Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 54, Issue 3, Pages 833-837Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201408907
Keywords
allosteric receptors; dynamic combinatorial chemistry; molecular dynamics; supramolecular chemistry; systems chemistry
Categories
Funding
- University of Groningen (Ubbo Emmius Fellowship)
- COST [CM1005, CM1304]
- Dynamol Marie Curie ITN
- ERC
- NWO
- Ministry of Education, Culture and Science [024.001.035]
Ask authors/readers for more resources
Allosteric synthetic receptors are difficult to access by design. Herein we report a dynamic combinatorial strategy towards such systems based on the simultaneous use of two different templates. Through a process of simultaneous casting (the assembly of a library member around a template) and molding (the assembly of a library member inside the binding pocket of a template), a Russian-doll-like termolecular complex was obtained with remarkable selectivity. Analysis of the stepwise formation of the complex indicates that binding of the two partners by the central macrocycle exhibits significant positive cooperativity. Such allosteric systems represent hubs that may have considerable potential in systems chemistry.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available