.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Andreas Frank, Christian Hils, Melina Weber, Klaus Kreger, Holger Schmalz, Hansooo-Werner Schmidt
Summary: By matching the functional groups of the surface patches on polymer fibers with the corresponding substituents of BTAs, specific superstructures can be induced.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Man-Di Wang, Gan-Tian Lv, Hong-Wei An, Ni-Yuan Zhang, Hao Wang
Summary: This study reports a programmable peptide molecule that enables specific and efficient assembly by binding to targeting receptor proteins. By designing different peptide sequences and receptor bindings, it is possible to promote oligomerization and functional regulation of protein complexes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Biochemistry & Molecular Biology
Tomoyuki Koga, Shinya Kingetsu, Nobuyuki Higashi
Summary: This study focuses on the hierarchical self-assembly of collagen-mimetic peptides with aromatic groups at the N-termini, forming nanofibers with diverse structures. Some CMPs successfully formed natural collagen-like nanofibers, while others formed rod-like micelle fibers. Additionally, the Py-CMP6 nanofiber was able to encapsulate a guest hydrophobic molecule and exhibit unique emission behavior.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Yijia Li, Linlu Zhao, Hongwei Chen, Ruizhen Tian, Fei Li, Quan Luo, Jiayun Xu, Chunxi Hou, Junqiu Liu
Summary: This dynamically reversible two-dimensional protein assembly system was designed based on host-guest interactions and triggered to disassemble via a competition mechanism. The artificially tunable and reversible protein assembly architectures have great potential for on/off switches in bio-systems.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Qingquan Han, Chao Zhang, Taoming Guo, Yajie Tian, Wei Song, Jiaxin Lei, Qi Li, Anhe Wang, Milin Zhang, Shuo Bai, Xuehai Yan
Summary: This study develops a hydrogel network with tissue-like modulus and excellent flexibility by using polyvinyl alcohol and polyvinylpyrrolidone, and integrates polydopamine nanoparticles to improve transparency, self-adhesion, and impedance of the hydrogel. The multichannel and wirelessly operated hydrogel electrode can establish a conformal and stable interface with tissue, exhibiting high channel uniformity, low interfacial contact impedance, low power noise, long-term stability, and tolerance to sweat and motion. Furthermore, the hydrogel electrode demonstrates unprecedented ability to classify high-quality prefrontal EEG signals into seven-category sustained attention with high accuracy, showing potential applications in assessing human consciousness and multifunctional diagnoses.
ADVANCED MATERIALS
(2023)
Article
Meteorology & Atmospheric Sciences
Qian Zou, Quanjia Zhong, Jiangyu Mao, Ruiqiang Ding, Deyu Lu, Jianping Li, Xuan Li
Summary: Based on a simple coupled Lorenz model, this study investigates how to assess an appropriate initial perturbation scheme for ensemble forecasting in a multiscale system. Four initial perturbation approaches are used, and the results show that the ensemble averages perform better than the control forecast after short lead times in a fast subsystem and after a relatively long period of time in a slow subsystem. Adding perturbations to fast variables or slow variables can contribute to an improvement in the forecasting skill for these variables. The nonlinear local Lyapunov vectors (NLLVs) show higher forecasting skill compared to bred vectors (BVs) or random perturbations (RPs).
ADVANCES IN ATMOSPHERIC SCIENCES
(2023)
Review
Chemistry, Physical
Yamei Liu, Rui Chang, Ruirui Xing, Xuehai Yan
Summary: Immunogenic cell death (ICD)-induced immunotherapy combines tumor cell killing and immune response to eliminate cancer. Bioactive peptide nanodrugs based on supramolecular assembly have been used as an intelligent delivery system, direct ICD inducers, and immune response enhancers to improve ICD-induced cancer immunotherapy.
Review
Multidisciplinary Sciences
Yamei Liu, Ruirui Xing, Junbai Li, Xuehai Yan
Summary: Covalently triggered peptide self-assembly has been developed for cancer theranostics, providing enhanced stability and functionality compared to noncovalent interactions. The review summarizes the design principles for constructing various peptide-based assemblies and discusses representative covalently assembled peptide-based nanodrugs, along with their challenges and potential in clinical applications for cancer diagnosis and therapeutics. This review offers new insights into the construction of peptide-based nanodrugs through covalent reaction and noncovalent self-assembly.
Review
Biochemistry & Molecular Biology
Bowen Li, Yan Huang, Qianli Zou
Summary: Liver fibrosis is a process of excessive accumulation of extracellular matrix caused by liver injury. Development of safe and effective antifibrotic drugs is important, but no effective therapeutic drugs have been approved for treating liver fibrosis. Peptides, with their advantages of biological origination, synthetic availability, and good biocompatibility, have been investigated as key components for constructing antifibrotic nanomaterials. This review focuses on peptide-based nanoarchitectonics for treating liver fibrosis, including liver-targeting peptides, delivery of antifibrotic peptides, and self-assembled peptide nanomaterials.
Article
Chemistry, Multidisciplinary
Wenjia Zhang, Shukun Li, Yamei Liu, Ruirui Xing, Zhengyu Jin, Xuehai Yan, Huadan Xue
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a devastating solid malignancy with a profuse fibrotic stromal reaction, hypoxia, and an immunosuppressive microenvironment. Immunotherapy has shown limited success in improving PDAC survival, so there is an urgent need for strategies that specifically target the immunosuppressive tumor microenvironment (TME) and immune-related therapeutic resistance. Photothermal immunotherapy, which combines local tumor hyperthermia with immune remodeling, has shown promise in PDAC treatment. This study develops an injectable peptide-based hydrogel integrated with near-infrared photothermal pigment and an immunomodulatory peptide for local PDAC administration and treatment, effectively inhibiting tumor recurrence and metastasis.
Article
Multidisciplinary Sciences
Ruirui Xing, Chengqian Yuan, Wei Fan, Xiaokang Ren, Xuehai Yan
Summary: This article introduces a green glass made from amino acids or peptides of biological origin, which has excellent glass-forming ability and optical characteristics. It can be used for three-dimensional printing and mold casting. Compared with commercial glasses and plastic materials, this glass has better biocompatibility, biodegradability, and biorecyclability.
Article
Chemistry, Multidisciplinary
Yanchen Liu, Haoning Gong, Zhiwei Wang, Chengqian Yuan, Jianren Lu, Xuehai Yan
Summary: A new antimicrobial peptide hydrogel based on supramolecular self-assembly is developed, which exhibits strong antimicrobial activity against resistant strains and high cytocompatibility. The hydrogel also has immunoregulative activity and shows promising potential in treating skin abscess disease caused by methicillin-resistant Staphylococcus aureus infection. This study not only provides insights into the design of supramolecular AMP hydrogels and their immune-related antimicrobial actions, but also advances the development of self-assembly peptide platforms to combat antimicrobial resistant infections.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Kai Liu, Alex Blokhuis, Chris van Ewijk, Armin Kiani, Juntian Wu, Wouter H. Roos, Sijbren Otto
Summary: Darwinian evolution involves inheritance and selection of variations in reproducing entities. The replicating entities can affect their environment, generating reciprocal feedback on evolutionary dynamics. The onset of such eco-evolutionary dynamics marks a stepping stone in the transition from chemistry to biology.
Article
Chemistry, Multidisciplinary
Bowen Li, Yan Huang, Jianwei Bao, Zixuan Xu, Xuehai Yan, Qianli Zou
Summary: We report the use of supramolecular nanoarchitectonics to fabricate nanodrugs from therapeutic peptides for treating liver fibrosis. Self-assembling antagonist peptides are designed and manipulated into uniform peptide nanoparticles with well-defined nanostructures and uniform sizes. The peptide nanoparticles show enhanced accumulation in liver sites and limited distribution in other tissues. In vivo results demonstrate greatly enhanced anti-fibrotic activity compared to the pristine antagonist along with good biocompatibility. These findings highlight the potential of self-assembly as a promising nanoarchitectonics approach to enhance the anti-fibrotic activity of therapeutic peptides for treating liver fibrosis.
Article
Multidisciplinary Sciences
Shukun Li, Rui Chang, Luyang Zhao, Ruirui Xing, Jan C. M. van Hest, Xuehai Yan
Summary: This study describes the enhanced TPA fluorescence imaging capacity of self-assembling near-infrared cyanine dye-based nanoprobes based on a photo-oxidation enhanced emission mechanism.
NATURE COMMUNICATIONS
(2023)
Article
Materials Science, Multidisciplinary
Peng Zhou, Ruirui Xing, Qi Li, Junbai Li, Chengqian Yuan, Xuehai Yan
Summary: Controlling the morphology of supramolecular hydrogels is crucial in tuning their mechanical properties. This study investigates the evolution of fibrillar networks in hydrogels by modulating droplets formed via liquid-liquid phase separation. The size and amount of droplets, as well as the structural evolution and network development, can be finely tuned by varying the thermal history. The findings provide insights into the role of phase-separated droplets in self-assembling networks and contribute to the engineering of supramolecular hydrogels with adjustable mechanical properties.
Review
Chemistry, Multidisciplinary
Rui Chang, Luyang Zhao, Ruirui Xing, Junbai Li, Xuehai Yan
Summary: This review summarizes recent advances in chromopeptide nanoarchitectonics, focusing on the design strategy, assembly mechanism, and structure-function relationship. The effect of peptide sequences and the variation in photophysical performance are critically emphasized. Various applications, including biomedicine and artificial photosynthesis, are discussed, along with the future prospects of chromopeptide nanoarchitectonics.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Engineering, Biomedical
Yan Xue, Jieling Li, Tianhe Jiang, Qingquan Han, Yafeng Jing, Shuo Bai, Xuehai Yan
Summary: An anisotropic and conductive hydrogel scaffold fabricated using gelatin methacryloyl (GelMA) and silver nanowire (AgNW) has shown great potential in promoting muscle repair through contact cues and electrical stimulation.
ADVANCED HEALTHCARE MATERIALS
(2023)
